Endothelin-1 profiles in advanced maternal age complicated with hypertensive disorders of pregnancy

2019 ◽  
Vol 516 (3) ◽  
pp. 941-944
Author(s):  
Kiichiro Furuya ◽  
Keiichi Kumasawa ◽  
Hitomi Nakamura ◽  
Tadashi Kimura
Keyword(s):  
Maternal Age ◽  
Advanced Maternal Age ◽  
Hypertensive Disorders Of Pregnancy ◽  
Endothelin 1 ◽  
Hypertensive Disorders

Impact of the mode of conception on gestational hypertensive disorders at very advanced maternal age

2020 ◽  
Vol 40 (2) ◽  
pp. 281-286
Author(s):  
Raanan Meyer ◽  
Raoul Orvieto ◽  
Yael Timerman ◽  
Tal Gorodesky ◽  
Shlomo Toussia-Cohen ◽  
...  
Keyword(s):  
Maternal Age ◽  
Advanced Maternal Age ◽  
Hypertensive Disorders ◽  
Very Advanced Maternal Age

scholarly journals Perinatal and maternal outcome in advanced maternal age, more than or equal to 35 years: a prospective observational study

2021 ◽  
Vol 10 (2) ◽  
pp. 696
Author(s):  
Deepti Nagendra Prasad ◽  
Beena Madhavth
Keyword(s):  
Health Care ◽  
Perinatal Outcome ◽  
Maternal Age ◽  
Prospective Observational Study ◽  
Advanced Maternal Age ◽  
Fetal Outcome ◽  
Maternal Outcome ◽  
Hypertensive Disorders ◽  
Care Assessment ◽  
Increasing Trend

Background: As there is increasing trend with pregnancy being delayed due to various reasons, this topic was studied so as to help patient and health care provider know the effect of advanced age on pregnancy and its outcome both related to mother and fetus. The objective of the study was to evaluate maternal and perinatal outcome in advanced maternal age in terms of fetal outcome, maternal outcome and labour outcome.Methods: 102 pregnant patients of age 35 years and more over 1 year from November 2015 to October 2016 in Holy family hospital, Bandra, Mumbai.Results: Incidence of hypertensive disorders, malpresentation, rate of conception on treatment and caesarean section is more in advanced maternal age.Conclusions: A proper pre-conceptional consultation and intensive antenatal care assessment can reduce the risks in advanced maternal age pregnancy.

scholarly journals Maternal Stroke

Circulation ◽  
2021 ◽  
Vol 143 (7) ◽  
pp. 727-738
Author(s):  
Islam Y. Elgendy ◽  
Syed Bukhari ◽  
Amr F. Barakat ◽  
Carl J. Pepine ◽  
Kathryn J. Lindley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Mortality ◽  
Maternal Age ◽  
The United States ◽  
Mortality Rates ◽  
Mortality Data ◽  
Postpartum Women ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Significant Burden

Maternal mortality rates have been steadily increasing in the United States, and cardiovascular mortality is the leading cause of death among pregnant and postpartum women. Maternal stroke accounts for a significant burden of cardiovascular mortality. Data suggest that rates of maternal stroke have been increasing in recent years. Advancing maternal age at the time of birth and the increasing prevalence of traditional cardiovascular risk factors, and other risk factors, as well, such as hypertensive disorders of pregnancy, migraine, and infections, may contribute to increased rates of maternal stroke. In this article, we provide an overview of the epidemiology of maternal stroke, explore mechanisms that may explain increasing rates of stroke among pregnant women, and identify key knowledge gaps for future investigation in this area.

scholarly journals Periodic Assessment of Antenatal and Post Natal Serum Endothelin-1 (ET-1) and Nitric Oxide (NO) Levels in Hypertensive Disorders of Pregnancy (HDP)

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Hidayah I ◽  
Tariq A.R. ◽  
N.A. Jamani ◽  
Maizura M.Z.
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Disease Risk ◽  
Chronic Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Sample Collection ◽  
Endothelin 1 ◽  
Hypertensive Disorders ◽  
Potent Vasoconstrictor

Hypertensive Disorders of Pregnancy (HDP) is an independent risk factor of cardiovascular (CVS) disease with endothelial dysfunction postulated to be the pathophysiology. Endothelin-1 (ET-1), a potent vasoconstrictor, has been identified as a pivotal mediator in HDP. Disturbances in nitric oxide (NO) bioavailability found in endothelial dysfunction may increase susceptibility to cardiovascular diseases such as hypertension. The study aims to determine serial ET-1 and NO levels in patients with HDP and its role in persistent endothelial dysfunction. Thirty-six pregnant women from the following categories (i) normal pregnant women (Control) (ii) chronic hypertension during pregnancy (CH) and (iii) pregnancy induced hypertension (PIH) participated in this study. Blood pressure indices measurements and sample collection were done at antepartum (32 weeks) and postpartum (8 weeks and 12 weeks). ET-1 and serum NO were measured using the Human ET-1 (Endothelin-1) ELISA Kit and Nitric Oxide (total) detection kit respectively. Results: Serum ET-1 was significantly higher in patients with CH (55.3 pg/ml) and PIH (35.6 pg/ml) compared to Control (11.8 pg/ml) during antenatal until 3 months postpartum (CH 38.3 pg/ml, PIH 29.5 pg/ml, Control 1.9 pg/ml). This was accompanied by significantly lower levels of serum NO in HDP patients. Persistently higher than normal levels of ET-1 and lower than normal levels of NO up to 3 months postpartum in patients with history of HDP indicate presence of persistent endothelial dysfunction despite BP normalisation in PIH patients. Long term NO/ET-1 imbalance may account for the increased CVS disease risk.

Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats

2010 ◽  
Vol 298 (3) ◽  
pp. R713-R719 ◽  
Author(s):  
John H. Tinsley ◽  
Sanique South ◽  
Valorie L. Chiasson ◽  
Brett M. Mitchell
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Systolic Blood Pressure ◽  
Interleukin 10 ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Hypertensive Disorders Of Pregnancy ◽  
Endothelin 1 ◽  
Protein Excretion ◽  
Hypertensive Disorders

Hypertensive disorders of pregnancy are characterized by systemic and placental inflammation; however, treatment for these conditions has remained elusive. We tested whether administration of the anti-inflammatory cytokine interleukin-10 (IL-10) during pregnancy would attenuate the hypertension, endothelial dysfunction, proteinuria, and inflammation seen in pregnant DOCA/saline-treated (PDS) rats. Normal pregnant (NP) rats and PDS were given daily intraperitoneal injections of recombinant IL-10 from gestational day 13 until death on day 20. Systolic blood pressure, aortic endothelium-dependent relaxation responses, and urinary protein excretion were measured on days 13 and 20 of gestation. Fetal number and development, plasma endothelin-1 levels, serum and placental levels of IFNγ and IL-10, and aortic and placental levels of platelet endothelial cell adhesion molecule (PECAM) were assessed on gestational day 20. Systolic blood pressure, aortic endothelial dysfunction, and urinary protein excretion were significantly increased at gestational day 13 in PDS rats. However, all of these were restored to NP levels following IL-10 treatment in PDS rats. IL-10 treatment also significantly increased the number of pups per litter in PDS rats and did not further affect fetal development. The beneficial effects of IL-10 in PDS rats were likely mediated by the decreased plasma levels of endothelin-1, decreased levels of circulating and placental IFNγ, as well as decreased aortic and placental expression of PECAM. These data demonstrate that exogenous IL-10 can normalize blood pressure and endothelial function in pregnancy-induced hypertensive rats and may be beneficial in women with hypertensive disorders of pregnancy.

Combined effects of increasing maternal age and nulliparity on hypertensive disorders of pregnancy and small for gestational age

2019 ◽  
Vol 18 ◽  
pp. 112-116 ◽  
Author(s):  
Thomas Desplanches ◽  
Camille Bouit ◽  
Jonathan Cottenet ◽  
Emilie Szczepanski ◽  
Catherine Quantin ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Maternal Age ◽  
Combined Effects ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

Effect of Maternal Age and Fetal Number on the Risk of Hypertensive Disorders of Pregnancy

2017 ◽  
Vol 35 (03) ◽  
pp. 311-316 ◽  
Author(s):  
Audrey Merriam ◽  
Julley Jung ◽  
Cynthia Gyamfi-Bannerman ◽  
Devin Smith
Keyword(s):  
Maternal Age ◽  
Reference Group ◽  
Secondary Analysis ◽  
Primary Objective ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Comparison Groups ◽  
Primary Cesarean Delivery ◽  
Differential Contribution

Objective Our primary objective was to compare the differential contribution of fetal number and maternal age to the risk of hypertensive disorders of pregnancy (HDP). Study Design This was a secondary analysis of a large study of primary cesarean delivery. Women with singleton, twin, or triplet gestations were included. Women were divided into groups based on fetal number and maternal age. The primary outcome was HDP. A logistic regression model was fit to adjust for confounders. The incidence of HDP was compared with the reference group and within exposure groups. Results Of the 70,417 women included, HDP occurred in 8,079 (12%) women. The frequency of HDP among the comparison groups ranged from 11 to 38%. Nearly all groups had significantly increased risk of HDP compared with young maternal age singletons. Twin and triplet gestations increased the risk of HDP over singletons irrespective of maternal age after adjusting for baseline disease and race. The risk of HDP did not significantly increase with maternal age when fetal number was similar. Conclusion Fetal number significantly increased the risk of HDP and contributed more to that risk than maternal age. Maternal age became significant in groups with age greater than 40 years.

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