scholarly journals Cryptosporidiosis.

1991 ◽  
Vol 4 (3) ◽  
pp. 325-358 ◽  
Author(s):  
W L Current ◽  
L S Garcia

Before 1982, only eight case reports of human cryptosporidiosis and fewer than 30 papers on Cryptosporidium spp. appeared in the biomedical literature. At that time, cryptosporidiosis was thought to be an infrequent infection in animals and rarely an opportunistic infection in humans. The concept of Cryptosporidium spp. as pathogens has changed dramatically within the past 8 years because of improved diagnostic techniques, increased awareness within the biomedical community, and the development of basic research programs in numerous laboratories. Presently, greater than 1,000 publications including over 400 case reports in the biomedical literature address Cryptosporidium spp. and cryptosporidiosis. Cryptosporidium parvum is now thought to be one of the three most common enteropathogens causing diarrheal illness in humans worldwide, especially in developing countries. It is likely that cryptosporidiosis was previously included in the 25 to 35% of diarrheal illness with unknown etiology. Because of the severity and length of diarrheal illness and because no effective therapy has been identified, cryptosporidiosis is one of the most ominous infections associated with AIDS. The role of C. parvum as an enteropathogen is well established; documentation of its role as a cause of hepatobiliary and respiratory diseases is now appearing in the literature. Our present understanding of the natural history, epidemiology, biology, and immunology of Cryptosporidium spp. as well as the clinical features, pathogenicity, and treatment of cryptosporidiosis are reviewed here.

2017 ◽  
Vol 2 (2_suppl) ◽  
pp. S6-S12 ◽  
Author(s):  
Yasushi Kawaguchi

Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, manifesting in patients as tissue fibrosis, endothelial dysfunction, and inflammation. The disease is characterized by autoantibodies, a hallmark of autoimmunity. Various cytokines and growth factors are elevated in the systemic circulation and fibrotic lesions of patients with SSc. In particular, several studies over the past 2 decades have shown that interleukin-6 (IL-6) appears to be involved in the pathogenesis of SSc. Based on the association between aberrant IL-6 production and tissue fibrosis in patients with SSc, the anti-IL-6 receptor antibody, tocilizumab, is being investigated in clinical trials. This article reviews the biological features of IL-6 and the IL-6 receptor; the role of IL-6 in the pathogenesis of SSc; and the potential for IL-6 inhibition to be used in the treatment of patients with SSc.


Author(s):  
Majerníková M ◽  
Sedláček J ◽  
Monhart Z

Bearing bone involvement is a possible sign of generalization variety of cancers. In many cases the process of bearing skeletal diagnosed at the time when the primary tumor is not obvious. The task of the physician is quickly to determine whether it is a benign process or not, and diagnosis of the primary process by which then determine the further progress of therapy. The search for causative bearing shell process, alternatively the primary tumor, is often common practice in the hands of internist. Departments of Clinical Oncology do not have to have sufficient capacity for complex treatment all of newly discovered deposits skeleton whose nature does not have to be always initially clear. Therefore, in the opinion of the authors in these cases, the role of internist as a significant diagnosis very important In our article, we introduce six case reports of patients who were bearing the ambiguous process of investigation of the skeleton in our department in 2014. In accordance with the literature data were represented kidney tumor, multiple myeloma, chondrosarcoma, and in one case the origo malignant process was not found.


Author(s):  
Lucheng Ji ◽  
Jiang Chen ◽  
Feng Lin

As a means of improving axial compressor performance, sweep technique has been investigated for over half a century and gained wide uses, in the past one decade. However, there is still diverse controversy about the roles of sweep in axial compressor design. In this paper, historical remarks about the sweep are presented firstly. Then, an understanding about the role of sweep is put forward. That is, the sweep is a degree of freedom (DOF) of blade design that emphasizes on matching the aerodynamic loading of every blade element along the whole span within the full operation range. The present understanding about the role of sweep may lead it a more sophisticated use.


2011 ◽  
Vol 57 ◽  
pp. 435-462 ◽  
Author(s):  
Ian Nicholas McCave ◽  
Henry Elderfield

Nick Shackleton was an international scientist of great renown who fundamentally changed our understanding of how Earth processes work. His research on ancient oceans and climates was both innovative and pioneering, and he clarified the precise role of carbon dioxide in warming and cooling the Earth's climate. His work contributed greatly to our present understanding of the mechanism and causes of global warming. When he began his research, the investigation of past climatic changes was an area of ‘academic’ interest only. Four decades later, his lifetime achievements define the emergence of our understanding of the operation of Earth's natural climate system. This understanding of the past is now central to efforts to predict the future climate we have begun to create. As well as his many scientific accomplishments, Nick Shackleton excelled in another area, that of music, which was almost as important to him as science, and he was a very accomplished clarinet player. In his work he was spirited and curiosity-driven. He let his students and an entire community share in his brilliance and vision.


2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kenya Kamimura ◽  
Minoru Nomoto ◽  
Yutaka Aoyagi

Angiomyolipoma (AML) is a benign mesenchymal tumor that is frequently found in the kidney and, rarely, in the liver. The natural history of hepatic AML has not been clarified, and, because of the similar patterns in imaging studies, such as ultrasonography, computed tomography, and magnetic resonance imaging, some of these tumors have been overdiagnosed as hepatocellular carcinoma in the past. With an increase in the number of case reports showing detailed imaging studies and immunohistochemical staining of the tumor with human melanoma black-45, the diagnostic accuracy is also increasing. In this paper, we focused on the role of noninvasive imaging studies and histological diagnosis showing distinctive characteristics of this tumor. In addition, because several reports have described tumor progression in terms of size, recurrence after surgical resection, metastasis to other organs, and portal thrombosis, we summarized these cases for the management and discussed the indications for the surgical treatment of this tumor.


2020 ◽  
Vol 72 (2) ◽  
pp. 304-310
Author(s):  
U. Zhanbershieva ◽  

With help of Zhyraus poetry we are talking about the past our country. It is worth noting that due to the breedom of speech, protection and power of art of Zhyrau. In this article considered fetures literature of khanate period. Also, there is ascending role of national literature. Poetry zhyrau period of the khanate spiritually enriches reader with it’s deep philosophical didactic content. The motives of zhyrau poetry reflected the independence of the nativeland and people;s unity. In article the author provided an overview of basic research in the Kazakh poetry zhyrau science, and also expressed their views on the matter. Furthermore the author made the artistic analysis of some of the famous zhyrau: Asan kaigy, Kaztugan, Dospambet, Akhtamberdy, Bukhar and assessed their creativity. The article defines the place and role of poetry zhyrau Khan;s period in Kazakh literature.


Author(s):  
Gianfranco Pacchioni

This chapter illustrates with examples how science and technology have changed our way of life. We live longer, we live better, although this is not always appreciated. A brief description of life in Edwardian London of the early 1900s provides an idea of the changes that have occurred over the past century. Reasons why basic research is useful are illustrated to give a positive feeling about the role of science. The time required to transform basic research into valuable applications, however, can be very long. How a fundamental discovery in basic science has turned into magnetic resonance diagnostics in medicine is provided as an example.


2020 ◽  
Vol 48 (3) ◽  
pp. 155-161
Author(s):  
Daniel A. Mendoza ◽  
Karen D. López ◽  
Raúl A. Echeverri ◽  
Laura Pastor ◽  
Steven Rueda ◽  
...  

Introduction: With the evolution of diagnostic techniques in traumatic brain injury (TBI), the study of neurological injury has made progress based on the concepts of primary and secondary injury, leading to the era of proteomics to understand the complex molecular events involved in the process. Objectives: This narrative review is intended to discuss the state of the art of the most frequently used biomarkers in TBI, their clinical utility, and the implications for therapeutic decisionmaking protocols. Materials and methods: In order to fulfill the objective of this paper, a literature review was conducted of the most important databases. Results: Several biomarkers have been studied as prognostic factors in patients with TBI. Learning about their sensitivity and specificity in neurological injury, and its post-trauma evolution over time, has been the goal of various papers in the past few years. Conclusion: Breakthroughs in the study of protein degradation make it necessary to broaden the spectrumand knowledge of new diagnostic methods in TBI. Further studies are needed to define the role of biomarkers and to promote protocols integrating specific values.


2019 ◽  
Vol 10 (1) ◽  
pp. 81-83
Author(s):  
Ammara Hameed ◽  
Sara Fatima ◽  
Tayyaba Hameed ◽  
Maryam Haider

Lipid emulsions are traditionally used as a part of total or partial parenteral nutrition. However in the past few years role of lipid emulsions has been identified in the management of poisoning and overdose caused by the lipophilic agents. Although most of the evidence comes from the various case reports. We are reporting 2 cases of poisoning in the paediatric age group. In both the cases multiple poisoning agents were involved with tricyclic antidepressants being the common agent in either case. Lipid emulsion therapy was used as an adjunct in addition to the traditional poisoning management. Both the girls recovered completely without any neurological deficit. The sequence of events observed provides a considerable evidence regarding the role of ILE therapy in the successful management of both the cases. However more research is required in the area to develop definitive guidelines regarding the use of Intravenous lipid emulsions in paediatric poisoning caused by lipophilic agents.


2014 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Sofia Shehzad

Medical science has progressed leaps and bounds over the past century or so. New concepts and understandings have developed overtime broadening the scope of scientific knowledge in terms of diagnosis and management of various diseases. Surgical procedures have become highly technical with surgeons world over, keen to try and adapt to the changing trends and requirements from time to time. The medical field is one which has always relied on sharing of knowledge amongst the stake holders especially the doctors and paramedical staff in an effort to learn from each other’s experience.  The need for this co-operation and co-ordination in this day and age is beyond the iota of any doubt.    One way for a constructive exchange of ideas and knowledge amongst the medical personnel is to rely on details of one’s experiences and views to be published in peer review journals accessible to others for enhancing the horizon of their professional practice The importance and impact of Medical journals was best described by a Chicago Physician Salisbury JH in 1906 as follows; “Medical school is attended, as a rule, but once in a lifetime; the meetings of the medical society are usually infrequent, but the medical journal, like the newspaper, is an ever-present friend whose influence and advice are potent for good or evil. 1”     To derive maximum benefit from published work it is important to ensure global review of research work and have a constant exchange of ideas2 by way of constructive criticism.   To ensure the credibility of their published journals, most of the editorial boards strive to attain high standards of published material. Research work in the form of original articles are favored by most medical  journals supplemented by book reviews, reviews of clinical practice, case reports, readers' letters, and their own editorials.3  Their significance is described as under; Original articles give information about objectives, methods, results, discussion and conclusions of a new research. Reviews are an overview of one particular topic of clinical Also included under this umbrella are systematic reviewsand meta-analysis. Reports of clinical cases of special interest or a short series of case reports are now sparingly published in journals. Readers letters and the editors own views on varied subjects adds to the amplitude of a journal.        In spite of their importance in disseminating key health information, medical journals have often have had a tenuous existence with a constantly changing spectrum and many journals struggling to define their role.     A lot depends on the quality of printed material and readiness of the reading physician to accept the findings printed.Various modalities are used to rate journals for the benefit of their readers.    Peer reviewed journals are now accepted as a norm for any publication to be deemed credible. With growing awareness other portals such as impact factor devised by’ Eugene Garfield’ are now frequently quoted to define the quality of a journal. Impact factor is a measure of average number of citations to recent published articles in an academic journal. It is calculated by taking into account the number of times that all items published in a journal over the period of 2 consecutive years are cited by indexed publications in the following e.g. year and dividing it by the total number of citable items published by that journal over the period of the 2 years in question. However it will be inappropriate to use it as a mean of comparison between different journals because it cannot be consistently reproduced in an independent audit4 , the speed of publication varies amongst disciplines and the nature of published articles (e.g. review articles which are cited more often).Way back in 1884, President Leartus Connor of America gave his vision for the medical journal as one which ought to be a medical school, a residency program, a clinical preceptor, a set of textbooks, and a medical society unto itself. He concluded, “it is the great unifier of the past and present, the diffuser of all new facts, new thoughts, all new and better appliances for the study of the human body and for the relief of its derangements5” Almost a century and three decades later his words have been imbibed in history as a guiding principle to define the role of journals in medical science.


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