HbA1c level may be a risk factor for oxygen therapy requirement in patients with coronavirus disease 2019

In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.

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Elevated HbA1c level: a risk factor for cardiovascular disease mortality in patients with chronic heart failure?

Nature Reviews Endocrinology ◽

10.1038/ncpendmet1069 ◽

2009 ◽

Vol 5 (3) ◽

pp. 130-131 ◽

Cited By ~ 3

Author(s):

Kay-Tee Khaw

Keyword(s):

Heart Failure ◽

Cardiovascular Disease ◽

Risk Factor ◽

Chronic Heart Failure ◽

Hba1c Level ◽

Cardiovascular Disease Mortality ◽

Disease Mortality

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High HbA1c Level as A Risk Factor of Low Tears Secretion After the Phacoemulsification Surgery

Bali Journal of Ophthalmology ◽

10.15562/bjo.v4i2.89 ◽

2021 ◽

Vol 4 (2) ◽

Author(s):

Ni Made Ayu Surasmiati ◽

Ida Ayu Ary Pramita ◽

Siska ◽

I Gusti Ayu Made Juliari ◽

I Wayan Gede Jayanegara

Keyword(s):

Risk Factor ◽

Hba1c Level ◽

High Hba1c

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Effect of Glycemic Control on Right Heart Functions in Type 2 Diabetes Mellitus Patients Free of Clinical Cardiovascular Disease

ACTA MEDICA IRANICA ◽

10.18502/acta.v58i3.3774 ◽

2020 ◽

Author(s):

Murat Ziyrek

Keyword(s):

Diabetes Mellitus ◽

Risk Factor ◽

Glycemic Control ◽

Negative Correlation ◽

Hba1c Level ◽

Independent Risk Factor ◽

Control Group ◽

Type 2 Dm ◽

Ventricle Function

Diabetes mellitus (DM) is one of the most common endocrine disorders. 90% percent of all diabetics are diagnosed with type 2 DM. DM is closely associated with various vascular diseases, and successful glycemic control prevents micro and macrovascular complications. Although there is data about the relation between glycemic control and left ventricle function, there is hardly any data about the relation between the right ventricular function. We analyzed the relationship between glycemic control and right ventricle function in type 2 DM patients free of clinical cardiovascular diseases (CVD). Patients were selected from the cardiology outpatient clinic. 53 patients formed the DM group; 51 patients formed the control group. All patients' demographic data were recorded. Biochemical tests and echocardiographic examinations were performed. RA and RV diameters were significantly higher in DM group (3.36±0.32 vs 3.13±0.34, P=0.015; 2.80±0.32 vs 2.56±0.22 P=0.005 respectively). Myocardial velocity during isovolumetric contraction (RV/IVV) and myocardial acceleration during Isovolumetric contraction (RV/IVA) were significantly lower in the DM group (14.4±3.17 vs 16.04±4.13 P=0,019; 3.25±0.75 vs 3.95±1,25 P=0.015). There was an intermediate negative correlation between RV/IVV and HBA1C (r=-0.406; P=0.036). HBA1C level was an independent risk factor for RV IVV (β=-0.406; P=0.036). It is shown that RA, RV diameter were significantly higher; RV/IVV and RV/IVA were significantly lower in diabetes mellitus patients free of CVD. Furthermore, there was a significant negative correlation between RV/IVV and HBA1C levels. HBA1C level was an independent risk factor for RV/IVV.

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Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents

Diabetes Mellitus ◽

10.14341/2072-0351-5423 ◽

2009 ◽

Vol 12 (1) ◽

pp. 52-53

Author(s):

Zh V Shutskaya ◽

E B Bashnina ◽

O V Mochkin ◽

T A Dubinina ◽

T Yu Tryasova

Keyword(s):

Risk Factor ◽

Hba1c Level ◽

Independent Risk Factor ◽

Homocysteine Level ◽

Study Groups ◽

Plasma Homocysteine ◽

Elevated Plasma ◽

Control Groups ◽

Plasma Homocysteine Level ◽

And Control

Aim. To consider homocysteinemia in children and adolescents with diabetes mellitus (DM1) as an independent risk factor of diabetic nephro- and retinopathy (DN and DR). Materials and methods. Twenty nine adolescents (19 girls and 10 boys) with DM1 were examined. DN and DR were diagnosed in conformity with medical aid standards for DM1patients. Plasma homocysteine level was measured by IEA. Results. Plasma homocysteine level in DN patients was higher (6.4?1.6, n=10) than in DR group (5.3?1.7, n=9) and controls (5.6?1.8, n=10). Patients of all study groups werecomparable in terms of age, DM duration, and HbA1c level. Conclusion. Plasma homocysteine level in DN patients was higher than in DR and control groups. It gives reason to consider this parameter as an independent risk factor alongwith some others in pathogenesis of diabetic microangiopathies (in the first place, nephropathy). Adolescents with DM1 and elevated plasma homocysteine level need additionalcorrection by specific medicines.

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