scholarly journals Correlations between Peripheral Blood Coxiella burnetii DNA Load, Interleukin-6 Levels, and C-Reactive Protein Levels in Patients with Acute Q Fever

2014 ◽  
Vol 21 (4) ◽  
pp. 484-487 ◽  
Author(s):  
M. N. T. Kremers ◽  
R. Janssen ◽  
C. C. H. Wielders ◽  
L. M. Kampschreur ◽  
P. M. Schneeberger ◽  
...  
Keyword(s):  
Coxiella Burnetii ◽  
Interleukin 6 ◽  
Q Fever ◽  
Severe Disease ◽  
Strong Positive Correlation ◽  
C Reactive Protein ◽  
Bacterial Dna ◽  
Protein Levels ◽  
Reactive Protein ◽  
Acute Q Fever

ABSTRACTFrom 2007 to 2010, the Netherlands experienced the largest reported Q fever outbreak, with >4,000 notified cases. We showed previously that C-reactive protein is the only traditional infection marker reflecting disease activity in acute Q fever. Interleukin-6 is the principal inducer of C-reactive protein. We questioned whether increased C-reactive protein levels in acute Q fever patients coincide with increased interleukin-6 levels and if these levels correlate with theCoxiella burnetiiDNA load in serum. In addition, we studied their correlation with disease severity, expressed by hospital admission and the development of fatigue. Interleukin-6 and C-reactive protein levels were analyzed in sera from 102 patients diagnosed with seronegative PCR-positive acute Q fever. Significant but weak negative correlations were observed between bacterial DNA loads expressed as cycle threshold values and interleukin-6 and C-reactive protein levels, while a significant moderate-strong positive correlation was present between interleukin-6 and C-reactive protein levels. Furthermore, significantly higher interleukin-6 and C-reactive protein levels were observed in hospitalized acute Q fever patients in comparison to those in nonhospitalized patients, while bacterial DNA loads were the same in the two groups. No marker was prognostic for the development of fatigue. In conclusion, the correlation between interleukin-6 and C-reactive protein levels in acute Q fever patients points to an immune activation pathway in which interleukin-6 induces the production of C-reactive protein. Significant differences in interleukin-6 and C-reactive protein levels between hospitalized and nonhospitalized patients despite identical bacterial DNA loads suggest an important role for host factors in disease presentation. Higher interleukin-6 and C-reactive protein levels seem predictive of more severe disease.

Plasma interleukin-6 and C-reactive protein levels in reactive versus clonal thrombocytosis

1994 ◽  
Vol 97 (4) ◽  
pp. 374-378 ◽  
Author(s):  
Ayalew Tefferi ◽  
Tiechin C. Ho ◽  
Gregory J. Ahmann ◽  
Jerry A. Katzmann ◽  
Philip R. Greipp
Keyword(s):  
Interleukin 6 ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study

2001 ◽  
Vol 87 (5) ◽  
pp. 412-416 ◽  
Author(s):  
Robert Y. Lin ◽  
Margarita R. Trivino ◽  
Arlene Curry ◽  
Gene R. Pesola ◽  
Richard J. Knight ◽  
...  
Keyword(s):  
Emergency Department ◽  
Interleukin 6 ◽  
Allergic Reactions ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
I-Fan Lin ◽  
Jiun-Nong Lin ◽  
Chia-Ta Tsai ◽  
Yu-Ying Wu ◽  
Yen-Hsu Chen ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Q Fever ◽  
C Reactive Protein ◽  
Murine Typhus ◽  
Reactive Protein ◽  
Acute Q Fever

Six-month results of stenting of the femoropopliteal artery and predictive value of interleukin-6: Comparison with high-sensitivity C-reactive protein

Vascular ◽  
2020 ◽  
Vol 28 (6) ◽  
pp. 715-721
Author(s):  
Songlin Guo ◽  
Zhang Zhang ◽  
Lei Wang ◽  
Liangxi Yuan ◽  
Junmin Bao ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Interleukin 6 ◽  
Odds Ratio ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Femoropopliteal Artery ◽  
Protein Levels ◽  
Reactive Protein ◽  
Stent Restenosis ◽  
In Stent Restenosis

Objectives To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values ( p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.

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