scholarly journals Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis

2020 ◽  
Vol 6 (37) ◽  
pp. eabc1586
Author(s):  
Chen Zhou ◽  
Mingming Zhen ◽  
Meilan Yu ◽  
Xue Li ◽  
Tong Yu ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Lipid Peroxidation ◽  
Hepatic Steatosis ◽  
Liver Diseases ◽  
Antioxidant Property ◽  
Hepatic Lipid Accumulation ◽  
Apolipoprotein B100 ◽  
Abnormal Mitochondria ◽  
Approved Drugs ◽  
Excessive Accumulation

Hepatic steatosis is a widespread metabolic disease characterized by excessive accumulation of triglyceride (TG) in liver. So far, effective approved drugs for hepatic steatosis are still in development, and removing the unnecessary TG from the hepatocytes is an enormous challenge. Here, we explore a promising anti-hepatic steatosis strategy by boosting hepatocellular TG transport using β-alanine–modified gadofullerene (GF-Ala) nanoparticles. We confirm that GF-Ala could reverse hepatic steatosis in oleic acid–induced hepatocytes, fructose-induced mice, and obesity-associated transgenic ob/ob mice. Observably, GF-Ala improves hepatomegaly and hepatic lipid accumulation, reduces lipid peroxidation, and repairs abnormal mitochondria. Of note, we demonstrate that GF-Ala markedly inhibits the posttranslational degradation of apolipoprotein B100 (ApoB100) and boosts hepatocellular TG transport based on their superior antioxidant property. Together, we conclude that GF-Ala could potently ameliorate hepatic TG transport and maintain hepatic metabolic homeostasis without apparent toxicity, being beneficial for treatments of hepatic steatosis and other fatty liver diseases.

Effects of novel prosteatogenic TM6SF2 and NCAN/SUGP1 polymorphisms on hepatic steatosis and non-invasive markers of liver injury in patients with chronic liver diseases

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
A Arslanow ◽  
C Stokes ◽  
S Weber ◽  
F Grünhage ◽  
F Lammert ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatic Steatosis ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Non Invasive

New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

2019 ◽  
Vol 25 (35) ◽  
pp. 3740-3750 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Xiaoqing Chen ◽  
Panpan Wu ◽  
Yu-Jing Lu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Liver Diseases ◽  
Therapeutic Agent ◽  
Heart Diseases ◽  
Pentacyclic Triterpenoids ◽  
Hepatic Drug ◽  
Approved Drugs ◽  
New Applications ◽  
Functional Mechanisms ◽  
Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

The life cycle and in silico elucidation of non-structural replicating proteins of HCV through a pharmacoinformatics approach

2021 ◽  
Vol 24 ◽  
Author(s):  
Rana Adnan Tahir ◽  
Sumera Mughal ◽  
Amina Nazir ◽  
Asma Noureen ◽  
Ayesha Jawad ◽  
...  
Keyword(s):  
Life Cycle ◽  
In Silico ◽  
Liver Diseases ◽  
Rna Virus ◽  
The Novel ◽  
Nonstructural Proteins ◽  
Drug Molecules ◽  
Liver Transplantations ◽  
Pharmacophore Generation ◽  
Approved Drugs

Background: Hepatitis C virus (HCV) is an enveloped and positive-stranded RNA virus that is a major causative agent of chronic liver diseases worldwide. HCV has become the main cause of liver transplantations and there is no effective drug for all hepatitis genotypes. Elucidation of life cycle and nonstructural proteins of HCV involved in viral replication are the attractive targets for the development of antiviral drugs. Methods: In this work, pharmacoinformatics approaches coupled with docking analyses were applied on HCV nonstructural proteins to identify the novel potential hits and HCV drugs. Molecular docking analyses were carried out on HCV approved drugs followed by the ligand-based pharmacophore generation to screen the antiviral libraries for novel potential hits. Results: Virtual screening technique has made known the top-ranked five novel compounds (ZINC00607900, ZINC03635748, ZINC03875543, ZINC04097464, and ZINC12503102) along with the least binding energy (-8.0 kcal/mol, -6.1 kcal/mol, -7.5 kcal/mol, -7.4 kcal/mol, and -7.3 kcal/mol respectively) and stability with non-structural proteins target. Conclusion: These promising hits exhibited better absorption and ADMET properties as compared to the selected drug molecules. These potential compounds extracted from in silico approach may be significant in drug design and development against Hepatitis and other liver diseases.

Dietary fucoidan extracted from macroalgae Saccharina japonica alleviate hepatic lipid accumulation of black seabream (Acanthopagrus schlegelii)

2021 ◽  
Author(s):  
chuanqi yu ◽  
fan lin ◽  
haoji guo ◽  
guoquan liu ◽  
xianda he ◽  
...  
Keyword(s):  
Risk Factor ◽  
Fish Species ◽  
Lipid Accumulation ◽  
Liver Diseases ◽  
Artificial Diet ◽  
Saccharina Japonica ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Black Seabream ◽  
Cultured Fish

The use of artificial diet often leads to the increase of risk factor for the development of liver diseases, such as hepatic lipid accumulation (HLA) in commercial cultured fish species....

Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT/SREBP-1/FASN pathway

2019 ◽  
Vol 10 (6) ◽  
pp. 3410-3420 ◽  
Author(s):  
Cong Zhang ◽  
Junjie Hu ◽  
Lei Sheng ◽  
Ming Yuan ◽  
Yong Wu ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Ellagic Acid ◽  
Lipid Accumulation ◽  
De Novo ◽  
De Novo Lipogenesis ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Ellagic acid alleviates hepatic lipid accumulation in mice by suppressing AKT-driven de novo lipogenesis.

In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

2002 ◽  
Vol 37 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Shuichi Seki ◽  
Takuya Kitada ◽  
Takao Yamada ◽  
Hiroki Sakaguchi ◽  
Kazuki Nakatani ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Dna Damage ◽  
Fatty Liver ◽  
Liver Diseases ◽  
Oxidative Dna Damage ◽  
Alcoholic Fatty Liver ◽  
In Situ Detection

scholarly journals REVERSAL OF ETHANOL-INDUCED HEPATIC STEATOSIS AND LIPID PEROXIDATION BY TAURINE: A STUDY IN RATS

2000 ◽  
Vol 35 (2) ◽  
pp. 215-215 ◽  
Author(s):  
S. Bleich
Keyword(s):  
Lipid Peroxidation ◽  
Hepatic Steatosis

SALIVA AS HIGHLY INFORMATIVE SUBSTRATE FOR NON-INVASIVE ANALYSIS OF LIPOPEROXIDE PROCESSES AND MUSCLE DAMAGE IN HIQHLY SKILLED ATHLETES

2019 ◽  
Vol 64 (7) ◽  
pp. 405-408 ◽  
Author(s):  
A. N. Ovchinnikov ◽  
A. V. Deryugina
Keyword(s):  
Lipid Peroxidation ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Oral Fluid ◽  
Track And Field ◽  
Highly Qualified ◽  
Lipid Peroxidation Products ◽  
Non Invasive ◽  
Markers Of Oxidative Stress ◽  
Excessive Accumulation

The purpose of the investigation was to study the efficiency of measuring markers of oxidative stress and muscle damage in the oral fluid in highly skilled sportsmen under physical exercise for the assessment of their functional state. 70 highly qualified athletes at the age of 16-20 years specializing in the cyclic kinds of sports (track and field, swimming) took part in the investigation. Sportsmen performed the control test which consisted of the series of 3×100 m distances by a flat race with an active 45 s rest between them for the track and field athletes, and 4×50 m by the main swimming style with an active rest between the distances also for 45 s for the swimmers. Activity of creatine kinase, content of lipid peroxidation products in the blood and oral fluid were measured standard biochemical methods. The performance of the functional tests induces the excessive accumulation of toxic products of lipoperoxidation and increases activity of creatine kinase in the oral fluid of highly qualified athletes. Correlation analysis shows, that the intensity of free radical and peroxide processes in athletes can be evaluated by means of the method of measuring the content of lipid peroxidation products in the oral fluid.

scholarly journals Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity

2015 ◽  
Vol 308 (6) ◽  
pp. E460-E469 ◽  
Author(s):  
Zheng Chen ◽  
Hong Shen ◽  
Chengxin Sun ◽  
Lei Yin ◽  
Fei Tang ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Disease Progression ◽  
Hepatic Steatosis ◽  
Proinflammatory Cytokines ◽  
Myeloid Cell ◽  
Metabolic Inflammation ◽  
Molecular Patterns ◽  
Specific Deletion

Myeloid cells, particularly macrophages, mediate metabolic inflammation, thus promoting insulin resistance and metabolic disease progression in obesity. Numerous cytokines, toxic metabolites, damage-associated molecular patterns, and pathogen-associated molecular patterns are involved in activating macrophages via their cognate receptors in obesity. TRAF3 (TNF receptor-associated factor 3) is a common signaling molecule for these ligands/receptors and negatively regulates the proinflammatory NF-κB and MAPK pathways, but its metabolic activity is unknown. We here show that myeloid cell TRAF3 is required for metabolic inflammation and metabolic disease progression in obesity. Myeloid cell-specific deletion of TRAF3 significantly attenuated insulin resistance, hyperglycemia, hyperinsulinemia, glucose intolerance, and hepatic steatosis in mice with either genetic ( ob/ob) or high-fat diet (HFD)-induced obesity. Myeloid cell-specific deletion of TRAF3 had the opposite effects on metabolic inflammation between obese and lean mice. It decreased the expression of proinflammatory cytokines in the liver and adipose tissue of obese mice and largely prevented HFD-induced inflammation in these metabolic tissues; by contrast, in lean mice, it increased the expression of proinflammatory cytokines in the liver and adipose tissue. These data suggest that, in obesity progression, myeloid TRAF3 functionally switches its activity from anti-inflammatory to proinflammatory modes, thereby coupling overnutrition to metabolic inflammation, insulin resistance, and metabolic disease.

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