scholarly journals Reconstruction of evolutionary changes in fat and toxin consumption reveals associations with gene losses in mammals: a case study for the lipase inhibitor PNLIPRP1 and the xenobiotic receptor NR1I3 .

Author(s):  
F Wagner ◽  
I Ruf ◽  
T Lehmann ◽  
R Hofmann ◽  
S Ortmann ◽  
...  
Epigenomics ◽  
2021 ◽  
Author(s):  
Ella Waters ◽  
Perla Pucci ◽  
Mark Hirst ◽  
Simon Chapman ◽  
Yuzhuo Wang ◽  
...  

Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but many remain uncharacterized because of their complex expression patterns and structures. The genetic loci encoding lncRNAs can be subject to accelerated evolutionary changes within the human lineage. HAR1 is a region that has a significantly altered sequence compared to other primates and is a component of two overlapping lncRNA loci, HAR1A and HAR1B. Although the functions of these lncRNAs are unknown, they have been associated with neurological disorders and cancer. Here, we explore the current state of understanding of evolution in human lncRNA genes, using the HAR1 locus as the case study.


2014 ◽  
Vol 60 (5) ◽  
pp. 561-570 ◽  
Author(s):  
Ke-Qing Song ◽  
Huai-Jun Xue ◽  
Rolf G. Beutel ◽  
Ming Bai ◽  
Dong-Ju Bian ◽  
...  

Abstract Habitat shift is a key innovation that has contributed to the extreme diversification of insects. Most groups are well-adapted to more or less specific environments and shifts usually only happen between similar habitats. To colonize a profoundly different habitat type does not only present ecological opportunities but also great challenges. We used Hydrophiloidea (water scavenger beetles) as a system to study transitions between terrestrial and aquatic environments. We estimated the diversification rate of different clades using phylogenetic trees based on a representative taxon sampling and six genes. We also investigated possible evolutionary changes in candidate genes following habitat shifts. Our results suggest that the diversification rate is relatively slow (0.039?0.050 sp/My) in the aquatic lineage, whereas it is distinctly increased in the secondarily terrestrial clade (0.055?0.075 sp/My). Our results also show that aquatic species have a G (Glycine) or S (Serine) amino acid at a given site of COI, while terrestrial species share an A (Alanine) amino acid with terrestrial outgroups. This indicates that habitat factors may create selection pressure on the evolution of functional genes and cause homoplasy in molecular evolution.


2021 ◽  
Vol 4 ◽  
pp. 27-50
Author(s):  
Thisali Liyanage ◽  
◽  
Tharusha Gooneratne ◽  

Faced with criticisms on traditional budgeting, contemporary organisations have moved towards better budgeting and beyond budgeting practices. Drawing evidence from Citrus Lanka, a fast-moving consumer goods (FMCG) manufacturing firm in Sri Lanka, this paper explores amid limitations of traditional budgeting, how and why the firm moved to better budgeting rather than embracing beyond budgeting. It adopts the qualitative methodology and case study approach and mobilises the theoretical notions; ‘stability’ and ‘change’ under institutional theory. The field data illustrate how Citrus Lanka instigated evolutionary changes (towards better budgeting) rather than revolutionary changes (towards beyond budgeting), witnessing ‘stability’ of budgeting and ‘change’ towards better budgeting. This paper contributes by adding to the burgeoning budgetary control literature and extends the use of institutional theory in management accounting research by espousing how the notions of ‘stability’ and ‘change’ can co-exist. The better budgeting practice presented in this paper is a pragmatic approach. It offers practitioner pointers to managers grappling with limitations of traditional budgeting and practical difficulties of beyond budgeting on improving budgetary control through better budgeting approaches. Such an understanding is useful for managers beyond the case study firm to those across different industries and nations in adapting to the ever-changing business environment by drawing on management accounting insights.


2014 ◽  
Vol 38 (01) ◽  
pp. 102-129
Author(s):  
ALBERTO MARTÍN ÁLVAREZ ◽  
EUDALD CORTINA ORERO

AbstractUsing interviews with former militants and previously unpublished documents, this article traces the genesis and internal dynamics of the Ejército Revolucionario del Pueblo (People's Revolutionary Army, ERP) in El Salvador during the early years of its existence (1970–6). This period was marked by the inability of the ERP to maintain internal coherence or any consensus on revolutionary strategy, which led to a series of splits and internal fights over control of the organisation. The evidence marshalled in this case study sheds new light on the origins of the armed Salvadorean Left and thus contributes to a wider understanding of the processes of formation and internal dynamics of armed left-wing groups that emerged from the 1960s onwards in Latin America.


2020 ◽  
Vol 43 ◽  
Author(s):  
Michael Lifshitz ◽  
T. M. Luhrmann

Abstract Culture shapes our basic sensory experience of the world. This is particularly striking in the study of religion and psychosis, where we and others have shown that cultural context determines both the structure and content of hallucination-like events. The cultural shaping of hallucinations may provide a rich case-study for linking cultural learning with emerging prediction-based models of perception.


2019 ◽  
Vol 42 ◽  
Author(s):  
Daniel J. Povinelli ◽  
Gabrielle C. Glorioso ◽  
Shannon L. Kuznar ◽  
Mateja Pavlic

Abstract Hoerl and McCormack demonstrate that although animals possess a sophisticated temporal updating system, there is no evidence that they also possess a temporal reasoning system. This important case study is directly related to the broader claim that although animals are manifestly capable of first-order (perceptually-based) relational reasoning, they lack the capacity for higher-order, role-based relational reasoning. We argue this distinction applies to all domains of cognition.


2019 ◽  
Vol 42 ◽  
Author(s):  
Penny Van Bergen ◽  
John Sutton

Abstract Sociocultural developmental psychology can drive new directions in gadgetry science. We use autobiographical memory, a compound capacity incorporating episodic memory, as a case study. Autobiographical memory emerges late in development, supported by interactions with parents. Intervention research highlights the causal influence of these interactions, whereas cross-cultural research demonstrates culturally determined diversity. Different patterns of inheritance are discussed.


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