scholarly journals Dynamics of Field Amplified Sample Stacking

2001 ◽  
Author(s):  
Rajiv Bharadwaj ◽  
Juan G. Santiago
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Concentration Field ◽  
Initial Step ◽  
Step Function ◽  
Buffer Concentration ◽  
Sample Stacking ◽  
Sample Concentration ◽  
Concentration Enhancement ◽  
Channel Configuration

Abstract We present an analysis and an experimental study of field amplified sample stacking. The analysis consists of a one dimensional, unsteady electromigration model of the concentration fields in sample stacking. The model predicts that the sample concentration develops as a non-linear concentration wave with a peak concentration increasing with time that reaches a maximum value determined by ratio of electric fields in the sample and the buffer region. The experimental work is a preliminary study of the effects of electroosmotic flow on sample stacking for a single fluid-fluid interface within a glass microchannel. Using a simple cross-channel configuration a high-gradient initial step-function in the buffer concentration field was established which causes an unsteady sample concentration process. The experimental results qualitatively confirm the wave-like profile of the stacked analyte predicted by the analytical model. Experiments also provide evidence of internal pressure generation due to mis-matched electroosmotic velocities during stacking. The effect of electric field strength and sample-to-background buffer concentration ratio, γ, are also presented. Stacked sample concentration at γ = 4 is found to initially increase with increasing electric field but saturates at higher electric fields. Stacking rates at higher γ ratios indicate that concentration enhancement is quickly limited by dispersion due to internally generated pressure gradients.

Electrokinetic Dispersion in Field Amplified Sample Stacking

2018 ◽  
Author(s):  
Kaushlendra Dubey ◽  
Amit Gupta ◽  
Supreet Singh Bahga
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Body Force ◽  
Vital Role ◽  
Scaling Analysis ◽  
Unstable Flow ◽  
Sample Stacking ◽  
Concentration Enhancement ◽  
High Electric Fields ◽  
Conductivity Gradient

In this work, we performed an experimental study of electrohydrodynamic effects on the dispersion of sample ions in field amplified sample stacking (FASS). A typical FASS experiment involves a streamwise electrical conductivity gradient collinear to the applied electric field to enhance the sample stacking. Earlier studies on FASS have focused on how the conductivity gradient sets a non-uniform electro-osmotic flow which causes the dispersion. However, the coupling of the electric field with conductivity gradient leads to a destabilizing electric body force and generates unstable flow. This work demonstrates that generated body force influences the dynamics of FASS. We present a scaling analysis to show that at high fields, electrohydrodynamic effects play a vital role in sample dispersion. To justify our scaling arguments, we performed experiments at varied electric fields which shows that at high electric fields maximum concentration enhancement is lowered significantly. To ensure the EHD effects on the dynamics of FASS, we have also performed experiments with suppressed EOF conditions.

Joule Heating Induced Temperature Gradient Focusing for Microfluidic Concentration of Samples

2010 ◽  
Author(s):  
Zhengwei Ge ◽  
Chun Yang
Keyword(s):  
Temperature Gradient ◽  
Electric Field ◽  
Joule Heating ◽  
Field Experiments ◽  
Dc Voltage ◽  
Sample Concentration ◽  
Great Achievement ◽  
Temperature Gradient Focusing ◽  
Concentration Enhancement ◽  
High Frequency Ac

Microfluidic concentration of sample species is achieved using the temperature gradient focusing (TGF) in a microchannel with a step change in the cross-section under a pure direct current (DC) field or a combined alternating current (AC) and DC electric field. Experiments were carried out to study the effects of applied voltage, buffer concentration and channel size on sample concentration in the TGF processes. These effects were analyzed and summarized using a dimensionless Joule number that is introduced in this study. In addition, Joule number effect in the Poly-dimethylsiloxane (PDMS)/PDMS microdevice was compared with the PDMS/Glass microdevice. A more than 450-fold concentration enhancement was obtained within 75 seconds in the PDMS/PDMS microdevice. Results also showed that the high frequency AC electric field which contributes to produce the temperature gradient and reduces the required DC voltage for the sample concentration. The lower DC voltage has generated slower electroosmotic flow (EOF), which reduces the backpressure effect associated with the finite reservoir size. Finally, a more than 2500-fold concentration enhancement was obtained within 14 minutes in the PDMS/PDMS microdevice, which was a great achievement in this TGF technique using inherent Joule heating effects.

Discussions and Communications: Propagation of Transient Electromagnetic Waves in a Conducting Medium

Geophysics ◽  
1955 ◽  
Vol 20 (4) ◽  
pp. 959-961 ◽  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Electromagnetic Waves ◽  
Step Function ◽  
Conducting Medium ◽  
Initial Value ◽  
Transient Electromagnetic ◽  
Ramp Function

Wait (1951) has calculated the transient electric fields for several types of step-function current sources placed inside a conducting medium. Now any generated pulse will require a finite build-up time to reach its final magnitude from its initial value of zero. In most cases, this type of pulse may be very well approximated by a ramp-function pulse (Figure 1). Expressions for the electric field of this type of pulse will be deduced in the following analysis.

Investigation of Particle Electrophoretic Motion in Converging-Diverging Microchannels

2005 ◽  
Author(s):  
Xiangchun Xuan ◽  
Bo Xu ◽  
Dongqing Li
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Particle Velocity ◽  
Velocity Ratio ◽  
Straight Channel ◽  
Cross Sectional ◽  
Diverging Channel ◽  
Acceleration And Deceleration ◽  
Pdms Chip ◽  
Channel Configuration

We studied experimentally the particle electrophoretic motion in converging-diverging microchannels on a poly(dimethylsiloxane) (PDMS) chip. The whole process of particle acceleration and deceleration was visualized through traditional optical microscopy, with which the accelerated particle electrophoretic separation is demonstrated. The effects of electric field, particle size, particle moving passage, and channel configuration on particle electrophoretic motion are examined individually. We find that the ratio of particle velocity in the throat to that in the straight channel is insensitive to both the particle moving passage and the length of converging/diverging channel, but increased for smaller particles moving through symmetric converging-diverging channels under lower electric fields. Moreover, we find that the particle velocity ratio in electrically driven flows is significantly lower than the cross-sectional area ratio of the straight channel to the throat. We have attributed this discrepancy to the particle-induced distortion in the electric potential distribution. The computed contour of electric field in a converging-diverging microchannel has revealed that the electric field is locally higher around the two poles of a particle than all other regions inside the channel.

Lubrication theory for electro-osmotic flow in a non-uniform electrolyte

2007 ◽  
Vol 576 ◽  
pp. 139-172 ◽  
Author(s):  
T. L. SOUNART ◽  
J. C. BAYGENTS
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Numerical Solutions ◽  
Fluid Velocity ◽  
Lubrication Theory ◽  
Debye Screening Length ◽  
Sample Stacking ◽  
Osmotic Flow ◽  
Analytic Expressions ◽  
Electro Osmotic Flow

A lubrication theory has been developed for the electro-osmotic flow of non-uniform buffers in narrow rectilinear channels. The analysis applies to systems in which the transverse dimensions of the channel are large compared with the Debye screening length of the electrolyte. In contrast with related theories of electrokinetic lubrication, here the streamwise variations of the velocity field stem from, and are nonlinearly coupled to, spatiotemporal variations in the electrolyte composition. Spatially non-uniform buffers are commonly employed in electrophoretic separation and transport schemes, including iso-electric focusing (IEF), isotachophoresis (ITP), field-amplified sample stacking (FASS), and high-ionic-strength electro-osmotic pumping. The fluid dynamics of these systems is controlled by a complex nonlinear coupling to the ion transport, driven by an applied electric field. Electrical conductivity gradients, attendent to the buffer non-uniformities, result in a variable electro-osmotic slip velocity and, in electric fields approaching 1 kV cm−1, Maxwell stresses drive the electrohydrodynamic circulation. Explicit semi-analytic expressions are derived for the fluid velocity, stream function, and electric field. The resulting approximations are found to be in good agreement with full numerical solutions for a prototype buffer, over a range of conditions typical of microfluidic systems. The approximations greatly simplify the computational analysis, reduce computation times by a factor 4–5, and, for the first time, provide general insight on the dominant fluid physics of two-dimensional electrically driven transport.

Tuning the Electric Field Response of MOFs by Rotatable Dipolar Linkers

2019 ◽  
Author(s):  
Johannes P. Dürholt ◽  
Babak Farhadi Jahromi ◽  
Rochus Schmid
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Structural Changes ◽  
Dielectric Behavior ◽  
Two Dimensions ◽  
Dielectric Constants ◽  
Electric Response ◽  
Dipole Strength ◽  
Metal Organic ◽  
Dynamics Simulations

Recently the possibility of using electric fields as a further stimulus to trigger structural changes in metal-organic frameworks (MOFs) has been investigated. In general, rotatable groups or other types of mechanical motion can be driven by electric fields. In this study we demonstrate how the electric response of MOFs can be tuned by adding rotatable dipolar linkers, generating a material that exhibits paralectric behavior in two dimensions and dielectric behavior in one dimension. The suitability of four different methods to compute the relative permittivity κ by means of molecular dynamics simulations was validated. The dependency of the permittivity on temperature T and dipole strength μ was determined. It was found that the herein investigated systems exhibit a high degree of tunability and substantially larger dielectric constants as expected for MOFs in general. The temperature dependency of κ obeys the Curie-Weiss law. In addition, the influence of dipolar linkers on the electric field induced breathing behavior was investigated. With increasing dipole moment, lower field strength are required to trigger the contraction. These investigations set the stage for an application of such systems as dielectric sensors, order-disorder ferroelectrics or any scenario where movable dipolar fragments respond to external electric fields.

scholarly journals Meta-Deflectors Made of Dielectric Nanohole Arrays with Anti-Damage Potential

Photonics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 107
Author(s):  
Haichao Yu ◽  
Feng Tang ◽  
Jingjun Wu ◽  
Zao Yi ◽  
Xin Ye ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Laser Cutting ◽  
High Complexity ◽  
Damage Potential ◽  
Optical Components ◽  
Nanohole Arrays ◽  
Intense Light ◽  
Polarization Of Light ◽  
Air Hole

In intense-light systems, the traditional discrete optical components lead to high complexity and high cost. Metasurfaces, which have received increasing attention due to the ability to locally manipulate the amplitude, phase, and polarization of light, are promising for addressing this issue. In the study, a metasurface-based reflective deflector is investigated which is composed of silicon nanohole arrays that confine the strongest electric field in the air zone. Subsequently, the in-air electric field does not interact with the silicon material directly, attenuating the optothermal effect that causes laser damage. The highest reflectance of nanoholes can be above 99% while the strongest electric fields are tuned into the air zone. One presentative deflector is designed based on these nanoholes with in-air-hole field confinement and anti-damage potential. The 1st order of the meta-deflector has the highest reflectance of 55.74%, and the reflectance sum of all the orders of the meta-deflector is 92.38%. The optothermal simulations show that the meta-deflector can theoretically handle a maximum laser density of 0.24 W/µm2. The study provides an approach to improving the anti-damage property of the reflective phase-control metasurfaces for intense-light systems, which can be exploited in many applications, such as laser scalpels, laser cutting devices, etc.

scholarly journals Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Marie C. Lefevre ◽  
Gerwin Dijk ◽  
Attila Kaszas ◽  
Martin Baca ◽  
David Moreau ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Flexible Electronics ◽  
Soft Tissues ◽  
Multiphoton Microscopy ◽  
Membrane Integrity ◽  
Tumor Model ◽  
Pulsed Electric Fields ◽  
In Ovo ◽  
Cell Membrane Integrity

AbstractGlioblastoma is a highly aggressive brain tumor, very invasive and thus difficult to eradicate with standard oncology therapies. Bioelectric treatments based on pulsed electric fields have proven to be a successful method to treat cancerous tissues. However, they rely on stiff electrodes, which cause acute and chronic injuries, especially in soft tissues like the brain. Here we demonstrate the feasibility of delivering pulsed electric fields with flexible electronics using an in ovo vascularized tumor model. We show with fluorescence widefield and multiphoton microscopy that pulsed electric fields induce vasoconstriction of blood vessels and evoke calcium signals in vascularized glioblastoma spheroids stably expressing a genetically encoded fluorescence reporter. Simulations of the electric field delivery are compared with the measured influence of electric field effects on cell membrane integrity in exposed tumor cells. Our results confirm the feasibility of flexible electronics as a means of delivering intense pulsed electric fields to tumors in an intravital 3D vascularized model of human glioblastoma.

scholarly journals Electro-Optic Control of Lithium Niobate Bulk Whispering Gallery Resonators: Analysis of the Distribution of Externally Applied Electric Fields

Crystals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 298
Author(s):  
Yannick Minet ◽  
Hans Zappe ◽  
Ingo Breunig ◽  
Karsten Buse
Keyword(s):  
Lithium Niobate ◽  
Electric Field ◽  
Electric Fields ◽  
Frequency Comb ◽  
Parametric Oscillation ◽  
Pockels Effect ◽  
Optical Mode ◽  
Cylindrical Resonator ◽  
Whispering Gallery ◽  
Electro Optic

Whispering gallery resonators made out of lithium niobate allow for optical parametric oscillation and frequency comb generation employing the outstanding second-order nonlinear-optical properties of this material. An important knob to tune and control these processes is, e.g., the linear electro-optic effect, the Pockels effect via externally applied electric fields. Due to the shape of the resonators a precise prediction of the electric field strength that affects the optical mode is non-trivial. Here, we study the average strength of the electric field in z-direction in the region of the optical mode for different configurations and geometries of lithium niobate whispering gallery resonators with the help of the finite element method. We find that in some configurations almost 100% is present in the cavity compared to the ideal case of a cylindrical resonator. Even in the case of a few-mode resonator with a very thin rim we find a strength of 90%. Our results give useful design considerations for future arrangements that may benefit from the strong electro-optic effect in bulk whispering gallery resonators made out of lithium niobate.

scholarly journals Double layers in the downward current region of the aurora

2003 ◽  
Vol 10 (1/2) ◽  
pp. 45-52 ◽  
Author(s):  
R. E. Ergun ◽  
L. Andersson ◽  
C. W. Carlson ◽  
D. L. Newman ◽  
M. V. Goldman
Keyword(s):  
Magnetic Field ◽  
Electron Beam ◽  
Phase Space ◽  
Electric Field ◽  
Electric Fields ◽  
Double Layers ◽  
Parallel Electric Field ◽  
Electrostatic Waves ◽  
Current Region ◽  
Decisive Evidence

Abstract. Direct observations of magnetic-field-aligned (parallel) electric fields in the downward current region of the aurora provide decisive evidence of naturally occurring double layers. We report measurements of parallel electric fields, electron fluxes and ion fluxes related to double layers that are responsible for particle acceleration. The observations suggest that parallel electric fields organize into a structure of three distinct, narrowly-confined regions along the magnetic field (B). In the "ramp" region, the measured parallel electric field forms a nearly-monotonic potential ramp that is localized to ~ 10 Debye lengths along B. The ramp is moving parallel to B at the ion acoustic speed (vs) and in the same direction as the accelerated electrons. On the high-potential side of the ramp, in the "beam" region, an unstable electron beam is seen for roughly another 10 Debye lengths along B. The electron beam is rapidly stabilized by intense electrostatic waves and nonlinear structures interpreted as electron phase-space holes. The "wave" region is physically separated from the ramp by the beam region. Numerical simulations reproduce a similar ramp structure, beam region, electrostatic turbulence region and plasma characteristics as seen in the observations. These results suggest that large double layers can account for the parallel electric field in the downward current region and that intense electrostatic turbulence rapidly stabilizes the accelerated electron distributions. These results also demonstrate that parallel electric fields are directly associated with the generation of large-amplitude electron phase-space holes and plasma waves.

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