The Urinary Antibiotic 5-Nitro-8-Hydroxyquinoline (Nitroxoline) Reduces the Formation and Induces the Dispersal of Pseudomonas aeruginosa Biofilms by Chelation of Iron and Zinc
2012 ◽
Vol 56
(11)
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pp. 6021-6025
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Keyword(s):
ABSTRACTSince cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations inPseudomonas aeruginosa, and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.
2011 ◽
Vol 56
(2)
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pp. 989-994
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2011 ◽
Vol 56
(3)
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pp. 1646-1649
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2014 ◽
Vol 59
(3)
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pp. 1789-1793
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2006 ◽
Vol 50
(1)
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pp. 382-384
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Keyword(s):
2012 ◽
Vol 56
(11)
◽
pp. 5698-5708
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2012 ◽
Vol 56
(7)
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pp. 3812-3818
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2015 ◽
Vol 59
(6)
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pp. 3329-3334
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2015 ◽
Vol 59
(7)
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pp. 4031-4039
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