Lack of Association between Interleukin-1βGene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis

Background. Interleukin-1β(IL-1β) plays an important role as a mediator of various inflammatory responses in chronic periodontitis. Several studies have investigated the potential relationship between IL-1βpolymorphism (rs16944) and susceptibility to chronic periodontitis; inflammatory process is involved, but conclusions is still controversial.Objective. The aim of this study was to determine whether the IL-1βpolymorphism (rs16944) is associated with susceptibility to chronic periodontitis.Material and Methods. For the case-control study, 51 patients with chronic periodontitis and 33 healthy control patients were recruited in the study. Genotyping was conducted by direct sequencing. SNPStats and SPSS 18.0 were used for the analysis of genetic data and to evaluate odds ratios, 95% confidence intervals, andPvalues; logistic regression models were used. And to perform meta-analysis, studies about IL-1βpolymorphism (rs16944) and chronic periodontitis were searched in PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases until July 2017.Results. In our case-control study, no significant relationship was revealed between IL-1βpolymorphism (rs16944) and chronic periodontitis (P>0.05in each model). When combined with the previous studies in the meta-analysis, the result was not associated with chronic periodontitis in any of the models (CC vs. CT + TT: OR = 0.97, 95% CI = 0.762–1.246; CC + CT vs. TT: OR = 0.90, 95% CI = 0.658–1.232; and C vs. T: OR = 0.93, 95% CI = 0.774–1.128). The subgroup analysis stratified by ethnicity showed a weak association between the IL-1βpolymorphism (rs16944) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017–1.758,P=0.037).Conclusion. Evidences from a case-control study and the meta-analysis suggest that IL-1βpolymorphism (rs16944) is not associated with susceptibility to chronic periodontitis.

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Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0153480 ◽

2016 ◽

Vol 11 (4) ◽

pp. e0153480 ◽

Cited By ~ 10

Author(s):

Himanshu Rai ◽

Nakul Sinha ◽

Sudeep Kumar ◽

Ajay Kumar Sharma ◽

Suraksha Agrawal

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Gene Cluster ◽

Case Control Study ◽

Meta Analysis ◽

Interleukin 1 ◽

Case Control ◽

North Indians ◽

Artery Disease ◽

Control Study

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Case-control study of hypertension and Parkinson’s disease

npj Parkinson s Disease ◽

10.1038/s41531-021-00202-w ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Yuen-Fann Ng ◽

Ebonne Ng ◽

Ee-Wei Lim ◽

Kumar M. Prakash ◽

Louis C. S. Tan ◽

...

Keyword(s):

Case Control Study ◽

Meta Analysis ◽

Asian Population ◽

Case Control ◽

Case Control Studies ◽

Matched Case ◽

And Gender ◽

Chinese Subjects ◽

Matched Case Control Study ◽

Control Study

AbstractWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.

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COX ‐2 gene polymorphisms and risk of chronic periodontitis: a case–control study and meta‐analysis

Oral Diseases ◽

10.1111/odi.12203 ◽

2013 ◽

Vol 21 (1) ◽

pp. 38-45 ◽

Cited By ~ 6

Author(s):

G Prakash ◽

M Umar ◽

S Ajay ◽

D Bali ◽

R Upadhyay ◽

...

Keyword(s):

Chronic Periodontitis ◽

Gene Polymorphisms ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Cox 2 ◽

Control Study

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The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

Frontiers in Oncology ◽

10.3389/fonc.2021.796774 ◽

2021 ◽

Vol 11 ◽

Author(s):

Xueren Gao ◽

Xianyang Li ◽

Shulong Zhang ◽

Xiaoting Wang

Keyword(s):

Breast Cancer ◽

Gastric Cancer ◽

Case Control Study ◽

Cancer Susceptibility ◽

Direct Sequencing ◽

Meta Analysis ◽

Case Control ◽

Control Study ◽

Increased Susceptibility ◽

Cancer Bioinformatics

Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.

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Lack of association between miR-146a rs2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis

Bioscience Reports ◽

10.1042/bsr20191729 ◽

2021 ◽

Vol 41 (1) ◽

Author(s):

Jiakai Jiang ◽

Sheng Zhang ◽

Weifeng Tang ◽

Zhiyuan Qiu

Keyword(s):

Colorectal Cancer ◽

Case Control Study ◽

Meta Analysis ◽

Pooled Analysis ◽

Case Control ◽

Case Control Studies ◽

Relationship Of ◽

Risk Of Cancer ◽

The Relationship ◽

Control Study

Abstract Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case–control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case–control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P=0.465; GG vs. CC: adjusted P=0.436, CG/GG vs. CC: adjusted P=0.387 and GG vs. CC/CG: adjusted P=0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12,168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P=0.537; GG vs. CC: P=0.517, CG/GG vs. CC: P=0.520 and GG vs. CC/CG: P=0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case–control studies are needed to confirm our results.

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Association of interleukin-1 family cytokines single nucleotide polymorphisms with susceptibility to systemic sclerosis: an independent case–control study and a meta-analysis

Immunologic Research ◽

10.1007/s12026-016-8797-7 ◽

2016 ◽

Vol 64 (4) ◽

pp. 1041-1052 ◽

Cited By ~ 7

Author(s):

Xiao-Lei Huang ◽

Guo-Cui Wu ◽

Yu-Jie Wang ◽

Xiao-Ke Yang ◽

Guo-Jun Yang ◽

...

Keyword(s):

Systemic Sclerosis ◽

Single Nucleotide Polymorphisms ◽

Case Control Study ◽

Meta Analysis ◽

Interleukin 1 ◽

Case Control ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Independent Case ◽

Control Study

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Poultry consumption and prostate cancer risk: a meta-analysis

PeerJ ◽

10.7717/peerj.1646 ◽

2016 ◽

Vol 4 ◽

pp. e1646

Author(s):

Qian He ◽

Zheng-ce Wan ◽

Xiao-bing Xu ◽

Jing Wu ◽

Guang-lian Xiong

Keyword(s):

Prostate Cancer ◽

Case Control Study ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Prostate Cancer Risk ◽

Case Control ◽

Case Control Studies ◽

Effect Model ◽

Control Study

Background.Several kinds of foods are hypothesized to be potential factors contributing to the variation of prostate cancer (PCa) incidence. But the effect of poultry on PCa is still inconsistent and no quantitative assessment has been published up to date. So we conducted this meta-analysis to clarify the association between them.Materials and Methods. We conducted a literature search of PubMed and Embase for studies examining the association between poultry consumption and PCa up to June, 2015. Pooled risk ratio (RR) and corresponding 95% confidence interval (CI) of the highest versus lowest poultry consumption categories were calculated by fixed-effect model or random-effect model.Results.A total of 27 (12 cohort and 15 case-control) studies comprising 23,703 cases and 469,986 noncases were eligible for inclusion. The summary RR of total PCa incidence was 1.03 (95% CI [0.95–1.11]) for the highest versus lowest categories of poultry intake. The heterogeneity between studies was not statistically significant (P= 0.768,I2= 28.5%). Synthesized analysis of 11 studies on high stage PCa and 8 studies on chicken exposure also demonstrated null association. We also did not obtain significant association in the subgroup of cohort study (RR = 1.04, 95% CI [0.98–1.10]), as well as in the subgroups of population-based case-control study and hospital-based case-control study. Then the studies were divided into three geographic groups: Western countries, Asia and South America. The pooled RRs in these areas did not reveal statistically significant association between poultry and PCa.Conclusions.This meta-analysis suggests no association between poultry consumption and PCa risk. Further well-designed studies are warranted to confirm the result.

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