Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis
Keyword(s):
ABSTRACT IQG-607 is a metal complex previously reported as a promising anti-tuberculosis (TB) drug against isoniazid (INH)-resistant strains of Mycobacterium tuberculosis. Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing, and all sequenced colonies carried alterations in the katG gene. The katG(S315T) mutation was sufficient to confer resistance to IQG-607 in both MIC assays and inside macrophages. Moreover, overexpression of the InhA(S94A) protein caused IQG-607's resistance.
2015 ◽
Vol 53
(4)
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pp. 1144-1148
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2015 ◽
Vol 53
(8)
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pp. 2716-2719
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2018 ◽
Vol 15
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pp. 239-245
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2018 ◽
Vol 51
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pp. 378-384
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2015 ◽
Vol 53
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pp. 2230-2237
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