Committee for Academic Affairs JSSHP Research Award 2018 Basic Research Establishment of advanced maternal age model mice: novel biomarker profiles in advanced maternal age with hypertensive disorders of pregnancy

Background: As there is increasing trend with pregnancy being delayed due to various reasons, this topic was studied so as to help patient and health care provider know the effect of advanced age on pregnancy and its outcome both related to mother and fetus. The objective of the study was to evaluate maternal and perinatal outcome in advanced maternal age in terms of fetal outcome, maternal outcome and labour outcome.Methods: 102 pregnant patients of age 35 years and more over 1 year from November 2015 to October 2016 in Holy family hospital, Bandra, Mumbai.Results: Incidence of hypertensive disorders, malpresentation, rate of conception on treatment and caesarean section is more in advanced maternal age.Conclusions: A proper pre-conceptional consultation and intensive antenatal care assessment can reduce the risks in advanced maternal age pregnancy.

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Maternal Stroke

Circulation ◽

10.1161/circulationaha.120.051460 ◽

2021 ◽

Vol 143 (7) ◽

pp. 727-738

Author(s):

Islam Y. Elgendy ◽

Syed Bukhari ◽

Amr F. Barakat ◽

Carl J. Pepine ◽

Kathryn J. Lindley ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Mortality ◽

Maternal Age ◽

The United States ◽

Mortality Rates ◽

Mortality Data ◽

Postpartum Women ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Significant Burden

Maternal mortality rates have been steadily increasing in the United States, and cardiovascular mortality is the leading cause of death among pregnant and postpartum women. Maternal stroke accounts for a significant burden of cardiovascular mortality. Data suggest that rates of maternal stroke have been increasing in recent years. Advancing maternal age at the time of birth and the increasing prevalence of traditional cardiovascular risk factors, and other risk factors, as well, such as hypertensive disorders of pregnancy, migraine, and infections, may contribute to increased rates of maternal stroke. In this article, we provide an overview of the epidemiology of maternal stroke, explore mechanisms that may explain increasing rates of stroke among pregnant women, and identify key knowledge gaps for future investigation in this area.

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Combined effects of increasing maternal age and nulliparity on hypertensive disorders of pregnancy and small for gestational age

Pregnancy Hypertension ◽

10.1016/j.preghy.2019.09.006 ◽

2019 ◽

Vol 18 ◽

pp. 112-116 ◽

Cited By ~ 1

Author(s):

Thomas Desplanches ◽

Camille Bouit ◽

Jonathan Cottenet ◽

Emilie Szczepanski ◽

Catherine Quantin ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Maternal Age ◽

Combined Effects ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders

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Effect of Maternal Age and Fetal Number on the Risk of Hypertensive Disorders of Pregnancy

American Journal of Perinatology ◽

10.1055/s-0037-1607297 ◽

2017 ◽

Vol 35 (03) ◽

pp. 311-316 ◽

Cited By ~ 2

Author(s):

Audrey Merriam ◽

Julley Jung ◽

Cynthia Gyamfi-Bannerman ◽

Devin Smith

Keyword(s):

Maternal Age ◽

Reference Group ◽

Secondary Analysis ◽

Primary Objective ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Increased Risk ◽

Comparison Groups ◽

Primary Cesarean Delivery ◽

Differential Contribution

Objective Our primary objective was to compare the differential contribution of fetal number and maternal age to the risk of hypertensive disorders of pregnancy (HDP). Study Design This was a secondary analysis of a large study of primary cesarean delivery. Women with singleton, twin, or triplet gestations were included. Women were divided into groups based on fetal number and maternal age. The primary outcome was HDP. A logistic regression model was fit to adjust for confounders. The incidence of HDP was compared with the reference group and within exposure groups. Results Of the 70,417 women included, HDP occurred in 8,079 (12%) women. The frequency of HDP among the comparison groups ranged from 11 to 38%. Nearly all groups had significantly increased risk of HDP compared with young maternal age singletons. Twin and triplet gestations increased the risk of HDP over singletons irrespective of maternal age after adjusting for baseline disease and race. The risk of HDP did not significantly increase with maternal age when fetal number was similar. Conclusion Fetal number significantly increased the risk of HDP and contributed more to that risk than maternal age. Maternal age became significant in groups with age greater than 40 years.

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