Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidative stress markers in Graves’ ophthalmopathy

We investigated oxidative stress markers and metal ions in patients with Alzheimer’s disease (AD). The serum levels of ceruloplasmin (CER), C-reactive protein (CRP), uric acid (UA), homocysteine (Hcy), copper, iron, and zinc were determined in 125 patients with AD (mild, n = 2 8; moderate, n = 42; and severe, n = 55) and 40 healthy control (HC) participants. Compared to HC, CER and UA levels were significantly lower in moderate and severe AD groups, whereas CRP and Hcy levels were significantly higher in the severe AD group. Copper level was significantly higher in moderate and severe AD groups than the other groups. Compared to HC, iron level was significantly higher in patients with AD, whereas zinc level was significantly lower in patients with AD. In patients with AD, the severity of cognitive impairment was positively correlated with CER, UA, and zinc levels, whereas it was negatively correlated with copper level. Taken together, our findings provide a novel approach to assess AD progression.

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Serum Levels of Oxidative Stress Markers in Patients with Type 2 Diabetes Mellitus and Non-alcoholic Steatohepatitis

Romanian Journal of Internal Medicine ◽

10.1515/rjim-2016-0035 ◽

2016 ◽

Vol 54 (4) ◽

pp. 228-236 ◽

Cited By ~ 5

Author(s):

F. Casoinic ◽

D. Sampelean ◽

Anca D. Buzoianu ◽

N. Hancu ◽

Dorina Baston

Keyword(s):

Oxidative Stress ◽

Fatty Liver Disease ◽

Serum Levels ◽

Protein Carbonyls ◽

Oxidative Stress Markers ◽

Multivariate Logistic Regression ◽

Alcoholic Fatty Liver ◽

Stress Markers ◽

Alcoholic Fatty Liver Disease

Abstract Introduction. Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls. Materials and methods. In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study. The serum levels of protein carbonyls and 8-isoprostane were determined by ELISA methods, while the serum levels of malondialdehyde (MDA) were detected by means of the spectrophotometric method. Clinical, demographic, and laboratory parameters were examined for all the subjects included in the study. Multivariate logistic regression was used to test the independent predictive factors in the relationships investigated here. Results. Patients with DMT2 and NASH displayed significantly higher serum levels of protein carbonyls (1.112 ± 0.42 nmol/dL), MDA (6.181 ± 1.81 ng/mL), and 8-isoprostane (338.6 ± 98.5 pg/mL) compared to patients with DMT2 without NAFLD, and controls. Results of multivariate logistic regression analyses indicate that in patients with DMT2 and NASH, the serum levels of oxidative stress markers were independently and positively associated with: HbA1c, duration of diabetes, the UKPDS cardiovascular risk score (for protein carbonyls); age, LDL-cholesterol (for 8-isoprostane); and triglycerides serum levels (for MDA). Conclusions. Our findings indicate that the process of oxidative stress tends to increase in patients with DMT2 and NASH, compared to patients with DMT2 without NAFLD, and controls. This evidence suggests that an antioxidant therapy might prove useful in the treatment of patients with DMT2 and NASH.

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Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Experimental Biomedical Research ◽

10.30714/j-ebr.2020361047 ◽

2020 ◽

Vol 3 (3) ◽

pp. 126-132

Author(s):

Ulku Mete Ural ◽

Ahmet Alver ◽

Hasan Efe ◽

Ayse Senturk ◽

Imran Ince ◽

...

Keyword(s):

Oxidative Stress ◽

Carbonic Anhydrase ◽

Serum Levels ◽

Oxidative Stress Markers ◽

Stress Markers

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The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666191116112950 ◽

2020 ◽

Vol 20 (5) ◽

pp. 718-727 ◽

Cited By ~ 2

Author(s):

Mahsa Omidian ◽

Mina Abdolahi ◽

Elnaz Daneshzad ◽

Mohsen Sedighiyan ◽

Mohadeseh Aghasi ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Clinical Trials ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Serum Levels ◽

Oxidative Stress Marker ◽

Cochrane Library ◽

Oxidative Stress Markers ◽

Stress Markers

Objective: Recent trial studies have found that resveratrol supplementation beneficially reduces oxidative stress marker, but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of resveratrol supplementation on oxidative stress parameters. Methods: We searched databases of Pubmed, Scopus and Cochrane Library up to December 2018 with no language restriction. Studies were reviewed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane handbook. To compare the effects of resveratrol with placebo, weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled based on the random-effects model. Results: Among sixteen clinical trials, we found that resveratrol supplementation increased GPx serum levels significantly (WMD: 18.61; 95% CI: 8.70 to 28.52; P<0.001) but had no significant effect on SOD concentrations (WMD: 1.01; 95% CI: -0.72 to 2.74; P= 0.25), MDA serum levels (WMD: -1.43; 95% CI: -3.46 to 0.61; P = 0.17) and TAC (WMD: -0.09; 95% CI: -0.29 to 0.11; P = 0.36) compared to placebo. Finally, we observed that resveratrol supplementation may not have a clinically significant effect on oxidative stress. Conclusion: However, the number of human trials is limited in this context, and further large prospective clinical trials are needed to confirm the effect of resveratrol supplement on oxidative stress markers.

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Evaluation of Serum Levels of Inflammation, Fibrinolysis and Oxidative Stress Markers in Coronary Artery Disease Prediction: A Cross-Sectional Study

Arquivos Brasileiros de Cardiologia ◽

10.5935/abc.20190214 ◽

2019 ◽

Cited By ~ 1

Author(s):

Iran Castro ◽

Hugo Fontana Filho

Keyword(s):

Oxidative Stress ◽

Serum Levels ◽

Cross Sectional Study ◽

Disease Prediction ◽

Oxidative Stress Markers ◽

Sectional Study ◽

Cross Sectional ◽

Stress Markers ◽

Artery Disease ◽

And Oxidative Stress

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Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density

Biomarker Insights ◽

10.1177/1177271919843825 ◽

2019 ◽

Vol 14 ◽

pp. 117727191984382 ◽

Cited By ~ 2

Author(s):

Fawaz Y Azizieh ◽

Diaa Shehab ◽

Khaled Al Jarallah ◽

Renu Gupta ◽

Raj Raghupathy

Keyword(s):

Oxidative Stress ◽

Bone Mineral Density ◽

Superoxide Dismutase ◽

Postmenopausal Women ◽

Bone Mineral ◽

Serum Levels ◽

Oxidative Stress Markers ◽

Mineral Density ◽

Stress Markers ◽

And Oxidative Stress

Introduction: Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial. The aim of this study was to measure circulatory levels of these parameters in postmenopausal women with normal or low BMD. Methods: The study population included 71 postmenopausal women, of whom 25 had normal BMD, 31 had osteopenia, and 15 had osteoporosis. Serum levels of RANKL, OPG, and 5 oxidative stress markers (catalase, peroxiredoxin 2 [PRX2], superoxide dismutase 1 [SOD1], superoxide dismutase 2 [SOD2], and thioredoxin [TRx1]) were measured using the Multiplex system. Results: As compared with subjects having normal BMD, subjects with low BMD had significantly lower median serum levels of OPG, catalase, SOD2, and PRX2 ( P = .004, .031, .044, and .041 respectively). Although levels of RANKL were not different between the 2 groups, the RANKL/OPG ratio was higher in women with low BMD ( P = .027). Conclusions: These data provide insights into the possible roles of OPG, RANKL, and oxidative stress in the pathogenesis of postmenopausal osteoporosis. However, the lack of association between these markers and BMD indicates that osteoporosis is complex and multivariate.

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