SAT0373 The role of the combination of bone and fall related risk factors on short-term subsequent fracture risk

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 598.2-598
Author(s):  
K. Huntjens ◽  
T. van Geel ◽  
S. van Helden ◽  
J. van den Bergh ◽  
P. Geusens ◽  
...  
2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Kirsten MB Huntjens ◽  
Tineke ACM van Geel ◽  
Svenhjalmar van Helden ◽  
Joop van den Bergh ◽  
Paul Willems ◽  
...  

2020 ◽  
Author(s):  
Vaibhav Singh ◽  
Ananda Kisor Pal ◽  
Dibyendu Biswas ◽  
Alakendu Ghosh ◽  
Brijesh P Singh

ABSTRACTObjectiveOsteoporosis causes fragility fractures that also occur in patients with bone mineral density (BMD) in the normal or osteopenic range, suggesting role of risk factors that are unrelated or partially related to BMD. The study aims at highlighting the link between 3 conditions, that are environment and occupation related risk factors and that are widely prevalent in India, and development of fragility fractures.MethodsA Case Control study was done by recruiting 110 Cases with history of recent fragility fractures and 84 Controls with no history of recent fractures. 3 study parameters, village dwelling, conventional farming, and poverty, were chosen the presence or absence of which were documented in participants. This was followed by an ODDS ratio analysis.ResultsThe Odds of village dwellers, conventional farmers, and socioeconomically poor individuals to develop fragility fractures were both significant and large.ConclusionUrbanization is a risk in the development of fragility fractures. However, this study points that village dwelling in India is associated with the development of fragility fractures. Similarly, Odds of farmers exposed to pesticides and agrochemicals to develop fragility fractures is large and significant. Pesticides and agrochemicals act as endocrine disruptors and bone health is closely linked to endocrine system. Fragility fractures among farmers may be due to endocrine disrupting properties of pesticides and agrochemicals. Socioeconomic deprivation is a known risk in the development of osteoporosis. This study too highlights that the odds of individuals living in poverty to develop fragility fractures is significant and large.


2020 ◽  
pp. 140349482097151
Author(s):  
Samantha M. Harris ◽  
Gro M. Sandal

Aim: The study aims to examine groups at risk for psychological distress in connection with the COVID-19 outbreak, and the role of trust in the healthcare system as a possible moderator. Methods: Data were collected from a large sample of the Norwegian population ( n = 4008) through the Norwegian Citizen Panel (NCP). A linear regression was conducted to examine the effects of COVID-19 related risk factors on psychological distress, using the 10-item Hopkins Symptom Checklist (HSCL-10). Finally, we conducted a moderation analysis to examine the interaction of trust in the healthcare system and COVID-19 related risk factors. Results: A linear regression showed that female gender, younger age, lower level of education, being infected with COVID-19, being medically vulnerable, working in the healthcare system, being in voluntary quarantine and having an immigrant background predicted mean HSCL-10 scores. The moderation analysis revealed that people in the medically vulnerable group, those below 61, and those in quarantine reported higher psychological distress when they also had lower trust in the healthcare system. Conclusions: Findings indicate important groups to take into consideration in mental healthcare strategies and policies. However, most participants in the current study reported psychological distress levels that were below the clinical cut-off, suggesting that the majority may have coped relatively well in the early stages of the pandemic.


Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1186
Author(s):  
Silvia Sgambellone ◽  
Laura Lucarini ◽  
Cecilia Lanzi ◽  
Emanuela Masini

Glaucoma is a multifactorial neuropathy characterized by increased intraocular pressure (IOP), and it is the second leading cause of blindness worldwide after cataracts. Glaucoma combines a group of optic neuropathies characterized by the progressive degeneration of retinal ganglionic cells (RGCs). Increased IOP and short-term IOP fluctuation are two of the most critical risk factors in glaucoma progression. Histamine is a well-characterized neuromodulator that follows a circadian rhythm, regulates IOP and modulates retinal circuits and vision. This review summarizes findings from animal models on the role of histamine and its receptors in the eye, focusing on the effects of histamine H3 receptor antagonists for the future treatment of glaucomatous patients.


Pain ◽  
2006 ◽  
Vol 126 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Jasper J. den Boer ◽  
Rob A.B. Oostendorp ◽  
Tjemme Beems ◽  
Marten Munneke ◽  
Andrea W.M. Evers

Author(s):  
Ragda Abdalla‐Aslan ◽  
Mordechai Findler ◽  
Liran Levin ◽  
Avraham Zini ◽  
Boaz Shay ◽  
...  

2019 ◽  
Vol 31 (10) ◽  
pp. 1483-1489 ◽  
Author(s):  
Xiaomei Zhong ◽  
Zhangying Wu ◽  
Cong Ouyang ◽  
Wanyuan Liang ◽  
Ben Chen ◽  
...  

ABSTRACTObjectives:Cognitive impairment in late-life depression is common and associated with a higher risk of all-cause dementia. Late-life depression patients with comorbid cardiovascular diseases (CVDs) or related risk factors may experience higher risks of cognitive deterioration in the short term. We aim to investigate the effect of CVDs and their related risk factors on the cognitive function of patients with late-life depression.Methods:A total of 148 participants were recruited (67 individuals with late-life depression and 81 normal controls). The presence of hypertension, coronary heart disease, diabetes mellitus, or hyperlipidemia was defined as the presence of comorbid CVDs or related risk factors. Global cognitive functions were assessed at baseline and after a one-year follow-up by the Mini-Mental State Examination (MMSE). Global cognitive deterioration was defined by the reliable change index (RCI) of the MMSE.Results:Late-life depression patients with CVDs or related risk factors were associated with 6.8 times higher risk of global cognitive deterioration than those without any of these comorbidities at a one-year follow-up. This result remained robust after adjusting for age, gender, and changes in the Hamilton Depression Rating Scale (HAMD) scores.Conclusions:This study suggests that late-life depression patients with comorbid CVDs or their related risk factors showed a higher risk of cognitive deterioration in the short-term (one-year follow up). Given that CVDs and their related risk factors are currently modifiable, active treatment of these comorbidities may delay rapid cognitive deterioration in patients with late-life depression.


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