Investigation of unusual growth and phenotypic characteristics of plasmid-containing and plasmid-free strains of oligotrophic bacterium Ancylobacter vacuolatus

Microbiology ◽  
2012 ◽  
Vol 81 (1) ◽  
pp. 35-43 ◽  
Author(s):  
I. V. Zlatkin ◽  
D. I. Nikitin ◽  
P. A. Sigalevich
Keyword(s):  
Phenotypic Characteristics ◽  
Oligotrophic Bacterium ◽  
Free Strains

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

2019 ◽  
Vol 15 (3) ◽  
pp. 172-173 ◽  
Author(s):  
Valdemar Grill ◽  
Bjørn O. Åsvold
Keyword(s):  
Genetic Background ◽  
Clinical Utility ◽  
Autoimmune Diabetes ◽  
Classical Type ◽  
Phenotypic Characteristics ◽  
Latent Autoimmune Diabetes ◽  
The Impact

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

scholarly journals Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations

2018 ◽  
Vol 3 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Adriana Nunziata ◽  
Jan-Bernd Funcke ◽  
Guntram Borck ◽  
Julia von Schnurbein ◽  
Stephanie Brandt ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Phenotypic Characteristics

scholarly journals Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization

2020 ◽  
Author(s):  
Mei R. Fu ◽  
Bradley E Aouizerat ◽  
Gary Yu ◽  
Yvette Conley ◽  
Deborah Axelrod ◽  
...  
Keyword(s):  
Breast Cancer Survivors ◽  
Latent Class ◽  
Severe Symptom ◽  
Repeated Measure ◽  
Phenotypic Characteristics ◽  
Post Surgery ◽  
Lower Education Level ◽  
Measure Design ◽  
Lower Education ◽  
Symptom Patterns

Abstract Purpose of the Study More than 50% of breast cancer survivors without a diagnosis of lymphedema suffer daily from numerous and co-occurring lymphedema symptoms. This study aimed to identify lymphedema symptom patterns and the association of such patterns with phenotypic characteristics and biomarkers using latent class analysis (LCA). A prospective, descriptive, and repeated-measure design was used to enroll 140 women and collect data. Recent Findings LCA identified three distinct lymphedema symptom classes at 8 weeks and 12 months post-surgery: low, moderate, and severe symptom classes and associated phenotypic characteristics. Participants were more likely to be in the severe symptom classes at 12 months post-surgery if they had lower education level, cording, an axillary syndrome at 8 weeks post-surgery, neoadjuvant chemotherapy, and radiation. Summary Pre-surgery level of IL1-a, IL-6, IL-8, and VEGF was associated with the severe symptom class at 8 weeks post-surgery, suggesting that such biomarkers may be used to predict risk for lymphedema symptoms.

Identification of HNF1A-MODY and HNF4A-MODY in Irish families: Phenotypic characteristics and therapeutic implications

2011 ◽  
Vol 37 (6) ◽  
pp. 512-519 ◽  
Author(s):  
M.P. Kyithar ◽  
S. Bacon ◽  
K.K. Pannu ◽  
S.R. Rizvi ◽  
K. Colclough ◽  
...  
Keyword(s):  
Phenotypic Characteristics ◽  
Therapeutic Implications

Survival and phenotypic characteristics of axotomized neurons in spinal ganglia

2005 ◽  
Vol 35 (5) ◽  
pp. 457-460 ◽  
Author(s):  
Yu. A. Chelyshev ◽  
I. S. Raginov ◽  
D. S. Guseva ◽  
R. F. Masgutov
Keyword(s):  
Spinal Ganglia ◽  
Phenotypic Characteristics

Phenotypic characteristics and gene expression profiles of human chondrocytes in tissuegene C

2021 ◽  
Vol 29 ◽  
pp. S211-S212
Author(s):  
I. Uzieliene ◽  
E. Bagdonas ◽  
J. Denkovskij ◽  
E. Bernotiene ◽  
H.-J. Yoon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Human Chondrocytes ◽  
Phenotypic Characteristics

scholarly journals Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Clémence Marais ◽  
Caroline Claude ◽  
Nada Semaan ◽  
Ramy Charbel ◽  
Simon Barreault ◽  
...  
Keyword(s):  
Critically Ill ◽  
Host Response ◽  
Secondary Infection ◽  
Myeloid Cells ◽  
Suppressor Cells ◽  
Human Leukocyte ◽  
Myeloid Derived Suppressor Cells ◽  
Phenotypic Characteristics ◽  
Leukocyte Antigen ◽  
Hla Dr

Abstract Background De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the occurrence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit. Methods Retrospective analysis of the circulating myeloid cells phenotypes of adult COVID-19 critically ill patients. Phenotyping circulating immune cells was performed by flow cytometry daily for routine analysis and twice weekly for lymphocytes and monocytes subpopulations analysis, as well as monocyte human leukocyte antigen (mHLA)-DR expression. Results Out of the 29 critically ill adult patients with severe COVID-19 analyzed, 12 (41.4%) developed secondary infection and six patients died during their stay. Monocyte HLA-DR kinetics was significantly different between patients developing secondary infection and those without, respectively, at day 5–7 and 8–10 following admission. The monocytes myeloid-derived suppressor cells to total monocytes ratio was associated with 28- and 60-day mortality. Those myeloid characteristics suggest three phenotypes: hyperactivated monocyte/macrophage is significantly associated with mortality, whereas persistent immunodepression is associated with secondary infection occurrence compared to transient immunodepression. Conclusions Myeloid phenotypes of critically ill COVID-19 patients may be associated with development of secondary infection, 28- and 60-day mortality.

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