scholarly journals POS0498 RELATIONSHIP BETWEEN IMPAIRED MELATONIN SECRETION AND DURATION, RADIOLOGICAL STAGE AND PHYSICAL ACTIVITY OF RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 481.3-482
Author(s):  
Y. Sikalo ◽  
L. Zhuravlyova ◽  
M. Oliinyk ◽  
V. Fedorov
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Serum Levels ◽  
The Body ◽  
Melatonin Secretion ◽  
Radiological Progression ◽  
Rank Correlation Method ◽  
Close Relationship ◽  
Radiological Stage

Background:There is a close relationship between the development of severe autoimmune diseases and disorders of the neuroendocrine immune regulation of the body [1]. The role of melatonin as the main mediator of neuroendocrinoimmune interactions in rheumatoid arthritis (RA) remains poorly understood [2].Objectives:The aim of the study was to determine the daily serum melatonin profile of RA patients with different duration of the disease, radiological stage and physical activity.Methods:The daily serum melatonin profile of patients with active RA (n=105, mean age 49.8±12.6 years, 75.5% of women) was compared with that of healthy subjects from the general population (n=30). In addition, we investigated daily serum melatonin secretion in relation to duration of the disease, radiological progression and physical activity (HAQ). Patients were divided into 4 groups depending on the RA duration (mean 8.4±6.6 years): 1st group - up to 2 years (n=12), 2nd group - 2-5 years (n=37), 3rd group - 6-10 years (n=26), 4th group - more than 10 years (n=30). Depending on the radiological progression, patients were divided into stages: 1st stage (n=16), 2nd stage (n=64), 3d stage (n=25). Melatonin serum levels was determined by the enzyme immunoassay at 8 and 20 o`clock. For statistical analysis were used the Man - Whitney test and the Spearman rank correlation method.Results:The melatonin serum levels in RA patients were in 2 and 3 times higher in the morning and evening time than those of healthy individuals in the control group (p=0.001). We noticed significant correlations between melatonin level and disease duration (rS =-0.5, p <0.01). Significant differences in melatonin levels were revealed in RA patients in 1st and 3rd groups (p=0.049), in 1st and 4th groups (p = 0.012), in 2nd and 3rd groups (p=0.001), in 2nd and 4th groups (p=0.001). Also we determined significant differences in melatonin levels between 1st and 2nd radiological stages (p =0,001) of RA patients. However, melatonin levels were not related to physical activity (HAQ).Conclusion:We found a close relationship between serum melatonin levels, duration of the disease and radiological progression in RA patients. The most significant changes in melatonin metabolism occur in patients with the duration of the disease up to 5 years and with lower radiological stages. Our data indicate the important role of neurotransmitter in the pathogenesis of RA, especially at the initial stage of the disease.References:[1]Sternberg EM. Neuroendocrine regulation of autoimmune/inflammatory disease. J Endocrinol. 2001 Jun;169(3):429-35. doi: 10.1677/joe.0.1690429. PMID: 11375112.[2]Mańka S, Majewska E. Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells. Postepy Hig Med Dosw (Online). 2016 Oct 4;70(0):1059-1067. doi: 10.5604/17322693.1221001. PMID: 27708210.Disclosure of Interests:None declared

scholarly journals The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2182 ◽  
Author(s):  
Oliver K Fuller ◽  
Martin Whitham ◽  
Suresh Mathivanan ◽  
Mark A Febbraio
Keyword(s):  
Physical Activity ◽  
Extracellular Vesicles ◽  
Potential Role ◽  
The Body ◽  
Therapeutic Effects ◽  
Health And Wellbeing ◽  
Systemic Factors ◽  
Diabetes And Obesity

Physical activity has systemic effects on the body, affecting almost every organ. It is important not only for general health and wellbeing, but also in the prevention of diseases. The mechanisms behind the therapeutic effects of physical activity are not completely understood; however, studies indicate these benefits are not confined to simply managing energy balance and body weight. They also include systemic factors which are released into the circulation during exercise and which appear to underlie the myriad of benefits exercise can elicit. It was shown that along with a number of classical cytokines, active tissues also engage in inter-tissue communication via extracellular vesicles (EVs), specifically exosomes and other small EVs, which are able to deliver biomolecules to cells and alter their metabolism. Thus, EVs may play a role in the acute and systemic adaptations that take place during and after physical activity, and may be therapeutically useful in the treatment of a range of diseases, including metabolic disorders such as type 2 diabetes and obesity; and the focus of this review, neurological disorders such as Alzheimer’s disease.

Role of physical activity in the management and assessment of rheumatoid arthritis patients

2017 ◽  
Vol 13 (4) ◽  
pp. 214-220 ◽  
Author(s):  
María Vanesa Hernández-Hernández ◽  
Federico Díaz-González
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity

CHANGES THE CYTOKINE PROFILE AND CALCIUM-REGULATING HORMONES IN RHEUMATOID ARTHRITIS

2019 ◽  
Vol 64 (11) ◽  
pp. 673-676
Author(s):  
Asmaya Saftar Huseynova
Keyword(s):  
Rheumatoid Arthritis ◽  
Parathyroid Hormone ◽  
Bone Loss ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Control Group ◽  
Tnf Α ◽  
High Production ◽  
Serological Variant

The aim was to study the level of some cytokines (İL-2, İL-6, İL-8 TNFα) and calcium regulating hormones (calcitonin, parathyroid hormone, 25 (OH) D) in the blood of patients with rheumatoid arthritis (RA) depending on rheumatoid factor (RF) and the assessment of the role of the revealed violations in the pathogenesis of bone loss in this pathology. For this purpose, 74 patients with RA (59 women, 15 men) aged from 27 to 71 were examined. On the basis of RF in the blood serum, the patients were divided into 2 groups: seronegative and seropositive RA. The control group included 16 healthy individuals (13 women, 3 men). The results obtained that the serological variant of RA affects the serum levels of proinflammatory cytokines and calcium-regulating hormones: more pronounced changes were found in seropositive RA. The high production of IL-2, IL-6, IL-8, TNF-α and parathyroid hormone detected in both groups of patients undoubtedly contributes to the mechanisms of bone loss in RA. In both groups we detected hypovitaminosis D. This results recommended to use this vitamin in the complex treatment of RA.

Role of physical activity in the management and assessment of rheumatoid arthritis patients

2017 ◽  
Vol 13 (4) ◽  
pp. 214-220 ◽  
Author(s):  
María Vanesa Hernández-Hernández ◽  
Federico Díaz-González
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity

Relation of the Serum Levels of DKK-1 and Osteoprotegerin with Bone Mass in Tightly Controlled Rheumatoid Arthritis.

2020 ◽  
Vol 16 ◽  
Author(s):  
Carmen Gómez-Vaquero ◽  
Irene Martín ◽  
Andrea Zacarías ◽  
Pedro Alía ◽  
Estíbaliz Loza ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Serum Levels ◽  
Mineral Density ◽  
Annual Percent Change ◽  
Activity Measures ◽  
Mean Time

Objective: To analyze the association between serum levels of osteoprotegerin (OPG) and Dickkopf-related protein 1 (DKK-1) and the annual percent change (%) in bone mineral density (BMD) in patients with tightly controlled rheumatoid arthritis (RA). Methods: Observational mixed-study. RA patients followed-up with a tight-control strategy were included. Bone densitometries were performed at baseline (T0) and follow-up (T1) and serum levels of OPG and DKK-1 were measured by ELISA also in T0 and T1; additional clinical variables included disease activity measures, and treatment for RA and osteoporosis. Descriptive bivariate and multivariate analyses, stratified by gender, were performed. Results: We included 97 RA patients (70% female, with a mean age of 53 years, and 76% with low activity by DAS28); 95% were treated with DMARDs and 37% with anti-osteoporotic drugs. Mean time between T0 and T1 was 2.7 years. Most patients had their BMD improved. The mean %BMD was +0.42% for lumbar spine, +0.15% for femoral neck and +0.91% for total femur. In men, baseline OPG was significantly associated with higher BMD loss (β coefficient -0.64) at femoral neck. In women, DKK-1 was associated with higher BMD loss at femoral neck (β coefficient -0.09), and total femur (β coefficient -0.11); however, DKK-1 was associated with lower BMD loss at lumbar spine (β coefficient 0.06). Conclusion: In tightly controlled RA patients, we have found no evidence of bone loss. The role of DKK1 and OPG seems small and might be related to sex and to location.

Life Style Evaluation by Accelerometer

2013 ◽  
pp. 331-340
Author(s):  
Laura Stefani ◽  
Gabriele Mascherini ◽  
Irene Scacciati ◽  
Giorgio Galanti
Keyword(s):  
Physical Activity ◽  
Life Style ◽  
Exercise Program ◽  
The Body ◽  
Early Improvement ◽  
Educational Role ◽  
Body Compositions ◽  
Regular Physical Exercise ◽  
Sedentary Subjects

The assessment of the Spontaneous Motor Activity (SMA) of the life style (LS) is fundamental to establish the daily Physical Activity (PA) dose as therapy. The recent employment the accelerometer (AiperMotion 440 PC –Aipermon GmBH – Germany), can immediately distinguish “active” from “sedentary” subjects providing a larger adhesion to the exercise program. The study aims to verify the role of the accelerometer. 28 obese-hypertensive were evaluated either by the questionnaire or by the accelerometer. A larger sedentary LS in the population investigated was found by the accelerometer respect of questionnaire. After three months of regular physical exercise, the body compositions parameters, investigated principally, resulted to be improved. The accelerometer determines a real and objective visualization of the LS expressed as PAL resulting on a direct early improvement of the parameters strongly related with the cardiovascular risk. The results support the educational role of the employ of the accelerometer.

Potential role of bioactive lipids in rheumatoid arthritis

2021 ◽  
Vol 27 ◽  
Author(s):  
Wheeler Torres ◽  
Mervin Chávez-Castillo ◽  
José L. Peréz-Vicuña ◽  
Rubén Carrasquero ◽  
María P. Díaz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Potential Role ◽  
The Body ◽  
Omega 3 ◽  
Bioactive Lipids ◽  
Dietary Interventions ◽  
Complex Disorder ◽  
Inflammatory Autoimmune Disease

: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, which involves a pathological inflammatory response against articular cartilage in multiple joints throughout the body. It is a complex disorder associated with comorbidities such as depression, lymphoma, osteoporosis and cardiovascular disease (CVD), which significantly deteriorate patients’ quality of life and prognosis. This has ignited a large initiative to elucidate the physiopathology of RA, aiming to identify new therapeutic targets and approaches in its multidisciplinary management. Recently, various lipid bioactive products have been proposed to have an essential role in this process; including eicosanoids, specialized pro-resolving mediators, phospholipids/sphingolipids, and endocannabinoids. Dietary interventions using omega-3 polyunsaturated fatty acids or treatment with synthetic endocannabinoids agonists have been shown to significantly ameliorate RA symptoms. Indeed, the modulation of lipid metabolism may be crucial in the pathophysiology and treatment of autoimmune diseases.

Post Translational Modification and its pathologic association in Rheumatoid Arthritis: A brief perspective

2021 ◽  
Vol 22 ◽  
Author(s):  
Vishnupreetha Vasudevan ◽  
Prachi Agnihotri ◽  
Sagarika Biswas
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Pain ◽  
Cyclic Peptide ◽  
Delayed Diagnosis ◽  
Living System ◽  
The Body ◽  
Post Translational Modification ◽  
And Function ◽  
Inflammatory Autoimmune Disease

: Post Translational Modification (PTM) is the process in which covalent addition of functional groups on protein happens to maintain their structure, function and stability. Every PTM process in our living system happens to increase the functional diversity of protein. But sometimes it happens without any regulation and occurrence of this specific change in proteins are leading to autoimmunity. Rheumatoid arthritis (RA) is one such chronic, inflammatory, autoimmune disease that affects joints. Proper treatment can be manageable for RA, but it is not completely curable. Delayed diagnosis of RA can cause severe bone pain, stiffness, inflammation, redness in joints and affect other parts of the body such as liver, kidney etc. Early diagnosis of disease is preferable to cure it effectively. Currently, Rheumatoid factor (RF) and anti-citrullinated cyclic peptide (Anti-CCP) are considered as biomarkers to diagnose RA. Other than citrullination several other PTM’s are also involved in generation of autoantibodies such as, carbamylation, glycosylation, glycation, acetylation, ubiquitination, proteolysis, phosphorylation, lipidation. Aim of this review is to elucidate several considerable changes in form, nature and function of above PTMs in RA, affecting joints and day to day life. This review will give a recent overview on the role of PTMs in the pathogenesis of RA, focusing on the modifications.

scholarly journals Clarifying the role of physical activity in osteoarthritis and rheumatoid arthritis

2017 ◽  
Vol 595 (16) ◽  
pp. 5713-5713 ◽  
Author(s):  
Normand A. Richard ◽  
Michael S. Koehle
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity

Circulating Leptin and Adiponectin Concentrations During Tumor Necrosis Factor Blockade in Patients with Active Rheumatoid Arthritis

2009 ◽  
Vol 36 (4) ◽  
pp. 724-730 ◽  
Author(s):  
CALIN POPA ◽  
MIHAI G. NETEA ◽  
JACQUELINE de GRAAF ◽  
FRANK H.J. van den HOOGEN ◽  
TIMOTHY R.D.J. RADSTAKE ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Disease Activity ◽  
Tumor Necrosis ◽  
Active Rheumatoid Arthritis ◽  
Disease Activity Score ◽  
Serum Levels ◽  
Plasma Leptin ◽  
Necrosis Factor

Objective.Adipocytokines, including leptin and adiponectin, may play an important role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of longterm therapeutic tumor necrosis factor (TNF) blockade on adipocytokine concentrations in patients with RA.Methods.We studied 58 RA patients starting anti-TNF therapy and 58 healthy controls matched for age, sex, and body mass index (BMI). Fasting blood samples were drawn at baseline, 2 weeks, and 6 months after the start of anti-TNF therapy and serum levels of leptin and adiponectin were measured.Results.Patients with RA had increased adiponectin (p < 0.001) and similar leptin concentrations compared with the controls. Leptin concentrations were significantly higher in patients with high BMI (p < 0.001) and correlated positively with BMI at all timepoints (r > 0.75). In contrast, serum adiponectin tended to be higher in lean RA patients and did not correlate with BMI at any timepoint. There were no clear correlations between serum concentrations of adipocytokines and disease activity (Disease Activity Score 28). Short or longterm TNF blockade alone had no influence on circulating leptin and adiponectin concentrations. Patients treated with anti-TNF and concomitant corticosteroids on a stable basis showed a significant decrease in adiponectin levels after 6 months of therapy (p < 0.025).Conclusion.In patients with RA, chronic inflammation and its suppression during anti-TNF therapy have limited influence on plasma leptin concentrations, while significantly decreasing circulating adiponectin levels. Our findings question the suggested key role of inflammatory markers in regulating adipocytokine patterns in RA.

Sign in / Sign up

Export Citation Format

Share Document