Chemical Attenuation in the Development of a Whole-Organism Malaria Vaccine
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ABSTRACT Malaria vaccine development has been dominated by the subunit approach; however, many subunit vaccine candidates have had limited efficacy in settings of malaria endemicity. As our search for an efficacious malaria vaccine continues, the development of a whole-organism vaccine is now receiving much scrutiny. One strategy currently being explored in the development of a whole-organism vaccine involves chemical attenuation of the malaria parasite. In vivo and in vitro chemical attenuation of both liver-stage and blood-stage Plasmodium parasites has been investigated. Here, we discuss both approaches of chemical attenuation in the development of a whole-organism vaccine against malaria.
The Plasmodium falciparum circumsporozoite protein produced in Lactococcus lactis is pure and stable
2019 ◽
Vol 295
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pp. 403-414
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2012 ◽
Vol 19
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pp. 1603-1608
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2012 ◽
Vol 19
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pp. 711-722
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2012 ◽
Vol 56
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pp. 2191-2193
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2012 ◽
Vol 57
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pp. 417-424
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