scholarly journals Olfactory groove meningioma with a 10-year history of smell loss and olfactory recovery after surgery

2021 ◽  
Vol 14 (8) ◽  
pp. e244145
Author(s):  
Andreas Steenholt Niklassen ◽  
Rasmus Langelund Jørgensen ◽  
Alexander Wieck Fjaeldstad
Keyword(s):  
Psychiatric Symptoms ◽  
Negative Impact ◽  
Olfactory Nerve ◽  
Olfactory Function ◽  
Olfactory Groove ◽  
Olfactory Loss ◽  
Olfactory Testing ◽  
History Of ◽  
Olfactory Groove Meningioma ◽  
Olfactory Impairment

A rare cause of olfactory impairment is olfactory groove meningiomas with insidious onset of non-specific symptoms like headache, olfactory dysfunction, psychiatric symptoms such as depression, personality changes, declining cognitive function, visual disturbances or seizures. A common complication of surgery is loss of olfactory function. Still, the preservation of olfactory function should be attempted as olfactory loss often has a severe negative impact on quality of life. This report describes a woman with an olfactory groove meningioma and a 10-year history of olfactory impairment. It includes preoperatively and postoperatively extended olfactory testing, a neurosurgical approach to preserve the olfactory function and postoperative olfactory rehabilitation. After rehabilitation, the patient regained a normal olfactory function, even though the right-sided olfactory nerve could not be preserved during surgery. The case demonstrates the importance of performing neuroimaging in selected patients with olfactory loss and a method for preserving and potentially improving postoperative olfactory function.

scholarly journals Olfactory Groove Meningioma: Does anosmia improve following surgery? Report of 20 surgically treated patients in Dhaka Medical College Hospital, Dhaka

2016 ◽  
Vol 24 (1) ◽  
pp. 44-46
Author(s):  
Sukriti Das ◽  
Md Manirul Islam ◽  
Md Mahfuzur Rahman ◽  
Md Zillur Rahman ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Olfactory Function ◽  
College Hospital ◽  
Olfactory Groove ◽  
Medical College ◽  
Olfactory Testing ◽  
Mri Scans ◽  
Function Preservation ◽  
Olfactory Groove Meningioma ◽  
Rare Benign Tumour ◽  
Ct And Mri

Objective: Olfactory Groove Meningioma(OGM) are rare benign tumour account for 8-13% of all intracranial meningiomas and reported about 12 % of all basal meningiomas. Anosmia is thought to be among the commonest symptoms, even though patients often present with headache, visual problem and mental dysfunction.Methods: Tweenty patients (male = 12 andfemale = 8) with olfactory groove meningioma were examined. In all patients extensive pre operative and post operative olfactory testing was performed using conventional soap and cotton soaked with perfume. In 14 cases, meningioma was lateralized (8 –Left, 6 –Right), in 6 patients meningioma were extended in both sides. CT and MRI scans were performed in all cases.Results:In preoperative testing, 14 patients were found to be anosmic on the side of the tumor, 2 were hyposmic and 4 were normosmic. Postoperative ipsilaterally all patients became anosmic but contralaterally 14 patients were anosmic ,2 were hyposmic and 4 were normosmic.Conclusion:The likelihood of normal post operative olfactory function preservation contra lateral to the tumour was possible in too some extent in smaller size.However,preservation of olfactory function ipsilateral to the tumor seems to be extremely difficult irrespective of tumor size or surgical approach.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 44-46

The Coexistence of Olfactory Groove with Optic Nerve Sheath Meningioma Presenting with Anosmia: Case Report

2020 ◽  
Vol 16 ◽  
Author(s):  
Hatice Ferhan Kömürcü ◽  
Gıyas Ayberk ◽  
Ömer Anlar
Keyword(s):  
Case Report ◽  
Optic Nerve ◽  
Visual Impairment ◽  
Optic Nerve Sheath ◽  
Olfactory Groove ◽  
Nerve Sheath ◽  
Optic Nerve Sheath Meningioma ◽  
History Of ◽  
Olfactory Groove Meningioma ◽  
Memory Disturbance

Introduction: Meningiomas are the third most common intracranial tumors in adults after glial tumors and metastases. Olfactory groove meningiomas often grow without symptoms due to their slow growth rates and location in the frontal lobe. Optic nerve sheath meningiomas are benign neoplasms of the meninges surrounding the optic nerve. The coexistence of olfactory groove and optic nerve sheath meningiomas without any history of neurofibromatosis or radiotherapy has never been reported in the literature. Case Report: A 36-year-old female patient presenting with anosmia, headache, memory disturbance, and visual impairment and operated with the diagnosis of olfactory groove meningioma was reported. In the postoperative period, optic nerve sheath meningioma was detected in the imaging performed due to the persistence of visual impairment. Conclusion: Olfactory groove and optic nerve sheath meningiomas are rare tumors and can be diagnosed late because they progress slowly. Early diagnosis and treatment may affect the prognosis and morbidity of these patients favorably.

Quality of Life in Patients With Olfactory Loss Is Better Predicted by Flavor Identification Than by Orthonasal Olfactory Function

2019 ◽  
Vol 44 (6) ◽  
pp. 371-377 ◽  
Author(s):  
Anna Oleszkiewicz ◽  
Dahae Park ◽  
Katarzyna Resler ◽  
Julia Draf ◽  
Anja Schulze ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Predictive Value ◽  
Wide Spectrum ◽  
Olfactory Function ◽  
Self Report ◽  
Hierarchical Regression ◽  
Upper Respiratory Tract ◽  
Olfactory Loss ◽  
Olfactory Testing

Abstract To date, most studies on the relationship between chemosensory performance and quality of life have focused on orthonasal measures of olfactory function. In the current investigation, we examined the predictive value of orthonasal and flavor identification indices of olfactory function on a wide spectrum of health and sociopsychological factors, including quality of life, life satisfaction, overall health, and depressive symptoms. Participants were 178 ENT patients (Mage = 58 ± 1), representing various causes of olfactory loss: idiopathic smell loss (n = 51; Mage = 63 ± 2), sinunasal disease (n = 27; Mage = 56 ± 3), head trauma (n = 33; Mage = 51 ± 2), and infections of the upper respiratory tract (n = 67; Mage = 59 ± 2). They completed self-report questionnaires and underwent olfactory testing using Sniffin’ Sticks (orthonasal olfactory testing) and “Taste Powder” (intraorally applied flavors for retronasal olfactory testing, additionally inducing taste sensation). Data were analyzed with hierarchical regression models wherein the first step included subjects’ sex, age, and orthonasal olfaction score. In the second step, we included the “Taste Powder” score. Tested models revealed that the first step was not significantly predicting variables of interest; however, there was an improvement of the model’s predictive value when the “Taste Powder” score was added. Results of this study suggest that flavor identification significantly improves predictions of health and sociopsychological functioning of ENT patients with various etiologies.

scholarly journals Severity of Anosmia as an Early Symptom of COVID-19 Infection May Predict Lasting Loss of Smell

2020 ◽  
Vol 7 ◽  
Author(s):  
Jerome R. Lechien ◽  
Fabrice Journe ◽  
Stephane Hans ◽  
Carlos M. Chiesa-Estomba ◽  
Vincent Mustin ◽  
...  
Keyword(s):  
Complete Recovery ◽  
Objective Evaluation ◽  
Patient Reported Outcome ◽  
Sudden Onset ◽  
Olfactory Function ◽  
Olfactory Loss ◽  
Olfactory Testing ◽  
Patient Reported ◽  
Smell Function ◽  
The University

Introduction: To evaluate the recovery rate of loss of smell (LOS) with objective olfactory testing in COVID-19 patients.Methods: Adults with confirmed COVID-19 and self-reported sudden LOS were prospectively recruited through a public call from the University of Mons (Belgium). Epidemiological and clinical data were collected using online patient-reported outcome questionnaires. Patients benefited from objective olfactory evaluation (Sniffin-Sticks-test) and were invited to attend for repeated evaluation until scores returned to normal levels.Results: From March 22 to May 22, 2020, 88 patients with sudden-onset LOS completed the evaluations. LOS developed after general symptoms in 44.6% of cases. Regarding objective evaluation, 22 patients (25.0%) recovered olfaction within 14 days following the onset of LOS. The smell function recovered between the 16th and the 70th day post-LOS in 48 patients (54.5%). At the time of final assessment at 2 months, 20.5% of patients (N = 18) had not achieved normal levels of olfactory function. Higher baseline severity of olfactory loss measured using Sniffin-Sticks was strongly predictive of persistent loss (p < 0.001).Conclusion: In the first 2 months, 79.5% of patients may expect to have complete recovery of their olfactory function. The severity of olfactory loss, as detected at the first Sniffin-Sticks-test, may predict the lack of mid-term recovery.

Olfaction in Olfactory Groove Meningiomas

2020 ◽  
Vol 81 (04) ◽  
pp. 310-317 ◽  
Author(s):  
Michaela Dedeciusova ◽  
Norbert Svoboda ◽  
Vladimir Benes ◽  
Jaromir Astl ◽  
David Netuka
Keyword(s):  
Surgical Resection ◽  
Surgical Approach ◽  
Significant Proportion ◽  
Olfactory Nerve ◽  
Olfactory Function ◽  
Olfactory Groove ◽  
Proactive Approach ◽  
Examination Techniques ◽  
Olfactory Detection ◽  
Permanent Morbidity

Abstract Background Clinical examination, including pre- and postoperative assessment of olfaction, is essential in evaluating surgical outcomes in patients with olfactory groove meningiomas (OGMs). A review of a recent series revealed a lack of assessment of olfaction in most of the studies. Tests determining olfactory detection should be used to reveal olfactory dysfunction. Specialized examination techniques (e.g., electro-olfactography, olfactory evoked potentials, and functional magnetic resonance imaging) are currently used in research. Methods Prospective analysis of 13 patients who underwent surgical resection of OGMs from December 2013 to December 2017 was performed. Data on clinical presentation, pre- and postoperative neurologic examinations, complications, recurrences, adjuvant treatment, and follow-up outpatient examinations were recorded. Olfactory function was assessed using the Sniffin' Sticks odor identification test preoperatively, postoperatively, and 1 year after surgery. Results All the meningiomas were resected via unilateral craniotomy, and gross total resection was achieved in all cases. Surgery-related permanent morbidity was 7.7% and overall mortality 0%. For the eight patients with preoperative normosmia, five remained normosmic (62.5%), one deteriorated to hyposmia (12.5%), and two deteriorated to anosmia (25%). For the two patients with preoperative hyposmia, one remained hyposmic and one deteriorated to anosmia. For the three anosmic patients, two remained anosmic, and one improved to hyposmia.The intact olfactory function preoperatively was associated with a better olfactory outcome. Overall, 62.5% of these patients remained normosmic, and none of the hyposmic or anosmic patients normalized their olfaction.Higher meningioma volume is associated with worse olfactory function before surgery (normosmia in 16.7% versus 100.0% in less voluminous) and following the surgery (normosmia in 16.7% versus 57.1% less voluminous).The unilateral surgical approach enabled the anatomical preservation of the contralateral olfactory nerve in 76.9% of our patients. Functional normosmia was achieved in 50% and hyposmia in 30% of these cases. Conclusions Assessment of olfactory function is both vital in preoperative decision making (surgical approach, radicality of resection) and when evaluating surgical outcome. Preoperative normosmia seems to be the most important prognostic factor for functional olfactory outcome. In normosmic patients the olfaction was preserved in 62.5% of cases. Moreover, higher meningioma volume is associated with worse olfactory function before and following the surgery. The greatest advantage of the unilateral surgical approach is anatomical preservation of the contralateral olfactory nerve with a satisfactory functional outcome. These results support a proactive approach, with early surgical resection using a unilateral approach even in cases with less voluminous OGMs that enables the preservation of olfactory function in a significant proportion of patients.

scholarly journals Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
José Francisco López-Gil ◽  
Mikel López Sáez de Asteasu ◽  
Mikel Izquierdo ◽  
Antonio García-Hermoso
Keyword(s):  
Muscle Strength ◽  
Negative Impact ◽  
Handgrip Strength ◽  
Adult Population ◽  
Population Sample ◽  
Negative Relationship ◽  
Olfactory Function ◽  
Cross Sectional ◽  
Moderation Analysis ◽  
Olfactory Impairment

AbstractThe aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40 years old and over. A cross-sectional study was performed with 2861 adults from the US National Health and Nutrition Examination Survey NHANES (2013–2014). An 8-item odor identification test was applied to determine olfactory function. Muscle strength was determined through a handgrip dynamometer (defined as the sum of the largest handgrip strength reading from right and left hands). Moderation analysis was performed to test whether the association between age and olfactory impairment was moderated by handgrip strength. Moderation analysis highlighted two regions of significance: the first region was found at < 56.6 kg, indicating that the adverse influence of age on olfactory function may be greater for the participants in this area; the second region was found at ≥ 56.6 kg, indicating that the negative impact of age on olfactory function disappeared for adults who were above this estimate point. In conclusion, handgrip strength, a general indicator of muscle strength, moderates the relationship between age and olfactory ability in a US adult population aged 40 years and older. Our findings are clinically relevant, since they emphasize the importance of muscular fitness in adulthood and old age by diminishing the deleterious effect of aging on olfactory performance.

Office Procedures for Quantitative Assessment of Olfactory Function

2007 ◽  
Vol 21 (4) ◽  
pp. 460-473 ◽  
Author(s):  
Richard L. Doty
Keyword(s):  
Sensory System ◽  
Complete Recovery ◽  
Olfactory Function ◽  
Airway Patency ◽  
Medical Interventions ◽  
Olfactory Loss ◽  
Electrophysiological Tests ◽  
Olfactory Testing ◽  
Nasal Disease ◽  
Psychophysical Tests

Background Despite the importance of the sense of smell for establishing the flavor of foods and beverages, as well as protecting against environmental dangers, this primary sensory system is commonly ignored by the rhinologist. Methods In this article basic issues related to practical measurement of olfactory function in the clinic are described and examples of the application of the two most common paradigms for such measurement—odor identification and detection–are presented. A listing is made of the 27 olfactory tests currently used clinically, along with their strengths and weaknesses. A brief review of common nasosinus-related disorders for which quantitative olfactory testing has been performed is provided. Results Although many psychophysical tests are available for quantifying olfactory loss, it is apparent that a number are limited in terms of practicality, sensitivity, and reliability. In general, sensitivity and reliability are positively correlated with test length. Given the strengths of the more reliable forced-choice pyschophysical tests and the limitations of electrophysiological tests, the common distinction between “subjective” and “objective” tests is misleading and should not be used. Complete recovery of olfactory function, as measured quantitatively, rarely follows surgical or medical interventions in patients with rhinosinusitis. Conclusion Given the availability of practical clinical olfactory tests, the modern rhinologist can easily quantify cranial nerve (CN) I function. The application of such tests has led to a new understanding of the effects of nasal disease on olfactory function. Except in cases of total or near-total nasal obstruction, olfactory and airway patency measures usually are unrelated, in accord with the concept that rhinosinusitis primarily influences olfactory function by apoptotic pathological changes within the olfactory neuroepithelium.

scholarly journals Beyond olfactory cortex – severity of post-traumatic olfactory loss is associated with response to odors in frontal-parietal-insular networks

2020 ◽  
Author(s):  
Robert Pellegrino ◽  
Michael C. Farruggia ◽  
Dana M. Small ◽  
Maria G. Veldhuizen
Keyword(s):  
Piriform Cortex ◽  
Posterior Cingulate Cortex ◽  
Olfactory Cortex ◽  
Olfactory Function ◽  
Neural Responses ◽  
Brain Response ◽  
Olfactory Loss ◽  
Post Traumatic ◽  
Olfactory Impairment ◽  
Cortical Regions

Olfactory impairment after trauma is associated with changes in olfactory cortex, including decreased gray matter density and decreased response to odors. Much less is known about the role of other cortical areas in olfactory impairment. We used fMRI in a sample of 63 participants, consisting of 25 with post-traumatic functional anosmia, 16 with post-traumatic hyposmia, and 22 healthy controls with normosmia to investigate whole brain response to odors. Similar neural responses were observed across the groups to odor versus odorless stimuli in the primary olfactory areas in piriform cortex, whereas response in the frontal operculum and anterior insula (fO/al) increased with olfactory function (normosmia > hyposmia > functional anosmia). Unexpectedly, a negative association was observed between response and olfactory function in the mediodorsal thalamus (mdT), ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (pCC). Finally, connectivity within a network consisting of vmPFC, fO, and pCC could be used to successfully classify participants as having functional anosmia or normosmia. We conclude that, at the neural level, olfactory impairment due to head trauma is best characterized by heightened responses and differential connectivity in higher-order areas beyond olfactory cortex.Significance StatementOlfactory impairment affects a quarter of the population, with subjective complaints usually confirmed with psychophysical measurements. Here, we demonstrate that the degree of olfactory impairment can also be categorized using neural responses to odors. Remarkably, regions with neural responses that were predictive usually showed an increase in response to odors with degree of impairment, rather than a reduction, as might be expected. Further, predictive cortical regions were not isolated to canonical olfactory areas.

scholarly journals WHAT ABOUT USING SNIFFIN STICKS 12 SCREENING TEST TO IDENTIFY POST-COVID-19 OLFACTORY DISORDERS?

2021 ◽  
Author(s):  
Clair VANDERSTEEN ◽  
Magali PAYNE ◽  
Louise Emilie DUMAS ◽  
Alexandra PLONKA ◽  
Gregoire D'ANDREA ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Negative Impact ◽  
Life Quality ◽  
Daily Clinical Practice ◽  
The Self ◽  
Analog Scale ◽  
Self Assessment ◽  
Sugar Intake ◽  
Olfactory Loss ◽  
Olfactory Impairment

Background: Olfactory impairment is a major sequela of SARS CoV 2 infection and has a negative impact on daily life quality. Olfactory loss can be assessed in many ways but seems to be little realized in a daily clinical practice. The sniffin Sticks test12 items (SST12) can be used in quick olfactory disorders screening. Its use in a post-covid19 situation was the main objective of this work. Methodology: Consecutive patients consulting to the ENT department with post-Covid-19 olfactory loss were included. The clinical examination included an analog scale for the self-assessment of olfactory recovery (VAS), self-reported salt and sugar intake, a nasofibroscopy, the complete Sniffin Stick Test (SST) and the SST12. Results: Among the 54 patients included, based on the SST12, 14,8% (n=8) of the patients could be classified as normosmic (SST12≥11), 48,1% (n=26) as hyposmic (6< SST12<10) and 37% (n=20) as functional anosmic (SST12≤6). We report excellent and significant correlations between SST12 and SST or VAS assessments. Salt and Sugar increased intake seems significantly related to SST12 results. Conclusions: SST12 is a reliable way to screen post COVID 19 olfactory disorders could be used in a daily clinical practice and might be used to prevent bad diet habits and so cardiovascular risk.

Sign in / Sign up

Export Citation Format

Share Document