Instability of different adolescent metabolic syndrome definitions tracked into early adulthood metabolic syndrome: Tehran Lipid and Glucose Study (TLGS)

2016 ◽  
Vol 18 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Golaleh Asghari ◽  
Anita Eftekharzadeh ◽  
Farhad Hosseinpanah ◽  
Sahar Ghareh ◽  
Parvin Mirmiran ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Adulthood

scholarly journals Body Mass Index and Its Change from Adolescence to Adulthood Are Closely Related to the Risk of Adult Metabolic Syndrome in China

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bingyang Liu ◽  
Yue Li ◽  
Jiamei Guo ◽  
Yuting Fan ◽  
Ling Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Glycosylated Hemoglobin ◽  
Early Adulthood ◽  
Study Groups ◽  
Relationship Of ◽  
Baseline Bmi ◽  
The Relationship

Aims. To investigate the influence of body mass index (BMI) and its change from adolescence to adulthood (ΔBMI) on the risk of metabolic syndrome (MetS) in early adulthood. Methods. We selected 931 students from 12 to 16 years of age in Liaoyang City, China. Ninety-three participants from 18 to 22 years of age with complete baseline data were available for follow-up after 5 years. Statistical analysis determined the relationship of MetS at follow-up with baseline BMI (BMIb), ΔBMI, and follow-up BMI (BMIf). Results. ΔBMI was positively correlated with the change of waist circumference (ΔWC), systolic blood pressure (ΔSBP), triglycerides (ΔTG), uric acid, and glycosylated hemoglobin (ΔHbA1c) in follow-up ( p < 0.05 ). For every 1 kg/m2 increase in BMIb, ΔBMI, and BMIf, the risk of MetS at follow-up increased 1.201-fold, 1.406-fold, and 1.579-fold, respectively. Both BMIb and ΔBMI were predictive of MetS at follow-up, with prediction thresholds of 23.47 kg/m2 and 1.95 kg/m2. The participants were divided by the predicted BMIb and ΔBMI threshold values into four study groups. Interestingly, the group with lower BMI but a higher increase in BMI presented the same metabolic derangements and Mets% of the group with higher BMI but lower Δ BMI. Conclusion. Both BMI of adolescence and ΔBMI were predictive of MetS and cardiovascular risk factors in adulthood. Control of both variables in adolescents would be more effective in decreasing the risk of MetS in young adults than control of BMI alone.

scholarly journals Relations of body weight status in early adulthood and weight changes until middle age with metabolic syndrome in the Chinese population

2017 ◽  
Vol 4 (11) ◽  
pp. 4011
Author(s):  
Liancheng Zhao ◽  
Huanhuan Liu ◽  
Long Zhou ◽  
Ying Li ◽  
Min Guo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Weight Gain ◽  
Weight Change ◽  
Chinese Population ◽  
Weight Status ◽  
Early Adulthood ◽  
Weight Changes ◽  
Body Weight Status ◽  
Increased Risk

Background: The evidences for the relationship between long-term weight gain and metabolic syndrome (MetS) in Chinese population were limited. Therefore, this study aims to explore the association of body weight status in early adulthood and weight changes with MetS.Methods: Data from China Multicenter Collaborative Study of Cardiovascular Epidemiology including 12808 participants aged 35–59 were used. Participants were surveyed for cardiovascular risk factors and a self-reported weight at age 25, which was defined as early adulthood. Weight change was calculated as the difference between baseline weight and early adulthood weight. MetS was defined according to AHA/NHLBI definition in 2009. Multivariate logistic regression model was used to examine the association between early adulthood weight status, weight change and MetS.Results: Mean age of participants was 46.7 years, including 6134 men and 6674 women. The overall prevalence of MetS was 21.8%. After adjusted for age, sex and other confounding factors, both BMI at 25 age and weight gain were positively associated with the risk of MetS. Being overweight (BMI, 24–27.9 kg m-2) or obese (BMI ≥28 kg m-2) at early adulthood was related to an increased risk of MetS, the odds ratio (OR) and 95%confidence interval (CI) was 3.24 (2.82–3.72) and 13.31 (8.72–20.31). In addition, weight gain was also associated with higher risk of MetS (P for trend<0.01).Conclusions: Overweight and obesity in early adulthood and weight gain were both independently related to an increased risk of MetS in the middle-aged Chinese men and women. 

scholarly journals Size at birth, growth trajectory in early life, and cardiovascular and metabolic risks in early adulthood: EPICure study

2020 ◽  
pp. fetalneonatal-2020-319328
Author(s):  
Yanyan Ni ◽  
Joanne Beckmann ◽  
John R Hurst ◽  
Joan K Morris ◽  
Neil Marlow
Keyword(s):  
Metabolic Syndrome ◽  
Early Adulthood ◽  
Inverse Association ◽  
Lower Socioeconomic ◽  
Infancy And Childhood ◽  
Extremely Preterm ◽  
Postmenstrual Age ◽  
Z Scores ◽  
The Uk ◽  
Size At Birth

ObjectiveTo investigate whether size at birth and growth trajectories in infancy and childhood are associated with determinants of cardiovascular and metabolic risks in young adults born extremely preterm (EP, <26 weeks of gestation).MethodsWe used longitudinal data from the EPICure study of 129 EP survivors up to 19 years in the UK and Ireland in 1995. Determinants of cardiovascular and metabolic risks at 19 years included the presence of metabolic syndrome, body mass index (BMI) and systolic blood pressure (SBP). Predictors were birth weight for gestation and gain in weight z-scores in the following periods: birth–postmenstrual age of 40 weeks (term), infancy (term–2.5 years), early childhood (2.5–6.0 years) and late childhood (6–11 years).ResultsMetabolic syndrome was present in 8.7% of EP participants at 19 years. Compared with subjects without metabolic syndrome, those with metabolic syndrome tended to have a smaller size at birth (difference in means: −0.55 SD, 95% CI −1.10 to 0.01, p=0.053) and a greater increase in weight z-scores from term to 2.5 years (difference in means: 1.00 SD, 95% CI −0.17 to 2.17, p=0.094). BMI at 19 years was positively related to growth from 2.5 to 6.0 years (β: 1.03, 95% CI 0.31 to 1.75, p=0.006); an inverse association with birthweight z-scores was found in the lower socioeconomic status group (β: −1.79, 95% CI −3.41 to –0.17, p=0.031). Central SBP was positively related to growth from 2.5 to 6.0 years (β: 1.75, 95% CI 0.48 to 3.02, p=0.007).ConclusionSize at EP birth and increased catch-up in weight from 2.5 to 6.0 years were associated with BMI and central SBP in early adulthood.

scholarly journals Association of Childhood Metabolic Syndrome and Metabolic Phenotypes with the Carotid Intima-Media Thickness (CIMT) in Early Adulthood: Tehran Lipid and Glucose Study

2021 ◽  
Author(s):  
Majid Valizadeh ◽  
Erfan Tasdighi ◽  
Maryam Barzin ◽  
Ramyar Hariri ◽  
Maryam Mahdavi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Early Adulthood ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Metabolic Phenotypes ◽  
Media Thickness ◽  
Increased Risk ◽  
Low Hdl

Abstract Background: The prevalence of metabolic syndrome (MetS) during adolescence has shown an increasing trend. This study aimed to investigate the association of MetS and metabolic phenotypes with a high carotid intima-media thickness (CIMT) in early adulthood in the framework of a large cohort study. Methods: MetS was defined as proposed by Cook, de Ferranti, the National Cholesterol Education Program (NCEP), and the pediatric International Diabetes Federation (IDF). Metabolic phenotypes were defined based on the binary clustering of cardiovascular risk factors. The participants were followed up for 18.2 years. Multivariate-adjusted odds ratios (ORs) were calculated for a high CIMT incidence (≥95th percentile).Results: In this study, 862 adolescents (52.3% males), with the mean age of 13.4±2.2 years, were included. The presence of MetS, based on the definitions proposed by Cook (OR=1.90, 95% CI: 1.01-3.57, P=0.046) and de Ferranti (OR=1.74; 95% CI: 1.04-2.90, P=0.033), was associated with the increased risk of a high CIMT in early adulthood. Metabolic phenotypes, including high waist circumference (WC)/hypertension (HTN), high WC/low high-density lipoprotein-cholesterol (HDL-C), and high triglyceride (TG)/high WC, showed higher risks of a high CIMT. However, these positive associations become insignificant after adjusting for the adulthood BMI, except for the high WC/low HDL-C phenotype (OR=2.04, 95% CI: 1.02-4.11, P=0.044). Conclusion: The high WC/low HDL-C phenotype had a better predictive value and could be used as a simpler alternative for MetS to identify adolescents with a higher risk of high CIMT during early adulthood.

scholarly journals Body Mass Index Trajectories in Adolescence And Incident Metabolic Syndrome in Early Adulthood

2021 ◽  
Author(s):  
Ming Ying ◽  
Xiangming Hu ◽  
Qiang Li ◽  
Zhujun Chen ◽  
Yingling Zhou
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Adulthood ◽  
Educational Background ◽  
Bmi Trajectories ◽  
The Relationship ◽  
Bmi Trajectory ◽  
High Bmi

Abstract Background: The incidence of metabolic syndrome (MetS) is increasing each year, and MetS is closely related to cardiovascular diseases. Body mass index (BMI) has been widely used to measure obesity, and the relationship between MetS and BMI has been widely reported. However, the relationship between the trajectory of BMI and MetS is still unclear.Methods: Six waves of the cross-sectional China Health and Nutrition Survey (CHNS) were completed in nine provinces in China from 1993 to 2009, with more than 12,000 participants. We enrolled individuals who were aged 10 to 20 years in 1993, and 554 participants were finally included in our study. A latent class growth mixed model was used to identify different BMI trajectory patterns based on the BMI value measured at each follow-up. Participants completed blood tests and a physical examination in 2009 to allow for the diagnosis of MetS. The primary aim was to explore the relationship between different BMI trajectories and the incidence of MetS through logistic regression, adjusting for baseline age, sex, BMI, waist circumference, residence, educational background, smoking status, alcohol consumption, and nutritional intake.Result: During a follow-up of 16 years, 61 (11.01%) participants developed MetS. In multivariate-adjusted models, different BMI trajectories were significantly associated with the occurrence of MetS in early adulthood. Childhood or adolescents with a low-high BMI trajectory or a high-high BMI trajectory showed a significantly higher risk of MetS in early adulthood than those with a low-low trajectory (low-high: OR=3.40, 95% CI: 1.14-10.13, P <0.05; high-high: OR=5.81, 95% CI: 1.63-20.69, P <0.05).Conclusion: Our study identified three BMI trajectories from adolescence through 16 years of follow-up and found that in addition to baseline BMI, BMI trajectories were also an independent risk factor for incident MetS in early adulthood.

scholarly journals Adolescent metabolic syndrome and its components associations with incidence of type 2 diabetes in early adulthood: Tehran lipid and glucose study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Golaleh Asghari ◽  
Mitra Hasheminia ◽  
Abolfazl Heidari ◽  
Parvin Mirmiran ◽  
Kamran Guity ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Family History ◽  
Early Adulthood ◽  
Incident Type ◽  
Low Hdl ◽  
History Of ◽  
Adjusted Model

Abstract Aim To investigate the association of youth metabolic syndrome (MetS) and its components, individually and in combination with early adulthood incident type 2 diabetes (T2DM). Methods A total of 2798 adolescents aged 11–19 years enrolled in the study. At baseline, MetS, its components including blood pressure (BP), waist circumference (WC), triglycerides (TGs), fasting plasma glucose, and low HDL-C, and different combinations of MetS components were defined. After a mean 11.3 years of follow-up, T2DM was determined. Multivariable Cox proportional hazard regression analysis adjusted for age, sex, family history of T2DM, and adult BMI was used for data analysis. The hazard ratio (HR) and 95% confidence interval (CI) were reported. Results During the follow-up, 44 incidents T2DM were developed. Among different individual components, only high WC [HR = 2.63, 95% CI (1.39–4.97)] and high TGs [HR = 1.82, 95% CI (1.00–3.34)] remained as significant predictors only in the age and sex adjusted model. Regarding combinations of MetS components, ‘high TGs and high WC’ [HR = 2.70, 95% CI (1.27–5.77)], ‘high BP and high WC’ [HR = 2.52, 95% CI (1.00–6.33)], ‘high TGs and high BP’ [HR = 2.27, 95% CI (1.02–5.05)] as well as MetS per se [HR = 2.82, 95% CI (1.41–5.64)] had a significant relationship with incident T2DM in the multivariable adjusted model. Among different confounders, being female and having family history of T2DM were consistently associated with higher risk of T2DM, in different combinations of MetS components. Conclusions Adolescence MetS and some combinations of MetS components predicted early adulthood T2DM. Thus, adolescents, particularly female ones, with combinations of MetS components as well as those with family history of T2DM could be targeted for lifestyle intervention.

Sign in / Sign up

Export Citation Format

Share Document