Biomechanical Evaluation of Autologous Mesenchymal Stem Cell Transplantation to Improve Fascial Repair

2009 ◽  
Author(s):  
Hazel Marie ◽  
Diana L. Fagan ◽  
Jeremy Heffner
Keyword(s):  
Wound Healing ◽  
Incisional Hernia ◽  
Surgical Repair ◽  
Vicious Cycle ◽  
Mesenchymal Stem Cell Transplantation ◽  
Healing Environment ◽  
Hernia Formation ◽  
Novel Approach ◽  
Life Threatening ◽  
Biomechanical Evaluation

Hernia repair continues to be one of the major problems faced by surgeons. Up to 10% of laparotomies are complicated by post-operative incisional hernia, carrying with it a myriad of complications ranging from cosmetic disfigurement to life-threatening strangulation of the bowel [1]. A large percentage of these incisional hernias will recur following surgical repair leading to a more vicious cycle of hernia, followed by repair, followed by hernia. It is therefore imperative to create a more optimum wound-healing environment. The intent of this study was to investigate a novel approach for significantly reducing the initial occurrence of incisional hernia and their associated morbidities, thereby halting the vicious cycle of hernia formation.

Psychological influences on wound healing

2019 ◽  
Vol 98 (8) ◽  
pp. 312-314
Keyword(s):  
Wound Healing ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Wound Complications ◽  
State Of Mind ◽  
Life Threatening ◽  
Psychological Influences ◽  
Fear And Anxiety ◽  
Care Costs

Surgical wound complications remain a major cause of morbidity; although usually not life threatening, they reduce the quality of life. They are also associated with excessive health care costs. Wound healing is affected by many factors – wound characteristics, infection, comorbidities and nutritional status of the patient. In addition, though, psychological stress and depression may decrease the inflammatory response required for bacterial clearance and so delay wound healing, as well. Although the patient´s state of mind can be influenced only to a certain extent, we should nevertheless stick to ERAS (Enhanced Recovery After Surgery) guidelines and try to diminish fear and anxiety by providing enough information preoperatively, pay due attention to postoperative analgesia and seek to provide an agreeable environment.

scholarly journals Surgical Repair of a Transannular Rupture During Transfemoral Transcatheter Aortic Valve Replacement

2021 ◽  
Vol 14 ◽  
pp. 117954762110381
Author(s):  
Ryaan EL-Andari ◽  
Sabin J Bozso ◽  
Jimmy JH Kang ◽  
Vinod K Manikala ◽  
Michael C Moon ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Transcatheter Aortic Valve Replacement ◽  
Surgical Repair ◽  
Hybrid Operating Room ◽  
Transcatheter Aortic Valve ◽  
Acute Decompensation ◽  
Life Threatening ◽  
Midline Sternotomy

Annular rupture is a rare but life-threatening complication of transcatheter aortic valve replacement (TAVR). Mortality rates are high if immediate intervention, most often necessitating surgical repair, is not performed. Herein, we describe an 87-year-old man who, after deployment of TAVR, experienced acute decompensation and required urgent conversion to a midline sternotomy to repair an aortic annular rupture. This case demonstrates an example of a rare but severe complication of TAVR. This report provides an in-depth description of the surgical approach to repair an aortic annular rupture and demonstrates the utility of performing minimally invasive procedures inside a hybrid operating room.

Axillary pullout syndrome: A novel approach to managing a devastating complication

Vascular ◽  
2021 ◽  
pp. 170853812110489
Author(s):  
Nathan W Kugler ◽  
Brian D Lewis ◽  
Michael Malinowski
Keyword(s):  
Stent Graft ◽  
Effective Means ◽  
Bypass Graft ◽  
Hybrid Approach ◽  
Inpatient Rehabilitation ◽  
Anastomotic Dehiscence ◽  
Open Approach ◽  
Novel Approach ◽  
Life Threatening ◽  
History Of

Objectives Axillary pullout syndrome is a complex, potentially fatal complication following axillary-femoral bypass graft creation. The re-operative nature, in addition to ongoing hemorrhage, makes for a complicated and potentially morbid repair. Methods We present the case of a 57-year-old man with history of a previous left axillary-femoral-femoral bypass who presented with acute limb-threatening ischemia as a result of bypass thrombosis managed with a right axillary-femoral bypass for limb salvage. His postoperative course was complicated by an axillary anastomotic dehiscence while recovering in inpatient rehabilitation resulting in acute, life-threatening hemorrhage. He was managed utilizing a novel hybrid approach in which a retrograde stent graft was initially placed across the anastomotic dehiscence for control of hemorrhage. He then underwent exploration, decompression, and interposition graft repair utilizing the newly placed stent graft to reinforce the redo axillary anastomosis. Results and Conclusion Compared with a traditional operative approach, the hybrid endovascular and open approach limited ongoing hemorrhage while providing a more stable platform for repair and graft revascularization. A hybrid approach to the management of axillary pullout syndrome provides a safe, effective means to the management of axillary anastomotic dehiscence while minimizing the morbidity of ongoing hemorrhage.

scholarly journals Food fortification: good to have or need to have?

2004 ◽  
Vol 10 (6) ◽  
pp. 771-777
Author(s):  
A. Verster
Keyword(s):  
Developing Countries ◽  
Folic Acid ◽  
Food Fortification ◽  
Micronutrient Deficiencies ◽  
Vicious Cycle ◽  
Child Bearing ◽  
Large Populations ◽  
Life Threatening ◽  
Iron And Folic Acid ◽  
Staple Foods

Only very small quantities of vitamins and minerals are needed for human health but deficiencies can have disproportionately large, often life-threatening, effects. Micronutrient deficiencies lead to a vicious cycle of malnutrition and infection in poorly nourished populations. Fortification of staple foods is the cheapest, most efficient and most effective way to supply large populations with essential micronutrients. This paper reviews the case for fortification of flour supplies with iron and folic acid and concludes that it is the best way to provide daily doses of these nutrients to populations in developing countries, especially for women of child-bearing age

scholarly journals Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Mina Abedi ◽  
Sepideh Alavi-Moghadam ◽  
Moloud Payab ◽  
Parisa Goodarzi ◽  
Fereshteh Mohamadi-jahani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Systemic Sclerosis ◽  
Mesenchymal Stem Cell ◽  
Epidemiological Data ◽  
Current Status ◽  
Future Perspectives ◽  
Mesenchymal Stem Cell Transplantation ◽  
Novel Approach ◽  
Contemporary Status

AbstractSystemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal organs. According to epidemiological data, women’s populations are more susceptible to systemic sclerosis than men. Until now, various therapeutic options are employed to manage the symptoms of the disease. Since stem cell-based treatments have developed as a novel approach to rescue from several autoimmune diseases, it seems that stem cells, especially mesenchymal stem cells as a powerful regenerative tool can also be advantageous for systemic sclerosis treatment via their remarkable properties including immunomodulatory and anti-fibrotic effects. Accordingly, we discuss the contemporary status and future perspectives of mesenchymal stem cell transplantation for systemic sclerosis.

Dehydrated Human Amniotic-Chorionic Membrane Reduces Incisional Hernia Formation in an Animal Model

2022 ◽  
Vol 270 ◽  
pp. 477-485
Author(s):  
Aran Yoo ◽  
Celia Short ◽  
Mandi J. Lopez ◽  
Catherine Takawira ◽  
Kazi N. Islam ◽  
...  
Keyword(s):  
Animal Model ◽  
Incisional Hernia ◽  
Hernia Formation ◽  
Chorionic Membrane

Management of Acute Wounds

2019 ◽  
Author(s):  
Lee D. Faucher ◽  
Angela L. Gibson
Keyword(s):  
Wound Healing ◽  
Wound Repair ◽  
Wound Closure ◽  
Wound Care ◽  
Connective Tissue Diseases ◽  
Skin Grafting ◽  
Adjunctive Treatment ◽  
Local Trauma ◽  
Life Threatening ◽  
Acute Wound

Acute wounds are the result of local trauma and may be associated with severe life-threatening injuries. All patients with acute wounds should be assessed for comorbidities such as malnutrition, diabetes, peripheral vascular disease, neuropathy, obesity, immune deficiency, autoimmune disorders, connective tissue diseases, coagulopathy, hepatic dysfunction, malignancy, smoking practices, medication use that could interfere with healing, and allergies. The authors address the key considerations in management of the acute wound, including anesthesia, location of wound repair (e.g. operating room or emergency department), hemostasis, irrigation, débridement, closure materials, timing and methods of closure, adjunctive treatment (e.g. tetanus and rabies prophylaxis, antibiotics, and nutritional supplementation), appropriate closure methods for specific wound types, dressings, postoperative wound care, and potential disturbances of wound healing.  This review contains 11 figures, 31 tables, and 92 references. Keywords: wound, wound infection, burns, suture, staple, wound closure, wound healing, dehiscence, skin grafting

Intensive Care Unit Operational Modeling and Analysis

2011 ◽  
pp. 132-147
Author(s):  
Yue Dong ◽  
Huitian Lu ◽  
Ognjen Gajic ◽  
Brian Pickering
Keyword(s):  
Health Care ◽  
Critical Care ◽  
Health Care Providers ◽  
Systems Engineering ◽  
Care Delivery ◽  
Healthcare Delivery ◽  
Organizational Factors ◽  
Modeling And Analysis ◽  
Novel Approach ◽  
Life Threatening

The outcome of critical illness depends not only on life threatening pathophysiologic disturbances, but also on several complex “system” dimensions: health care providers’ performance, organizational factors, environmental factors, family preferences and the interactions between each component. Systems engineering tools offer a novel approach which can facilitate a “systems understanding” of patient-environment interactions enabling advances in the science of healthcare delivery. Due to the complexity of operations in critical care medicine, certain assumptions are needed in order to understand system behavior. Patient variation and uncertainties underlying these assumptions present a challenge to investigators wishing to model and improve health care delivery processes. In this chapter we present a systems engineering approach to modeling critical care delivery using sepsis resuscitation as an example condition.

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