The Role of Personality in Motivation to use an Affective Feedback System

2021 ◽  
Vol 47 (8) ◽  
pp. 793-802
Author(s):  
S. Jiménez ◽  
R. Juárez-Ramírez ◽  
V. H. Castillo ◽  
A. Ramírez-Noriega ◽  
Bogart Yail Márquez ◽  
...  
2007 ◽  
Vol 35 (2) ◽  
pp. 318-321 ◽  
Author(s):  
J.L.A. Mitchell ◽  
T.K. Thane ◽  
J.M. Sequeira ◽  
R. Thokala

One strategy for inhibiting tumour cell growth is the use of polyamine mimetics to depress endogenous polyamine levels and, ideally, obstruct critical polyamine-requiring reactions. Such polyamine analogues make very unusual drugs, in that extremely high intracellular concentrations are required for growth inhibition or cytotoxicity. Cells exposed to even sub-micromolar concentrations of such analogues can achieve effective intracellular levels because these compounds are incorporated by the very aggressive polyamine uptake system. Once incorporated to these levels, many of these analogues induce the synthesis of a regulatory protein, antizyme, which inhibits both polyamine synthesis and the transporter they used to enter the cell. Thus this feedback system allows steady-state maintenance of effective cellular doses of such analogues. Accordingly, effective cellular levels of polyamine analogues are generally inversely related to their capacity to induce antizyme. Antizyme activity is down-regulated by interaction with several binding partners, most notably antizyme inhibitor, and at least a few tumour tissues exhibit deficiencies in antizyme expression. Our studies explore the role of antizyme induction by several polyamine analogues in their physiological response and the possibility that cell-to-cell differences in antizyme expression may contribute to variable sensitivities to these agents.


2020 ◽  
Author(s):  
Jolle W. Jolles ◽  
Nils Weimar ◽  
Tim Landgraf ◽  
Pawel Romanczuk ◽  
Jens Krause ◽  
...  

AbstractUnderstanding the emergence of collective behaviour has long been a key research focus in the natural sciences. Besides the fundamental role of social interaction rules, a combination of theoretical and empirical work indicates individual speed may be a key process that drives the collective behaviour of animal groups. Socially-induced changes in speed by interacting animals make it difficult to isolate the effects of individual speed on group-level behaviours. Here we tackled this issue by pairing guppies with a biomimetic robot. We used a closed-loop tracking and feedback system to let a robotic fish naturally interact with a live partner in real time, and programmed it to strongly copy and follow its partner’s movements while lacking any preferred movement speed or directionality of its own. We show that individual differences in guppies’ movement speed were highly repeatable and shaped key collective patterns: higher individual speeds resulted in stronger leadership, lower cohesion, higher alignment, and better temporal coordination in the pairs. By combining the strengths of individual-based models and observational work with state-of-the-art robotics, we provide novel evidence that individual speed is a key, fundamental process in the emergence of collective behaviour.


2021 ◽  
Vol 120 (4) ◽  
pp. 809-822
Author(s):  
Fabien Brugière

Drawing from a transurban field research conducted in the ride-hailing sector in Paris and Brussels regions, this article investigates platformization as a productive model defined by the articulation of an outsourced labor regime with an algorithmic and data-driven type of management. Beyond the formal sharing of an independent contractor status, nuanced by a variety of positions including salaried work, platform drivers are unified in practice by their common economic dependence on platforms. This situation gives them the role of an adjustment variable in platforms’ commercial strategy, forcing them to raise their work time to adapt to the cost decreases in the mid-2010s, which dramatically reduced their income. To ensure a flexible flow into the workforce, platforms have favored the development of small intermediaries to outsource hiring and thereby skirt labor law and evade taxes. Market pressure is also enforced by its inclusion, with other productive goals such as service fluidity and quality, into a digital model of management inspired by lean production. The application is configured to operate as a device of technical and hegemonic control that incorporates just-in-time and intensification commands. Digital control is completed by the inclusion of a customer feedback system used to implement service standardization and further involvement in work.


2021 ◽  
Author(s):  
Andreas Angourakis ◽  
Jonas Alcaina-Mateos ◽  
Marco Madella ◽  
Debora Zurro

The domestication of plants and the origin of agricultural societies has been the focus of much theoretical discussion on why, how, when, and where these happened. The 'when' and 'where' have been substantially addressed by bioarchaeology, thanks to advances in methodology and the broadening of the geographical and chronological scope of evidence. However, the 'why' and 'how' have lagged behind, holding on to relatively old models with limited explanatory power. Armed with the evidence now available, we can return to theory by revisiting the mechanisms allegedly involved, disentangling their connection to the diversity of trajectories, and identifying the weight and role of the parameters involved. We present the Human-Plant Coevolution (HPC) model, which represents the dynamics of coevolution between a human and a plant population. The model consists of an ecological positive feedback system (mutualism), which can be reinforced by positive evolutionary feedback (coevolution). The model formulation is the result of wiring together relatively simple simulation models of population ecology and evolution, through a computational implementation in R.  The HPC model captures a variety of potential scenarios, though which conditions are linked to the degree and timing of population change and the intensity of selective pressures. Our results confirm that the possible trajectories leading to neolithisation are diverse and involve multiple factors. However, simulations also show how some of those factors are entangled, what are their effects on human and plant populations under different conditions, and what might be the main causes fostering agriculture and domestication.


Author(s):  
Imlirenla Jamir ◽  
Pranaya Diwate ◽  
Vipin Kumar ◽  
Gambhir Singh Chauhan

Landslides, despite being the surficial impression of climate-tectonic-erosion linkage, are rarely explored in this context in Himalaya. The need for such study becomes more crucial in the evaluation of the regional hillslope denudation budget. We are of the understanding that the distributional pattern of landslides can reveal the relative significance of tectonic and climate. To test this hypothesis, ~ 55 landslides of the Tons River valley, Himalaya along with the tectonic and climate proxies are used in the present study. Steepness index and valley floor width to valley height ratio are used to infer the tectonic regime whereas; Tropical Rainfall Measurement Mission based daily rainfall data and swath profile of Normalized Difference Vegetation Index are used to deduce spatial variability in climate. The study revealed the possible existence of a positive feedback system in the Higher Himalaya Crystalline and the simultaneous role of tectonic-climate in the Lesser Himalaya Crystalline. The LHS is found to possess a zone of landslide cluster, possibly due to local fault.


2019 ◽  
Vol 26 (5) ◽  
pp. 492-502
Author(s):  
Giorgia Cona ◽  
Arianna Casagrande ◽  
Sabrina Lenzoni ◽  
Elena Pegoraro ◽  
Virginia Bozzoni ◽  
...  

AbstractObjective:This study explored mental rotation (MR) performance in patients with myotonic dystrophy 1 (DM1), an inherited neuromuscular disorder dominated by muscular symptoms, including muscle weakness and myotonia. The aim of the study was twofold: to gain new insights into the neurocognitive mechanisms of MR and to better clarify the cognitive profile of DM1 patients. To address these aims, we used MR tasks involving kinds of stimuli that varied for the extent to which they emphasized motor simulation and activation of body representations (body parts) versus visuospatial imagery (abstract objects). We hypothesized that, if peripheral sensorimotor feedback system plays a pivotal role in modulating MR performance, then DM1 patients would exhibit more difficulties in mentally rotating hand stimuli than abstract objects.Method:Twenty-four DM1 patients and twenty-four age- and education-matched control subjects were enrolled in the study and were required to perform two computerized MR tasks involving pictures of hands and abstract objects.Results:The analysis of accuracy showed that patients had impaired MR performance when the angular disparities between the stimuli were higher. Notably, as compared to controls, patients showed slower responses when the stimuli were hands, whereas no significant differences when stimuli were objects.Conclusion:The findings are coherent with the embodied cognition view, indicating a tight relation between body- and motor-related processes and MR. They suggest that peripheral, muscular, abnormalities in DM1 lead to alterations in manipulation of motor representations, which in turn affect MR, especially when body parts are to mentally rotate.


2020 ◽  
Vol 6 (1) ◽  
pp. 11-17
Author(s):  
Matthew Metzgar

AbstractBusinesses and organizations are turning to fast feedback devices that measure consumer satisfaction. These standalone devices often have four or five different smiley-face buttons that can quickly gauge consumer sentiment. These devices are becoming popular due to the short time commitment needed to provide feedback.This instructor has piloted the use of a smiley-face survey tool that is used at the end of each class session. Initial results suggest the role of the instructor may play a lesser role in student happiness for a given class. External factors, such as outside event or incoming GPA, appear to have a larger effect on class satisfaction. Data from classes and sample email exchanges will be presented. This type of fast feedback system has many potential benefits and low startup costs.


1995 ◽  
Vol 269 (1) ◽  
pp. C163-C169 ◽  
Author(s):  
L. J. Janssen ◽  
S. M. Sims

Our goal was to investigate the role of Ca2+ entry in regulating Cl- current (ICl) in smooth muscle cells from canine trachealis. When studies were done using the perforated patch configuration, depolarization elicited a dihydropyridine-sensitive Ca2+ current (ICa), followed in many cells by a sustained current. This sustained current reversed direction close to the Cl- equilibrium potential, consistent with its representing ICl. The ICl was also apparent as slowly deactivating tail currents seen upon repolarization to negative potentials. The Cl- channel blocker niflumic acid abolished both the sustained and tail currents, without affecting ICa. Several observations indicated that the ICl was dependent on Ca2+ entry. ICl was increased in magnitude when Ca2+ influx was augmented [by prolonging the depolarization or using BAY K 8644 or acetylcholine (ACh)] and decreased in magnitude when Ca2+ influx was reduced (using nifedipine). Based on these findings, we conclude that depolarization causes Ca2+ entry, with resultant elevation of cytosolic free Ca2+ concentration leading to activation of ICl (ICl(Ca)). We investigated whether Ca(2+)-induced Ca2+ release from the sarcoplasmic reticulum was involved in activation of ICl(Ca), by depleting intracellular stores of Ca2+ using cyclopiazonic acid to block the sarcoplasmic Ca(2+)-adenosinetriphosphatase and repeated stimulation with ACh. In such Ca(2+)-depleted cells, depolarization-mediated Ca2+ entry continued to activate ICl(Ca), suggesting that Ca(2+)-induced Ca2+ release was not required for its activation. We conclude that Ca2+ entry can activate Cl- channels in tracheal smooth muscle. This represents a positive-feedback system, which would promote excitation and contraction of airway muscle.


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