scholarly journals Human-Plant Coevolution: A modelling framework for theory-building on the origins of agriculture

2021 ◽  
Author(s):  
Andreas Angourakis ◽  
Jonas Alcaina-Mateos ◽  
Marco Madella ◽  
Debora Zurro
Keyword(s):  
Population Change ◽  
Explanatory Power ◽  
Simulation Models ◽  
Feedback System ◽  
Selective Pressures ◽  
Modelling Framework ◽  
Simple Simulation ◽  
Computational Implementation ◽  
Agricultural Societies

The domestication of plants and the origin of agricultural societies has been the focus of much theoretical discussion on why, how, when, and where these happened. The 'when' and 'where' have been substantially addressed by bioarchaeology, thanks to advances in methodology and the broadening of the geographical and chronological scope of evidence. However, the 'why' and 'how' have lagged behind, holding on to relatively old models with limited explanatory power. Armed with the evidence now available, we can return to theory by revisiting the mechanisms allegedly involved, disentangling their connection to the diversity of trajectories, and identifying the weight and role of the parameters involved. We present the Human-Plant Coevolution (HPC) model, which represents the dynamics of coevolution between a human and a plant population. The model consists of an ecological positive feedback system (mutualism), which can be reinforced by positive evolutionary feedback (coevolution). The model formulation is the result of wiring together relatively simple simulation models of population ecology and evolution, through a computational implementation in R.  The HPC model captures a variety of potential scenarios, though which conditions are linked to the degree and timing of population change and the intensity of selective pressures. Our results confirm that the possible trajectories leading to neolithisation are diverse and involve multiple factors. However, simulations also show how some of those factors are entangled, what are their effects on human and plant populations under different conditions, and what might be the main causes fostering agriculture and domestication.

scholarly journals Modelling Agroforestry’s Contributions to People—A Review of Available Models

Agronomy ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2106
Author(s):  
Philipp Kraft ◽  
Ehsan Eyshi Rezaei ◽  
Lutz Breuer ◽  
Frank Ewert ◽  
André Große-Stoltenberg ◽  
...  
Keyword(s):  
Simulation Models ◽  
Agroforestry Systems ◽  
Ecosystem Functions ◽  
Modelling Framework ◽  
Code Structure ◽  
Wide Range ◽  
Long Time ◽  
Community Effort ◽  
Different Levels

Climate change, increasing environmental pollution, continuous loss of biodiversity, and a growing human population with increasing food demand, threaten the functioning of agro-ecosystems and their contribution to people and society. Agroforestry systems promise a number of benefits to enhance nature’s contributions to people. There are a wide range of agroforestry systems implemented representing different levels of establishment across the globe. This range and the long time periods for the establishment of these systems make empirical assessments of impacts on ecosystem functions difficult. In this study we investigate how simulation models can help to assess and predict the role of agroforestry in nature’s contributions. The review of existing models to simulate agroforestry systems reveals that most models predict mainly biomass production and yield. Regulating ecosystem services are mostly considered as a means for the assessment of yield only. Generic agroecosystem models with agroforestry extensions provide a broader scope, but the interaction between trees and crops is often addressed in a simplistic way. The application of existing models for agroforestry systems is particularly hindered by issues related to code structure, licences or availability. Therefore, we call for a community effort to connect existing agroforestry models with ecosystem effect models towards an open-source, multi-effect agroforestry modelling framework.

Science and Dialectics in the Philosophies of Deleuze, Bachelard and DeLanda

Paragraph ◽  
2006 ◽  
Vol 29 (2) ◽  
pp. 98-114 ◽  
Author(s):  
James Williams
Keyword(s):  
Gilles Deleuze ◽  
Explanatory Power ◽  
Scientific Theories ◽  
Gaston Bachelard ◽  
Contemporary Science

This article charts differences between Gilles Deleuze's and Gaston Bachelard's philosophies of science in order to reflect on different readings of the role of science in Deleuze's philosophy, in particular in relation to Manuel DeLanda's interpretation of Deleuze's work. The questions considered are: Why do Gilles Deleuze and Gaston Bachelard develop radically different philosophical dialectics in relation to science? What is the significance of this difference for current approaches to Deleuze and science, most notably as developed by Manuel DeLanda? It is argued that, despite its great explanatory power, DeLanda's association of Deleuze with a particular set of contemporary scientific theories does not allow for the ontological openness and for the metaphysical sources of Deleuze's work. The argument turns on whether terms such as ‘intensity’ can be given predominantly scientific definitions or whether metaphysical definitions are more consistent with a sceptical relation of philosophy to contemporary science.

Language Ideology and Second Language Learning

2008 ◽  
Vol 155 ◽  
pp. 95-115 ◽  
Author(s):  
Theresa McGarry
Keyword(s):  
Second Language ◽  
Second Language Acquisition ◽  
Language Acquisition ◽  
Language Learning ◽  
Language Ideology ◽  
Second Language Learning ◽  
Classroom Practices ◽  
Explanatory Power

AbstractThe increasing recognition of the concept language ideology and the corresponding increasing use of the term have not yet been matched by applications in the field of second language acquisition. However, applications of the concept in analysis of actual classroom practices have shown it to have considerable explanatory power. Greater consideration of language ideology in SLA is necessary not only to achieve greater understanding of the role of ideology in various areas but also to show connections between these areas that may yield important generalizations and to impel the application of the concept in areas where it has been neglected by highlighting its uneven treatment.

scholarly journals The role of habitat configuration in shaping animal population processes: a framework to generate quantitative predictions

Oecologia ◽  
2021 ◽  
Author(s):  
Peng He ◽  
Pierre-Olivier Montiglio ◽  
Marius Somveille ◽  
Mauricio Cantor ◽  
Damien R. Farine
Keyword(s):  
Population Level ◽  
R Package ◽  
Habitat Configuration ◽  
Modelling Framework ◽  
Alternative Habitat ◽  
Animal Populations ◽  
Research Questions ◽  
Habitat Networks ◽  
Animal Habitat

AbstractBy shaping where individuals move, habitat configuration can fundamentally structure animal populations. Yet, we currently lack a framework for generating quantitative predictions about the role of habitat configuration in modulating population outcomes. To address this gap, we propose a modelling framework inspired by studies using networks to characterize habitat connectivity. We first define animal habitat networks, explain how they can integrate information about the different configurational features of animal habitats, and highlight the need for a bottom–up generative model that can depict realistic variations in habitat potential connectivity. Second, we describe a model for simulating animal habitat networks (available in the R package AnimalHabitatNetwork), and demonstrate its ability to generate alternative habitat configurations based on empirical data, which forms the basis for exploring the consequences of alternative habitat structures. Finally, we lay out three key research questions and demonstrate how our framework can address them. By simulating the spread of a pathogen within a population, we show how transmission properties can be impacted by both local potential connectivity and landscape-level characteristics of habitats. Our study highlights the importance of considering the underlying habitat configuration in studies linking social structure with population-level outcomes.

scholarly journals Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1792
Author(s):  
Debashri Manna ◽  
Devanand Sarkar
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Cancer Development ◽  
Epigenetic Alterations ◽  
Hallmarks Of Cancer ◽  
Comprehensive Description ◽  
Molecular Abnormalities ◽  
Selective Pressures ◽  
Resistance To Chemotherapy

Cancer development results from the acquisition of numerous genetic and epigenetic alterations in cancer cells themselves, as well as continuous changes in their microenvironment. The plasticity of cancer cells allows them to continuously adapt to selective pressures brought forth by exogenous environmental stresses, the internal milieu of the tumor and cancer treatment itself. Resistance to treatment, either inherent or acquired after the commencement of treatment, is a major obstacle an oncologist confronts in an endeavor to efficiently manage the disease. Resistance to chemotherapy, chemoresistance, is an important hallmark of aggressive cancers, and driver oncogene-induced signaling pathways and molecular abnormalities create the platform for chemoresistance. The oncogene Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) is overexpressed in a diverse array of cancers, and its overexpression promotes all the hallmarks of cancer, such as proliferation, invasion, metastasis, angiogenesis and chemoresistance. The present review provides a comprehensive description of the molecular mechanism by which AEG-1 promotes tumorigenesis, with a special emphasis on its ability to regulate chemoresistance.

scholarly journals Changes in mean forest age in Canada’s forests could limit future increases in area burned but compromise potential harvestable conifer volumes

2017 ◽  
Vol 47 (6) ◽  
pp. 755-764 ◽  
Author(s):  
Yan Boulanger ◽  
Martin Girardin ◽  
Pierre Y. Bernier ◽  
Sylvie Gauthier ◽  
André Beaudoin ◽  
...  
Keyword(s):  
Simulation Models ◽  
Stand Age ◽  
Almost Everywhere ◽  
Age Related ◽  
New Information ◽  
Simple Simulation ◽  
Regional Vulnerability ◽  
Vegetation Feedbacks ◽  
Burning Rates ◽  
Negative Impacts

Forest fire activity is projected to increase with climate change in Canada, but vegetation feedbacks are usually not considered. Using new information on the selectivity or avoidance of fire as a function of stand age and composition, we ran simple simulation models that consider the changes in the regional age matrices induced by fire and harvesting to project future burn rates. We also projected estimated future regional vulnerability of timber supply to fire by considering these new burn rates. The inclusion of age-related feedbacks would have a large impact on projected increases in burn rates, mostly in a very fire active zone under aggressive climate forcing. Projected burn rates would still increase, but would be 50% less in 2100 than if projected without this biotic feedback in some zones. Negative feedbacks would be virtually nonexistent when potential burning rates are below 1%, whereas realized burning rates would be lowered by more than a 0.5 percentage point when potential burning rates exceed 2.5%. Including fire–vegetation feedbacks had virtually no impact on total volume harvested. As fire burns more old-growth coniferous stands, slightly negative impacts were projected on conifer harvested almost everywhere. These results underline the need to incorporate fire–vegetation feedbacks when projecting future burn rates.

Reimagining a Realist Evaluation Research in Entrepreneurship Skills Development and the Idea of University Education

2021 ◽  
Vol 12 (1) ◽  
pp. 133-133
Author(s):  
Valile Valindawo M. Dwayi
Keyword(s):  
Explanatory Power ◽  
Evaluation Research ◽  
Realist Evaluation ◽  
University Education ◽  
Skills Development ◽  
Research Approach ◽  
Espoused Values ◽  
Innovation And Technology ◽  
Sustainability Challenges

This article reports on the evaluation researchproject, which focussed on the viability and sustainability challenges in one particular case of a university over a period of five years. Such a university remains categorised as structurally disadvantaged despite almost thirty years into constitutional democracy in South Africa. As such, the research project was conducted against the complexity of the university transformation project, which take place against the enduring social ills as high unemployment rate, increasing inequalities and abject poverties especially from the enduring legacy of the old racist apartheid system. The role of university education in such a context becomes the reflexive imperative in consideration of university, not only as the public good and equity, but for social justice and equity discourses. Such discourses need to be made more loud than is presently the case. The research therefore focussed on the role of entrepreneurship skills development, which then were juxtaposed with the espoused values of of science, innovation and technology as the key performance indicators for the academic project. As such, the article will revolve around the main argument that scholarship of engagament in univeristy spaces, where entrepreneurship skills development ought to be the enabling system, need to be reimagined in terms of the contemporary research disciplines. Critical realist philosophy, and the realist social theory as the explanatory program, provide the alternative research approach to the mainstream approaches due to their explanatory power for for transcendentalism and based on retroductive arguemnts about the social world. Such an approach does not only foreground the contemporary debates in social sciences, and the emerging fields of study within it, but also help to elaborate on the purist positions that tend to be promoted in some business science fields and their inadvertent pragmatic and black box logic. Keywords: Viability, Sustainability, Entrepreneurship skills development, Historically disadvantaged universities, realist evaluative research

Psychopathology arises from intertemporal bargaining as well as from emotional trauma

2015 ◽  
Vol 38 ◽  
Author(s):  
George Ainslie
Keyword(s):  
Defense Mechanisms ◽  
Explanatory Power ◽  
Hyperbolic Discounting ◽  
Emotional Trauma ◽  
Additional Mechanism

AbstractThe role of emotional trauma in psychopathology is limited. One additional mechanism is predictable from hyperbolic discounting: When a person uses willpower to control urges each success or failure takes on extra significance through recursive self-prediction, potentially motivating several constricting defense mechanisms. The need for eliciting emotion in psychotherapy is as the authors say it is, but their hypothesis about reconsolidation of memories adds no explanatory power.

scholarly journals The challenges of adopting BIM for setting and infrastructure management of University of Minho

2018 ◽  
Vol 48 ◽  
pp. 02002 ◽  
Author(s):  
Paulo J. S. Cruz ◽  
Miguel Azenha
Keyword(s):  
Shared Knowledge ◽  
Facilities Management ◽  
Infrastructure Management ◽  
Knowledge Resources ◽  
Global Challenge ◽  
Modelling Framework ◽  
Building Information ◽  
Relevant Role ◽  
The University

The University of Minho (UMinho) is aware of the relevant role of higher education institutions in the global challenge of sustainability. The integration of sustainability values into its strategy encompasses all the fields of its activity. Taking into account the growing importance of shared knowledge resources as a reliable basis for decisions during infrastructures life cycle, the UMinho is currently undergoing an important process of implementing a ‘Building Information Modelling’ framework (BIM). This paper briefly describes the implementation steps that are current towards such a goal, in particular in terms of facilities management aspects.

Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemotherapy

2007 ◽  
Vol 35 (2) ◽  
pp. 318-321 ◽  
Author(s):  
J.L.A. Mitchell ◽  
T.K. Thane ◽  
J.M. Sequeira ◽  
R. Thokala
Keyword(s):  
Regulatory Protein ◽  
Feedback System ◽  
Uptake System ◽  
Polyamine Synthesis ◽  
Polyamine Analogues ◽  
Binding Partners ◽  
Polyamine Transport ◽  
Polyamine Uptake ◽  
Tumour Cell Growth

One strategy for inhibiting tumour cell growth is the use of polyamine mimetics to depress endogenous polyamine levels and, ideally, obstruct critical polyamine-requiring reactions. Such polyamine analogues make very unusual drugs, in that extremely high intracellular concentrations are required for growth inhibition or cytotoxicity. Cells exposed to even sub-micromolar concentrations of such analogues can achieve effective intracellular levels because these compounds are incorporated by the very aggressive polyamine uptake system. Once incorporated to these levels, many of these analogues induce the synthesis of a regulatory protein, antizyme, which inhibits both polyamine synthesis and the transporter they used to enter the cell. Thus this feedback system allows steady-state maintenance of effective cellular doses of such analogues. Accordingly, effective cellular levels of polyamine analogues are generally inversely related to their capacity to induce antizyme. Antizyme activity is down-regulated by interaction with several binding partners, most notably antizyme inhibitor, and at least a few tumour tissues exhibit deficiencies in antizyme expression. Our studies explore the role of antizyme induction by several polyamine analogues in their physiological response and the possibility that cell-to-cell differences in antizyme expression may contribute to variable sensitivities to these agents.

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