Does the Antimigraine Action of Flunarizine Involve the Dopaminergic System? A Clinical-Neuroendocrinological Study

Cephalalgia ◽  
1999 ◽  
Vol 19 (1) ◽  
pp. 27-31 ◽  
Author(s):  
LM Cupini ◽  
E Troisi ◽  
F Placidi ◽  
M Diomedi ◽  
M Silvestrini ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Therapeutic Response ◽  
Dopaminergic System ◽  
Dopamine Receptor Agonist ◽  
System A ◽  
Before And After ◽  
Headache Diary ◽  
Daily Headache ◽  
Prolactin Response ◽  
Late Follicular Phase

We have investigated the prolactin response to bromocriptine (BRC), a D2 dopamine receptor agonist in migrainous women before and after treatment with flunarizine. We evaluated whether this test was predictive of therapeutic efficacy of flunarizine treatment and whether the therapeutic response to flunarizine treatment was related to its effect on dopaminergic system at tuberoinfundibular level. Ten migrainous women underwent a BRC test in the late follicular phase before and after 1 and 3 months of treatment with flunarizine 10 mg at bedtime. Blood samples of prolactin (PRL), growth hormone, follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone were taken at basal condition. PRL was also evaluated 1 and 2 h after BRC (2.5 mg) administration. Each patient kept a daily headache diary for 1 month prior to the test and throughout the study. The level of PRL inhibition after BRC administration, observed before flunarizine treatment, was not predictive of the therapeutic response observed after 1 and 3 months of treatment. The effect of flunarizine on PRL level was not related to the therapeutic efficacy of the drug. These data suggest that flunarizine does not attenuate the activity of dopaminergic neurons in migrainous patients, and that the antimigraine effect of flunarizine does not seem related to its action on dopaminergic system at least at tuberoinfundibular level.

Daily Headache Diary Improves Diagnosis

2011 ◽  
Vol 39 (11) ◽  
pp. 28-29
Author(s):  
DAMIAN McNAMARA
Keyword(s):  
Headache Diary ◽  
Daily Headache

2-Phenyl-3-(phenylselanyl)benzofuran elicits acute antidepressant-like action in male Swiss mice mediated by modulation of the dopaminergic system and reveals therapeutic efficacy in both sexes

2021 ◽  
Author(s):  
Taís da Silva Teixeira Rech ◽  
Amália Gonçalves Alves ◽  
Dianer Nornberg Strelow ◽  
Letícia Devantier Krüger ◽  
Luiz Roberto Carraro Júnior ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Dopaminergic System ◽  
Swiss Mice

CHANGES IN THE CONCENTRATION OF PITUITARY AND STEROID HORMONES IN THE FOLLICULAR FLUID OF HUMAN GRAAFIAN FOLLICLES THROUGHOUT THE MENSTRUAL CYCLE

1975 ◽  
Vol 64 (3) ◽  
pp. 555-571 ◽  
Author(s):  
K. P. McNATTY ◽  
W. M. HUNTER ◽  
A. S. McNEILLY ◽  
R. S. SAWERS
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Follicular Fluid ◽  
Follicle Stimulating Hormone ◽  
Secretory Activity ◽  
Follicular Phase ◽  
Hormonal Changes ◽  
Peripheral Plasma ◽  
Before And After ◽  
Late Follicular Phase

SUMMARY The concentrations of FSH, LH, prolactin, oestradiol and progesterone were measured in peripheral plasma and follicular fluid of women throughout the menstrual cycle. With the exception of prolactin, concentrations of pituitary and steroid hormones in follicular fluid correlated with those in peripheral plasma. Follicle-stimulating hormone was present in a greater number of small follicles ( < 8 mm) during or just after the peaks of FSH in peripheral plasma. During the mid-follicular phase the concentration of both FSH and oestradiol in fluid from large follicles ( ≥ 8 mm) was high. During the late follicular phase the large follicles ( ≥ 8 mm) contained high amounts of progesterone in addition to oestradiol, low physiological levels of prolactin, and concentrations of LH and FSH about 30 and 60% respectively of those found in plasma. By contrast no large 'active' follicles ( ≥ 8 mm) were found during the luteal phase although many contained both LH and FSH. Luteinizing hormone was present in a proportion of small follicles ( < 8 mm) during the late follicular and early luteal but not at other stages of the menstrual cycle. It is suggested that a precise sequence of hormonal changes occur within the microenvironment of the developing Graafian follicle; the order in which they occur may be of considerable importance for the growth of that follicle and secretory activity of the granulosa cells both before and after ovulation.

scholarly journals Computed Tomography and Bronchoscopy in Endobronchial Tuberculosis

2003 ◽  
Vol 10 (8) ◽  
pp. 445-448 ◽  
Author(s):  
Halil Yanardag ◽  
Cüneyt Tetikkurt ◽  
Seza Tetikkurt ◽  
Sabriye Demirci ◽  
Tuncer Karayel
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Therapeutic Response ◽  
Histopathological Examination ◽  
Computed Tomographic ◽  
Before And After ◽  
Endobronchial Tuberculosis ◽  
Age Range

BACKGROUND: The therapeutic response to endobronchial tuberculosis is usually evaluated by bronchoscopy. Currently, there are no published studies investigating the use of computed tomography for the evaluation of therapeutic response in endobronchial tuberculosis.OBJECTIVE: A retrospective study was performed to evaluate the bronchoscopic and computed tomographic features of endobronchial tuberculosis before and after treatment. The aim of this study was to investigate the usefulness of computed tomography for the assessment of treatment.METHODS: The clinical, pathological and bronchoscopic features of endobronchial tuberculosis were evaluated in 55 patients. The age range of the patients was 21 to 52 years. Computed tomography and bronchoscopy were performed before and after treatment.RESULTS: Diagnosis of tuberculosis was confirmed by culture and histopathological examination. Bronchoscopic examination revealed 89 endobronchial lesions of various types in 55 patients. The exudative type was the most common. Follow-up bronchoscopy revealed that exudative-, ulcerative- and granular-type lesions healed completely. Computed tomography performed after treatment correlated well with the follow-up bronchoscopic findings.CONCLUSION: The results suggest that follow-up computed tomography is useful for the evaluation of therapeutic response and complications associated with endobronchial tuberculosis, and may replace bronchoscopy.

Drug dreams, drug craving e misura dell'attivitŕ del sistema limbico attraverso il Limbic System Checklist (LSCL-33): uno studio pilota su un caso clinico

2009 ◽  
pp. 85-91
Author(s):  
Claudio Colace
Keyword(s):  
Limbic System ◽  
Crucial Role ◽  
Clinical Utility ◽  
Dopaminergic System ◽  
Drug Craving ◽  
System A

- This case report‘suggests that drugs dreams and drug craving are associate with a temporo-limbic irritability. This data are consistent with Johnson's neuropsychoanalytic hypothesis about drug dreams and with current neuropsychological approach to dreaming that ascribes to a mesolimbic- mesocortical dopaminergic system a crucial role in the instigation of dream. The data observed also confirm the clinical utility of drugs dreams in to signal an increase of drug craving with the possibility for therapist to anticipate actions of containment of this.

scholarly journals Label-free quantitative proteomic analysis reveals potential biomarkers for early healing in cutaneous leishmaniasis

PeerJ ◽  
2019 ◽  
Vol 6 ◽  
pp. e6228 ◽  
Author(s):  
Andrés Montoya ◽  
Manuel Carlos López ◽  
Ivan D. Vélez ◽  
Sara M. Robledo
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Differential Expression ◽  
Calcium Binding ◽  
Therapeutic Response ◽  
Label Free ◽  
Early Biomarkers ◽  
Parasitological Diagnosis ◽  
Pcr Rflp ◽  
Before And After ◽  
Globally Distributed

Background Leishmaniasis is a parasitic disease caused by more than 20 species of the Leishmania genus. The disease is globally distributed and is endemic in 97 countries and three territories in the tropical and subtropical regions. The efficacy of the current treatments is becoming increasingly low either due to incomplete treatment or resistant parasites. Failure of treatment is frequent, and therefore, the search for early biomarkers of therapeutic response in cutaneous leishmaniasis (CL) is urgently needed. Objective The aim of this study was to compare the proteomic profiles in patients with CL before and after 7 days of treatment and identify early biomarkers of curative response. Methods Four patients with a parasitological diagnosis of leishmaniasis with confirmation of species by PCR-RFLP were recruited. All patients had a single lesion, and a protein from the middle of the ulcer was quantified by liquid chromatography and mass spectrometry. Results A total of 12 proteins showed differential expression in the comparative LC-electrospray ionization MS/MS (LC-ESI-MS/MS) triplicate analysis. Seven of them were up-regulated and five of them were down-regulated. Calcium binding proteins A2, A8, and A9 and hemoglobin subunits alpha-2 and delta showed high correlation with epidermis development and immune response. Conclusion We identified changes in the profiles of proteins that had a positive therapeutic response to the treatment. The proteins identified with differential expression are related to the reduction of inflammation and increased tissue repair. These proteins can be useful as biomarkers for early monitoring of therapeutic response in CL.

Alcoholism and the dopaminergic system: a review

1996 ◽  
Vol 1 (4) ◽  
pp. 333-348 ◽  
Author(s):  
ERNEST NOBLE
Keyword(s):  
Dopaminergic System ◽  
System A

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

2021 ◽  
Author(s):  
Yue Yan ◽  
Binlong Chen ◽  
Qingqing Yin ◽  
Zenghui Wang ◽  
Ye Yang ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Therapeutic Efficacy ◽  
Near Infrared ◽  
Therapeutic Response ◽  
Intracellular Distribution ◽  
Infrared Light ◽  
Dual Responsive ◽  
Efficient Delivery ◽  
Ratiometric Imaging ◽  
Intracellular Targets

Abstract Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while the extracellular targets are equally important for cancer treatment. Notably, the contribution of extracellularly distributed nanoparticles to therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up the intracellular and extracellular fluorescence signals by acidic endocytic pH and near-infrared light. Enabled by MRIN nanotechnology, we accurately quantify the extracellular and intracellular distribution of nanoparticles in several tumor models, which account for 65-80% and 20-35% of total tumor exposure, respectively. Given that the majority of nanoparticles are trapped in extracellular regions, we successfully dissect the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy, thereby maximize the treatment outcome. Our study provides key strategies to precisely quantify nanocarrier microdistribtion and engineer multifunctional nanomedicines for efficient theranostics.

scholarly journals An ACGME Duty Hour Compliant 3-Person Night Float System for Neurological Surgery Residency Programs

2014 ◽  
Vol 6 (2) ◽  
pp. 315-319 ◽  
Author(s):  
Brian T. Ragel ◽  
Mark Piedra ◽  
Paul Klimo ◽  
Kim J. Burchiel ◽  
Heidi Waldo ◽  
...  
Keyword(s):  
Work Schedule ◽  
Meaningful Difference ◽  
Residency Programs ◽  
Night Float ◽  
System A ◽  
Oregon Health ◽  
Before And After ◽  
Work Hour ◽  
Operative Experience ◽  
Neurological Surgery

Abstract Background In 2003, the Accreditation Council for Graduate Medical Education (ACGME) instituted the 24+6-hour work schedule and 80-hour workweek, and in 2011, it enhanced work hour and supervision standards. Innovation In response, Oregon Health & Science University's (OHSU) neurological surgery residency instituted a 3-person night float system. Methods We analyzed work hour records and operative experience for 1 year before and after night float implementation in a model that shortened a combined introductory research and basic clinical neurosciences rotation from 12 to 6 months. We analyzed residents' perception of the system using a confidential survey. The ACGME 2011 work hour standards were applied to both time periods. Results After night float implementation, the number of duty hour violations was reduced: 28-hour shift (11 versus 235), 8 hours off between shifts (2 versus 20), 80 hours per week (0 versus 17), and total violations (23 versus 275). Violations increased only for the less than 4 days off per 4-week interval rule (10 versus 3). No meaningful difference was seen in the number of operative cases performed per year at any postgraduate year (PGY) training level: PGY-2 (336 versus 351), PGY-3 (394 versus 354), PGY-4 (803 versus 802), PGY-5 (1075 versus 1040), PGY-7 (947 versus 913), and total (3555 versus 3460). Residents rated the new system favorably. Conclusions To meet 2011 ACGME duty hour standards, the OHSU neurological surgery residency instituted a 3-person night float system. A nearly complete elimination of work hour violations did not affect overall resident operative experience.

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