Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening
2010 ◽
Vol 76
(24)
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pp. 8255-8258
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Keyword(s):
ABSTRACT We report the screening of 16,000 synthetic compounds for induction and inhibition of quorum sensing in a Pseudomonas putida N-acylated l-homoserine lactone (AHL) sensor strain engineered with the LasR transcriptional activator. LasR controls virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa and is of significant interest as a therapeutic target. Nine compounds that inhibit and 14 compounds that induce LasR activity were identified in our high-throughput screen.
2002 ◽
Vol 184
(10)
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pp. 2576-2586
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Novel Pseudomonas aeruginosa Quorum-Sensing Inhibitors Identified in an Ultra-High-Throughput Screen
2006 ◽
Vol 50
(11)
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pp. 3674-3679
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2003 ◽
Vol 185
(7)
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pp. 2080-2095
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2021 ◽
2006 ◽
Vol 188
(2)
◽
pp. 815-819
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2006 ◽
Vol 188
(9)
◽
pp. 3365-3370
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