Measurement of in Vivo Lumbar Intervertebral Disc Pressure during Spinal Manipulation: A Feasibility Study

2006 ◽  
Vol 22 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Anthony J. Lisi ◽  
Conor W. O’Neill ◽  
Derek P. Lindsey ◽  
Robert Cooperstein ◽  
Elaine Cooperstein ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Feasibility Study ◽  
Pressure Transducer ◽  
Spinal Manipulation ◽  
Lumbar Disc ◽  
Treatment Method ◽  
Lumbar Intervertebral Disc ◽  
Asymptomatic Adult

This paper presents the first reported measurements of lumbar intervertebral disc pressure in vivo during spinal manipulation. A pressure transducer was inserted into the nucleus pulposus of one normal-appearing lumbar disc in an asymptomatic adult volunteer. Pressures were recorded during several body positions and maneuvers, then during spinal manipulation, and lastly during a repetition of the preintervention body positions. Baseline pressures in the prone and side-lying positions measured 110 kPa and 150 kPa, respectively. During the manipulation, pressure rose to a peak of 890 kPa over 250 ms. Immediately following, pressures in the prone and side-lying positions measured 150 kPa and 165 kPa, respectively. These data do not support the hypotheses that manipulation can reduce a herniation by decreasing intradiscal pressure, or cause a herniation by raising pressure to failure levels. Further work may lead to a better understanding of this treatment method.

Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction

2008 ◽  
Author(s):  
John I. Boxberger ◽  
Joshua D. Auerbach ◽  
Sounok Sen ◽  
George R. Dodge ◽  
Dawn M. Elliott
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Post Treatment ◽  
In Vivo Model ◽  
Long Term Effects ◽  
Early Human

Reduced nucleus pulposus glycosaminoglycan (GAG) content is one of the earliest clinically detectable changes during the course of intervertebral disc degeneration [1,2]. Depletion of nucleus GAG by small percentages consistent with this early loss has been experimentally linked to altered motion segment mechanical function, and thus, potentially increases the risk of damage accumulation directly due to elevated stresses and strains and through altered cellular function [3]. Recently, our laboratory has established an in vivo model in a rat lumbar disc which moderately decreases nucleus GAG to levels observed in early human degeneration. In this model, GAG loss is accompanied by a state of hypermobility at both 4 and 12 weeks post treatment [4], potentially making the disc susceptible to mechanical failure. The objective of this study was to determine the long term effects of nucleus GAG depletion and to determine if altered discs demonstrate hallmark features of disc degeneration. We hypothesized that GAG will remain depleted 24 weeks post treatment, potentially decreasing to lower levels, and further that geometrical and mechanical changes consistent with degeneration will be observed.

scholarly journals An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc

Spine ◽  
2008 ◽  
Vol 33 (2) ◽  
pp. 146-154 ◽  
Author(s):  
John I. Boxberger ◽  
Joshua D. Auerbach ◽  
Sounok Sen ◽  
Dawn M. Elliott
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
In Vivo Model ◽  
Lumbar Intervertebral Disc

scholarly journals In Vivo Lumbar Intervertebral Disc Deformation During Lateral Bending Motion Under Different Load-Bearing Conditions

2021 ◽  
Author(s):  
Haoxiang Xu ◽  
Wangqiang Wen ◽  
Zepei Zhang ◽  
Bowen Kou ◽  
Jincheng Wu ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Tensile Deformation ◽  
Lumbar Disc ◽  
Lateral Bending ◽  
Lumbar Intervertebral Disc ◽  
Load Bearing ◽  
Compression Deformation ◽  
Left And Right

Abstract Background Lumbar Intervertebral Disc Degeneration (LDD) is one of the largest health worldwide problems, based on lost working time and associated costs. Inappropriate mechanical loading is considered to be an important factor in the development of LDD. L3-4 and L4-L5 were the commonly affected levels. Recent studies have measured geometric deformation of lumbar intervertebral discs during an in vivo functional weightbearing of the lumbar. The purpose of the present study was to determine the lumbar disc deformation in living human subjects during lateral bending motion under different load-bearing conditions. Methods 11 healthy subjects, 6 males and 5 females, aged 21 ≤ 39 years, with an average age of 30 ± 5 years, were recruited for the present study. Using the combination of dual fluoroscopic imaging system(DFIS)and CT, the sagittal images of L3-5 segments scanned by CT were transformed into three-dimensional reconstruction models and then matched to the instantaneous images of lumbar spine motion taken by a double fluorescent X-ray system under different loads. Motions were reproduced with the use of the combined imaging technique during left and right bending movements. Then, the kinematics data of the height, tension and compression deformation, and shear deformation of the lumbar intervertebral disc were obtained by using computer-related software. Result The data indicated that the tendency of tensile deformation during left and right bending was approximately symmetric. During the functional bending of the body, there was a greater compression deformation behind the same side of the movement and a higher tension deformation in front of the contralateral movement. The magnitude changed along the diagonal towards the posterolateral direction. During left bending, the upper vertebrae had a larger deformation range and tension deformation than the lower vertebrae. Meanwhile, it was not found that the small load had a significant effect on the tensile deformation of the intervertebral disc. Conclusion Lumbar disc deformation showed direction-specific and level-specific changes during lateral bending motion. These results could help understand the physiological motion characters of the lumbar spine and provide data support for other biomechanical studies.

Association between Measures of Vertebral Endplate Morphology and Lumbar Intervertebral Disc Degeneration

2017 ◽  
Vol 68 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Semra Duran ◽  
Mehtap Cavusoglu ◽  
Hatice Gul Hatipoglu ◽  
Deniz Sozmen Cılız ◽  
Bulent Sakman
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Vertebral Endplate ◽  
Lumbar Intervertebral Disc ◽  
Sagittal Diameter ◽  
Magnetic Resonance Imaging Mri ◽  
Vertebral Endplates

Purpose The aim of this study was to evaluate the association between vertebral endplate morphology and the degree of lumbar intervertebral disc degeneration via magnetic resonance imaging (MRI). Methods In total, 150 patients who met the inclusion criteria and were 20–60 years of age were retrospectively evaluated. Patients were evaluated for the presence of intervertebral disc degeneration or herniation, and the degree of degeneration was assessed at all lumbar levels. Vertebral endplate morphology was evaluated based on the endplate sagittal diameter, endplate sagittal concave angle (ECA), and endplate sagittal concave depth (ECD) on sagittal MRI. The association between intervertebral disc degeneration or herniation and endplate morphological measurements was analysed. Results In MRI, superior endplates ( ie, inferior endplates of the superior vertebra) were concave and inferior endplates ( ie, superior endplates of the inferior vertebra) were flat at all disc levels. A decrease in ECD and an increase in ECA were detected at all lumbar levels as disc degeneration increased ( P < .05). At the L4-L5 and L5-S1 levels, a decrease in ECD and an increase in ECA were detected in the group with herniated lumbar discs ( P < .05). There was no association between lumbar disc degeneration or herniation and endplate sagittal diameter at lumbar intervertebral levels ( P > .05). At all levels, ECD of women was significantly lesser than that of men and ECA of women was significantly greater than that of men ( P < .05). Conclusions There is an association between vertebral endplate morphology and lumbar intervertebral disc degeneration. Vertebral endplates at the degenerated disc level become flat; the severity of this flattening is correlated with the degree of disc degeneration.

scholarly journals Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Fan-jie Liu ◽  
Liang-yu Xie ◽  
Hua-zhong Li ◽  
Sheng-nan Cao ◽  
Yuan-zhen Chen ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Western Blot ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Intervertebral Disc Herniation ◽  
Lumbar Intervertebral Disc ◽  
Real Time Quantitative Pcr ◽  
Lumbar Intervertebral Disc Herniation ◽  
Mrna And Protein Expression

Objective. Angiopoietin-like protein 4 (ANGPTL4), encoding a glycosylated secreted protein, has been reported to be closely related to many kinds of diseases, including diabetes, tumor, and some musculoskeletal pathologies, such as rheumatoid arthritis, osteoarthritis, and osteoporosis. The aim of the current study is to investigate the role of ANGPTL4 in intervertebral disc degeneration and analyze the association of ANGPTL4 expression with Pfirrmann grades. Methods. A total of 162 nucleus pulposus tissues were collected from lumbar intervertebral disc herniation patients undergoing interforaminal endoscopic surgery. Real-time quantitative PCR and western blot were performed to determine the mRNA and protein expression of ANGPTL4 in nucleus pulposus samples. Statistical analysis was performed to analyze the association of ANGPTL4 expression with Pfirrmann grades. Results. Based on the clinical data of 162 patients, results showed that Pfirrmann grades were significantly associated with patients’ age ( r = 0.162 , P = 0.047 ) and were not significantly associated with patients’ gender ( P > 0.05 ). RT-qPCR and western blot results showed that the mRNA ( r = 0.287 , P < 0.05 ) and protein ( r = 0.356 , P < 0.05 ) expressions of ANGPTL4 were both closely associated with Pfirrmann grades. The expression of ANGPTL4 was remarkably increased in the groups of high IVDD Pfirrmann grades. Conclusion. The results demonstrated that ANGPTL4 expression was positively associated with the Pfirrmann grades and the severity of intervertebral disc degeneration. ANGPTL4 may be served as a candidate biomarker for intervertebral disc degeneration.

scholarly journals Injectable Hydrogel Combined with Nucleus Pulposus-Derived Mesenchymal Stem Cells for the Treatment of Degenerative Intervertebral Disc in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Feng Wang ◽  
Li-ping Nan ◽  
Shi-feng Zhou ◽  
Yang Liu ◽  
Ze-yu Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Rat Model ◽  
Injectable Hydrogel ◽  
Cell Scaffold ◽  
Ivd Degeneration

Stem cell-based tissue engineering in treating intervertebral disc (IVD) degeneration is promising. An appropriate cell scaffold can maintain the viability and function of transplanted cells. Injectable hydrogel has the potential to be an appropriate cell scaffold as it can mimic the condition of the natural extracellular matrix (ECM) of nucleus pulposus (NP) and provide binding sites for cells. This study was aimed at investigating the effect of injectable hydrogel-loaded NP-derived mesenchymal stem cells (NPMSC) for the treatment of IVD degeneration (IDD) in rats. In this study, we selected injectable 3D-RGD peptide-modified polysaccharide hydrogel as a cell transplantation scaffold. In vitro, the biocompatibility, microstructure, and induced differentiation effect on NPMSC of the hydrogel were studied. In vivo, the regenerative effect of hydrogel-loaded NPMSC on degenerated NP in a rat model was evaluated. The results showed that NPMSC was biocompatible and able to induce differentiation in hydrogel in vivo. The disc height index (almost 87%) and MRI index (3313.83±227.79) of the hydrogel-loaded NPMSC group were significantly higher than those of other groups at 8 weeks after injection. Histological staining and immunofluorescence showed that the hydrogel-loaded NPMSC also partly restored the structure and ECM content of degenerated NP after 8 weeks. Moreover, the hydrogel could support long-term NPMSC survival and decrease cell apoptosis rate of the rat IVD. In conclusion, injectable hydrogel-loaded NPMSC transplantation can delay the level of IDD and promote the regeneration of the degenerative IVD in the rat model.

Effects of Reloading After Simulated Microgravity on Proteoglycan Metabolism in the Nucleus Pulposus and Anulus Fibrosus of the Lumbar Intervertebral Disc

Spine ◽  
2007 ◽  
Vol 32 (25) ◽  
pp. E734-E740 ◽  
Author(s):  
Hiroki Yasuoka ◽  
Takashi Asazuma ◽  
Kuniaki Nakanishi ◽  
Yasuo Yoshihara ◽  
Atsushi Sugihara ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Simulated Microgravity ◽  
Anulus Fibrosus ◽  
Lumbar Intervertebral Disc

The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics

2008 ◽  
Vol 41 (10) ◽  
pp. 2104-2111 ◽  
Author(s):  
Marco Cannella ◽  
Amy Arthur ◽  
Shanee Allen ◽  
Michael Keane ◽  
Abhijeet Joshi ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Neutral Zone ◽  
Lumbar Intervertebral Disc

scholarly journals Lumbago is different from prolapse of lumbar intervertebral disc

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Wei Zhou ◽  
Yanbo Qiu ◽  
Shaoqiu Zhou ◽  
Wei Zhao
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Lumbar Disc ◽  
Posterior Longitudinal Ligament ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Disc Protrusion ◽  
Medical Reform ◽  
System Disease

<p>There are many errors found in the content of textbook in National Higher Education.For example:One of the errors found in the“Surgery”version no 418 is about movement system disease section.In chapter 677 Section III,the content misinterpretation of the cause of low back pain is the intervertebral disc protrusion that stimulate the outer annulus and the posterior longitudinal ligament in the sinus nerve fibers.For the past twenty years,feedbacks had been reflected repeatedly to the involved party but no one had admitted the contents of the textbook are wrong.The errors had brought great economy loss,physical and mental pain to patients.Every year,the country has to spend billions of dollars in the waste of medical reform reimbursement.This article is aimed to discuss about low back pain is not due to lumbar disc herniation.</p>

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