Hydrodynamic Behavior of Magnetic Nanocomposite Spheres Under Magnetic Fields

2011 ◽  
Author(s):  
H. L. Wamocha ◽  
R. Asmatulu ◽  
T. S. Ravigururajan
Keyword(s):  
Magnetic Field ◽  
Study Drug ◽  
Magnetic Nanocomposite ◽  
Test Results ◽  
Hydrodynamic Behavior ◽  
Oil Emulsion ◽  
Pump Speed ◽  
In Vivo Tests ◽  
The Magnetic Field

In the present study, drug carrying magnetic nanocomposite spheres were fabricated using oil-in-oil emulsion/solvent evaporation method and characterized via different techniques. The spheres with a diameter of 200 nm and 3 μm consist of poly (lactic-co-glycolic acid) (PLGA), a drug and magnetic nanoparticles (e.g., Fe3O4 or Co0.5Zn0.5Fe2O4). The spheres were initially dispersed in both deionized (DI) water and viscous glycerol solutions, and pumped in a magnetic field at different tube diameters, pump speeds and concentrations to study the hydrodynamic behavior of drug-carrying magnetic nanocomposite spheres. The test results showed that the magnetic field, tube diameter, pump speed and magnetic nanoparticle concentrations in the spheres drastically changed the capturing efficiency of the spheres. In the in vivo tests of the spheres, these parameters should be considered in order to increase the efficiency of the drug delivery systems.

Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Guidance System ◽  
Test Results ◽  
Test Parameters ◽  
Magnetic Guidance ◽  
The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

scholarly journals Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2147
Author(s):  
Roman Verkhovskii ◽  
Alexey Ermakov ◽  
Olga Sindeeva ◽  
Ekaterina Prikhozhdenko ◽  
Anastasiia Kozlova ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Blood Flow ◽  
Blood Cells ◽  
Circulatory System ◽  
Drug Carriers ◽  
Fine Tuning ◽  
Circulation Time ◽  
Polyelectrolyte Microcapsules ◽  
The Magnetic Field

Drug carriers based on polyelectrolyte microcapsules remotely controlled with an external magnetic field are a promising drug delivery system. However, the influence of capsule parameters on microcapsules’ behavior in vivo is still ambiguous and requires additional study. Here, we discuss how the processes occurring in the blood flow influence the circulation time of magnetic polyelectrolyte microcapsules in mouse blood after injection into the blood circulatory system and their interaction with different blood components, such as WBCs and RBCs. The investigation of microcapsules ranging in diameter 1–5.5 μm allowed us to reveal the dynamics of their filtration by vital organs, cytotoxicity, and hemotoxicity, which is dependent on their size, alongside the efficiency of their interaction with the magnetic field. Our results show that small capsules have a long circulation time and do not affect blood cells. In contrast, the injection of large 5.5 μm microcapsules leads to fast filtration from the blood flow, induces the inhibition of macrophage cell line proliferation after 48 h, and causes an increase in hemolysis, depending on the carrier concentration. The obtained results reveal the possible directions of fine-tuning microcapsule parameters, maximizing capsule payload without the side effects for the blood flow or the blood cells.

scholarly journals Magnetofection In Vivo by Nanomagnetic Carriers Systemically Administered into the Bloodstream

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1927
Author(s):  
Artem A. Sizikov ◽  
Petr I. Nikitin ◽  
Maxim P. Nikitin
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Method Development ◽  
Magnetic Nanostructures ◽  
Field Application ◽  
Efficient Tool ◽  
Systemic Injection ◽  
Main Emphasis ◽  
The Magnetic Field

Nanoparticle-based technologies are rapidly expanding into many areas of biomedicine and molecular science. The unique ability of magnetic nanoparticles to respond to the magnetic field makes them especially attractive for a number of in vivo applications including magnetofection. The magnetofection principle consists of the accumulation and retention of magnetic nanoparticles carrying nucleic acids in the area of magnetic field application. The method is highly promising as a clinically efficient tool for gene delivery in vivo. However, the data on in vivo magnetofection are often only descriptive or poorly studied, insufficiently systematized, and sometimes even contradictory. Therefore, the aim of the review was to systematize and analyze the data that influence the in vivo magnetofection processes after the systemic injection of magnetic nanostructures. The main emphasis is placed on the structure and coating of the nanomagnetic vectors. The present problems and future trends of the method development are also considered.

scholarly journals Research results on the effects of magnetic fields on crude oil

2020 ◽  
Vol 5 (3) ◽  
pp. 050-058
Author(s):  
Nora Mamulaishvili ◽  
Gaioz Partskhaladze ◽  
Gocha Chavleshvili ◽  
Otar Janelidze ◽  
Nigar Salimova
Keyword(s):  
Magnetic Field ◽  
Crude Oil ◽  
Component Composition ◽  
Oil Well ◽  
Formation Water ◽  
Water Emulsion ◽  
Oil Emulsion ◽  
Oil Water ◽  
The Magnetic Field ◽  
Petroleum Emulsion

The paper presents the results of the process of demulsification of crude oil, well No. 15 of the Supsa field. The reasons for the formation of persistent petroleum emulsion are considered, the component composition of crude oil is determined, including the content of the amount of formation water. The experiments were carried out at low (20-30)Hz and high (50-80) Hz frequencies of the magnetic field. The destruction of the oil-water emulsion was carried out without heat treatment under conditions of stabilization of the magnetic field and demulsifier Alkan 202. The technological scheme and parameters of crude oil dehydration are given. The influence of the magnetic field on the rate of destruction of the water-oil emulsion and the amount of released water is shown.

scholarly journals Eddy Currents Based Stray Loss Model For Variable Load Conditions of Medium Power Induction Motors

2021 ◽  
Author(s):  
Rajendra Kumar ◽  
Praveen Kumar ◽  
Teruo Kanekawa ◽  
Koji Oishi
Keyword(s):  
Magnetic Field ◽  
Induction Motor ◽  
Eddy Currents ◽  
Induction Motors ◽  
Variable Load ◽  
Test Results ◽  
Loss Model ◽  
Development And Validation ◽  
The Impact ◽  
The Magnetic Field

<div>This paper presents an eddy current based stray loss model for induction motors taking into account the impact of motor’s loading. The model uses the various motor inductances and, other nameplate data of an induction motor as primary variables. The Magnetic field distribution in a motor is prominently affected by the stator and rotor slot geometries. Distortions in the magnetic field have a direct impact on SL as well as on various inductances of the motor. The development and validation of the model is accomplished by testing total 26 numbers of induction motors of different geometries and materials at different loading conditions. In a further step, the applicability of the model in designing an IM is presented by re-designing a 75kW induction motor and comparing the experimental test results with the initial IM.</div>

scholarly journals HOLOGRAPHIC EXPERIMENTS ON DEFECTS

2010 ◽  
Vol 25 (23) ◽  
pp. 4397-4473 ◽  
Author(s):  
MATTHIAS C. WAPLER
Keyword(s):  
Magnetic Field ◽  
Heat Bath ◽  
Hydrodynamic Behavior ◽  
Unusual Behavior ◽  
Net Charge ◽  
High Frequencies ◽  
Background Magnetic Field ◽  
Collisionless Regime ◽  
The Magnetic Field ◽  
Matter Fields

Using the AdS/CFT correspondence, we study the anisotropic charge transport properties of both supersymmetric and nonsupersymmetric matter fields on (2+1)-dimensional defects coupled to a (3+1)-dimensional [Formula: see text] "heat bath." We focus on the cases of a finite external background magnetic field, finite net charge density and finite mass and their combinations. In this context, we also discuss the limitations due to operator mixing that appears in a few situations and that we ignore in our analysis. At high frequencies, we discover a spectrum of quasiparticle resonances due to the magnetic field and finite density and at small frequencies, we perform a Drude-like expansion around the DC limit. Both of these regimes display many generic features and some features that we attribute to strong coupling, such as a minimum DC conductivity and an unusual behavior of the "cyclotron" and plasmon frequencies, which become related to the resonances found in the conformal case in an earlier paper. We further study the hydrodynamic regime and the relaxation properties, from which the system displays a set of different possible transitions to the collisionless regime. The mass dependence can be cast in two regimes: a generic relativistic behavior dominated by the UV and a nonlinear hydrodynamic behavior dominated by the IR. In the massless case, we furthermore extend earlier results from the literature to find an interesting selfduality under a transformation of the conductivity and the exchange of density and magnetic field.

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