A NANOSIMS 50L INVESTIGATION INTO IMPROVING THE PRECISION AND ACCURACY OF THE 235U/238U RATIO DETERMINATION BY USING THE MOLECULAR 235U16O AND 238U16O SECONDARY IONS

2019 ◽  
Author(s):  
N. Alex Zirakparvar ◽  
◽  
Cole Hexel ◽  
Andrew Miskowiec ◽  
Julie Smith ◽  
...  
Keyword(s):  
Secondary Ions ◽  
Ratio Determination ◽  
Precision And Accuracy ◽  
238U Ratio

scholarly journals A NanoSIMS 50 L Investigation into Improving the Precision and Accuracy of the 235U/238U Ratio Determination by Using the Molecular 235U16O and 238U16O Secondary Ions

Minerals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 307 ◽  
Author(s):  
N. Zirakparvar ◽  
Cole Hexel ◽  
Andrew Miskowiec ◽  
Julie Smith ◽  
Michael Ambrogio ◽  
...  
Keyword(s):  
Reference Materials ◽  
The Other ◽  
Primary Beam ◽  
Uranium Compounds ◽  
Accuracy And Precision ◽  
Secondary Ions ◽  
Precision And Accuracy ◽  
Improved Accuracy ◽  
Secondary Ion ◽  
238U Ratio

A NanoSIMS 50 L was used to study the relationship between the 235U/238U atomic and 235U16O/238U16O molecular uranium isotope ratios determined from a variety of uranium compounds (UO2, UO2F2, UO3, UO2(NO3)2·6(H2O), and UF4) and silicates (NIST-610 glass and the Plesovice zircon reference materials, both containing µg/g uranium). Because there is typically a greater abundance of 235U16O+ and 238U16O+ molecular secondary ions than 235U+ and 238U+ atomic ions when uranium-bearing materials are sputtered with an oxygen primary ion beam, the goal was to understand whether use of 235U16O/238U16O has the potential for improved accuracy and precision when compared to the 235U/238U ratio. The UO2 and silicate reference materials showed the greatest potential for improved accuracy and precision through use of the 235U16O/238U16O ratio as compared to the 235U/238U ratio. For the UO2, which was investigated at a variety of primary beam currents, and the silicate reference materials, which were only investigated using a single primary beam current, this improvement was especially pronounced at low 235U+ count rates. In contrast, comparison of the 235U16O/238U16O ratio versus the 235U/238U ratio from the other uranium compounds clearly indicates that the 235U16O/238U16O ratio results in worse precision and accuracy. This behavior is based on the observation that the atomic (235U+ and 238U+) to molecular (235U16O+ and 238U16O+) secondary ion production rates remain internally consistent within the UO2 and silicate reference materials, whereas it is highly variable in the other uranium compounds. Efforts to understand the origin of this behavior suggest that irregular sample surface topography, and/or molecular interferences arising from the manner in which the UO2F2, UO3, UO2(NO3)2·6(H2O), and UF4 were prepared, may be a major contributing factor to the inconsistent relationship between the observed atomic and molecular secondary ion yields. Overall, the results suggest that for certain bulk compositions, use of the 235U16O/238U16O may be a viable approach to improving the precision and accuracy in situations where a relatively low 235U+ count rate is expected.

Applications of Time-OF-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

1990 ◽  
Vol 48 (2) ◽  
pp. 308-309
Author(s):  
Bruno Schueler ◽  
Robert W. Odom
Keyword(s):  
Mass Spectrometry ◽  
Secondary Ion Mass Spectrometry ◽  
Structural Information ◽  
Time Of Flight ◽  
Biological Tissues ◽  
Polymer Surfaces ◽  
Tof Sims ◽  
Secondary Ions ◽  
Ion Mass Spectrometry ◽  
Secondary Ion

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides unique capabilities for elemental and molecular compositional analysis of a wide variety of surfaces. This relatively new technique is finding increasing applications in analyses concerned with determining the chemical composition of various polymer surfaces, identifying the composition of organic and inorganic residues on surfaces and the localization of molecular or structurally significant secondary ions signals from biological tissues. TOF-SIMS analyses are typically performed under low primary ion dose (static SIMS) conditions and hence the secondary ions formed often contain significant structural information.This paper will present an overview of current TOF-SIMS instrumentation with particular emphasis on the stigmatic imaging ion microscope developed in the authors’ laboratory. This discussion will be followed by a presentation of several useful applications of the technique for the characterization of polymer surfaces and biological tissues specimens. Particular attention in these applications will focus on how the analytical problem impacts the performance requirements of the mass spectrometer and vice-versa.

Scanning ion microscopy images

1987 ◽  
Vol 45 ◽  
pp. 180-181
Author(s):  
R. Levi-Setti ◽  
J.M. Chabala ◽  
Y.L. Wang
Keyword(s):  
Metal Ion ◽  
Secondary Emission ◽  
Scanning Method ◽  
Ion Channeling ◽  
Secondary Ions ◽  
High Resolution Images ◽  
Ion Microscopy ◽  
Z Contrast ◽  
Focused Beams ◽  
Microscopy Images

Finely focused beams extracted from liquid metal ion sources (LMIS) provide a wealth of secondary signals which can be exploited to create high resolution images by the scanning method. The images of scanning ion microscopy (SIM) encompass a variety of contrast mechanisms which we classify into two broad categories: a) Emission contrast and b) Analytical contrast.Emission contrast refers to those mechanisms inherent to the emission of secondaries by solids under ion bombardment. The contrast-carrying signals consist of ion-induced secondary electrons (ISE) and secondary ions (ISI). Both signals exhibit i) topographic emission contrast due to the existence of differential geometric emission and collection effects, ii) crystallographic emission contrast, due to primary ion channeling phenomena and differential oxidation of crystalline surfaces, iii) chemical emission or Z-contrast, related to the dependence of the secondary emission yields on the Z and surface chemical state of the target.

RADIOIMMUNOASSAY OF OESTRONE AND OESTRADIOL IN THE PERIPHERAL PLASMA OF THE DOMESTIC FOWL IN VARIOUS PHYSIOLOGICAL STATES AND OF HYPOPHYSECTOMIZED AND OVARIECTOMIZED FOWLS

1974 ◽  
Vol 75 (1) ◽  
pp. 133-140 ◽  
Author(s):  
B. E. Senior
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Diethyl Ether ◽  
Bovine Serum ◽  
Domestic Fowl ◽  
Laying Hens ◽  
Peripheral Plasma ◽  
The Mean ◽  
Precision And Accuracy ◽  
Chicken Ovary

ABSTRACT A radioimmunoassay was developed to measure the levels of oestrone and oestradiol in 0.5–1.0 ml of domestic fowl peripheral plasma. The oestrogens were extracted with diethyl ether, chromatographed on columns of Sephadex LH-20 and assayed with an antiserum prepared against oestradiol-17β-succinyl-bovine serum albumin using a 17 h incubation at 4°C. The specificity, sensitivity, precision and accuracy of the assays were satisfactory. Oestrogen concentrations were determined in the plasma of birds in various reproductive states. In laying hens the ranges of oestrone and oestradiol were 12–190 pg/ml and 29–327 pg/ml respectively. Levels in immature birds, in adult cockerels and in an ovariectomized hen were barely detectable. The mean concentrations of oestrone and oestradiol in the plasma of four non-laying hens (55 pg/ml and 72 pg/ml respectively) and one partially ovariectomized hen (71 pg/ml and 134 pg/ml respectively) were well within the range for laying hens. It is evident that the large, yolk-filled follicles are not the only source of oestrogens in the chicken ovary.

971-P: The Precision and Accuracy of Many Modern Blood Glucose Meters at High Altitude

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 971-P
Author(s):  
SUN ZENGMEI ◽  
WU YUNHONG ◽  
WANG SUYUAN ◽  
ZHAO YANFANG ◽  
YANG JING ◽  
...  
Keyword(s):  
Blood Glucose ◽  
High Altitude ◽  
Precision And Accuracy

Hubungan Tingkat Pengetahuan dengan Presisi dan Akurasi Pemipetan Menggunakan Mikropipet Metode Forward

2019 ◽  
Vol 2 (1) ◽  
pp. 5
Author(s):  
Hendra Budi Sungkawa ◽  
Inten Ayu Kusuma
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Support Service ◽  
Control Area ◽  
Test Results ◽  
Medical Support ◽  
Testing Procedures ◽  
Service Unit ◽  
Level Of Knowledge ◽  
Precision And Accuracy

Abstract : Pipetting is one of the most important activities in health laboratory analysis. Knowledge of pipetting must be owned by every health laboratory. Students of health analyst as a candidate of health laboratory who will become medical support service unit is expected to be able to do the pipetting precision and accurately. To get a thorough and accurate results then the results of the analysis must be located within a specifc control area and both in precision and accuracy. Precision and accuracy are responsible for analytical interpretation of test results and testing procedures. The method use in this research is the forward method by 61 people research samples which determined by simple random sampling. While the research design used was observational analytics. Based on the results of the research obtained the level of knowledge of respondents research is 71,38; precision pipetting 99,69% and accuracy pipetting 99,58%. From the data that has been obtained then analyzed statistically using tau kendau test. The result indicates that the level of knowledge and precision has a p=0,640 and correlation coeffcient of -0,044 so that the Ho is accepted, meaning there is no relationship between the level of knowledge and precision meaningful. Meanwhile, the level of knowledge and accuracy of the p=0,574 and correlation coeffcient value is -0,053 so that Ho is accepted, it means there is no relationship between the level of knowledge with accuracy. Abstrak: Pemipetan merupakan salah satu kegiatan yang sangat penting dalam analisa laboratorium kesehatan. Pengetahuan pemipetan harus dimiliki oleh setiap tenaga laboratorium kesehatan. Mahasiswa analis kesehatan sebagai calon tenaga laboratorium kesehatan yang akan menjadi unit pelayanan penunjang medis diharapkan mampu melakukan pemipetan dengan teliti dan akurat. Untuk mendapatkan hasil yang teliti dan akurat maka hasil analisa harus terletak di dalam daerah kontrol tertentu dan baik dalam presisi maupun akurasi. Presisi dan akurasi bertanggung jawab terhadap interpretasi analitik hasil pengujian serta prosedur pengujian. Metode yang dilakukan dalam penelitian ini adalah metode forward oleh sampel penelitian sebanyak 61 orang yang ditentukan secara simple random sampling. Sedangkan desain penelitian yang digunakan adalah observasional analitik. Berdasarkan dari hasil penelitian diperoleh nilai tingkat pengetahuan responden penelitian adalah 71,38; presisi pemipetan 99,69% dan akurasi pemipetannya 99,58%. Dari data yang telah didapatkan kemudian dianalisis secara statistik menggunakan uji kendal tau. Untuk tingkat pengetahuan dengan presisi didapatkan hasil nilai p=0,640 dan koefsien korelasi -0,044 sehingga Ho diterima, berarti tidak ada hubungan antara tingkat pengetahuan dan presisi. Untuk tingkat pengetahuan dengan akurasi nilai p=0,574 dan koefsien korelasi adalah -0,053 sehingga Ho diterima, berarti tidak ada hubungan antara tingkat pengetahuan dengan akurasi.

UV spectroscopic method for determination of phenytoin in bulk and injection forms

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Spectroscopic Method ◽  
Ich Guidelines ◽  
Precision And Accuracy ◽  
Routine Quality Control

Recent study was conducted to develop a simple UV spectrophotometric method to determine Phenytoin in bulk and injection form according to official requirement and validate as per ICH guidelines. λmax of Phenytoin was found 202 nm. Linearity existed perceived in the concentration assortment 2-8 μg/ml (r2 = 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines. The existent method was establish to be simple, linear, precise, accurate as well as sensitive and can be applied for routine quality control enquiry for the analysis of Phenytoin in bulk and injection form.

Auto-Metrology on TEM Images of FinFET

2014 ◽  
Author(s):  
Sajal Biring
Keyword(s):  
Data Analysis ◽  
Data Interpretation ◽  
Visual Judgment ◽  
Manual Measurement ◽  
Size And Shape ◽  
Highly Sensitive ◽  
Edge Detecting ◽  
Geometrical Data ◽  
Precision And Accuracy ◽  
Device Size

Abstract The FinFET has been introduced in the last decade to provide better transistor performance as the device size shrinks. The performance of FinFET is highly sensitive to the size and shape of the fin, which needs to be optimized with tighter control. Manual measurement of nano-scale features on TEM images of FinFET is not only a time consuming and tedious task, but also prone to error owing to visual judgment. Here, an auto-metrology approach is presented to extract the measured values with higher precision and accuracy so that the uncertainty in the manual measurement can be minimized. Firstly, a FinFET TEM image is processed through an edge detecting algorithm to reveal the fin profile precisely. Finally, an algorithm is utilized to calculate out the required geometrical data relevant to the FinFET parameters and summarizes them to a table or plots a graph based on the purpose of data interpretation. This auto-metrology approach is expected to be adopted by academia and/or industry for proper data analysis and interpretation with higher precision and efficiency.

QUANTITATIVE DETERMINATION OF CURCUMIN IN TURMERIC POWDER AND TURMERIC–HONEY BALL PILLS BY HPLC

2018 ◽  
Vol 8 (4) ◽  
pp. 42-47
Author(s):  
Tien Nguyen Huu ◽  
Tram Le Thi Bao ◽  
Ngoc Nguyen Thi Nhu ◽  
Thang Phan Phuoc ◽  
Khan Nguyen Viet
Keyword(s):  
Acetic Acid ◽  
Gastric Mucosa ◽  
Quantitative Determination ◽  
Mobile Phase ◽  
Curcuma Longa ◽  
Biological Marker ◽  
Hplc Method ◽  
Chromatography Analysis ◽  
Precision And Accuracy

Background: Curcumin is a major ingredient in turmeric (Curcuma longa L., Zingiberaceae), which has important activities such as anti-tumor, anti-inflammatory, antioxidant, anti-ischemia, protection of gastric mucosa etc,. Curcumin can be considered as a biological marker of turmeric and turmeric products. Objectives: Developing an HPLC method for quantification of curcumin in turmeric powder and turmeric - honey ball pills; applying this method for products on the market. Materials and methods: turmeric powder and turmeric - honey ball pills collected in Thua Thien Hue province. After optimization process, the method was validated and applied to evaluate the content of curcumin. Results: The chromatography analysis was performed with: Zorbaz Eclipse XDB-C18 (150 × 4.6 nm; 5 µm); Mobile phase: acetonitril: 2% acetic acid (45:55), Flow rate was kept constant at 1.0 ml/min; Detector PDA (420 nm). The method was validated for the HPLC system compatibility, specificity, linearity range, precision and accuracy; the recovery greater than 98%. Conclusion: The developed HPLC method can determine curcumin in turmeric powder and turmeric - honey ball pills. Key words: Curcumin, turmeric powder, turmeric-honey ball pills, quantitative determination, HPLC

Sign in / Sign up

Export Citation Format

Share Document