Trigeminal neuralgia leading to a diagnosis of ovarian cancer: a timely coincidence or a case of paraneoplastic syndrome?

2021 ◽  
Vol 14 (7) ◽  
pp. e243480
Author(s):  
Jonathan Gaughran ◽  
Tom Lyne ◽  
Ahmad Sayasneh
Keyword(s):  
Ovarian Cancer ◽  
Trigeminal Neuralgia ◽  
Paraneoplastic Syndrome ◽  
Inferior Alveolar Nerve ◽  
Connective Tissue Disorder ◽  
Oral Medicine ◽  
Lower Lip ◽  
Blood Tests ◽  
History Of ◽  
The Right

A 51-year-old woman was referred to oral medicine with a 2-month history of progressive paraesthesia of the right lip, chin and oral mucosa. Examination revealed decreased sensation to the right dermatone of the inferior alveolar nerve and allodynia to light touch of the lower lip. An MRI of the head revealed bilateral cisternal trigeminal nerve pathological enhancement. While blood tests suggested a connective tissue disorder as the cause of the trigeminal neuralgia, a subsequent diagnosis of high-grade serous ovarian cancer gave a differential diagnosis of paraneoplastic syndrome.

scholarly journals Hereditary haemorrhagic telangiectasia: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110030
Author(s):  
Asfandyar Mufti ◽  
Muskaan Sachdeva ◽  
Khalad Maliyar ◽  
Marissa Joseph
Keyword(s):  
Arteriovenous Malformations ◽  
Genetic Disorder ◽  
Clinical Manifestations ◽  
Hereditary Haemorrhagic Telangiectasia ◽  
Lower Lip ◽  
Recurrent Epistaxis ◽  
Receptor Like Kinase ◽  
History Of ◽  
The Right ◽  
Symptoms And Signs

Background: Hereditary haemorrhagic telangiectasia is an autosomal dominant genetic disorder characterized by abnormalities in blood vessel formation. The clinical manifestations of patients affected with hereditary haemorrhagic telangiectasia include mucocutaneous telangiectasias and visceral arteriovenous malformations. Case Summary: We report the case of a 30-year-old female diagnosed with hereditary haemorrhagic telangiectasia presenting with the classic triad of recurrent epistaxis, mucocutaneous telangiectasias and family history of hereditary haemorrhagic telangiectasia with activin receptor-like kinase 1 mutation. Upon skin examination, she was noted to have telangiectasias under left naris, inner lower lip and surface of the tongue, and a vascular malformation on the right forearm. Conclusion: Although the skin involvement and epistaxis may be mild symptoms and signs of hereditary haemorrhagic telangiectasia, timely recognition of these can ensure vigilant monitoring of potential severe complications from cerebral and pulmonary visceral arteriovenous malformations.

Trigeminal Neuralgia Caused by a Pontine Abscess: Case Report

Neurosurgery ◽  
2004 ◽  
Vol 55 (6) ◽  
pp. E1450-E1452 ◽  
Author(s):  
Ahmet Bekar ◽  
Hasan Kocaeli ◽  
Emel Yilmaz ◽  
Şeref Doğan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Trigeminal Neuralgia ◽  
Sphenoid Sinus ◽  
Clinical Presentation ◽  
Resonance Imaging ◽  
Repeat Magnetic Resonance Imaging ◽  
Corneal Reflex ◽  
History Of ◽  
The Right

Abstract OBJECTIVE AND IMPORTANCE: Various intracranial abnormalities, including infectious conditions, may manifest as trigeminal neuralgia. CLINICAL PRESENTATION: A 33-year-old man presented with a 15-day history of right-sided facial pain and numbness. Neurological examination revealed diminished corneal reflex and facial sensation in the right V1–V2 distribution. Magnetic resonance imaging revealed a contrast-enhancing lesion centered at the right pons with extension of the enhancement to the sphenoid sinus. INTERVENTION: Broad-spectrum antibiotics were administered for 6 weeks. This resulted in alleviation of symptoms and resolution of the lesion as revealed by repeat magnetic resonance imaging. CONCLUSION: Presentation of a pons abscess with trigeminal neuralgia is rare, and to the best of our knowledge has not been reported previously. The patient was treated successfully with antibiotics alone.

scholarly journals Breast Carcinomatous Lymphangitis as an Unusual Presentation of Ovarian Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2106
Author(s):  
Barbara Muoio ◽  
Giorgio Treglia ◽  
Paola Migliora ◽  
Maria Del Grande
Keyword(s):  
Ovarian Cancer ◽  
Diagnostic Laparoscopy ◽  
Unusual Presentation ◽  
Serous Carcinoma ◽  
Ovarian Serous Carcinoma ◽  
Abdomen Ct ◽  
History Of ◽  
Ovarian Lesion ◽  
The Right ◽  
Ovarian Masses

We describe the case of a 45-year-old woman with an unusual presentation of metastatic ovarian cancer. The patient presented to the oncological clinic with a three-week history of skin rash on the right breast. She underwent a chest and abdomen CT scan, which showed skin thickening of the right breast, right pleural effusion and bilateral cystic ovarian masses. Biopsy of a left ovarian lesion by diagnostic laparoscopy revealed the presence of ovarian serous carcinoma. Biopsy of the breast skin lesion revealed the presence of carcinomatous lymphangitis and immunohistochemistry documented the ovarian origin.

scholarly journals Anti-Ma-associated paraneoplastic cerebellar degeneration in a patient with nodular lymphocyte-predominant Hodgkin lymphoma: a case report

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ryoma Inui ◽  
Kenki Saito ◽  
Yoshimitsu Shimomura ◽  
Daisuke Yamashita ◽  
Michi Kawamoto ◽  
...  
Keyword(s):  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Paraneoplastic Syndrome ◽  
Cerebellar Degeneration ◽  
Paraneoplastic Cerebellar Degeneration ◽  
Downbeat Nystagmus ◽  
Primary Position ◽  
First Case ◽  
History Of ◽  
The Right

Abstract Background Paraneoplastic cerebellar degeneration (PCD) is a devastating paraneoplastic syndrome that occasionally occurs in patients with Hodgkin lymphoma (HL). Anti-Ma2 is a well-characterized onconeuronal antibody and one of the causes of PCD. There has been only one previous report of anti-Ma2-associated paraneoplastic syndrome as a complication of HL. Here we present a rare case of anti-Ma2-associated PCD in a patient with nodular lymphocyte-predominant HL (NLPHL). Case presentation A 77-year-old man with a 3-month history of gait instability and a 2-month history of oscillopsia was referred to our hospital for further investigation. On examination, his cognition was normal. He had nystagmus in all directions of gaze; specifically, he had horizontal and rotatory nystagmus in the primary position, downbeat nystagmus after right, left, and up gaze, and upbeat nystagmus after down gaze. Although his limb ataxia was mild, his trunk ataxia was so pronounced that he was unable to walk without support. We strongly suspected paraneoplastic syndrome and tested for neuronal autoantibodies. The anti-Ma2 antibody was strongly positive in the blood and cerebrospinal fluid but other antineuronal autoantibodies were negative. Computed tomography showed an enlarged lymph node in the right axilla but no masses. Biopsy confirmed a diagnosis of NLPHL. The NLPHL cells stained with anti-Ma-2 antibody in the cytoplasm, suggesting these abnormal cells contained protein that was cross-reactive with Ma-2. Conclusions To the best of our knowledge, this is the first case of anti-Ma2-associated PCD in a patient with NLPHL that was confirmed using immunostaining of the lymph node tissue with anti-Ma2 antibody. Our case confirms an association between anti-Ma2-associated PCD and NLPHL.

scholarly journals A Suspected Metastatic Liposarcoma of the Inferior Alveolar Nerve Canal: A Case Report and Literature Review

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Sara Pourshahidi ◽  
Marzieh Yousefian ◽  
Soheila Manifar ◽  
Farzaneh Mosavat ◽  
Mohsen Esfandbod ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
English Language ◽  
Inferior Alveolar Nerve ◽  
Suspected Case ◽  
Lower Lip ◽  
Case Presentation ◽  
First Case ◽  
History Of ◽  
Inferior Alveolar Nerve Canal

Introduction: Liposarcoma is the most common soft tissue sarcoma, but it is relatively scarce in the head and neck. The metastatic liposarcoma is more infrequent than the primary one. Case Presentation: Here is presented a suspected case of metastatic liposarcoma in the inferior alveolar nerve canal in a 40-year-old female patient with a chief complaint of the chin and lower lip numbness and medical history of liposarcoma in the thigh. The present study was a case report for metastatic liposarcoma in the head and neck regions, according to the English language literature found in PubMed and Google Scholar. The search was performed using the keywords "Metastatic Liposarcoma" and "Head" and "Neck". Conclusions: According to the findings, the reported case may be the first case of the metastasis of liposarcoma in the inferior alveolar nerve canal. Ominous signs, such as numbness, should be considered in patients with a history of cancer, due to their warning for metastasis or recurrence of the tumor.

WED 011 Subacute combined degeneration of the cord: laugh until you are weak

2018 ◽  
Vol 89 (10) ◽  
pp. A2.3-A2
Author(s):  
Francis Anna ◽  
Matar Maz
Keyword(s):  
Nitrous Oxide ◽  
Peripheral Neuropathy ◽  
Neurological Examination ◽  
Mri Findings ◽  
Subacute Combined Degeneration ◽  
Blood Tests ◽  
Mri Brain ◽  
Sensory Modalities ◽  
History Of ◽  
The Right

A 33 year old lady presented to her GP with a 2 week history of numbness affecting her thighs. Routine blood tests revealed normal haemoglobin and folate levels with a borderline B12 concentration of 103 ng/L. Over the subsequent 2 weeks the numbness spread to involve her feet and her hands. Despite commencing cobalamin injections her symptoms continued to progress. She was admitted to hospital 4 weeks after the onset of symptoms with disabling sensory ataxia.All reflexes were either absent or elicited only with reinforcement. Plantars were downgoing. There was impairment of all sensory modalities in a glove-and-stocking distribution, with proprioception accurate at the ankle on the right and the knee on the left. Her gait was broad-based. The remainder of the neurological examination was unremarkable.A full peripheral neuropathy screen revealed no abnormality. An MRI spine showed longitudinally extensive myelitis mainly affecting the dorsal cord extending from C4 to T3. MRI brain and lumbar puncture were pristine.Guided by the MRI findings direct questioning elicited a long history of frequent recreational nitrous oxide use. We review the accumulating literature regarding nitrous oxide-induced subacute combined degeneration of the cord and explore the pathophysiological mechanisms underlying it.

scholarly journals Condylar Fracture in a Child with Entrapment of the Inferior Alveolar Nerve

2016 ◽  
Vol 9 (2) ◽  
pp. 149-151
Author(s):  
Constantinus Politis ◽  
Yi Sun ◽  
Jimoh Agbaje ◽  
Ivo Lambrichts ◽  
Maria Piagkou ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Infratemporal Fossa ◽  
Inferior Alveolar Nerve ◽  
Mandibular Condyle ◽  
Condylar Fracture ◽  
Lower Lip ◽  
Pterygoid Process ◽  
Subcondylar Fracture ◽  
Rubbing Behavior ◽  
The Right

The aim of this article is to report the clinical case of a right subcondylar fracture in a 4-year-old boy. The displaced and medial angulated fragmented mandibular condyle in coexistence with an enlarged lateral pterygoid process was compressing the inferior alveolar nerve (IAN) during its course in the area of the infratemporal fossa. This was expressed by exhibiting a rubbing behavior with resulting superficial ulceration at the right lower lip. Hypoesthesia of the lower lip may be a sign of the IAN entrapment after a subcondylar fracture in a child. In contrast to the adults where an open reduction is necessary to relieve the symptoms of hypoesthesia, in pediatric population, a conservative approach seems sufficient.

scholarly journals Pleuropulmonary Solitary Fibrous Tumour with Paraneoplastic Syndrome

2020 ◽  
Vol 5 (2) ◽  
pp. 251
Author(s):  
Ummu Afeera Zainulabid ◽  
Megat Razeem Abdul Razak ◽  
Nor Hafliza Md Salleh ◽  
Noriah Othman ◽  
Dahlia Mohamed
Keyword(s):  
Paraneoplastic Syndrome ◽  
Health Sciences ◽  
Solitary Fibrous Tumour ◽  
Shortness Of Breath ◽  
Rare Type ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
History Of ◽  
The Right

The pleuropulmonary solitary fibrous tumour (SFT) is a rare type of tumour. This paper outlined a 63-year-old female who came to the hospital with two weeks history of chronic cough, shortness of breath, and hypoglycemia. Contrast-Enhanced CT Thorax showed a huge heterogeneously-enhancing mass occupying the right hemithorax. US-guided biopsy followed by histological examination showed the features of an SFT. In view of the association between pleuropulmonary SFT and hypoglycaemia, the patient was highly likely to be suffering from a paraneoplastic syndrome known as Doege-Potter Syndrome.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 251-253

Trigeminal neuralgia secondary to asymmetry of the petrous bone

1970 ◽  
Vol 33 (5) ◽  
pp. 596-598 ◽  
Author(s):  
Sixto Obrador ◽  
Victor G. Queimadelos ◽  
Manuel Soto
Keyword(s):  
Trigeminal Neuralgia ◽  
Petrous Bone ◽  
Therapeutic Result ◽  
Basilar Impression ◽  
Content Type ◽  
History Of ◽  
Trigeminal Root ◽  
Extradural Approach ◽  
The Right ◽  
Fine Print

✓ This patient with a 12-year history of right trigeminal neuralgia had a marked asymmetry of the skull and petrous bone due to unilateral basilar impression of the right side. Partial section of the trigeminal root through a right subtemporal extradural approach was performed, with a good therapeutic result. Stretching and angulation of the root over the ridge of the elevated petrous bone was the probable cause of the trigeminal pain.

Acute onset trismus in a 15-year-old

Dental Update ◽  
2019 ◽  
Vol 46 (11) ◽  
pp. 1075-1077
Author(s):  
Manal Mohammed ◽  
Andrea Beech ◽  
Jeremy Farrier
Keyword(s):  
Inferior Alveolar Nerve ◽  
Acute Onset ◽  
General Anaesthetic ◽  
First Line ◽  
Mri Scan ◽  
Common Complaint ◽  
History Of ◽  
Muscular Spasm ◽  
The Right ◽  
Radiotherapy Treatment

Trismus can be a common complaint encountered in general dental practice. A 15-year-old female presented to the Emergency Department with a history of acute onset and worsening trismus, pain and extra-oral swelling following placement of a restoration in the lower right first molar tooth. An initial diagnosis of trismus associated with either muscular spasm or a haematoma following an inferior alveolar nerve (IAN) block was assumed. The patient was reviewed the following week, the trismus and swelling having increased. An urgent MRI scan showed a large heterogeneous mass in the right masticator space. A biopsy under general anaesthetic diagnosed a rhabdomyosarcoma. The patient was referred to the oncology team for chemo/radiotherapy treatment. CPD/Clinical Relevance: Although ‘common things occur commonly’, it is important to remember that common symptoms and presentations can lead to more rare diagnoses. Prompt referral for specialist advice needs to be sought should first line management of trismus prove to be unsuccessful.

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