Understanding the bactericidal mechanism of Cu(OH)2 nanorods in water through Mg-substitution: high production of toxic hydroxyl radicals by non-soluble particles

To date, there is still a lack of definite knowledge regarding the toxicity of Cu(OH)2 nanoparticles towards bacteria. This study was aimed at shedding light on the role played by...

Relationship between mechano-bactericidal activity and nanoblades density on chemically strengthened glass

Establishing the correlation between the topography and the bactericidal performance is the key to improve the mechano-bactericidal activity. However, due to the complexity of the mechano-bactericidal mechanism, the correlation between density and bactericidal performance is still not clear. Based on this, a series of nanoblades (NBs) with various density but similar thickness and height were prepared on the chemically strengthened glass (CSG) substrate by a simple alkaline etching method. The mechano-bactericidal properties of NBs on CSG (NBs@CSG) surfaces exposed to Escherichia coli were evaluated. The results show that with the NB density increasing, the mechano-bactericidal performance of the surface increased first and then decreased. Besides, the bactericidal performance of NBs@CSG is not affected after four consecutive ultrasonic cleaning bactericidal experiments. This article can provide guidance for the design of the new generation of mechano-bactericidal surfaces. In addition, this technology is expected to be applied to the civil aviation cabin window lining.

Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity

Aim: Over the last decades, few significant achievements have been made in tuberculosis (TB) therapy. As a result, there is an urgent need for new anti-TB drugs. Results: Two new classes of bis-(imidazole/benzimidazole)-pyridine derivatives were designed, synthesized and evaluated for their antimycobacterial activity. Conclusion: The synthesis is efficient and straightforward, involving only two successive N-alkylations. The anti-TB assay reveal that our compounds have an excellent anti-TB activity against both replicating and nonreplicating Mtb, are not cytotoxic, exhibited a very good intracellular activity and are active against drug-resistant Mtb strains, some compounds have a bactericidal mechanism. The absorption, distribution, metabolism, excretion and toxicity studies performed for one compound are promising, indicating that it is a good candidate for a future drug.