Electrospun Fibers Loaded with Cordia myxa L. Fruit Extract: Fabrication, Characterization, Biocompatibility and Efficacy in Wound Healing

Electrical driven self-organization of electrospun fibers is used to create topographically bioinspired three-dimensional multilayered constructs, with tunable morphological and physicochemical properties for ideal wound dressings.

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The Effect of Carica Pubescens Lenne and K. Koch Fruit Extract from Dieng Plateau and Cangar to the Amount of Fibroblasts Cells on the Healing of Oral Mucosal Inflammation

Journal of Islamic Pharmacy ◽

10.18860/jip.v1i1.3457 ◽

2016 ◽

Vol 1 (1) ◽

pp. 20

Author(s):

Risma Aprinda Kristanti

Keyword(s):

Wound Healing ◽

Mucosal Inflammation ◽

Gingival Tissue ◽

Control Group ◽

Apical Region ◽

Gingival Fibroblasts ◽

Fruit Extract ◽

Significant Difference ◽

Gingival Mucosa ◽

Mucosal Wound

The purposes of this research are to know the effect of C.pubescens fruit extract on the amount of gingival fibroblasts in wound healing of Rattus norvegicus mouth cavity’s mucosal and to know the effect of C.pubescens comes from two different areas (Dieng and Cangar) on the amount of gingival fibroblasts in wound healing of Rattus norvegicus oral mucosa. Twenty eight rats are divided to be four groups (K1, K2, K3, and K4), each rat is wounded 1 cm on the gingival mucosa of lower jaw (specifically on the apical region of incisive teeth). K1 is the control group with aquadest treatment on the wound. The wound in the K2 is treated with C.pubescens fruit extract from Dieng. The wound in the K3 is treated with C.pubescens fruit extract from Cangar. And the treatment for K4 is medicated by policresulen (common medicine for oral mucosal wound). On the fifth day of the treatment, all rats are sacrificed, and the gingival tissue is taken up for the next step. Gingival tissue is smeared by Haematoxylin Eosin (HE) to analyze the amount of gingival fibroblasts histologically. The result of this research shows that the highest average amount of gingival fibroblasts comes from K4 (policresulen treatment). And there is no significant difference on the number of Rattus norvegicus gingival fibroblasts from all of the groups (K1, K2, K3, and K4). Keywords: fibroblast, gingival, wound, mucosa, mouth, C.pubescens

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The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)

Journal Of Tropical Pharmacy And Chemistry ◽

10.25026/jtpc.v5i1.228 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Sara Nurmala ◽

Moerfia Moerfia ◽

Santi Novianti

Keyword(s):

Wound Healing ◽

Allium Cepa ◽

The United States ◽

Abelmoschus Esculentus ◽

Male Rats ◽

Cell Multiplication ◽

Fruit Extract ◽

White Rats ◽

Allium Cepa L ◽

Anti Inflammatory

Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.

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Wound Healing properties of OPAL A (patented Carica papaya fruit extract)

10.26226/morressier.595a9c5ad462b80296c9f6bc ◽

2017 ◽

Author(s):

REDDY SREEKANTH VOOTUKURI

Keyword(s):

Wound Healing ◽

Carica Papaya ◽

Fruit Extract

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Evaluation of wound healing potential of pomegranate (Punica granatum) whole fruit extract on skin burn wound in rats (Rattus norvegicus)

Journal of Advanced Veterinary and Animal Research ◽

10.5455/javar.2019.f333 ◽

2019 ◽

Vol 6 (2) ◽

pp. 202 ◽

Cited By ~ 3

Author(s):

Bambang Lukiswanto ◽

Alya Miranti ◽

Sri Sudjarwo ◽

Hardany Primarizky ◽

Wiwik Yuniarti

Keyword(s):

Wound Healing ◽

Rattus Norvegicus ◽

Punica Granatum ◽

Skin Burn ◽

Burn Wound ◽

Fruit Extract

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Wound healing activity of Terminalia bellerica Roxb. and gallic acid in experimentally induced diabetic animals

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0133 ◽

2019 ◽

Vol 17 (2) ◽

Cited By ~ 1

Author(s):

Manish Pal Singh ◽

Avneet Gupta ◽

Siddhraj Singh Sisodia

Keyword(s):

Wound Healing ◽

Gallic Acid ◽

Dead Space ◽

Diabetic Rats ◽

Fruit Extract ◽

Standard Drug ◽

Terminalia Bellerica ◽

Wound Model ◽

Wound Healing Activity ◽

Experimentally Induced

AbstractBackgroundDiabetic wound are the major problem of society because of its delay healing of wound in hyperglycemia patient. The target of this study need to know the gallic acid compelling synergistically wound healing in diabetic animals as it is available in fruit extract or is more effective in given pure form in diabetic animals.MethodsThe wound healing effects of fruit extract Terminalia bellerica Roxb. and gallic acid were evaluated in experimentally induced hyperglycemic animals. In this investigation, excision and dead space wound models were used. The contraction wound %, re-epithelialization days, area of scar, histopathological examination of tissue, hydroxyproline level and weight of tissue granuloma were evaluated in this study.ResultsTerminalia bellerica fruit extract (400 mg/Kg) and gallic acid (200 mg/Kg) have been ingested by orally in streptozotocin induced diabetic rats. They were founded significantly (p<0.05) improved percentage wound contraction and decreased the size of scar area and days of re-epithelialization in excision wound model. Also, they were improved the level of hydroxyproline level in diabetic rats as compared to diabetic control group in dead space wound model. Standard drug vitamin C was also founded significantly improved wound healing activity in rats. These results suggested that treated groups accelerated wound healing activity in diabetic rat.ConclusionsThe observations and results obtained in the present study indicated the wound healing efficacy of fruit ethanolic extract and gallic acid in diabetic animals. Yet, the wound healing effect was increasingly reported with gallic acid.

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Electrospun antibacterial nanofibers for wound dressings and tissue medicinal fields: A Review

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545820300128 ◽

2020 ◽

Vol 13 (05) ◽

pp. 2030012 ◽

Cited By ~ 1

Author(s):

Zhimei Wei ◽

Liqun Wang ◽

Shouyu Zhang ◽

Tonghai Chen ◽

Jie Yang ◽

...

Keyword(s):

Wound Healing ◽

Biomedical Applications ◽

Bacterial Infections ◽

Antibacterial Agents ◽

Antimicrobial Agents ◽

Electrospinning Process ◽

Wound Dressings ◽

Electrospun Fibers ◽

Chronic Infections ◽

Antibacterial Material

Bacterial infections are a major cause of chronic infections. Thus, antibacterial material is an urgent need in clinics. Antibacterial nanofibers, with expansive surface area, enable efficient incorporation of antibacterial agents. Meanwhile, structure similar to the extracellular matrix can accelerate cell growth. Electrospinning, the most widely used technique to fabricate nanofiber, is often used in many biomedical applications including drug delivery, regenerative medicine, wound healing and so on. Thus, this review provides an overview of all recently published studies on the development of electrospun antibacterial nanofibers in wound dressings and tissue medicinal fields. This reviewer begins with a brief introduction of electrospinning process and then discusses electrospun fibers by incorporating various types of antimicrobial agents used as in wound dressings and tissue. Finally, we finish with conclusions and further perspectives on electrospun antibacterial nanofibers as 2D biomedicine materials.

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