scholarly journals Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line

2003 ◽  
Vol 7 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Yan Liu ◽  
Xiao-Dong Song ◽  
Wen Liu ◽  
Tian-Yi Zhang ◽  
Ji Zuo
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Cell Line ◽  
Pc12 Cell ◽  
Glucose Deprivation ◽  
Pc12 Cell Line ◽  
And Oxidative Stress

Effects of SARA on Oxygen–Glucose Deprivation in PC12 Cell Line

2013 ◽  
Vol 38 (5) ◽  
pp. 961-971 ◽  
Author(s):  
Jiao-Qi Wang ◽  
Jin-Ting He ◽  
Zhen-Wu Du ◽  
Zong-Shu Li ◽  
Yong-Feng Liu ◽  
...  
Keyword(s):  
Cell Line ◽  
Pc12 Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Pc12 Cell Line

s-Methyl cysteine enhanced survival of nerve growth factor differentiated PC12 cells under hypoxic conditions

2014 ◽  
Vol 5 (6) ◽  
pp. 1125-1133 ◽  
Author(s):  
Chun-lin Liu ◽  
Te-chun Hsia ◽  
Mei-chin Yin
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Pc12 Cell ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Protective Effects ◽  
Nerve Growth ◽  
Pc12 Cell Line ◽  
Hypoxic Conditions

A nerve growth factor-differentiated PC12 cell line was used to investigate the protective effects ofs-methyl cysteine (SMC) at 1, 2, 4, and 8 μM under oxygen–glucose deprivation (OGD) conditions.

scholarly journals Development of an Ischemic Tolerance Model in a PC12 Cell Line

2005 ◽  
Vol 25 (2) ◽  
pp. 154-162 ◽  
Author(s):  
Joëlle A Hillion ◽  
Kenzo Takahashi ◽  
Dragan Maric ◽  
Christl Ruetzler ◽  
Jeffery L Barker ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Pc12 Cell ◽  
Annexin V ◽  
Glucose Deprivation ◽  
In Vitro Models ◽  
Ischemic Tolerance ◽  
Cellular Mechanisms ◽  
Pc12 Cell Line

Although ischemic tolerance has been described in a variety of primary cell culture systems, no similar in vitro models have been reported with any cell line. A model of ischemic preconditioning in the rat pheochromocytoma PC12 cell line is described here. When compared to nonpreconditioned cells, preexposure of PC12 cells to 6 hours of oxygen and glucose deprivation (OGD) significantly increased cell viability after 15 hours of OGD 24 hours later. Flow cytometry analysis of cells labeled with specific markers for apoptosis, Annexin V, and Hoechst 33342, and of DNA content, revealed that apoptosis is involved in OGD-induced PC12 cell death and that preconditioning of the cells mainly counteracts the effect of apoptosis. Immunocytochemistry of caspase-3, a central executioner in the apoptotic process, further confirmed the activation of apoptotic pathways in OGD-induced PC12 cell death. This model may be useful to investigate the cellular mechanisms involved in neuronal transient tolerance following ischemia.

scholarly journals Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0239625
Author(s):  
Prasanna M. Chandramouleeswaran ◽  
Manti Guha ◽  
Masataka Shimonosono ◽  
Kelly A. Whelan ◽  
Hisatsugu Maekawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
And Oxidative Stress
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