scholarly journals HEAT SHOCK PROTEINS AS THE DRUGGABLE TARGETS IN LEISHMANIASIS: PROMISES AND PERILS

2020 ◽  
Author(s):  
Pragya Prasanna ◽  
Arun Upadhyay
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Chemotherapeutic Agents ◽  
Inflammatory Reactions ◽  
Physiological Importance ◽  
Cellular Processes ◽  
Insect Gut ◽  
Shock Proteins ◽  
Drug Resistant Strains ◽  
Druggable Targets

Leishmania, the causative agent of leishmaniasis, is an intracellular pathogen that thrives in the insect gut and mammalian macrophages to complete its life cycle. Apart from temperature difference (26oC to 37oC), it encounters several harsh conditions, including oxidative stress, inflammatory reactions, and low pH. Heat shock proteins (HSPs) play essential roles in cell survival by strategically reprogramming cellular processes and signaling pathways. HSPs assist cells in multiple functions, including differentiation, adaptation, virulence, and persistence in the host cell. Due to cyclical epidemiological patterns, limited chemotherapeutic options, drug resistance, and the absence of a vaccine, control of leishmaniasis remain a far-fetched dream. The essential roles of HSPs in parasitic differentiation and virulence and increased expression in drug-resistant strains highlight their importance in combating the disease. In this review, we highlighted the diverse physiological importance of HSPs present in Leishmania, emphasizing their significance in disease pathogenesis. Subsequently, we assessed the potential of HSPs as a chemotherapeutic target and underlined the challenges associated with it. Furthermore, we have summarized a few ongoing drug discovery initiatives that need to be explored further to develop clinically successful chemotherapeutic agents in the future.

scholarly journals Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer

2014 ◽  
Vol 31 (6) ◽  
pp. 2482-2492 ◽  
Author(s):  
LIANG MA ◽  
FUMINORI SATO ◽  
RYUTA SATO ◽  
TAKANORI MATSUBARA ◽  
KENICHI HIRAI ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Chemotherapeutic Agents ◽  
Anticancer Effect ◽  
Dual Targeting ◽  
Shock Proteins

scholarly journals Heat Shock Proteins. Properties. Role in Adaptation. Methodological Approaches to Definition

Biomeditsina ◽  
2020 ◽  
pp. 60-67
Author(s):  
N. Ye. Maksimovich ◽  
E. I. Bon
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Diagnostic Marker ◽  
Cellular Responses ◽  
Altered Expression ◽  
Cellular Processes ◽  
Response To Stress ◽  
Methodological Approaches ◽  
Shock Proteins ◽  
Adaptation Processes

The aim of this review article is to generalize and systematize literature data on the properties of heat shock proteins, as well as their role in adaptation processes and experimental methods of their investigation. The synthesis of heat shock proteins is a universal response to stress, which plays an important role in protecting cells from negative external impacts. Heat shock proteins participate in fundamental cellular processes. Altered expression of heat shock proteins can serve as an important diagnostic marker of cellular responses to damage.

scholarly journals Heat Shock Proteins and Neurodegenerative Disorders

2008 ◽  
Vol 8 ◽  
pp. 270-274 ◽  
Author(s):  
Eliza Ting-Li Soo ◽  
Yee-Kong Ng ◽  
Boon-Huat Bay ◽  
George Wai-Cheong Yip
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Neurodegenerative Disorders ◽  
Current Knowledge ◽  
Cellular Damage ◽  
Protective Function ◽  
Cellular Processes ◽  
Evolutionarily Conserved ◽  
Shock Proteins ◽  
Stressful Stimulus

Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion disease.

scholarly journals Heat Shock Proteins in Cancer Immunotherapy

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jugal Kishore Das ◽  
Xiaofang Xiong ◽  
Xingcong Ren ◽  
Jin-Ming Yang ◽  
Jianxun Song
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Cancer Immunotherapy ◽  
Molecular Size ◽  
Clinical Settings ◽  
Aberrant Expression ◽  
Cellular Processes ◽  
Proliferation And Differentiation ◽  
Cellular Aggregation ◽  
Shock Proteins

Heat shock proteins (HSPs) are highly conserved molecular chaperones with divergent roles in various cellular processes. The HSPs are classified according to their molecular size as HSP27, HSP40, HSP60, HSP70, and HSP90. The HSPs prevent nonspecific cellular aggregation of proteins by maintaining their native folding energetics. The disruption of this vital cellular process, driven by the aberrant expression of HSPs, is implicated in the progression of several different carcinomas. Many HSPs are also actively involved in promoting the proliferation and differentiation of tumor cells, contributing to their metastatic phenotype. Upregulation of these HSPs is associated with the poor outcome of anticancer therapy in clinical settings. On the other hand, these highly expressed HSPs may be exploited as viable immunotherapeutic targets for different types of cancers. This review discusses recent advances and perspectives on the research of HSP-based cancer immunotherapy.

Heat shock proteins in willow (Salix viminalis)

1990 ◽  
Vol 80 (2) ◽  
pp. 301-306
Author(s):  
Tiina Vahala ◽  
Tage Eriksson ◽  
Peter Engstrom
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Salix Viminalis ◽  
Shock Proteins
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