scholarly journals Identification of RNase 8 as a Novel Human Antimicrobial Protein

2006 ◽  
Vol 50 (9) ◽  
pp. 3194-3196 ◽  
Author(s):  
Bente Rudolph ◽  
Rainer Podschun ◽  
Hany Sahly ◽  
Sabine Schubert ◽  
Jens M. Schröder ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Host Defense ◽  
Broad Spectrum ◽  
Multidrug Resistant ◽  
Rnase A ◽  
Antimicrobial Protein ◽  
Pathogenic Microorganisms ◽  
Human Rnase ◽  
Resistant Strains ◽  
Rnase A Superfamily

ABSTRACT The antimicrobial activity of the human RNase A superfamily member RNase 8 was evaluated. Recombinant RNase 8 exhibited broad-spectrum microbicidal activity against potential pathogenic microorganisms (including multidrug-resistant strains) at micro- to nanomolar concentrations. Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense.

CURRENTLY USED ANTI-TUBERCULAR AGENTS, THEIR ANALOGUES AND RECENTLY DEVELOPED DRUGS

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (07) ◽  
pp. 5-19
Author(s):  
A Mohammad ◽  
Keyword(s):  
Antimicrobial Activity ◽  
Side Effects ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Duration Of Treatment ◽  
Duration Of Therapy ◽  
Drug Molecules ◽  
Prolonged Duration ◽  
Resistant Strains ◽  
Reduced Toxicity

Tuberculosis (TB) is one of most prevailing diseases, responsible for the morbidity and mortality of a large number of populations worldwide. Traditionally, it has relied on a limited number of drugs such as isoniazid, rifampicin, ethambutol, streptomycin, ethionamide and pyrazinamide. However, many of these drugs have different disadvantages such as prolonged duration of treatment, host toxicity and ineffectiveness against resistant strains. This has motivated the search of newer drug molecules, capable of rapid mycobactericidal action with shortened duration of therapy, reduced toxicity and enhanced activity against multidrug resistant strains. These observations have been guiding for the currently used and newly developed anti-tubercular agents that possess potent antimicrobial activity and their side effects, activity against multi drug resistant Mycobacterium, and also in patients co-infected with HIV/AIDS.

Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo

2020 ◽  
Vol 8 (2) ◽  
pp. 739-745 ◽  
Author(s):  
Weinan Jiang ◽  
Ximian Xiao ◽  
Yueming Wu ◽  
Weiwei Zhang ◽  
Zihao Cong ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Host Defense ◽  
Multidrug Resistant ◽  
Host Defense Peptide

Host defense peptide mimicking peptide polymer displayed potent in vitro and in vivo antimicrobial activity against clinically isolated multidrug resistant Pseudomonas aeruginosa.

scholarly journals The RNase a superfamily: Generation of diversity and innate host defense

2006 ◽  
Vol 10 (4) ◽  
pp. 585-597 ◽  
Author(s):  
Kimberly D. Dyer ◽  
Helene F. Rosenberg
Keyword(s):  
Host Defense ◽  
Rnase A ◽  
Rnase A Superfamily

scholarly journals In Vitro Susceptibility of Multidrug Resistant Strains of Salmonella to Essential Oils

2020 ◽  
Vol 15 (1) ◽  
pp. 1934578X1987890
Author(s):  
Valeria Listorti ◽  
Roberta Battistini ◽  
Carlo Ercolini ◽  
Clara Tramuta ◽  
Elisabetta Razzuoli ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Resistance ◽  
Essential Oils ◽  
Multidrug Resistant ◽  
Animal Origin ◽  
Diffusion Method ◽  
Thymus Vulgaris ◽  
In Vitro Susceptibility ◽  
Resistant Strains

Antimicrobial resistance has become a global threat to public health. There is a critical need to find new antimicrobial substances from natural sources. The aim of this study was to investigate the antimicrobial activity of essential oils (EOs) obtained from Origanum vulgare, Thymus serpyllum, Thymus vulgaris, and Melaleuca alternifolia against multidrug resistant strains of Salmonella isolated from samples of diverse animal origin. The strains were biochemically identified, serotyped, and characterized for their antimicrobial resistance profiles. The antimicrobial activity of the EOs against the strains was evaluated using the Kirby-Bauer diffusion method, followed by determination of the minimal inhibitory concentration and minimum bactericidal concentrations. The EOs of T. serpyllum and O. vulgare, which contain carvacrol as the main compound, show excellent antimicrobial activity.

scholarly journals Lichen Xanthones as Models for New Antifungal Agents

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2617 ◽  
Author(s):  
Diana Resende ◽  
Patrícia Pereira-Terra ◽  
Ângela Inácio ◽  
Paulo Costa ◽  
Eugénia Pinto ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Fungicidal Activity ◽  
Antifungal Agents ◽  
Multidrug Resistant ◽  
Antimicrobial Compounds ◽  
Pathogenic Microorganisms ◽  
Antibacterial And Antifungal Activity ◽  
Chemistry Research ◽  
Antibacterial And Antifungal

Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. All the synthesized compounds were evaluated for their antimicrobial activity. Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal activity against dermatophytes clinical strains (T. rubrum, M. canis, and E. floccosum (MIC = 4–8 µg/mL)). Moreover, when evaluated for its synergistic effect for T. rubrum, compound 18 exhibited synergy with fluconazole (ΣFIC = 0.289). These results disclosed new hit xanthones for both antibacterial and antifungal activity.

IBS Therapeutic has Broad Spectrum Antimicrobial Activity

2021 ◽  
Author(s):  
Ashley L. Cunningham ◽  
Orhi Esarte Palomero ◽  
Bradley J. Voss ◽  
M. Stephen Trent ◽  
Bryan W. Davies
Keyword(s):  
Antimicrobial Activity ◽  
Irritable Bowel Syndrome ◽  
Broad Spectrum ◽  
Enteric Pathogens ◽  
Drug Resistant ◽  
Antibacterial And Antifungal Activity ◽  
Resistant Strains ◽  
Irritable Bowel ◽  
Antibacterial And Antifungal ◽  
Drug Resistant Strains

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multi-drug resistant strains. Our results suggest otilonium bromide could act on enteric pathogens and may offer a new scaffold for poorly absorbed intestinal antimicrobial therapy.

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