Study of the influence of over-the-counter vitamin supplement intake on urine fluorescence to optimize cancer detection by fluorescence cystoscopy

2015 ◽  
Vol 20 (6) ◽  
pp. 066011 ◽  
Author(s):  
Matthieu Zellweger ◽  
Carla Martoccia ◽  
Matthieu Mengin ◽  
Christophe Iselin ◽  
Hubert van den Bergh ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Vitamin Supplement ◽  
Over The Counter ◽  
Fluorescence Cystoscopy ◽  
Supplement Intake

scholarly journals Vitamin C inhibits SARS coronavirus-2 main protease essential for viral replication

2021 ◽  
Author(s):  
Tek Narsingh Malla ◽  
Suraj Pandey ◽  
Ishwor Poudyal ◽  
Luis Aldama ◽  
Dennis Feliz ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Vitamin C ◽  
Antiviral Treatment ◽  
Cysteine Proteases ◽  
Vitamin Supplement ◽  
Sars Coronavirus ◽  
Over The Counter ◽  
Main Protease ◽  
Approved Drugs

There is an urgent need for anti-viral agents that treat and/or prevent Covid-19 caused by SARS-Coronavirus (CoV-2) infections. The replication of the SARS CoV-2 is dependent on the activity of two cysteine proteases, a papain-like protease, PL-pro, and the 3C-like protease known as main protease Mpro or 3CLpro. The shortest and the safest path to clinical use is the repurposing of drugs with binding affinity to PLpro or 3CLpro that have an established safety profile in humans. Several studies have reported crystal structures of SARS-CoV-2 main protease in complex with FDA approved drugs such as those used in treatment of hepatitis C. Here, we report the crystal structure of 3CLpro in complex Vitamin C (L-ascorbate) bound to the protein's active site at 2.5 Angstrom resolution. We also demonstrate that L-ascorbate inhibits the 3CLpro in vitro at mmol/L concentrations. The crystal structure of the Vitamin C 3CLpro complex may aid future studies on the effect of Vitamin C not only on the coronavirus main protease but on related proteases of other infectious viruses. Since ascorbate is readily available, as an over-the-counter vitamin supplement, our results have the potential for development of a global and inexpensive antiviral treatment.

Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies

2014 ◽  
Vol 32 (1) ◽  
Author(s):  
Yan Liu ◽  
Qiuyan Yu ◽  
Zhenli Zhu ◽  
Jun Zhang ◽  
Meilan Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Vitamin Supplement ◽  
Supplement Intake

scholarly journals Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study

2012 ◽  
Vol 6 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Megha Agarwal ◽  
Puja K Mehta ◽  
James H Dwyer ◽  
Kathleen M Dwyer ◽  
Anne M Shircore ◽  
...  
Keyword(s):  
Vitamin C ◽  
Serum Cholesterol ◽  
Critical Role ◽  
Dietary Vitamin ◽  
Vitamin Supplement ◽  
Carotid Imt ◽  
Vitamin C Supplementation ◽  
The Impact ◽  
Supplement Intake ◽  
Early Atherosclerosis

Objective:To determine the relationship of vitamin c intake from supplements vs food on early atherosclerosis detected by carotid intima media thickness (IMT).Background:Oxidative stress and endothelial dysfunction play a critical role in the pathogenesis of atherosclerosis. Dietary vitamin C appears to have anti-oxidant properties and beneficial relations to endothelial function, yet vitamin C taken as a vitamin supplement does not appear to protect from cardiovascular events. The impact of vitamin c intake from supplements vs food on progression of atherosclerosis is unknown.Methods:We examined 3-year progression of carotid IMT in a randomly sampled cohort of 573 healthy women and men aged 40-60 years. Progression of carotid IMT was determined bilaterally with B-mode ultrasound at 3 examinations (1.5-year intervals). Intake of dietary vitamin C was measured by six, 24-hour recall interviews. Intake of vitamin C from vitamin supplements was measured by questionnaire in quartiles of supplement intake and no supplement. Vitamin C wasmeasured in plasma as ascorbic acid.Results:Carotid IMT progressed 10.0±16.5 μm/year (mean±SD) among all those with follow-up (n=500; 87%). For those who took vitamin C supplements, carotid IMT progression increased with dose (p-trend=0.0009). Among persons in the highest quartile (857-5000 mg/day) of vitamin C supplement intake compared to those not consuming any vitamin C supplements, carotid IMT progression increased three-fold (20.3±2.6 versus 7.6±1.8 μm/year (mean±SD); p<0.001). The adverse association of vitamin C supplement intake with carotid IMT was two-fold greater in the upper tertile of serum cholesterol compared to the lower two tertiles (p=0.01). In contrast to the adverse association of vitamin C supplements, vitamin C intake from food had a weak protective relationship on carotid IMT progression (reduced progression -5.0±1.9 μm/year; p=0.008).Conclusions:Vitamin C supplementation is associated with accelerated early atherosclerosis measured by carotid IMT compared to a protective association with vitamin C from food. Theadverse association of vitamin C supplementation may be greater in patients with higher serum cholesterol levels. The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies. Given these observations,vitamin C supplementation does not appear to be currently advisable for prevention or treatment of atherosclerosis.

A Prospective Study of Vitamin Supplement Intake and Cataract Extraction among U.S. Women

Epidemiology ◽  
1999 ◽  
Vol 10 (6) ◽  
pp. 679-684 ◽  
Author(s):  
Lisa Chasan-Taber ◽  
Walter C. Willett ◽  
Johanna M. Seddon ◽  
Meir J. Stampfer ◽  
Bernard Rosner ◽  
...  
Keyword(s):  
Prospective Study ◽  
Cataract Extraction ◽  
Vitamin Supplement ◽  
A Prospective Study ◽  
Supplement Intake

Vitamin Supplement Intake Is Related to Dietary Intake and Physical Activity: The Child and Adolescent Trial for Cardiovascular Health (CATCH)

2006 ◽  
Vol 106 (12) ◽  
pp. 2018-2023 ◽  
Author(s):  
Lindsay Reaves ◽  
Lyn M. Steffen ◽  
Johanna T. Dwyer ◽  
Larry S. Webber ◽  
Leslie A. Lytle ◽  
...  
Keyword(s):  
Physical Activity ◽  
Dietary Intake ◽  
Cardiovascular Health ◽  
Child And Adolescent ◽  
Vitamin Supplement ◽  
Supplement Intake

scholarly journals Interactive Effects of Snps Located Within CD28/B7Pathway and Environment on Susceptibility to Recurrent Spontaneous Abortion

2017 ◽  
Vol 43 (6) ◽  
pp. 2185-2199 ◽  
Author(s):  
Guiling Wang ◽  
Jing Sun
Keyword(s):  
Environmental Factors ◽  
Spontaneous Abortion ◽  
Night Shift ◽  
Living Environment ◽  
Interactive Effects ◽  
Recurrent Spontaneous Abortion ◽  
Vitamin Supplement ◽  
Regression Analyses ◽  
Genomic Dnas ◽  
Supplement Intake

Aims: This study was aimed to explore the interaction between environment and CD28/B7 pathway to provide the potential epidemiology for prevention and treatment of recurrent spontaneous abortion (RSA). Methods: The retrospective study included 630 RSA cases and 1320 healthy women during their middle and late prenatal care. Their living environment was investigated, and the influence of environmental factors on pregnancy abortion was analyzed. The genomic DNAs were extracted from the study subjects, and the polymorphisms of CD28 and B7 were analyzed. Finally, the interaction of gene and environment on RSA was analyzed with the logistic regression analyses. Results: The multi-variate regression analysis indicated that vitamin supplement, intake of fresh fruits or vegetables, night shift, staying up late, history miscarriage, as well as history induced abortion were, independently, risk factors for RSA (all P< 0.05). Moreover, rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28, rs1915087 (C>T) of B7-2, as well as rs6804441 (A>G) and rs41271391 (G>T) of B7-1 were correlated with modified RSA risk (all P< 0.05). The haplotypes TGT and TAG could also regulate the risk of RSA (both P< 0.05). The synthetic influences of the aforementioned SNPs and environmental factors could also significantly affect the susceptibility to RSA (all P< 0.05). Conclusion: The interaction of environment and SNPs of CD28/B7 pathway on RSA risk was distinct from CD28/B7 pathway or environment alone.

scholarly journals Vitamin D Toxicity due to a Commonly Available “Over the Counter” Remedy from the Dominican Republic

2011 ◽  
Vol 96 (2) ◽  
pp. 291-295 ◽  
Author(s):  
Hyesoo Lowe ◽  
Natalie E. Cusano ◽  
Neil Binkley ◽  
William S. Blaner ◽  
John P. Bilezikian
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Dominican Republic ◽  
Serum Calcium ◽  
Laboratory Evaluation ◽  
Vitamin D Metabolites ◽  
Vitamin Supplement ◽  
Over The Counter ◽  
Baseline Serum ◽  
Vitamin D Toxicity

abstract Context: Hypercalcemia in ambulatory patients is occasionally caused by vitamin D toxicity. Objective: We report nine patients presenting to Columbia University Medical Center with hypercalcemia due to a supplement from the Dominican Republic containing massive amounts of vitamin D. Methods: Case histories and laboratory evaluation (calcium, PTH, vitamin D metabolites) are discussed in the context of other published cases of vitamin D toxicity. The supplement was analyzed by HPLC to quantitate vitamin D and A content. Results: Nine patients presented with hypercalcemia (range, 10.8–17.2 mg/dl; normal, 8.4–9.8 mg/dl), suppressed PTH (range, &lt;3 to 11 pg/ml), and elevated 25-hydroxyvitamin D (range, 94–525 ng/ml; normal, 30–80 ng/ml) levels. All reported recently taking an over-the-counter vitamin supplement called Soladek readily available in the Dominican Republic and in Upper Manhattan. Although serum calcium values before the ingestion of Soladek were not elevated (baseline serum calcium range, 8.7–9.2 mg/dl), most had a disorder that can be associated with hypercalcemia [squamous cell cancer (n = 1), Pneumocystis or mycobacterial infection (n = 3), lymphoma (n = 1), granulomatous disease (n = 1), hyperthyroidism (n = 2)]. According to the manufacturer's label, each 5-ml vial of Soladek contains vitamin D (600,000 IU), vitamin A (120,000 IU), and vitamin E (5 mg). Laboratory analysis by HPLC revealed that the supplement actually contained vitamin D3 (864,000 IU) and vitamin A (predominantly retinyl palmitate 123,500 IU) per vial. Conclusion: Although hypercalcemia due to exogenous use of vitamin D is unusual, it is important to consider it in the differential diagnosis, particularly among individuals with access to Soladek.

Risk of limb deficiency defects associated withNAT1,NAT2,GSTT1,GSTM1, andNOS3 genetic variants, maternal smoking, and vitamin supplement intake

2006 ◽  
Vol 140A (18) ◽  
pp. 1915-1922 ◽  
Author(s):  
Suzan L. Carmichael ◽  
Gary M. Shaw ◽  
Wei Yang ◽  
David M. Iovannisci ◽  
Edward Lammer
Keyword(s):  
Genetic Variants ◽  
Maternal Smoking ◽  
Vitamin Supplement ◽  
Limb Deficiency ◽  
Supplement Intake
Sign in / Sign up

Export Citation Format

Share Document