Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non‐diabetic rats

2021 ◽  
Author(s):  
Ahmad Za’al Alsarayreh ◽  
Sawsan Atallah Oran ◽  
Jumah Mutie Shakhanbeh
Keyword(s):  
Wound Healing ◽  
Diabetic Rats ◽  
Fruit Extract ◽  
Rhus Coriaria

Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals

2019 ◽  
Vol 17 (2) ◽  
Author(s):  
Manish Pal Singh ◽  
Avneet Gupta ◽  
Siddhraj Singh Sisodia
Keyword(s):  
Wound Healing ◽  
Gallic Acid ◽  
Dead Space ◽  
Diabetic Rats ◽  
Fruit Extract ◽  
Standard Drug ◽  
Terminalia Bellerica ◽  
Wound Model ◽  
Wound Healing Activity ◽  
Experimentally Induced

AbstractBackgroundDiabetic wound are the major problem of society because of its delay healing of wound in hyperglycemia patient. The target of this study need to know the gallic acid compelling synergistically wound healing in diabetic animals as it is available in fruit extract or is more effective in given pure form in diabetic animals.MethodsThe wound healing effects of fruit extract Terminalia bellerica Roxb. and gallic acid were evaluated in experimentally induced hyperglycemic animals. In this investigation, excision and dead space wound models were used. The contraction wound %, re-epithelialization days, area of scar, histopathological examination of tissue, hydroxyproline level and weight of tissue granuloma were evaluated in this study.ResultsTerminalia bellerica fruit extract (400 mg/Kg) and gallic acid (200 mg/Kg) have been ingested by orally in streptozotocin induced diabetic rats. They were founded significantly (p<0.05) improved percentage wound contraction and decreased the size of scar area and days of re-epithelialization in excision wound model. Also, they were improved the level of hydroxyproline level in diabetic rats as compared to diabetic control group in dead space wound model. Standard drug vitamin C was also founded significantly improved wound healing activity in rats. These results suggested that treated groups accelerated wound healing activity in diabetic rat.ConclusionsThe observations and results obtained in the present study indicated the wound healing efficacy of fruit ethanolic extract and gallic acid in diabetic animals. Yet, the wound healing effect was increasingly reported with gallic acid.

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1872
Author(s):  
Hamideh Afzali ◽  
Mohammad Khaksari ◽  
Sajad Jeddi ◽  
Khosrow Kashfi ◽  
Mohammad-Amin Abdollahifar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fibrous Tissue ◽  
Diabetic Rats ◽  
Male Rats ◽  
Numerical Density ◽  
Basal Cells ◽  
Diabetic Wound Healing ◽  
Diabetic Wounds ◽  
Endothelial Growth Factor

Impaired skin nitric oxide production contributes to delayed wound healing in type 2 diabetes (T2D). This study aims to determine improved wound healing mechanisms by acidified nitrite (AN) in rats with T2D. Wistar rats were assigned to four subgroups: Untreated control, AN-treated control, untreated diabetes, and AN-treated diabetes. AN was applied daily from day 3 to day 28 after wounding. On days 3, 7, 14, 21, and 28, the wound levels of vascular endothelial growth factor (VEGF) were measured, and histological and stereological evaluations were performed. AN in diabetic rats increased the numerical density of basal cells (1070 ± 15.2 vs. 936.6 ± 37.5/mm3) and epidermal thickness (58.5 ± 3.5 vs. 44.3 ± 3.4 μm) (all p < 0.05); The dermis total volume and numerical density of fibroblasts at days 14, 21, and 28 were also higher (all p < 0.05). The VEGF levels were increased in the treated diabetic wounds at days 7 and 14, as was the total volume of fibrous tissue and hydroxyproline content at days 14 and 21 (all p < 0.05). AN improved diabetic wound healing by accelerating the dermis reconstruction, neovascularization, and collagen deposition.

Electrospun Fibers Loaded with Cordia myxa L. Fruit Extract: Fabrication, Characterization, Biocompatibility and Efficacy in Wound Healing

2021 ◽  
pp. 102528
Author(s):  
Ramin Seyedian ◽  
Fatemeh Isavi ◽  
Maryam Najafiasl ◽  
Sasan Zaeri
Keyword(s):  
Wound Healing ◽  
Electrospun Fibers ◽  
Fruit Extract ◽  
Cordia Myxa

Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway

2020 ◽  
Vol 187 ◽  
pp. 110647 ◽  
Author(s):  
Peng Zhang ◽  
Libang He ◽  
Jie Zhang ◽  
Xifan Mei ◽  
Yiyao Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Rats

Wound-healing effects of low-level laser therapy in diabetic rats involve the modulation of MMP-2 and MMP-9 and the redistribution of collagen types I and III

2013 ◽  
Vol 15 (4) ◽  
pp. 210-216 ◽  
Author(s):  
Andreia Aparecida Da Silva ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Ana Carolina Araruna Alves ◽  
Caroline Sobral Rambo ◽  
Solange Almeida Dos Santos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Laser Therapy ◽  
Diabetic Rats ◽  
Low Level Laser Therapy ◽  
Collagen Types ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser
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