scholarly journals A Novel Approach to Design Lesion-Specific Stents for Minimum Recoil

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Muhammad Farhan Khan ◽  
David Brackett ◽  
Ian Ashcroft ◽  
Christopher Tuck ◽  
Ricky Wildman

Stent geometries are obtained by topology optimization for minimized compliance under different stenosis levels and plaque material types. Three levels of stenosis by cross-sectional area, i.e., 30%, 40%, and 50% and three different plaque material properties, i.e., calcified, cellular, and hypocellular, were studied. The raw optimization results were converted to clear design concepts and their performance was evaluated by implanting them in their respective stenosed artery types using finite element analysis. The results were compared with a generic stent in similar arteries, which showed that the new designs showed less recoil. This work provides a concept that stents could be tailored to specific lesions in order to minimize recoil and maintain a patent lumen in stenotic arteries.

Author(s):  
Ashish Tiwari ◽  
Pankaj Wahi ◽  
Niraj Sinha

Human tibia, the second largest bone in human body, is made of complex biological material having inhomogeneity and anisotropy in such a manner that makes it a functionally graded material. While analyses of human tibia assuming it to be made of different material regions have been attempted in past, functionally graded nature of the bone in the mechanical analysis has not been considered. This study highlights the importance of functional grading of material properties in capturing the correct stress distribution from the finite element analysis (FEA) of human tibia under static loading. Isotropic and orthotropic material properties of different regions of human tibia have been graded functionally in three different manners and assigned to the tibia model. The nonfunctionally graded and functionally graded models of tibia have been compared with each other. It was observed that the model in which functional grading was not performed, uneven distribution and unrealistic spikes of stresses occurred at the interfaces of different material regions. On the contrary, the models with functional grading were free from this potential artifact. Hence, our analysis suggests that functional grading is essential for predicting the actual distribution of stresses in the entire bone, which is important for biomechanical analysis. We find that orthotropic nature of the bone tends to increase the maximum von Mises stress in the entire tibia, while inclusion of cross-sectional inhomogeneity typically increases the stresses across normal cross section. Accordingly, our analysis suggests that both orthotropy as well as cross-sectional inhomogeneity should be included to correctly capture the stress distribution in the bone.


Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2327 ◽  
Author(s):  
Deqiao Xie ◽  
Jianfeng Zhao ◽  
Huixin Liang ◽  
Zongjun Tian ◽  
Lida Shen ◽  
...  

Distortion is a common but unrevealed problem in metal additive manufacturing, due to the rapid melting in metallurgy and the intricate thermal-mechanical processes involved. We explain the distortion mechanism and major influencing factors by assumption of constraining force, which is assumed between the added layer and substrate. The constraining force was set to act on the substrate in a static structural finite element analysis (FEA) model. The results were compared with those of a thermal-mechanical FEA model and experiments. The constraining force and the associated static structural FEA showed trends in distortion and stress distribution similar to those shown by thermal-mechanical FEA and experiments. It can be concluded that the constraining force acting on the substrate is a major contributory factor towards the distortion mechanism. The constraining force seems to be primarily related to the material properties, temperature, and cross-sectional area of the added layer.


2008 ◽  
Vol 2 (1) ◽  
Author(s):  
Milton E. Aguirre ◽  
Mary Frecker

A size and shape optimization routine is developed for a 1.0mm diameter multifunctional instrument for minimally invasive surgery. The instrument is a compliant mechanism capable of both grasping and cutting. Multifunctional instruments are expected to be beneficial in the operating room because of their ability to perform multiple surgical tasks, thereby decreasing the total number of instrument exchanges in a single procedure. With fewer instrument exchanges, the risk of inadvertent tissue trauma as well as overall surgical time and costs are reduced. The focus of this paper is to investigate the performance effects of allowing the cross-sectional area along the length of the device to vary. This investigation is accomplished by defining various cross-sectional segments in terms of parametric variables and optimizing the dimensions of the instrument to provide a sufficient opening of the forceps jaws while maintaining adequate cutting and grasping forces. Two optimization problems are considered. First, all parametric segments are set equal to one another to achieve size optimization. Second, each segment is allowed to vary independently, thereby achieving shape optimization. Large deformation finite element analysis and optimization are conducted using ANSYS®. Finally, prototypes are fabricated using wire EMD and experiments are conducted to evaluate the instrument performance. As a result of allowing the cross-sectional area to vary, i.e., conducting shape optimization, the forceps and scissors blocked forces increased by as much as 83.2% and 87%, respectively. During prototype evaluations, it is found that the finite element analysis predictions were within 10% of the measured tool performance. Therefore, for this application, it is concluded that performing shape optimization does significantly influence the performance of the instrument.


2020 ◽  
Author(s):  
Jingchi Li ◽  
Zhipeng Xi ◽  
Xiaoyu Zhang ◽  
Shenglu Sun ◽  
Lin Xie ◽  
...  

Abstract Background: As a widely used biomechanical research method, finite element analysis (FEA) is an important tool for investigating the pathogenesis of disc degenerative diseases and optimizing spine surgical methods. However, the definitions of the relative nucleus position and its cross-sectional area ratio do not conform to a uniform standard, thus affecting the accuracy (ACC) of the FEA. Hence, this study aimed to determine a precise definition of the relative nucleus position and its cross-sectional area ratio to increase the ACC of the following FEA studies. Methods: The lumbar relative nucleus position and its cross-sectional area ratio were measured from magnetic resonance imaging data and then calibrated and validated via FEA. Imaging data from patients without disc degeneration were used. The L4-L5 nucleus and disc cross-sectional areas and the distances between the edges of the annulus and nucleus were measured; the ratios between these values were calculated as P1 and P2, respectively. The FEA model was constructed using these measured values, and the relative nucleus position was calibrated by estimating the differences in the range of motion (ROM) between the model, wherein the ligaments, facet joints and nucleus were suppressed, and that of an in vitro study. Then, the ACC was re-estimated in the model with all non-bony structures by comparing the ROM, the intradiscal pressure (IDP), the facet contact force (FCF) and the disc compression (DC) under different sizes and directions of moments magnitudes to validate the measured and calibrated indicators. Results: The interobserver homogeneity was acceptable, and the measured P1 and P2 values were 1.22 and 38%, respectively. Furthermore, an ACC of up to 99% was attained for the model under flexion–extension conditions when the calibrated P1 value (1.62) was used, with a model validation of greater than 90% attained under al most all of the loading conditions considering the different indicators and moment magnitude s. Conclusion: The measured and calibrated relative nucleus position and its cross-sectional area ratio increase the ACC of the FEA model and can therefore be used in subsequent studies.


2016 ◽  
Vol 83 (9) ◽  
Author(s):  
Shilei Han ◽  
Olivier Bauchau

Based on the symplectic transfer-matrix method, this paper develops a novel approach for the analysis of beams presenting periodic heterogeneities along their span. The approach, rooted in the Hamiltonian formalism, generalizes developments presented earlier by the authors for spanwise uniform beams. Starting from the kinematics of a unit cell, the approach proceeds through a set of structure-preserving symplectic transformations and decomposes the solution into its central and extremity components. The geometric configuration and material properties of the unit cell may be arbitrarily complex as long as the cell's two end cross sections are identical. The proposed approach identifies an equivalent, homogenized beam with uniform curvatures and sectional stiffness characteristics along its span. Numerical examples are presented to demonstrate the capabilities of the analysis. Predictions are found to be in excellent agreement with those obtained by full finite-element analysis.


2006 ◽  
Vol 100 (1) ◽  
pp. 294-303 ◽  
Author(s):  
Khaled F. Mansour ◽  
James A. Rowley ◽  
M. Safwan Badr

A noninvasive measurement of pharyngeal cross-sectional area (CSA) during sleep would be advantageous for research studies. We hypothesized that CSA could be calculated from the measured pharyngeal pressure and flow by finite element analysis (FEA). The retropalatal airway was visualized by using a fiber-optic scope to obtain the measured CSA (mCSA). Flow was measured with a pneumotachometer, and pharyngeal pressure was measured with a pressure catheter at the palatal rim. FEA was performed as follows: by using a three-dimensional image of the upper airway, a mesh of finite elements was created. Specialized software was used to allow the simultaneous calculation of velocity and area for each element by using the measured pressure and flow. In the development phase, 677 simultaneous measurements of CSA, pressure, and flow from one subject during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep were entered into the software to determine a series of equations, based on the continuity and momentum equations, that could calculate the CSA (cCSA). In the validation phase, the final equations were used to calculate the CSA from 1,767 simultaneous measurements of pressure and flow obtained during wakefulness, NREM, and REM sleep from 14 subjects. In both phases, mCSA and cCSA were compared by Bland-Altman analysis. For development breaths, the mean difference between mCSA and cCSA was 0.0 mm2 (95% CI, −0.1, 0.1 mm2). For NREM validation breaths, the mean difference between mCSA and cCSA was 1.1 mm2 (95% CI 1.3, 1.5 mm2). Pharyngeal CSA can be accurately calculated from measured pharyngeal pressure and flow by FEA.


Forests ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 783 ◽  
Author(s):  
Wengang Hu ◽  
Hui Wan ◽  
Huiyuan Guan

Elastic constants of wood are fundamental parameters used in finite element analysis of wood structures. However, few studies and standards regulate the dimensions of sample used to measure elastic constants of wood. The size effect on mechanical properties (i.e., elastic constants and proportional limit stresses) of European beech (Fagus sylvatica L.) wood was studied with five different sizes samples. The data of experiments were inputted into a finite element model of self-designed chair and the loading capacity of chair was investigated by finite element method (FEM) and experiment. The results showed that nonlinear relationships were found between proportional limit stresses, cross-sectional area, and height of specimen by response surface method with R2 greater than 0.72 in longitudinal, radial, and tangential directions. Elastic moduli and shear moduli increased with the height of specimen when cross-sectional area was kept constant, and decreased with an increased cross-sectional area of specimen, when the height was a constant, while the trends of Poisson’s ratio were not as expected. The comparisons between experiment and FEM suggested that the accuracy of FEM simulation increase with the raise of width-height ratio (≤1) of specimens used to determine the elastic constants. It is recommended to use small cubic wood specimen to determine the elastic mechanical properties used for finite element analysis of beech wood structures. Further research to find optimized wood specimen dimensions to get mechanical properties for FEM is quite necessary.


2004 ◽  
Vol 83 (5) ◽  
pp. 420-424 ◽  
Author(s):  
A.A. El Zohairy ◽  
A.J. de Gee ◽  
N. de Jager ◽  
L.J. van Ruijven ◽  
A.J. Feilzer

The higher microtensile bond strength values found for specimens with a smaller cross-sectional area are often explained by the lower occurrence of internal defects and surface flaws. We hypothesized that this aberrant behavior is mainly caused by the lateral way of attachment of the specimens to the testing device, which makes the strength dependent on the thickness. This study showed that composite bars of 1×1×10, 1×2×10, and 1×3×10mm attached at their 1-mm-wide side (situation A) fractured at loads of the same magnitude, as a result of which the microtensile strength (μTS), calculated as F/A (force at fracture/cross-sectional area), significantly increased for specimens with decreasing thickness. Attachment at the 1-, 2-, or 3-mm-wide side (situation B) resulted in equal μTS values (P > 0.05). Finite element analysis showed different stress patterns for situation A, but comparable patterns for situation B. Both situations showed the same maximum stress at fracture.


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