Association of A‐197G polymorphism in interleukin‐17 gene with chronic periodontitis: Evidence from six case‐control studies with a computational biology approach

2019 ◽  
Vol 10 (4) ◽  
Author(s):  
Amir Farmohammadi ◽  
Atefeh Tavangar ◽  
Mohammad Ehteram ◽  
Mohammad Karimian
Keyword(s):  
Computational Biology ◽  
Chronic Periodontitis ◽  
Case Control ◽  
Interleukin 17 ◽  
Case Control Studies

scholarly journals Lack of Association between Interleukin-1βGene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Seoung-Jin Hong ◽  
Sang Wook Kang ◽  
Su Kang Kim ◽  
Young Sik Kim ◽  
Ju Yeon Ban
Keyword(s):  
Chronic Periodontitis ◽  
Case Control Study ◽  
Inflammatory Responses ◽  
Direct Sequencing ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Information Service ◽  
Case Control ◽  
Case Control Studies ◽  
Control Study

Background. Interleukin-1β(IL-1β) plays an important role as a mediator of various inflammatory responses in chronic periodontitis. Several studies have investigated the potential relationship between IL-1βpolymorphism (rs16944) and susceptibility to chronic periodontitis; inflammatory process is involved, but conclusions is still controversial.Objective. The aim of this study was to determine whether the IL-1βpolymorphism (rs16944) is associated with susceptibility to chronic periodontitis.Material and Methods. For the case-control study, 51 patients with chronic periodontitis and 33 healthy control patients were recruited in the study. Genotyping was conducted by direct sequencing. SNPStats and SPSS 18.0 were used for the analysis of genetic data and to evaluate odds ratios, 95% confidence intervals, andPvalues; logistic regression models were used. And to perform meta-analysis, studies about IL-1βpolymorphism (rs16944) and chronic periodontitis were searched in PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases until July 2017.Results. In our case-control study, no significant relationship was revealed between IL-1βpolymorphism (rs16944) and chronic periodontitis (P>0.05in each model). When combined with the previous studies in the meta-analysis, the result was not associated with chronic periodontitis in any of the models (CC vs. CT + TT: OR = 0.97, 95% CI = 0.762–1.246; CC + CT vs. TT: OR = 0.90, 95% CI = 0.658–1.232; and C vs. T: OR = 0.93, 95% CI = 0.774–1.128). The subgroup analysis stratified by ethnicity showed a weak association between the IL-1βpolymorphism (rs16944) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017–1.758,P=0.037).Conclusion. Evidences from a case-control study and the meta-analysis suggest that IL-1βpolymorphism (rs16944) is not associated with susceptibility to chronic periodontitis.

Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies

Gene ◽  
2018 ◽  
Vol 668 ◽  
pp. 97-106 ◽  
Author(s):  
Felipe Rodolfo Pereira da Silva ◽  
Any Carolina Cardoso Guimarães Vasconcelos ◽  
Luiz Felipe de Carvalho França ◽  
David Di Lenardo ◽  
Hélio Mateus Silva Nascimento ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144319 ◽  
Author(s):  
Ce Zhu ◽  
Fei Li ◽  
May. Chun. Mei Wong ◽  
Xi-Ping Feng ◽  
Hai-Xia Lu ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Interleukin-6-174G/C Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Junfei Zhu ◽  
Bin Guo ◽  
Min Fu ◽  
Wushuang Guo ◽  
Yifang Yuan ◽  
...  
Keyword(s):  
Risk Factor ◽  
Interleukin 6 ◽  
Chronic Periodontitis ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Caucasian Population ◽  
Dominant Model ◽  
Case Control Studies ◽  
Meta Analyses

Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility.Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0.Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560–0.849,P=0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568–0.838,P<0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577–0.980,P=0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576–0.944,P=0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497–0.845,P=0.001; GC versus GG: OR = 0.621, 95% CI = 0.441–0.876,P=0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470–0.896,P=0.009).Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.

Case-Control Studies

2009 ◽  
Author(s):  
Ruth H. Keogh ◽  
D. R. Cox
Keyword(s):  
Case Control ◽  
Case Control Studies

Clinical Trials in Thrombosis: Secondary Prevention of Myocardial Infarction

1976 ◽  
Vol 35 (01) ◽  
pp. 049-056 ◽  
Author(s):  
Christian R Klimt ◽  
P. H Doub ◽  
Nancy H Doub
Keyword(s):  
Myocardial Infarction ◽  
Secondary Prevention ◽  
Case Control ◽  
Therapeutic Effects ◽  
Case Control Studies ◽  
Definitive Answer ◽  
Inhibition Of Platelet Aggregation ◽  
Prospective Trials

SummaryNumerous in vivo and in vitro experiments, investigating the inhibition of platelet aggregation and the prevention of experimentally-induced thrombosis, suggest that anti-platelet drugs, such as aspirin or the combination of aspirin and dipyridamole or sulfinpyrazone, may be effective anti-thrombotic agents in man. Since 1971, seven randomized prospective trials and two case-control studies have been referenced in the literature or are currently being conducted, which evaluate the effects of aspirin, sulfinpyrazone, or dipyridamole in combination with aspirin in the secondary prevention of myocardial infarction. A critical review of these trials indicates a range of evidence from no difference to a favorable trend that antiplatelet drugs may serve as anti-thrombotic agents in man. To date, a definitive answer concerning the therapeutic effects of these drugs in the secondary prevention of coronary heart disease is not available.

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