scholarly journals Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate

2001 ◽  
Vol 75 (3) ◽  
pp. 1565-1570 ◽  
Author(s):  
Tzenan Giroglou ◽  
Luise Florin ◽  
Frank Schäfer ◽  
Rolf E. Streeck ◽  
Martin Sapp
Keyword(s):  
Human Papillomavirus ◽  
Cell Surface ◽  
Heparan Sulfate ◽  
Chondroitin Sulfate ◽  
Cell Lines ◽  
Human Papillomavirus Type 16 ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Secondary Receptor ◽  
Kinetics Of

ABSTRACT Using pseudoinfection of cell lines, we demonstrate that cell surface heparan sulfate is required for infection by human papillomavirus type 16 (HPV-16) and HPV-33 pseudovirions. Pseudoinfection was inhibited by heparin but not dermatan or chondroitin sulfate, reduced by reducing the level of surface sulfation, and abolished by heparinase treatment. Carboxy-terminally deleted HPV-33 virus-like particles still bound efficiently to heparin. The kinetics of postattachment neutralization by antiserum or heparin indicated that pseudovirions were shifted on the cell surface from a heparin-sensitive into a heparin-resistant mode of binding, possibly involving a secondary receptor. Alpha-6 integrin is not a receptor for HPV-33 pseudoinfection.

Absence ofp15INK4Bandp16INK4AGene Alterations in Primary Cervical Carcinoma Tissues and Cell Lines with Human Papillomavirus Infection

1998 ◽  
Vol 70 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Jin Woo Kim ◽  
Sung Eun Namkoong ◽  
Soon Won Ryu ◽  
Ho Shik Kim ◽  
Jin Woong Shin ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cell Lines ◽  
Cervical Carcinoma ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

scholarly journals Alterations of T-cell surface markers in older women with persistent human papillomavirus infection

2010 ◽  
Vol 128 (3) ◽  
pp. 597-607 ◽  
Author(s):  
Ana Cecilia Rodríguez ◽  
Alfonso J. García-Piñeres ◽  
Allan Hildesheim ◽  
Rolando Herrero ◽  
Matthew Trivett ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
Cell Surface ◽  
Older Women ◽  
Surface Markers ◽  
Cell Surface Markers ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

scholarly journals Heparan Sulfate-Independent Cell Binding and Infection with Furin-Precleaved Papillomavirus Capsids

2008 ◽  
Vol 82 (24) ◽  
pp. 12565-12568 ◽  
Author(s):  
Patricia M. Day ◽  
Douglas R. Lowy ◽  
John T. Schiller
Keyword(s):  
Cell Surface ◽  
Heparan Sulfate ◽  
Cell Surface Receptor ◽  
Furin Cleavage ◽  
Human Papillomavirus Type 16 ◽  
Papillomavirus Infection ◽  
Distinct Cell ◽  
Subsequent Step ◽  
Surface Receptor ◽  
Infected Cells

ABSTRACT Papillomavirus infection normally involves virion binding to cell surface heparan sulfate proteoglycans (HSPGs). However, we found that human papillomavirus type 16 pseudovirions efficiently bound and infected cells lacking HSPGs if their L2 capsid protein was precleaved by furin, a cellular protease required for infection. The inability of pseudovirions to efficiently bind and infect cultured primary keratinocytes was also overcome by furin precleavage, suggesting that the defect involves altered HSPG modification. We conclude that the primary function of HSPG binding is to enable cell surface furin cleavage of L2 and that binding to a distinct cell surface receptor(s) is a subsequent step of papillomavirus infection.

Epidemiology of Human Papillomavirus Infection

2000 ◽  
Vol 34 (6) ◽  
pp. 194-200 ◽  
Author(s):  
Joakim Dillner ◽  
Chris J. L. M. Meijer ◽  
Geo von Krogh ◽  
Simon Horenblas
Keyword(s):  
Human Papillomavirus ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

Management of patients in conditions of female consultation at persistent course of papillomavirus infection of the cervix

2017 ◽  
pp. 34-36
Author(s):  
N.A. Shcherbina ◽  
◽  
D.I. Demidenko ◽  
A.D. Demidenko ◽  
N.V. Kapustnik ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Key Words ◽  
Maximum Effect ◽  
Cervical Epithelium ◽  
Results Of Treatment ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Complex Therapy ◽  
Effect Of Treatment

Under our supervision there were 66 women with a diagnosis of "dysplasia of cervical epithelium mild" on the background of persistent human papillomavirus infection (PVI). With the aim of improving the treatment of dysplasia of the 1st degree in rehabilitation activities after cryoablation there were applied drugs Distreptaza and inducer of interferon. The results of treatment were evaluated after 3 months. For patients of the 1st group (18 women) who underwent only cryoablation, the efficacy of therapy was 77.8%. In the 2nd group (22 women) after cryoablation was used inducer of interferon, the effectiveness made up of 90.9%. The maximum effect of treatment - 100% recorded in 3rd group (26 patients), where after cryoablation was carried out treatment with Distreptaza and inducer of interferon. The results of treatment obtained in this group allow to recommend the complex therapy of PVI in conditions of female consultation. Key words: dysplasia, HPV, cryosurgery, Distreptaza, inducer of interferon.

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