Hemolytic Potential of Hydrodynamic Cavitation

2000 ◽  
Vol 122 (4) ◽  
pp. 321-326 ◽  
Author(s):  
Sean D. Chambers ◽  
Robert H. Bartlett ◽  
Steven L. Ceccio

The purpose of this study was to determine the hemolytic potentials of discrete bubble cavitation and attached cavitation. To generate controlled cavitation events, a venturi-geometry hydrodynamic device, called a Cavitation Susceptibility Meter (CSM), was constructed. A comparison between the hemolytic potential of discrete bubble cavitation and attached cavitation was investigated with a single-pass flow apparatus and a recirculating flow apparatus, both utilizing the CSM. An analytical model, based on spherical bubble dynamics, was developed for predicting the hemolysis caused by discrete bubble cavitation. Experimentally, discrete bubble cavitation did not correlate with a measurable increase in plasma-free hemoglobin (PFHb), as predicted by the analytical model. However, attached cavitation did result in significant PFHb generation. The rate of PFHb generation scaled inversely with the Cavitation number at a constant flow rate, suggesting that the size of the attached cavity was the dominant hemolytic factor. [S0148-0731(00)00404-0]

1997 ◽  
Vol 332 ◽  
pp. 377-394 ◽  
Author(s):  
Dhiman Chatterjee ◽  
Vijay H. Arakeri

A careful study of the existing literature available in the field of cavitation reveals the potential of ultrasonics as a tool for controlling and, if possible, eliminating certain types of hydrodynamic cavitation through the manipulation of nuclei size present in a flow. A glass venturi is taken to be an ideal device to study the cavitation phenomenon at its throat and its potential control. A piezoelectric transducer, driven at the crystal resonant frequency, is used to generate an acoustic pressure field and is termed an ‘ultrasonic nuclei manipulator (UNM)'. Electrolysis bubbles serve as artificial nuclei to produce travelling bubble cavitation at the venturi throat in the absence of a UNM but this cavitation is completely eliminated when a UNM is operative. This is made possible because the nuclei, which pass through the acoustic field first, cavitate, collapse violently and perhaps fragment and go into dissolution before reaching the venturi throat. Thus, the potential nuclei for travelling bubble cavitation at the venturi throat seem to be systematically destroyed through acoustic cavitation near the UNM. From the solution to the bubble dynamics equation, it has been shown that the potential energy of a bubble at its maximum radius due to an acoustic field is negligible compared to that for the hydrodynamic field. Hence, even though the control of hydrodynamic macro cavitation achieved in this way is at the expense of acoustic micro cavitation, it can still be considered to be a significant gain. These are some of the first results in this direction.


2012 ◽  
Vol 45 (4) ◽  
pp. 674-678 ◽  
Author(s):  
Lukas Lomb ◽  
Jan Steinbrener ◽  
Sadia Bari ◽  
Daniel Beisel ◽  
Daniel Berndt ◽  
...  

Serial femtosecond crystallography (SFX) using X-ray free-electron laser (FEL) sources has the potential to determine the structures of macromolecules beyond the limitation of radiation damage and without the need for crystals of sufficient size for conventional crystallography. In SFX, a liquid microjet is used to inject randomly oriented crystals suspended in their storage solution into the FEL beam. Settling of crystals in the reservoir prior to the injection has been found to complicate the data collection. This article details the development of an anti-settling sample delivery instrument based on a rotating syringe pump, capable of producing flow rates and liquid pressures necessary for the operation of the injector. The device has been used successfully with crystals of different proteins, with crystal sizes smaller than 20 µm. Even after hours of continuous operation, no significant impairment of the experiments due to sample settling was observed. This article describes the working principle of the instrument and sets it in context with regard to the experimental conditions used for SFX. Hit rates for longer measuring periods are compared with and without the instrument operating. Two versions of the instrument have been developed, which both deliver sample at a constant flow rate but which differ in their minimum liquid flow rates and maximum pressures.


2008 ◽  
Vol 131 (1) ◽  
Author(s):  
Hoseyn Sayyaadi

The collapsing phenomenon of cavitation bubbles generates extremely high local pressures and temperatures that can be utilized for the chemical oxidation process. This process is carried out in cavitation reactors. A Venturi tube is one of the most common forms of hydrodynamic cavitation reactors, which is suitable for industrial scale applications. In this work, the hydraulic performance and efficiency in chemical reaction of a new form of hydrodynamic cavitation reactors, which is called “tandem Venturi,” were studied and compared with the conventional type of the single Venturi. The tandem Venturi is used for enhancement of the chemical reaction of hydrodynamic cavitating flow. The reaction enhancement is useful especially for the reaction of aqueous solutions not containing volatile organic compounds (VOCs). The operating pressure, inlet pressure, flow rate, and consequently the cavitation number were controlled and systematically varied for both single and tandem Venturis. Moreover, a specified amount of H2O2 was injected into the flow as required. The effects of operating pressure and the cavitation number on cavitating flow characteristics for single and tandem Venturis were experimentally observed and the results were compared. In addition, the performance of the tandem-Venturi reactor for degradation of non-VOC contaminants (2-chlorophenol) was studied. Its performance was compared with the performance of a conventional Venturi reactor. Two different categories were conducted for the experiments. In the first category, the effect of the net cavitating flow on degradation of non-VOC for the single and tandem Venturis was compared. In the second category, the effect of H2O2 injection into the cavitating flow on degradation of non-VOC (“cavitation-oxidation” process) was studied. The performance of the single and tandem Venturis for the cavitation-oxidation process was compared. Further investigation was performed to assess the advantage of utilizing the tandem Venturi from the viewpoint of efficiency of the oxidation process. The results of the energy efficiency were compared with the corresponding efficiency of the single Venturi. Finally, the relationship between the main parameters of cavitation reaction flow with the chemical performance was discussed.


2012 ◽  
Vol 9 (3) ◽  
Author(s):  
Il Doh ◽  
Young-Ho Cho

A pumpless fuel supply using pressurized fuel with autonomous flow regulation valves is presented. Since micropumps and their control circuitry consume a portion of the electrical power generated in fuel cells, fuel supply without micropumps makes it possible to provide more efficient and inexpensive fuel cells than conventional ones. The flow regulation valves in the present system maintain the constant fuel flow rate from the pressurized fuel chamber even though the fuel pressure decreases. They autonomously adjust fluidic resistance of the channel according to fuel pressure so as to maintain constant flow rate. Compared to previous pumpless fuel supply methods, the present method offers more uniform fuel flow without any fluctuation using a simple structure. The prototypes were fabricated by a polymer micromolding process. In the experimental study using the pressurized deionized water, prototypes with pressure regulation valves showed constant flow rate of 5.38 ± 0.52 μl/s over 80 min and 5.89 ± 0.62 μl/s over 134 min, for the initial pressure in the fuel chamber of 50 and 100 kPa, respectively, while the other prototypes having the same fluidic geometry without flow regulation valves showed higher and gradually decreasing flow rate. The present pumpless fuel supply method providing constant flow rate with autonomous valve operation will be beneficial for the development of next-generation fuel cells.


Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2607 ◽  
Author(s):  
Kyunghee Kim ◽  
Jeongeun Lee ◽  
Bo Moon ◽  
Ye Seo ◽  
Chan Park ◽  
...  

In this study, a portable urea sensor that monitors the urea concentration in flow conditions was fabricated. We propose an electrochemical sensor that continually measures the urea concentration of samples flowing through it at a constant flow rate in real time. For the electrochemical sensing, a porous silk fibroin membrane with immobilized urease was mounted in a polydimethylsiloxane (PDMS) sensor housing. The fabricated urea sensor elicited linear current–concentration characteristics in the clinically significant concentration range (0.1–20 mM) based on peritoneal dialysis. The sensor maintained the linear current–concentration characteristics during operation in flow conditions.


Author(s):  
Debabrata Adhikari ◽  
Suhasini Gururaja

Modeling resin flow for a Vacuum Assisted Resin Transfer Molding (VARTM) process involves developing an approach for coupled flow-compaction, porosity-permeability, resin-cure and stress-development phenomena. In the present work, a modified transient incompressible resin flow model has been developed for VARTM without considering the constant flow rate assumption. The use of High Permeability Medium (HPM) during VARTM results in a through-thickness flow in addition to in-plane flow developing due to the pressure gradient. Results have been validated with existing literature. Fill time comparisons for with and without HPM cases have been presented. Some preliminary results of 2D plane flow have also been obtained which show promise in replicating the physics of vacuum assisted resin infusion composite manufacturing process.


2020 ◽  
Vol 29 (2) ◽  
pp. 244-258
Author(s):  
Maciej Malarski ◽  
Marek Kalenik

Bath gray water organoleptically did not appear to be significantly contaminated liquid. However, in order to re-use them, they need proper treatment. When recirculated in a household, they cannot pose a threat to human life. Based on their appearance, it seems that the solution to the problem is the use of cartridges filter. The article presents the results of the filtration of gray water from the bath through the filtration system with a housing double stage polypropylene-carbon filter FCCA-STO and to determine the impact of individual filter layers on wastewater treatment, tests were carried out on a single polypropylene FCPS10 and carbon FCCA filtration cartridge. The aim of the study was to determine the suitability of the selected housing filter cartridges for the treatment of bathing gray water for their reuse. For the tests were used natural bathing gray water from a two-family building inhabited by seven people. Wastewater were fed to the filter with a constant flow rate of 0.1 dm3·s–1. The assessment of the work of the filters based on parameters such as: COD, BOD5, suspension, dry residue, decay and turbidity. The conducted tests have shown a slight improvement in most of the quality parameters of gray water after filtration through selected housing cartridge filters. Only for turbidity, the reduction in the value of the pollution indicator was noticeable. The cartridge fi lters used in tests, acted like ordinary mechanical filtration cartridges. For the considered gray water, the use of analyzed cartridge fi lters can only be used for their initial purifi cation.


2018 ◽  
Vol 851 ◽  
pp. 507-544 ◽  
Author(s):  
Roberto Inghilesi ◽  
Claudia Adduce ◽  
Valentina Lombardi ◽  
Federico Roman ◽  
Vincenzo Armenio

Unconfined three-dimensional gravity currents generated by lock exchange using a small dividing gate in a sufficiently large tank are investigated by means of large eddy simulations under the Boussinesq approximation, with Grashof numbers varying over five orders of magnitudes. The study shows that, after an initial transient, the flow can be separated into an axisymmetric expansion and a globally translating motion. In particular, the circular frontline spreads like a constant-flow-rate, axially symmetric gravity current about a virtual source translating along the symmetry axis. The flow is characterised by the presence of lobe and cleft instabilities and hydrodynamic shocks. Depending on the Grashof number, the shocks can either be isolated or produced continuously. In the latter case a typical ring structure is visible in the density and velocity fields. The analysis of the frontal spreading of the axisymmetric part of the current indicates the presence of three regimes, namely, a slumping phase, an inertial–buoyancy equilibrium regime and a viscous–buoyancy equilibrium regime. The viscous–buoyancy phase is in good agreement with the model of Huppert (J. Fluid Mech., vol. 121, 1982, pp. 43–58), while the inertial phase is consistent with the experiments of Britter (Atmos. Environ., vol. 13, 1979, pp. 1241–1247), conducted for purely axially symmetric, constant inflow, gravity currents. The adoption of the slumping model of Huppert & Simpson (J. Fluid Mech., vol. 99 (04), 1980, pp. 785–799), which is here extended to the case of constant-flow-rate cylindrical currents, allows reconciling of the different theories about the initial radial spreading in the context of different asymptotic regimes. As expected, the slumping phase is governed by the Froude number at the lock’s gate, whereas the transition to the viscous phase depends on both the Froude number at the gate and the Grashof number. The identification of the inertial–buoyancy regime in the presence of hydrodynamic shocks for this class of flows is important, due to the lack of analytical solutions for the similarity problem in the framework of shallow water theory. This fact has considerably slowed the research on variable-flow-rate axisymmetric gravity currents, as opposed to the rapid development of the knowledge about cylindrical constant-volume and planar gravity currents, despite their own environmental relevance.


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