HBA1C IS ASSOCIATED WITH FRAILTY IN A GROUP OF ABORIGINAL AUSTRALIANS

2018 ◽  
pp. 1-4
Author(s):  
Z. Hyde ◽  
K. Smith ◽  
L. Flicker ◽  
D. Atkinson ◽  
S. Fenner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Hba1c Level ◽  
Binary Logistic Regression ◽  
Glycated Haemoglobin ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Aboriginal Australians ◽  
Obesity And Diabetes ◽  
Hba1c Levels

In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.

scholarly journals Correlation between HbA1c level and monocyte percentage in obesity

2020 ◽  
Vol 8 (1) ◽  
pp. 75
Author(s):  
Edward Kurnia Setiawan Limijadi ◽  
Meita Hendrianingtyas
Keyword(s):  
Diabetes Mellitus ◽  
Hba1c Level ◽  
Monitoring And Evaluation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Obesity And Diabetes ◽  
Neutrophil Percentage ◽  
Private Laboratory ◽  
Spearman Test ◽  
Hba1c Levels

Background : HbA1c is one of the parameters that can be useful for diagnosing diabetes mellitus that can occur in obesity. Monocyte as an inflammatory cell is widely studied in relation to diabetes mellitus and obesity. The purpose of this study is to analyze the correlation between HbA1c levels and monocyte percentage in obesity.Methods : A Cross-sectional study of 30 medical students at a private laboratory in Semarang on March – April 2017 was done. The monocyte percentage included incomplete blood count was examined with the Sysmex XS-800i hematology analyzer, while HbA1c level was examined with Hemocue HbA1c 501 System. Spearman test was done for analyzing data with p <0.05 was considered statistically significant. Result and discussion : Median of HbA1c level was 5.8 ± 0.23%. Medians of leukocyte count, lymphocyte percentage, neutrophil percentage, and monocyte percentage were 8,600 ± 339,77 /μl, lymphocyte percentage 33% ± 1.19%, neutrophil percentage 56% ± 1.35%, and monocyte percentage of 9.0% ± 0.26%, respectively. Spearman test showed that correlation value (r) was 0.131 (p = 0.489).Conclusion and suggestion : There was no correlation between HbA1c levels and monocyte percentage in obesity. The increased of monocyte percentage can be used as monitoring and evaluation parameters in obesity that can lead to diabetes mellitus. Further study can be done in an obese population with older age as well as other parameters related to obesity and diabetes mellitus.

scholarly journals The association between serum uric acid and diabetic complications in patients with type 2 diabetes mellitus by gender: a cross-sectional study

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10691
Author(s):  
Yimeng Hu ◽  
Qinge Li ◽  
Rui Min ◽  
Yingfeng Deng ◽  
Yancheng Xu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Clinical Characteristics ◽  
Independent Risk Factor ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Background The relationship between serum uric acid (SUA) and several diabetic complications or co-morbidities remains a matter of debate. The study aims to explore the association between SUA levels and the prevalence of non-alcoholic fatty liver disease (NAFLD), diabetic retinopathy (DR), diabetic nephropathy (DN) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 2,809 participants (1,784 males and 1,025 females) were included in this cross-sectional study. Clinical characteristics and the prevalence of each of the four diseases were analyzed based on gender-specific quartiles of SUA levels. The Pearson correlation analysis and linear-regression analysis were used to access the correlation between SUA levels and clinical characteristics. Furthermore, a binary logistic regression analysis was carried out to determine whether SUA was an independent risk factor for each of the four complications. Results SUA levels were positively correlated to BMI, BUN, Scr and TG, but negatively associated with eGFR, HDL, FBG, 2h-PG and HbA1c% for the patients with T2DM. The prevalence of NAFLD and DN, but not DR or DPN, were increased with SUA levels from the first to the fourth quartile. Binary logistic regression further disclosed that SUA was an independent risk factor for NAFLD (ORs Male = 1.002, ∗P = 0.0013; ORs Female = 1.002, ∗P = 0.015) and DN (ORs Male = 1.006, ∗P < 0.001; ORs Female = 1.005, ∗P < 0.001), but not for DR and DPN. After adjustment for the confounders, SUA levels were significantly associated with NAFLD within the 3rd (ORs = 1.829, P = 0.004) and 4th quartile (ORs = 2.064, P = 0.001) for women, but not independently associated with SUA for man. On the other hand, our results revealed increased prevalence of DN for SUA quartile 2 (ORs = 3.643, P = 0.039), quartile 3 (ORs = 3.967, P = 0.024) and quartile 4 (ORs = 9.133, P < 0.001) in men; however, SUA quartiles were significantly associated with DN only for quartile 4 (ORs = 4.083, P = 0.042) in women Conclusion For patients with T2DM, elevated SUA concentration is an independent risk factor for the prevalence of NAFLD and DN after adjustment for other indicators, but not DR or DPN.

scholarly journals Effects of Sitagliptin on HbA1c levels in uncontrolled hyperglycemia in diabetics using conventional OAD’s.

2020 ◽  
Vol 27 (05) ◽  
pp. 963-967
Author(s):  
Amar Nazir ◽  
Fida Muhammad Sheikh ◽  
Sheraz Saleem
Keyword(s):  
Diabetes Mellitus ◽  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
Cross Sectional ◽  
Entire Study ◽  
Dipeptidyl Peptidase 4 ◽  
Diagnostic Center ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
Hba1c Levels

Objectives: The study anticipates to appraise HbA1c levels after three months of sitagliptin addition (100mg/day) to patients already using conventional oral antidiabetics in patients of type II diabetes mellitus who have a meager retort to these existing anti diabetics. Study Design: Mainly cross sectional prospective multicenter, open labeled study. Setting: Department of Medicine University medical diagnostic center & District Head Quarter Hospital Sargodha. Period: January 2017 to June 2017. Material & Methods: 100 inadequately controlled diabetics using different types of oral anti diabetics were chosen and an especially designed performa was accomplished. In our study we gave preference to those patients who were on preexisting oral anti diabetics and now dipeptidyl peptidase 4 inhibitors were added for the first time. The patients were instructed (at the baseline visit) to report during the subsequent visit about glycemic control. Patients were not clued-up that glycosylated hemoglobin control was the main seek of the study, so there was no chance for Pygmalion effect. Results: Levels of glycosylated hemoglobin were significantly reduced after three months of treatment compared to baseline, with a mean alteration in HbA1c level from baseline of −0.77% (range, −0.68 to − -0.86%) in the entire study population at three months. The percentage of patients who achieved an HbA1c level of <6.9% significantly increased after three months of treatment, reaching 58.1%. Conclusion: HbA1c significantly lowered in patients with type 2 diabetes mellitus on conventional OADs after adding sitagliptin.

scholarly journals Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Viruses ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 700 ◽  
Author(s):  
Sarathkumara ◽  
Gamage ◽  
Lokupathirage ◽  
Muthusinghe ◽  
Nanayakkara ◽  
...  
Keyword(s):  
Risk Factor ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Unknown Etiology ◽  
Hantavirus Infection ◽  
Sectional Study ◽  
Cross Sectional

Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.

scholarly journals Study of prevalence of hypertension and its various risk factor in type 2 diabetes mellitus patients

2019 ◽  
Vol 6 (4) ◽  
pp. 1069
Author(s):  
Narendra M. Uma ◽  
Mahendra C. Parmar ◽  
Siddarth Shah ◽  
Sonal M. Dindod
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Pressure Control ◽  
Cross Sectional Study ◽  
Health Issues ◽  
Cross Sectional ◽  
Medical College ◽  
Intervention Measures ◽  
Artery Disease ◽  
Relative Deficiency

Background: Surgical diabetes is syndrome of hyperglycemia and disturbance of carbohydrate, fat and protein metabolism associated with absolute or relative deficiency of insulin secretions. Diabetes mellitus and hypertension considered as a major medical and public health issues worldwide, and both are important risk factors for both macrovascular and microvascular diseases like coronary artery disease, heart failure and cerebrovascular diseases.Methods: This cross-sectional study was conducted among 175 patients coming to Govt. medical college and SSG hospital, Vadodara from 2014 to 2015 having diabetes mellitus were studied and evaluated for hypertension  and its various risk factor like age, obesity.Results: one hundred and twenty-nine (127) out of 175 subjects had hypertension, thus giving a prevalence rate of 73.7% of which 64 males (49.6%) were hypertensive compared with 65 (50.3%) females. Mean age of patients having hypertension with Diabetes Mellitus (case) is 59.87 compare to DM without hypertension (control) was 56.21. Mean BMI in diabetes cases with hypertension was 30.93 while without hypertension was 23.47 suggest obese are more prone to develop hypertension. Waist hip ratio DM with hypertension was 0.96 while was 0.81 in DM without hypertension.Conclusion: Hypertension and its associated risk factor like obesity, dyslipidemia are important risk factor for development of complication in diabetes patients so early detection and intervention measures should be undertaken for aggressive control of  blood pressure control , obesity and it will  likely to offer the greatest promise for reducing the incidence of complications and its associated mortality.

scholarly journals Frequency of Undiagnosed Diabetes Mellitus among Patients with Stroke

2019 ◽  
Vol 5 (2) ◽  
pp. 81-88
Author(s):  
Yaser Moaddabi ◽  
◽  
Alia Saberi ◽  
Hamidreza Hatamian ◽  
Babak Bakhshayesh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Undiagnosed Diabetes ◽  
Chi Square ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
Exact Test ◽  
The North ◽  
Undiagnosed Diabetes Mellitus

Background: Stroke is one of the common causes of disability and death in the world. Furthermore, diabetes mellitus is among the main risk factors for cerebrovascular events. However, a high percentage of individuals with diabetes mellitus are unaware of their disease. Objectives: To determine the frequency of Undiagnosed Diabetes mellitus (UD) in patients with stroke. Materials & Methods: In a descriptive cross-sectional study, all patients with stroke hospitalized in neurology ward of an academic hospital in the north of Iran were included in the study in 2016. A questionnaire was used to collect data including all demographic, laboratory and clinical factors such as high blood pressure, hypercholesterolemia and stroke type. Finally, the data were analyzed using Chi square, Fisher’s exact test and multinomial binary logistic regression in SPSS V. 21. Results: Most samples were male (53.8%) with a mean age of 69.2±10.1 years. The percentage of the UD was 21.7% based on level of HbA1c. The highest percentage of UD was observed in Subarachnoid Hemorrhage(SAH) (66.7%). The frequency of UD in patients with family history of diabetes mellitus (16.7%) was lower than that in patients without that history (27.7%). There was a significant relationship between UD and cholesterol and triglyceride levels and, in general, dyslipidemia (P<0.05). Conclusion: In this study, a large percentage of patients with stroke suffered UD. Therefore, it is recommended that extensive screening be conducted for diabetes mellitus in the community in order to prevent stroke.

scholarly journals Diagnosing Diabetes Mellitus With Glycated Haemoglobin in Newly Diagnosed HIV-positive Patients in Buffalo City Municipality, South Africa: A Cross-sectional Study

2019 ◽  
Vol 12 (1) ◽  
pp. 263-268
Author(s):  
Olufunso O. Sogbanmu ◽  
Larry O. Obi ◽  
Daniel T. Goon ◽  
Anthony Okoh ◽  
Benson Iweriebor ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
South Africa ◽  
Logistic Regression ◽  
Glycated Haemoglobin ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Hiv Patients ◽  
Cross Sectional

Background: The HbA1c estimates long-term glycaemic control in individuals. However, scanty data exist on the determination of Diabetes Mellitus (DM) in newly diagnosed HIV patients using the HbA1c screening tool in the South African context. Thus, this study examines the prevalence of diabetes mellitus in newly diagnosed HIV-positive patients in Buffalo City Municipality, East London, South Africa. Methodology: This was a cross-sectional study of 335 newly HIV-diagnosed patients between August 2016 and July 2017. Demographic (age, gender, residence, employment status and level of education) and behavioural variables (smoking and alcohol use (past 30 days)) were by self-reporting. Information on HbA1c and other clinical variables were obtained from the medical records of the patients. Diabetes mellitus was defined based on the Society for Endocrinology, Metabolism and Diabetes of South Africa (SEMDSA) 2017 guideline of HbA1c of above 6.5%. Weight and height were measured using standard protocols. Logistic regression analyses were applied to determine the predictors of abnormal glycated haemoglobin. Results: Majority of the participants were female (72%). The prevalence of patients with HbA1c greater than 6.5% was 6%. The multivariate analysis indicates only age (p=0.031) and race (0.019) significantly shows a correlation to increase the risk of development of DM in newly diagnosed HIV positive patients. The binary logistic regression analysis shows that age (above 46 years) (p=0.001; AOR (6.60); CI (2.08-20.9) was directly related to the development of DM. Conclusion: Consistent with other studies, the exclusive non-fasting HbA1c, which is a marker of glycaemic control, only underestimate glycemia in HIV patients with diabetes in this present study. Notwithstanding, HIV patients who are over 40 years are likely to develop DM. As such, screening older individuals diagnosed with HIV is crucial in offering a timely point of care and interventions.

scholarly journals Oral candidal carriage and its association with dental carious lesions in asymptomatic adults: a cross-sectional study from the UAE

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Suhail H. Al-Amad ◽  
Betul Rahman ◽  
Nadia Khalifa ◽  
Manal A. Awad
Keyword(s):  
Diabetes Mellitus ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Plaque Index ◽  
Sectional Study ◽  
Periodontal Health ◽  
Cross Sectional ◽  
Health Indices ◽  
Oral Rinse ◽  
Whole Saliva

Abstract Background Candida’s potential association with dental caries has previously been reported in children. This research aimed at investigating the associations between Candida species in whole saliva and dental and periodontal health indices in a sample of adult patients. Methods A cross-sectional study involving 160 patients investigated the associations between Candida species collected by oral rinse technique, and Decayed, Missing, and Filled Surfaces (DMFS), and periodontal health indices. Chi-square and Independent Samples t-test were used to assess the associations between Candida carriage and confounding variables. Binary logistic regression was used to assess association strengths between Candida carriage and DMFS, adjusted for socio-demographic variables, diabetes mellitus and plaque index. Results Candida colonies were identified in 49 (30.6%) patients with CFUs ranging from 103 to 105 colonies per mL. The quantity of Candida CFUs increased with age (r = 0.200; p < 0.05). Among all dental and periodontal health indices, only DMFS was significantly associated with higher values of Candida carriage (p = 0.034), and this association was independent from sex, age, smoking, diabetes mellitus and plaque index (OR: 1.014; 95% CI 1.0–1.03; p = 0.048). Conclusion The association between Candida species in whole saliva and DMFS reported here supports an etiological role of Candida in dental cariogenesis among adults.

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