scholarly journals Antenatal steroid exposure and outcomes of very premature infants: a regional cohort study

Author(s):  
D Wong ◽  
ME Abdel-Latif ◽  
AL Kent ◽  
Neonatology ◽  
2013 ◽  
Vol 103 (1) ◽  
pp. 67-73 ◽  
Author(s):  
C. Maas ◽  
S. Mitt ◽  
A. Full ◽  
J. Arand ◽  
W. Bernhard ◽  
...  

2021 ◽  
Author(s):  
Xiaoling Wang ◽  
Yan Ma ◽  
Shenghui Wang ◽  
Wenbin Dong ◽  
Xiaoping Lei

Abstract Background: A previous study showed that the lungs are involved in the biogenesis of platelets (PLTs). Thus, the present study aimed to investigate the association between bronchopulmonary dysplasia (BPD), a chronic lung disease, and PLT parameters in very premature infants.Methods: The study subjects were premature infants with a gestational age of < 30 weeks and birth weight of < 1500 g in a preterm birth cohort study recruited between January 1, 2015, and August 31, 2019. BPD was defined as the need for oxygen supplementation more than 28 days after birth. The PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) level were compared between BPD and non-BPD infants. A generalized estimating equation model was used to adjust for confounding factors. A forward stepwise logistic regression model was used to calculate the adjusted odds ratio (OR) for thrombocytopenia in the BPD group.Results: The final study subjects were 134 very premature infants, namely, 64 infants with BPD and 70 infants without BPD. The BPD infants had lower PLT counts (F=25.39, P=0.00) and PCT levels (F=41.16, P=0.00) than the non-BPD infants. However, the MPV (F=37.65, P=0.00) and PDW (F=28.43, P=0.00) were higher in the BPD group. After adjusting for potential confounding factors, the BPD infants had a higher risk of thrombocytopenia than the non-BPD infants (adjusted OR 3.18, 95% CI 1.21, 8.35), and the risk of BPD was increased in very premature infants with a PLT count ≤ 177*109/l (OR 4.74, 95% CI 1.93–11.62) at the end of the second week.Conclusions: Abnormal PLT parameters were observed in BPD infants, and a PLT count ≤ 177*109/l was an early predictor for BPD in very premature infants.


2003 ◽  
Vol 143 (5) ◽  
pp. 630-633 ◽  
Author(s):  
Fleur de Lorijn ◽  
T.I Omari ◽  
J.H Kok ◽  
J.A.J.M Taminiau ◽  
M.A Benninga

2014 ◽  
Vol 2 ◽  
Author(s):  
Elizabeth Doll ◽  
Jacob Wilkes ◽  
Lawrence J. Cook ◽  
E. Kent Korgenski ◽  
Roger G. Faix ◽  
...  

Author(s):  
Margaret A. Lafferty ◽  
Amy Mackley ◽  
Pam Green ◽  
Deborah Ottenthal ◽  
Robert Locke ◽  
...  

Objective The study aimed to assess in a prospective randomized study the effect of Mozart's music on time to regain birth weight (BW) and development of oral feeding skills in babies born between 280/7 and 316/7 weeks of gestation. Study Design Healthy premature infants born between 280/7 and 316/7 completed weeks of gestation were randomized within 3 days of birth to either music or no music exposure. Infants in the music group were exposed to Mozart's double piano sonata twice per day for 14 days. The primary outcome was time to regain birth weight. The secondary outcome was development of oral feeding skills as evaluated by a speech/language pathologist blinded to the intervention. We hypothesized that exposure to Mozart's double piano sonata would decrease time to regain BW and improve feeding skills. A total of 32 newborns were needed to detect a 3-day difference in time to regain BW. Results Forty infants were enrolled and randomized. There were no significant differences between the two groups regarding the time to regain BW (p = 0.181) and the time to achievement of full oral feeds (p = 0.809). Conclusion Exposure to Mozart's double piano sonata for 14 days after birth did not significantly improve time to regain BW or time to achieve full oral feedings in very premature infants. It is possible that Mozart's music has no effect or that the duration of music exposure was not sufficient to have a physiologic effect on growth and oral feeding skills. Key Points


2021 ◽  
pp. 54-57
Author(s):  
Kali Shankar Das ◽  
Athokpam Poireiton ◽  
Niladri Sekhar Mandal ◽  
Samim Ahmed

OBJECTIVE: Retinopathy of prematurity (ROP) is a severe morbidity that can lead to blindness in premature babies. Neonatal hyperglycemia has been related to the growth of ROP in a variety of studies. However, there aren't many observational trials to show whether hyperglycemia is linked to ROP in the absence of other comorbidities. The aim of this research was to see if hyperglycemia in premature babies is linked to ROP in a different way. STUDY DESIGN: Premature infants (<1500 g or⩽ 32 weeks gestational age) were enrolled in a prospective longitudinal cohort study. All demographic, clinical and laboratory data were collected. Bedside whole-blood glucose concentration was measured every 8 hours daily for rst 7 , days of live. For any glucose reading <50 or>150 mg dl 1 serum sample was sent to the laboratory for conrmation. Hyperglycemia was dened as any blood glucose level⩾ 150 mg dl − 1. ROP patients were compared with non-ROP patients in a bivariate analysis. Variables signicantly associated with ROP were studied in a logistic regression model. RESULT:Atotal of 100 patients were enrolled with gestational age <32weeks and birth weight <1500g. Forty-eight patients (48%) were identied with hyperglycemia. On eye examination, 30 cases (30%) had ROP (19 with stage 1, 10 with stage 2 and 1 with stage 3). There were more cases of ROPin the hyperglycemia group compared with the euglycemia group (45.83% vs 15.38%, P = 0.007). Patients who developed ROP had signicantly higher maximum and average glucose concentrations when compared with non-ROP patients. Multiple factors have been associated with ROP on bivariate analysis, including gestational age, exposure to oxygen, respiratory support and poor weight gain. However, in a logistic regression model including all signicant variables, average blood glucose in the rst week of life was the factor independently associated with ROPwith an odds ratio of: 1.77 (95% condence interval: 1.08 to 2.86), P= 0.024 CONCLUSION: In a prospective cohort study of premature infants, elevated average blood glucose concentrations in the rst week of life is an independent risk factor associated with the development of ROP.


PEDIATRICS ◽  
1994 ◽  
Vol 93 (1) ◽  
pp. A52-A52

...from therapeutic nihilism based on the prevailing belief that any measures taken to increase the survival rate [of very premature infants] would result in increasing numbers of handicapped children who would be a burden to their families, to overzealous intervention which suggests it is mothers not infants whose interests should be ignored.


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