Lag time changes between capillary blood glucose and in-vivo interstitial glucose levels by HATR-FTIR spectroscopy

2011 ◽  
Author(s):  
Natalja Skrebova Eikje
Keyword(s):  
Blood Glucose ◽  
Ftir Spectroscopy ◽  
Lag Time ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Interstitial Glucose ◽  
Time Changes

DIABETIC INTERSTITIAL GLUCOSE IN THE SKIN TISSUE BY ATR-FTIR SPECTROSCOPY VERSUS CAPILLARY BLOOD GLUCOSE

2010 ◽  
Vol 03 (02) ◽  
pp. 81-90
Author(s):  
NATALJA SKREBOVA EIKJE
Keyword(s):  
Blood Glucose ◽  
Glucose Metabolism ◽  
Ftir Spectroscopy ◽  
Continuous Monitoring ◽  
Skin Tissue ◽  
Promising Alternative ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Interstitial Glucose

Recently introduced horizontal attenuated total reflectance (HATR) Fourier transform infrared (FTIR) spectroscopy for real-time assessment and continuous monitoring of glucose biomolecules in the skin tissue directly on the patients might appear a promising alternative to interpret the activity of interstitial glucose metabolism in vivo by means of evaluating the dynamics of changes of glucose concentrations in interstitial fluid (IF). In the present study, in vivo spectra by ATR-FTIR spectroscopy were obtained post-prandially during a 120–180-minute continuous monitoring in three patients with type 2 diabetes and compared to pre-prandial spectra. In all patients with diabetes interstitial glucose levels at 1030 and 1041 cm-1 reflected the best relationship with blood glucose. The lag time (LT) required for glucose to diffuse from the capillary to epidermal skin tissue was calculated between 0 and 60 minutes at all measured glucose biomolecules. Data showed intra- and inter-subject variations of each glucose biomolecule, pointing to similarities and differences among interstitial glucose metabolism of the patients. Finally, the findings suggest that HATR-FTIR spectroscopy might have the potential for clinical interpretation of activity of glucose metabolism for diagnosis, management, and treatment of patients with diabetes.

INTRAOPERATIVE GLUCOSE LEVELIN NON-DIABETIC PATIENT UNDERGOING ELECTIVE MAJOR SURGERY UNDER GENERALANAESTHESIA RECEIVING DIFFERENT CRYSTALLOID SOLUTIONS AS MAINTENANCE FLUID (A COMPARISON BETWEEN NS AND RL)

2021 ◽  
pp. 30-32
Author(s):  
Saunak Nath ◽  
Niladri Sekhar Mukhopadhyay ◽  
Avinab Das
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Capillary Blood ◽  
Major Surgery ◽  
Diabetic Patients ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Dence Interval ◽  
The Mean

INTRODUCTION: The present study was undertaken to observe the effect of different maintenance uid regimen on intraoperative blood glucose levels in non-diabetic patients undergoing elective major surgery under general anesthesia. AIMS AND OBJECTIVES: This study was conducted to observe the effect of different maintenance uids in intraoperative blood glucose levels of non-diabetic patients undergoing elective major non-cardiac surgery under general anesthesia. MATERIALS AND METHODS: The present study was conducted in the Department of Anesthesiology of Assam Medical College, Dibrugarh for a period of one year. Hospital based observational study. Patients undergoing elective major surgeries at operation theatres of Department of General Surgery of Assam Medical College & Hospital, Dibrugarh. One (1) year from July 2015 to June 2016. RESULT: The mean difference of capillary blood glucose level between baseline and 1.5 hours after intubation for those procedures lasted that long in Group N was 22.87 mg/dl with a 95% condence interval of 103.83-108.61 while in Group R it was 26.82 mg/dl with a 95% condence interval of 108.41-111.59. The mean difference of capillary blood glucose level between baseline and 2 hours after intubation for those procedures lasted that long in Group N was 34.14 mg/dl with a 95% condence interval of 117.29–117.71 while in Group R it was 34.07 with a 95% condence interval of 116.38–118.12. CONCLUSION: This study we can come to a conclusion that though there is a rising trend in change in intraoperative capillary blood glucose level in both the solutions used perioperatively, yet the mean change in intraoperative capillary blood glucose level in non-diabetic patients undergoing major surgeries under general anaesthesia receiving either 0.9% sodium chloride or Ringer's lactate solutions as maintenance uid perioperatively, is comparable, yet needs larger groups of study

Correlation between glycaemic state and tooth mobility in periodontal patients

2021 ◽  
pp. 1-12
Author(s):  
Quratulain Saeed ◽  
Sarwat Memon ◽  
Mervyn Hosein ◽  
Aswad Ahmed ◽  
Sana Ikram
Keyword(s):  
Blood Glucose ◽  
Linear Regression ◽  
Glycosylated Hemoglobin ◽  
Capillary Blood ◽  
Strong Positive Correlation ◽  
Capillary Blood Glucose ◽  
Positive Correlation ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Tooth Mobility

Objective: To evaluate the association of tooth mobility with blood glucose levels and control in patients with periodontitisMethodology: The study was conducted at the department of Oral Medicine, Ziauddin Dental Hospital, Karachi. The study design was cross-sectional. The duration of this study was of 6 months, between December 2018 and May 2019. The study population involved 348 patients with chronic periodontitis. After recording demographic details and dental charting, tooth mobility scores were correlated with gingival crevicular blood glucose, finger capillary blood glucose and glycosylated hemoglobin levels by Pearson’s correlation. Linear regression was applied to assess the inter-relation between variables.Results: The mean age of individuals who participated in this study was 43+/-10.4 years. The average number of teeth present in patients with glucose levels <180mg/dl was 25.5+/-2.5 compared to 23.2+/-2.9 in individuals with glucose values of >200mg/dl. A moderate positive correlation (r=0.658) was seen between gingival crevicular blood glucose levels and tooth mobility. Finger capillary blood glucose levels also showed good correlation (R=0.653) with tooth mobility scores. HbA1c scores showed a strong positive correlation(R=0.733). Linear regression confirmed increased HbA1c as a risk factor for tooth mobility (R2=0.524, p value= 0.000).Conclusion: Tooth mobility and glycaemic levels are strongly interrelated. This study provides evidence that poor glycaemic control may contribute to the etiology of tooth mobility in patients with periodontitis. Continuous...

Standards of admission capillary blood glucose levels in cesarean born neonates

2017 ◽  
Vol 13 (5) ◽  
pp. 433-438 ◽  
Author(s):  
Tatiana Smolkin ◽  
Irena Ulanovsky ◽  
Pnina Carasso ◽  
Imad R. Makhoul
Keyword(s):  
Blood Glucose ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals To evaluate the effect of neostigmine on blood glucose levels in euglycemic albino rats through OGTT

2017 ◽  
Vol 6 (8) ◽  
pp. 2038
Author(s):  
Suresha R. N. ◽  
Siddamma Amoghimath ◽  
Jayanthi M. K.
Keyword(s):  
Blood Glucose ◽  
Test Group ◽  
Capillary Blood ◽  
Control Group ◽  
Albino Rats ◽  
Oral Glucose ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk

Background: Diabetes mellitus (DM) consists of a group of syndromes characterised by hyperglycaemia, altered metabolism of lipids, carbohydrates and proteins and an increased risk of complications from vascular disease. There are genetic and environmental components that affect the risk of developing either type 1 or type 2 diabetes mellitus.Methods: Twelve Swiss albino rats weighing around 150-200gmsof either sex were randomly selected from the central animal facility, JSSMC, Mysore and divided into two groups. The control group received distilled water (25ml/kg body wt.) per orally, test group received Neostigmine (0.5mg/kg/day) per orally for 5 days. On the fifth day, following overnight fasting, 1 hour after drug administration in all the group of rats OGTT was performed, by administering oral glucose in dose of 0.6gm/kg body weight. The capillary blood glucose level was measured at 0, 60 and 150 minutes, by rat tail snipping method using (ACCUCHEK) glucometer.Results: The Capillary Blood Glucose levels of Neostigmine group was less when compared to control group at all-time intervals.Conclusions: Neostigmine showed the hypoglycemic activity when given for 5 days orally in euglycemic albino rats through OGTT.

scholarly journals The relationship between blood glycosylated haemoglobin and home capillary blood glucose levels in diabetics

Diabetologia ◽  
1980 ◽  
Vol 19 (1) ◽  
pp. 31-34 ◽  
Author(s):  
R. B. Paisey ◽  
D. G. Macfarlane ◽  
R. J. Sherriff ◽  
M. Hartog ◽  
R. R. Slade ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Capillary Blood ◽  
Glycosylated Haemoglobin ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
The Relationship

scholarly journals How Much Accuracy of Interstitial Glucose Measurement Is Enough? Is There a Need for New Evidence?

2016 ◽  
Vol 11 (2) ◽  
pp. 296-298 ◽  
Author(s):  
Norbert Hermanns ◽  
Dominic Ehrmann ◽  
Bernhard Kulzer
Keyword(s):  
Blood Glucose ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Blood Glucose Measurement ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose ◽  
Measurement Systems ◽  
Interstitial Glucose ◽  
New Evidence

This analytical comment discusses what standards are needed for the evaluation of the accuracy of glucose measurement systems continuously measuring glucose in the interstitial fluid. Since accuracy standards for continuous glucose monitoring (CGM)/flash glucose monitoring (FGM) systems are currently based on modeling studies or consensus of experts, we raised the question whether non-inferiority trials evaluating the safety and efficacy of CGM/FGM measurements compared to capillary blood glucose measurement with point-of-care devices could help to establish clarity about the needed accuracy standards of CGM/FGM. Such trials could also support the replacement of capillary blood glucose measurements by modern CGM/FGM systems.

scholarly journals Fasting salivary glucose levels is not a better measure for identifying diabetes mellitus than serum or capillary blood glucose levels: comparison in a Ghanaian population

Heliyon ◽  
2019 ◽  
Vol 5 (3) ◽  
pp. e01286 ◽  
Author(s):  
Richard K.D. Ephraim ◽  
Enoch Odame Anto ◽  
Emmanuel Acheampong ◽  
Linda Ahenkorah Fondjo ◽  
Richmond B. Barnie ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Capillary Blood ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Correlation between Levels of Sulcular and Capillary Blood Glucose

2009 ◽  
Vol 10 (2) ◽  
pp. 10-17 ◽  
Author(s):  
Amir Moeintaghavi ◽  
Mohammad Reza Talebi Ardakani ◽  
Ahmad Haerian ◽  
Mohammad Afkhami Ardakani ◽  
Mahdi Hashemzadeh
Keyword(s):  
Blood Glucose ◽  
Capillary Blood ◽  
Periodontal Pocket ◽  
Gingival Tissue ◽  
Diabetic Patients ◽  
Capillary Blood Glucose ◽  
Blood Samples ◽  
Glucose Levels ◽  
Anterior Teeth ◽  
Blood Glucose Levels

Abstract Aim The aim of this study was to evaluate the correlation between capillary blood glucose levels (CBGLs) and sulcular blood glucose levels (SBGLs) using blood obtained from gingival tissue during routine periodontal examinations to determine if sulcular blood samples can be used as a non-invasive means to diagnosis blood glucose levels. Methods and Materials Thirty non-diabetics and 30 diabetic patients with moderate to severe periodontitis were included in the study and subjected to routine clinical periodontal examinations. Blood was collected using a 1.6-1.8 mm diameter micro bite collection tube to transport the sample from the gingival sulci of anterior teeth following periodontal pocket probing to a test strip of a glucose self-monitoring device. As a control, capillary blood was taken with a finger-stick. Statistical analysis was performed using the Pearson's correlation coefficient and a t-test. Results The blood glucose levels in patients ranged from 58 mg/dl to 477 mg/dl, and the values of blood samples taken from gingival sulcus or finger tip of the same patient showed a very high intra-patient correlation (r =0.99, p< 0.0001). Conclusion The results of this study suggest sulcular blood from a routine periodontal examination may be used for diabetes mellitus screening. Clinical Significance Considering 50% of diabetics remain undiagnosed, testing sulcular blood may provide a suitable method for identifying potential diabetic patients during routine dental visits since there is a correlation with capillary blood. Appropriate referrals to a physician can then be made when warranted. Citation Ardakani MRT, Moeintaghavi A, Haerian A, Ardakani MA, Hashemzadeh M. Correlation between Levels of Sulcular and Capillary Blood Glucose. J Contemp Dent Pract 2009 March; (10)2:010-017.

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