Inhibition effect of preservatives or disinfectants on F. concentricum from postharvest asparagus ( Asparagus officinalis L.) spear in vitro and in vivo

2021 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Lixiu Pan ◽  
Yonggang Fang ◽  
Xiangyang Wang ◽  
Shuang Gu
Keyword(s):  
Asparagus Officinalis ◽  
Inhibition Effect

The Inhibition Effect of Caveolin-1 on PANC1 Human Pancreatic Tumor Growth In vitro and In vivo*

2012 ◽  
Vol 38 (12) ◽  
pp. 1121-1131
Author(s):  
Xiao-Hui WANG ◽  
Ya-Min ZHENG ◽  
Ye-Qing CUI ◽  
Shuang LIU ◽  
Hai-Chen SUN ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Pancreatic Tumor ◽  
Caveolin 1 ◽  
Inhibition Effect

scholarly journals The Inhibition Effect of Triptolide on Human Endometrial Carcinoma Cell Line HEC-1B: a in vitro and in vivo Studies

2015 ◽  
Vol 16 (11) ◽  
pp. 4571-4576 ◽  
Author(s):  
Jing Ni ◽  
Qiang Wu ◽  
Zhi-Hua Sun ◽  
Jian Zhong ◽  
Yu Cai ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
In Vivo Studies ◽  
Inhibition Effect ◽  
Endometrial Carcinoma Cell ◽  
Endometrial Carcinoma Cell Line

scholarly journals Inhibition effect of Oncostatin M on metastatic human lung cancer cells 95-D in vitro and on murine melanoma cells B16BL6 in vivo

2006 ◽  
Vol 27 (4) ◽  
pp. 197-202 ◽  
Author(s):  
Liming OUYANG ◽  
Li yun SHEN ◽  
Ting LI ◽  
Jianwen LIU
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Oncostatin M ◽  
Human Lung Cancer ◽  
Inhibition Effect ◽  
Human Lung Cancer Cells ◽  
Murine Melanoma Cells

scholarly journals Radiation Synthesis of Silver Nanoparticles/Chitosan for Controlling Leaf Fall Disease on Rubber Trees Causing by Corynespora cassiicola

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Le Thi An Nhien ◽  
Nguyen Duc Luong ◽  
Le Thi Thuy Tien ◽  
Le Quang Luan
Keyword(s):  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Fungal Growth ◽  
Corynespora Cassiicola ◽  
Sem Images ◽  
Inhibition Effect ◽  
Foliar Treatment ◽  
Inhibitory Efficiency

Silver nanoparticles (AgNPs) were successfully prepared by γ-rays irradiation of solution containing 1.0–10 mM of silver nitrate and 1% chitosan. The optical characteristics and particles sizes of AuNPs were determined by UV-Vis spectra and TEM images, respectively. The size of AgNPs increased by the increase of silver concentration or the decrease of chitosan molecular weight in irradiated solution. The in vitro test showed that AgNPs inhibited the growth of Corynespora cassiicola on rubber-leaf extract media with the inhibitory efficiency of 52.1–100% by treatment of AgNPs with particle size from 15 to 5 nm, respectively. In addition, antifungal activity was found to reach ~100% by the addition of 90 ppm AgNPs. The in vivo foliar treatment of AgNPs on 9-month-old rubber plants showed that the treatment with 2.5–12.5 ppm AgNPs on tested plants after inoculation by spraying with C. cassiicola spores enhanced the rate of non-disease-infected plants from 6.0 to 93.3%, respectively, compared to the untreated control. The inhibition effect of AgNPs on fungal growth of C. cassiicola mycelial was also elucidated via SEM images. The AgNPs/chitosan synthesized by γ-irradiation is potentially promising to use as a fungicidal product for treating C. cassiicola, a serious pathogen fungus on rubber trees.

scholarly journals Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models

2018 ◽  
Vol 67 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Le Yang ◽  
Chenyang Yan ◽  
Feng Zhang ◽  
Bo Jiang ◽  
Shouhong Gao ◽  
...  
Keyword(s):  
Inhibition Effect ◽  
Cyp3a4 Inhibition

scholarly journals In-Vitro Antidiabetic Activity of Clinacanthus nutans Extracts

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
Abdullah N. ◽  
Kasim K. F.
Keyword(s):  
Blood Glucose ◽  
Amylase Activity ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Antidiabetic Activity ◽  
Inhibition Effect ◽  
Glucose Diffusion ◽  
Clinacanthus Nutans

Diabetes mellitus is a prevalent disease which characterized by hyperglycemia. It is a condition in which blood glucose levels are elevated due to decrease in cellular glucose uptake and metabolism. The management of blood glucose level is critical in the treatment of this disease and this had been offered by α-amylase inhibitors. The present study was designed to determine the in vitro antidiabetic of Clinacanthus nutans extracts. The antidiabetic action was observed by the inhibition effects of the C. nutans extracts on α-amylase activity and glucose diffusion across the dialysis tube. It was found that the antidiabetic action of the C. nutans extracts was not related to glucose diffusion as they did not show any significant glucose entrapment ability. The ethanolic leaves extract of C. nutans exhibited the most significant inhibition effect on α-amylase activity (64.25%) compared to other extracts. However, its inhibitory activity was moderate when compared to the commercial drugs (captopril and acarbose). The ethanolic leaves extract (the best extract) was tested for the presence for flavonoids, saponins and tannin (most reported antidiabetic compounds). Its antidiabetic action might be due to the presence of flavonoids and tannins. However, the absence of saponins might be responsible for its moderate inhibition effect comparable to control. This study suggested the in vivo studies of this plant should be carried out to confirm its antidiabetic mechanism

Quercetin Displays Anti-Myeloma Activity and Synergistic Effect with Dexamethasone in Vitro and In Vivo Xenograft Models

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 5339-5339
Author(s):  
Xing Guo ◽  
Donghua He ◽  
Li Yang ◽  
Yi Li ◽  
Qingxiao Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Inhibition Effect ◽  
Synergistic Inhibition ◽  
Cycle Arrest ◽  
Xenograft Mice ◽  
G2 Phase ◽  
Synergistic Inhibition Effect

Abstract Background: Multiple myeloma (MM) is a hematological malignancy with clonal plasma cell hyperplasia, which is still an incrurable disease since chemoresistance remains the major problem in MM management. Quercetin, a kind of dietary flavonoids, has shown its anticancer activity in many kinds of cancer cell lines and we tried to explore the effect of quercetin in MM. Methods: In vitro, we examined the proliferation of MM cell lines(RPMI8226,ARP-1,MM1R) after treatment with quercetin combined with or without dexamethasone by MTT.Flow cytometry was used to detect apoptosis and cell cycle of MM cells induced by quercetin with or without dexamethasone.Then we detected mRNA and protein expression associated with apoptosis and cell cycle arrest by semiquantitative real time-polymerase chain (qRT-PCR)and western blot analysis. In vivo,a xenograft mice model of human myeloma was established and the mice received vehicle or quercetin alone or dexamethasone alone or quercetin combinded with dexamethasone, and the tumorburdern and the tumor tissue samples were analyzed by tumor volume and immunohistochemistry. Results: Quercetin inhibited proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase(quercetin group vs control,p<0.05).Western blot showed that quercetin activated caspase3,caspase9,PARP-1 and increased cytochrome C release. C-myc and cyclinD1 expression were down-regulated and p21 were upregulated. Quercetinalso displays synergistic inhibition effect with dexamethasone in vitro (quercetin with dexamethasone vs quercetin only or dexamethasone only,p<0.05) and western bolt confirmed these results.In vivo,tumor burdern of xenograft mice modeltreated by quercetin was significantly lower than those of control(quercetin group vs control,p<0.05). Conclusions: Quercetin inhibits proliferation of MM cells by inducing apoptosis and cell cycle arrest in the G0/G1 or G2 phase through downregulating c-myc and cyclinD1 and upregulating p21 .Quercetinalso displays synergistic inhibition effect with dexamethasone.Thus,quercetin combination with dexamethasone therapy may be an effective option for MM patients. Disclosures No relevant conflicts of interest to declare.

Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro

2010 ◽  
Vol 122 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Yuqing Duan ◽  
Haihui Zhang ◽  
Feifei Xu ◽  
Bijun Xie ◽  
Xianwen Yang ◽  
...  
Keyword(s):  
B16 Melanoma ◽  
Inhibition Effect ◽  
Lotus Seedpod

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Ultrastructural Correlations between Clonal Human Tumor Colonies and in Vivo Neoplasms

1982 ◽  
Vol 40 ◽  
pp. 210-211
Author(s):  
M.J. Murphy ◽  
R.R. Price ◽  
J.C. Sloman
Keyword(s):  
Cultured Cells ◽  
Human Tumor ◽  
Cell Type ◽  
Tumor Mass ◽  
Initial Cell ◽  
Cloning Assay ◽  
Human Tumor Cloning ◽  
The Relationship

The in vitro human tumor cloning assay originally described by Salmon and Hamburger has been applied recently to the investigation of differential anti-tumor drug sensitivities over a broad range of human neoplasms. A major problem in the acceptance of this technique has been the question of the relationship between the cultured cells and the original patient tumor, i.e., whether the colonies that develop derive from the neoplasm or from some other cell type within the initial cell population. A study of the ultrastructural morphology of the cultured cells vs. patient tumor has therefore been undertaken to resolve this question. Direct correlation was assured by division of a common tumor mass at surgical resection, one biopsy being fixed for TEM studies, the second being rapidly transported to the laboratory for culture.

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