scholarly journals CD138-negative plasma cell myeloma: a diagnostic challenge and a unique entity

2019 ◽  
Vol 12 (11) ◽  
pp. e232233
Author(s):  
Audi Francesca Setiadi ◽  
Yuri Sheikine
Keyword(s):  
B Cell ◽  
Plasma Cell ◽  
Correct Diagnosis ◽  
In Situ Hybridisation ◽  
Careful Analysis ◽  
Fluorescence In Situ Hybridisation ◽  
Plasma Cell Myeloma ◽  
Diagnostic Challenge ◽  
Mantle Cell ◽  
Plasma Cell Neoplasms

Plasma cell neoplasms may exhibit variations in morphology and immunophenotype, which can mimic mature B-cell lymphoproliferative disorders and pose diagnostic challenges. This case illustrates a rare entity of plasma cell myeloma, where the entire plasma cell population exhibited lymphoid morphology, negativity for CD138, positivity for CD20 and cyclin D1, and positive fluorescence in situ hybridisation for t(11;14) and del(17 p), mimicking a mature B-cell lymphoproliferative disorder, in particular mantle cell lymphoma. In this case, a careful analysis of flow cytometry gating strategies and use of other ancillary tests were keys for correct diagnosis. In addition to the diagnostic implications due to its rarity, CD138-negative plasma cell myeloma may represent a unique entity, which is associated with ‘stem cell’-like clonogenic properties, more aggressive clinical behaviour and resistance to chemotherapy.

Plasma cell myeloma with tumorous liver involvement, presenting as a carcinoma of unknown primary

2020 ◽  
pp. 1-3
Keyword(s):  
Plasma Cell ◽  
Correct Diagnosis ◽  
Elevated Serum ◽  
Serum Levels ◽  
Unknown Primary ◽  
Plasma Cell Myeloma ◽  
Diagnostic Challenge ◽  
Tumor Mass ◽  
Carcinoma Of Unknown Primary ◽  
Bone Marrow Trephine Biopsy

Background: A hepatic tumor mass by plasma cell myeloma is rare and is reported in 16% of patients with plasma cell myeloma. Unusual morphological variants of plasma cell myeloma in such a localisation may be a diagnostic challenge. Case presentation: A 60-year-old woman with low-back pain had MRT and CT scan results showing osteo-destructive lesions on different sites and a tumor mass in the liver. Her clinical presentation was classified as a carcinoma of unknown primary. Elevated serum-levels of the immunoglobulin heavy chain IgA and the immunoglobulin light chain kappa gave rise for a bone marrow trephine biopsy, revealing infiltration by a plasma cell myeloma with typical morphology (Fig.1A). Though the histological specimen of the liver resembled a clear cell carcinoma, the immunophenotype revealed plasma cell myeloma. Conclusion: In tumours with an extraordinary morphology and not conclusive immunohistochemical results, the use of plasma cell antibodies may lead to the correct diagnosis.

CD20-negative low-grade B cell lymphoma showing immunophenotypic and genotypic features resembling plasma cell myeloma

2013 ◽  
Vol 209 (7) ◽  
pp. 459-462
Author(s):  
Rie Tabata ◽  
Ryoji Yasumizu ◽  
Chiharu Tabata ◽  
Masaru Kojima
Keyword(s):  
B Cell ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
Plasma Cell Myeloma

Small Lymphoid Proliferations in Extranodal Locations

2007 ◽  
Vol 131 (3) ◽  
pp. 383-396
Author(s):  
Dinesh S. Rao ◽  
Jonathan W. Said
Keyword(s):  
B Cell ◽  
Medical Center ◽  
Correct Diagnosis ◽  
Cell Types ◽  
Correct Identification ◽  
Low Grade ◽  
Molecular Features ◽  
Mantle Cell ◽  
Ancillary Studies ◽  
Widespread Dissemination

Abstract Context.—Low-grade non-Hodgkin lymphomas frequently involve extranodal sites including the gastrointestinal tract, skin, and lung, either selectively or as part of widespread dissemination. Differentiation from inflammatory or infectious conditions requires knowledge of specific histologic characteristics of the various entities as well as ancillary techniques. Objective.—To describe the key features and provide diagnostic clues to the identification of specific extranodal low-grade lymphomas of T-cell and B-cell types including small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, extranodal marginal zone B-cell lymphomas of mucosal-associated lymphoid tissue, and hairy cell leukemia. Histologic and cytologic features are highlighted, as well as appropriate integration of results of ancillary diagnostic studies including flow cytometry, immunohistochemistry, molecular features, and cytogenetics. Data Sources.—The published literature as well as personal experience from a specialized hematopathology practice at a large university medical center. Conclusions.—Correct identification of extranodal low-grade lymphomas and differentiation from hyperplastic and inflammatory or infectious processes require the ability to distinguish each of the specific entities discussed. Ancillary studies are often indispensable in reaching a correct diagnosis.

Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected

2009 ◽  
Vol 62 (10) ◽  
pp. 948-950 ◽  
Author(s):  
L Stefancikova ◽  
M Moulis ◽  
P Fabian ◽  
I Falkova ◽  
I Vasova ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Complex Analysis ◽  
Cell Lymphoma ◽  
In Situ Hybridisation ◽  
D1 Protein ◽  
Fluorescence In Situ Hybridisation ◽  
Cyclin D2 ◽  
Mantle Cell ◽  
High Level

Background and Aim:The cytogenetic and diagnostic hallmark of mantle cell lymphoma (MCL) is translocation t(11;14)(q13;q32), resulting in overexpression of cyclin D1. Cyclin D1 expression was analysed in 32 cases of MCL.Methods:The t(11;14) translocation was detected by fluorescence in situ hybridisation, level of cyclin D1 mRNA by competitive RT-PCR, and level of cyclin D1 and D2 proteins by immunohistochemistry and/or immunoblotting.Results:In 30 cases, the presence of translocation t(11;14), a high level of cyclin D1 mRNA, and a high level of the cyclin D1 protein were confirmed. Two cyclin D1-negative cases overexpressing cyclin D2 were detected by immunoblotting.Conclusions:There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. Anti-cyclin D1 antibodies with low specificity can bind both cyclin D1 and cyclin D2, thus providing false cyclin D1-positive signals in immunohistochemical analysis.

Aberrant Expression of Golgin-84 in Non-Hodgkin Lymphomas and Plasma Cell Myeloma

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4633-4633
Author(s):  
Ling Chen ◽  
Yaling Yang ◽  
C. Cameron Yin ◽  
Gary Lu ◽  
Su Chen ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Plasma Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Cells ◽  
Plasma Cell Myeloma ◽  
Expression Levels ◽  
Non Hodgkin Lymphoma

Abstract Abstract 4633 Background: Golgins are proteins of the Golgi complex. Several Golgins have been implicated in apoptosis. Expression of Golgin-84, a Golgin protein, is altered in apoptotic WEHI-231, a B-cell lymphoma line, suggesting that Golgin-84 may play a role in lymphoid tumorigenesis. Here, we aimed to determine the expression levels of Golgin-84 in human primary non-Hodgkin lymphomas and plasma cell myeloma. Design: Golgin-84 expression was investigated in non-Hodgkin lymphoma cell lines by using Western blot analysis and polyclonal antibodies. Using immunohistochemical stains, Western blotting analysis and Q-PCR, Golgin-84 expression was assessed in 5 reactive lymph nodes, 149 cases of primary non-Hodgkin lymphoma and 28 cases of primary plasma cell myeloma. Results: Immunohistochemical stains, Western blotting analysis and Q-PCR on 5 reactive lymph nodes demonstrated that Golgin-84 was expressed at low levels in lymphoid cells of germinal centers, mantle cells, marginal zones, and interfollicular areas. Golgin-84 was variably expressed in non-Hodgkin lymphoma cell lines tested, with the highest levels in cells from high-grade tumors (e.g. anaplastic large cell lymphoma; ALCL, Diffuse large B-cell lymphoma (DLBCL), ALCL and peripheral T-cell lymphoma unspecified (PTCL)) and the lowest levels in mantle cell lymphoma (MCL) cells. DLBCL, ALCL and PTCL frequently showed high expression of Golgin-84. Most lymphoplasmacytic lymphomas (LPL) and plasma cell myeloma (PCM) expressed high levels of Golgin-84. Expression levels of Golgin-84 were lower in MCL and low-grade B-cell non-Hodgkin lymphomas, including chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL), and marginal zone lymphoma (MZL). Conclusions: Golgin-84 expression levels are low in lymphoid cells of normal lymph nodes. Most (>90%) cases of LPL and PCM, and at least half of cases of DLBCL, ALCL and PTCL express high levels of Golgin-84. These findings suggest that Golgin-84 may be involved in tumorigenesis or lymphoma progression, particularly in neoplasms with plasmacytic differentiation. Disclosures: No relevant conflicts of interest to declare.

Mantle Cell Lymphoma: A Report of a Case with a Blend of Atypical Features

2013 ◽  
Vol 4 ◽  
pp. IJCM.S10608
Author(s):  
Firyal A. Ibrahim ◽  
Halima El Omri ◽  
Ruba Y. Taha ◽  
Ibrahim Al Hijji ◽  
Mohamad ElKhalifa ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Correct Diagnosis ◽  
Molecular Data ◽  
Prolymphocytic Leukemia ◽  
Mantle Cell ◽  
Incorrect Diagnosis ◽  
Practical Challenge ◽  
Morphological Variants

Mantle cell lymphoma is an aggressive B-cell neoplasm with special clinical and pathological characteristics. As the morphological variants of mantle cell lymphoma are currently acknowledged, a practical challenge for achieving the correct diagnosis is encountered especially when the cytogenetic/molecular data are not widely available. Here we describe a case of mantle cell lymphoma (MCL) presented with a blend of atypical clinical, morphological, and immunophenotypic features that led to an incorrect diagnosis of B-cell prolymphocytic leukemia (B-PLL).

scholarly journals Liver involvement by plasma cell myeloma mimicking clear cell carcinoma, a potential pitfall.

2020 ◽  
Author(s):  
Fotini-Rosi Vagena ◽  
Heinz Sill ◽  
Christine Beham-Schmid
Keyword(s):  
Bone Marrow ◽  
Cell Carcinoma ◽  
Plasma Cell ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Correct Diagnosis ◽  
Low Back ◽  
Plasma Cell Myeloma ◽  
Morphological Variants ◽  
Histological Specimen

Abstract Background: Unusual morphological variants of plasma cell myeloma are a diagnostic challenge.Case presentation: A 60 year old woman with low-back pain was diagnosed with a plasma cell myeloma in the bone marrow. Concurrently a tumour was found in the liver. The histological specimen of the liver resembled a clear cell carcinoma, but the immunophenotype revealed plasma cell myeloma.Conclusion: In tumours with an extraordinary morphology and not conclusive immunohistochemical results the use of plasma cell antibodies may lead to the correct diagnosis.

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