Association between interpregnancy interval and hypertensive disorders of pregnancy: Effect modification by maternal age

Author(s):  
Amanuel T. Gebremedhin ◽  
Gizachew A. Tessema ◽  
Annette K. Regan ◽  
Gavin Pereira
Circulation ◽  
2021 ◽  
Vol 143 (7) ◽  
pp. 727-738
Author(s):  
Islam Y. Elgendy ◽  
Syed Bukhari ◽  
Amr F. Barakat ◽  
Carl J. Pepine ◽  
Kathryn J. Lindley ◽  
...  

Maternal mortality rates have been steadily increasing in the United States, and cardiovascular mortality is the leading cause of death among pregnant and postpartum women. Maternal stroke accounts for a significant burden of cardiovascular mortality. Data suggest that rates of maternal stroke have been increasing in recent years. Advancing maternal age at the time of birth and the increasing prevalence of traditional cardiovascular risk factors, and other risk factors, as well, such as hypertensive disorders of pregnancy, migraine, and infections, may contribute to increased rates of maternal stroke. In this article, we provide an overview of the epidemiology of maternal stroke, explore mechanisms that may explain increasing rates of stroke among pregnant women, and identify key knowledge gaps for future investigation in this area.


2019 ◽  
Vol 18 ◽  
pp. 112-116 ◽  
Author(s):  
Thomas Desplanches ◽  
Camille Bouit ◽  
Jonathan Cottenet ◽  
Emilie Szczepanski ◽  
Catherine Quantin ◽  
...  

2017 ◽  
Vol 35 (03) ◽  
pp. 311-316 ◽  
Author(s):  
Audrey Merriam ◽  
Julley Jung ◽  
Cynthia Gyamfi-Bannerman ◽  
Devin Smith

Objective Our primary objective was to compare the differential contribution of fetal number and maternal age to the risk of hypertensive disorders of pregnancy (HDP). Study Design This was a secondary analysis of a large study of primary cesarean delivery. Women with singleton, twin, or triplet gestations were included. Women were divided into groups based on fetal number and maternal age. The primary outcome was HDP. A logistic regression model was fit to adjust for confounders. The incidence of HDP was compared with the reference group and within exposure groups. Results Of the 70,417 women included, HDP occurred in 8,079 (12%) women. The frequency of HDP among the comparison groups ranged from 11 to 38%. Nearly all groups had significantly increased risk of HDP compared with young maternal age singletons. Twin and triplet gestations increased the risk of HDP over singletons irrespective of maternal age after adjusting for baseline disease and race. The risk of HDP did not significantly increase with maternal age when fetal number was similar. Conclusion Fetal number significantly increased the risk of HDP and contributed more to that risk than maternal age. Maternal age became significant in groups with age greater than 40 years.


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