“IDEAL” Aging Is Associated with Lower Resting Metabolic Rate: The Baltimore Longitudinal Study of Aging

Abstract Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as postexercise phosphocreatine recovery time constant (τ PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between τ PCr and RMR, adjusting for potential confounders. Independent of age, sex, lean body mass, muscle density, and fat mass, higher RMR was significantly associated with shorter τ PCr, indicating greater mitochondrial oxidative capacity. Higher RMR is associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.

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High Basal Metabolic Rate Is a Risk Factor for Mortality: The Baltimore Longitudinal Study of Aging

The Journals of Gerontology Series A ◽

10.1093/gerona/63.7.698 ◽

2008 ◽

Vol 63 (7) ◽

pp. 698-706 ◽

Cited By ~ 83

Author(s):

C. Ruggiero ◽

E. J. Metter ◽

V. Melenovsky ◽

A. Cherubini ◽

S. S. Najjar ◽

...

Keyword(s):

Risk Factor ◽

Longitudinal Study ◽

Metabolic Rate ◽

Basal Metabolic Rate ◽

Baltimore Longitudinal Study ◽

High Basal Metabolic Rate

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THE BALTIMORE LONGITUDINAL STUDY OF AGING: OPPORTUNITIES FOR RESEARCH ON WOMEN'S AGING AND HEALTH

Innovation in Aging ◽

10.1093/geroni/igz038.1290 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S355-S356

Author(s):

Eleanor M Simonsick ◽

Eleanor Simonsick ◽

Ann Z Moore ◽

Michelle Shardell ◽

Nancy C Shaffer ◽

...

Keyword(s):

Longitudinal Study ◽

Resting Metabolic Rate ◽

Cardiovascular Fitness ◽

Birth Cohorts ◽

Brain Volumes ◽

Ongoing Research ◽

Glucose Challenge ◽

Aging And Health ◽

Baltimore Longitudinal Study ◽

The Life Course

Abstract The Baltimore Longitudinal Study of Aging (BLSA), an ongoing continuous enrollment cohort study of normative aging established in 1958 currently conducted by the NIA Intramural Research Program, began including women in 1978. To date, nearly 1200 women aged 17-94 at enrollment (median=53 Q1-Q3=40-70) have been followed for up to 21 visits spanning 40 years (median visits=6; Q1-Q3=3-9). Over 3 days, participants receive comprehensive examinations, interviews, imaging and functional and cognitive evaluations; repeat visits occur every 1-4 years depending on age. The BLSA offers opportunities to examine distributions of, change in and interrelationships among several rarely concurrently ascertained parameters (e.g., cardiovascular fitness, resting metabolic rate, glucose challenge response, five-factor personality, brain volumes, and diet) over the life course and across birth cohorts. The BLSA also maintains an extensive biorepository. This talk will summarize the extensive measurement catalogue and timeline and provide illustrative examples from ongoing research on women’s aging and health.

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Resting metabolic rate and work efficiency of rural Beninese women: a 2-y longitudinal study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/61.3.466 ◽

1995 ◽

Vol 61 (3) ◽

pp. 466-472 ◽

Cited By ~ 9

Author(s):

E A Ategbo ◽

J M van Raaij ◽

F L de Koning ◽

J G Hautvast

Keyword(s):

Longitudinal Study ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Work Efficiency

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Greater Skeletal Muscle Oxidative Capacity Is Associated With Higher Resting Metabolic Rate: Results From the BLSA

Innovation in Aging ◽

10.1093/geroni/igaa057.409 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 124-124

Author(s):

Marta Zampino ◽

Richard Semba ◽

Fatemeh Adelnia ◽

Jennifer Schrack ◽

Richard Spencer ◽

...

Keyword(s):

Skeletal Muscle ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Oxidative Capacity ◽

Muscle Quality ◽

Resonance Spectroscopy ◽

Linear Regression Models ◽

Cross Sectional ◽

Mitochondrial Oxidative Capacity ◽

Baltimore Longitudinal Study

Abstract Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength and fitness. However, while the decline in these phenotypes have been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as post-exercise phosphocreatine recovery time constant (tau-PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between tau-PCr and RMR, adjusting for potential confounders. We found that independent of age, sex, lean body mass, muscle density and fat mass, higher RMR was significantly associated with shorter tau-PCr, indicating greater mitochondrial oxidative capacity. In conclusion, higher RMR appears to be associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.

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The impact of multimorbidity on resting metabolic rate in community-dwelling women over a ten-year period: A cross-sectional and longitudinal study

The journal of nutrition health & aging ◽

10.1007/s12603-016-0840-9 ◽

2016 ◽

Vol 21 (7) ◽

pp. 781-786 ◽

Cited By ~ 3

Author(s):

A. Nagel ◽

A. Jungert ◽

A. Spinneker ◽

Monika Neuhäuser-Berthold

Keyword(s):

Longitudinal Study ◽

Metabolic Rate ◽

Resting Metabolic Rate ◽

Community Dwelling ◽

Cross Sectional ◽

The Impact

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1344: Metabolic Factors Associated with Benign Prostatic Hyperplasia: The Baltimore Longitudinal Study of Aging

The Journal of Urology ◽

10.1016/s0022-5347(18)33557-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 432-433 ◽

Cited By ~ 4

Author(s):

J. Kellogg Parsons ◽

H. Ballentine Carter ◽

Alan W. Partin ◽

B. Gwen Windham ◽

E. Jeffrey Metter ◽

...

Keyword(s):

Longitudinal Study ◽

Benign Prostatic Hyperplasia ◽

Prostatic Hyperplasia ◽

Metabolic Factors ◽

Factors Associated ◽

Baltimore Longitudinal Study

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Nutrient pattern of unsaturated fatty acids and vitamin E increase resting metabolic rate of overweight and obese women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000664 ◽

2020 ◽

pp. 1-9

Author(s):

Habib Yarizadeh ◽

Leila Setayesh ◽

Caroline Roberts ◽

Mir Saeed Yekaninejad ◽

Khadijeh Mirzaei

Keyword(s):

Vitamin E ◽

Metabolic Rate ◽

Unsaturated Fatty Acids ◽

Resting Metabolic Rate ◽

Blood Parameters ◽

Cross Sectional Study ◽

Obese Women ◽

Cross Sectional ◽

Dietary Nutrients ◽

Nutrient Patterns

Abstract. Objectives: Obesity plays an important role in the development of chronic diseases including cardiovascular disease and diabetes. A low resting metabolic rate (RMR) for a given body size and composition is a risk factor for obesity, however, there is limited evidence available regarding the association of nutrient patterns and RMR. The aim of this study was to determine the association of nutrient patterns and RMR in overweight and obese women. Study design: This cross-sectional study was conducted on 360 women who were overweight or obese. Method: Dietary intake was assessed using a semi-quantitative standard food frequency questionnaire (FFQ). Nutrient patterns were also extracted by principal components analysis (PCA). All participants were evaluated for their body composition, RMR, and blood parameters. Result: Three nutrient patterns explaining 64% of the variance in dietary nutrients consumption were identified as B-complex-mineral, antioxidant, and unsaturated fatty acid and vitamin E (USFA-vit E) respectively. Participants were categorized into two groups based on the nutrient patterns. High scores of USFA-vit E pattern was significantly associated with the increase of RMR (β = 0.13, 95% CI = 0.79 to 68.16, p = 0.04). No significant associations were found among B-complex-mineral pattern (β = −0.00, 95% CI = −49.67 to 46.03, p = 0.94) and antioxidant pattern (β = 0.03, 95% CI −41.42 to 22.59, p = 0.56) with RMR. Conclusion: Our results suggested that the “USFA-vit E” pattern (such as PUFA, oleic, linoleic, vit.E, α-tocopherol and EPA) was associated with increased RMR.

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