Modeling the Active Response of Cells to Mechanical Stimulation

2008 ◽  
Author(s):  
Patrick McGarry ◽  
Robert M. McMeeking ◽  
Anthony G. Evans ◽  
Vikram S. Deshpande
Keyword(s):  
Mechanical Properties ◽  
Mechanical Stimulation ◽  
Crucial Role ◽  
Extra Cellular Matrix ◽  
Active Response ◽  
Cellular Behavior ◽  
High Substrate ◽  
Surrounding Environment ◽  
Substrate Rigidity ◽  
Motile Cells

The mechanical properties of a cells surrounding environment, or extra cellular matrix (ECM), play a crucial role in cellular behavior. For example, it has been shown that cells tend to spread more on rigid substrates [1, 2] and that motile cells move from regions of low substrate rigidity to regions of high substrate rigidity [3].

Use of Flexible Materials with a Novel Pressure Driven Equibiaxial Cell Stretching Device for Mechanical Stimulation of Single Mammalian Cells

2003 ◽  
Vol 773 ◽  
Author(s):  
James D. Kubicek ◽  
Stephanie Brelsford ◽  
Philip R. LeDuc
Keyword(s):  
Cell Fate ◽  
Mechanical Stimulation ◽  
Mammalian Cells ◽  
Cellular Response ◽  
Single Cells ◽  
Complex Nature ◽  
Cellular Behavior ◽  
Cell Stretching ◽  
Stimulation Of ◽  
Pressure Driven

AbstractMechanical stimulation of single cells has been shown to affect cellular behavior from the molecular scale to ultimate cell fate including apoptosis and proliferation. In this, the ability to control the spatiotemporal application of force on cells through their extracellular matrix connections is critical to understand the cellular response of mechanotransduction. Here, we develop and utilize a novel pressure-driven equibiaxial cell stretching device (PECS) combined with an elastomeric material to control specifically the mechanical stimulation on single cells. Cells were cultured on silicone membranes coated with molecular matrices and then a uniform pressure was introduced to the opposite surface of the membrane to stretch single cells equibiaxially. This allowed us to apply mechanical deformation to investigate the complex nature of cell shape and structure. These results will enhance our knowledge of cellular and molecular function as well as provide insights into fields including biomechanics, tissue engineering, and drug discovery.

scholarly journals Biomechanical Properties of Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 887
Author(s):  
Gaël Runel ◽  
Noémie Lopez-Ramirez ◽  
Julien Chlasta ◽  
Ingrid Masse
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Crucial Role ◽  
Biomechanical Properties ◽  
Supplementary Information ◽  
Cancer Cell Growth ◽  
Diagnosis And Prognosis ◽  
Surrounding Environment ◽  
Surrounding Extracellular Matrix

Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion.

The Anisotropy and Tension/Compression Behavior of Human Cervical Tissue

2007 ◽  
Author(s):  
Kristin M. Myers ◽  
Anastassia Paskaleva ◽  
Michael House ◽  
Simona Socrate
Keyword(s):  
Mechanical Properties ◽  
Preterm Birth ◽  
Crucial Role ◽  
Cervical Tissue ◽  
Spontaneous Preterm Birth ◽  
Compression Behavior ◽  
Healthy Pregnancy ◽  
Mechanical Barrier

The cervix plays a crucial role in maintaining a healthy pregnancy, acting as a mechanical barrier to hold the fetus inside the uterus during gestation. Altered mechanical properties of the cervical tissue are suspected to play an important role in spontaneous preterm birth. However, not much is known about the mechanical properties of human cervical tissue and the etiology of spontaneous preterm birth.

Computational Simulation of a MEMS-Based Microactuator for Tissue Engineering Applications

2008 ◽  
Author(s):  
Joseph Keyes ◽  
Michael Junkin ◽  
Pak Kin Wong ◽  
Jonathan P. Vande Geest
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Stimulation ◽  
Biological Function ◽  
Computational Simulation ◽  
3D Microstructure ◽  
Tissue Replacement ◽  
Engineered Tissue ◽  
Biomechanical Stimulation ◽  
The Relationship

The relationship between the 3D microstructure of tissue-engineered constructs (TECs) and their resulting mechanical and biological function is critical in providing TECs with clinically meaningful mechanical properties in reasonable incubation times. We hypothesize that the next generation of TECs must incorporate a controllable and optimized microstructure (and resulting mechanical properties) if they are to mechanically and biologically mimic tissue function. While the development of a robustly engineered tissue replacement will undoubtedly require simultaneous biochemical and biomechanical stimulation, this paper will focus on the development of a device to impose localized micro-mechanical stimulation.

scholarly journals Mechanical and physical properties of fine-grained concrete for concrete additive manufacturing

2019 ◽  
Vol 91 ◽  
pp. 02041
Author(s):  
Sergey Udodov ◽  
Yuriy Galkin ◽  
Philip Belov
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Physical Properties ◽  
Crucial Role ◽  
Physical And Mechanical Properties ◽  
Concrete Composition ◽  
Fine Grained ◽  
Mechanical And Physical Properties ◽  
Time Periods

Additive manufacturing (3D printing) is becoming more and more common in the field of modern construction. However, for wider implementation of this technology, it is necessary to solve a number of material-oriented scientific problems related to development of concrete composition with targeted rheological, stress-strain, physical and mechanical properties. It has been established that time periods between successful applications of layers play the crucial role in ensuring monolithic features of the “printed” structures. Application of mathematics planning of the experiment allowed establishing the main principles of formation of basic physical and mechanical properties of fine-grained concrete depending on material composition.

scholarly journals Research on the Microstructure and Property of an Anion Rubber Modified Asphalt

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Wei Hong ◽  
Qingshan Li ◽  
Guoquan Guan ◽  
Youbo Di ◽  
Jing Sun ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Development Process ◽  
Asphalt Pavement ◽  
Social Benefits ◽  
Modified Asphalt ◽  
The Road ◽  
Surrounding Environment ◽  
Rubber Particles ◽  
Ft Ir ◽  
Thermal Stability Of

The anion rubber modified asphalt (ARMA) mixture was first successfully developed with a unique process. In the development process, rubber and asphalt were mixed in the same proportion. Furthermore, the microstructure and modification mechanism of the material were characterized by SEM, FT-IR, TG, and XRD tests. The mechanical property of the mixture was also tested in accordance with the relevant standards. In the end, the material’s capacity of releasing anion was measured by DLY-6A232 atmospheric ion gauge. The results indicated that the addition of anion additive into the rubber modified asphalt (RMA) was a mere physical mixture, and the anion additives and rubber particles uniformly dispersed in the ARMA. The addition of anion additive could improve the thermal stability of the RMA. Compared with the traditional asphalt pavement material, the ARMA material shows excellent mechanical properties as well as the ability of releasing anion. Moreover, the material has enormous economic and social benefits by taking full advantage of a large amount of waste tires, thus improving the road surrounding environment.

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