Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020

Background/aimsTo assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint Committee on Cancer (AJCC) 8 classification system.MethodsWe evaluated data of 117 patients with histologically proven eyelid SCC at a large tertiary German university centre between January 2009 and March 2020. This retrospective, monocentric analysis included descriptive statistics and non-parametric tests (p<0.05).ResultsHistologically controlled excision and follow-up was performed in 88 (75.2%) patients. In the remaining patients with higher T-category, individual adjuvant therapy combinations were initiated. We found higher numbers of nodal metastasis and recurrence for male patients and higher T-category (p=0.035, p=0.008 and p=0.001, p<0.001). Recurrence rates proved higher for patients with multiple lesions (p=0.008). Disease-specific survival (DSS) was 95.7% at 2 and 94.9% at 5 years of follow-up. Six patients (5.1%) died from eyelid SCC with nodal metastasis and higher T-category being negative prognostic factors (p<0.001 and p=0.009). Mortality was associated with tumour location in the medial upper eyelid, nodal metastasis being more frequent (p=0.001 and p=0.009) and tumour of the lower eyelid alone as positive predictor (p=0.012). T category differed in 34 (29.1%) patients when comparing AJCC 7 and 8 (p<0.001). Changes in T category as per the AJCC 8 classification resulted in better prediction of DSS (p=0.024).ConclusionSpecial attention should be paid to male patients, tumour location in the upper medial eyelid and lymph node diagnostics. Prediction of DSS proved superior as per the AJCC 8 staging system.

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Preoperative combined cisplatin-based chemotherapy and radiotherapy for squamous cell carcinoma of the oral cavity—evaluation of more than 5-year follow up cases

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0901-5027(97)81222-2 ◽

1997 ◽

Vol 26 ◽

pp. 126

Author(s):

H. Shimooka ◽

T. Kirita ◽

N. Kamikaidou ◽

K. Yamamoto ◽

K. Ohgi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell

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Oral findings during follow-up of nasopharyngeal squamous cell carcinoma treatment: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x211033037 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110330

Author(s):

Atsushi Musha ◽

Nobuteru Kubo ◽

Naoko Okano ◽

Hidemasa Kawamura ◽

Yuhei Miyasaka ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Concurrent Chemoradiotherapy ◽

Nasopharyngeal Cancer ◽

Inflammatory Conditions ◽

Positron Emission ◽

History Of ◽

Oral Area

A 50-year-old woman with a long history of nasopharyngeal cancer (T2N2M0, squamous cell carcinoma) underwent chemoradiotherapy and surgery. In the past, to prevent tumor recurrence or metastasis, she underwent concurrent chemoradiotherapy or neck dissection. However, during a follow-up 10 years after the surgery, intense F-18 fluorodeoxyglucose uptake was detected in the oral area (SUVmax 6.0). A biopsy of the area with F-18 fluorodeoxyglucose uptake revealed pathological inflammation. Radiography showed the presence of a wisdom tooth, located at the F-18 fluorodeoxyglucose accumulation site, and pericoronitis of this tooth was detected. Our findings indicate the importance of considering the effect of inflammatory conditions, such as periodontal disease, in using F-18 fluorodeoxyglucose positron emission tomography/computed tomography during follow-up after head and neck cancer treatment.

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Squamous cell carcinoma of the scrotum in HIV: two case reports

African Journal of Urology ◽

10.1186/s12301-021-00177-3 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Jeff John ◽

Ken Kesner ◽

John Lazarus

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Case Reports ◽

Treatment Options ◽

Punch Biopsy ◽

Delayed Treatment ◽

Clinical Presentations ◽

T1 N0 M0

Abstract Background Squamous cell carcinoma (SCC) of the scrotum was the first malignancy known to be associated with exposure to an occupational carcinogen—in this case, soot trapped in the breeches of chimney sweeps. Better civil rules and regulations and the replacement of hearths with other forms of heating have rendered SCC of the scrotum a rarity. We report two cases of scrotal SCC with vastly differing clinical presentations and management. Case presentation Case 1 had T1 N0 M0 disease and presented with a small (< 2 cm), innocuous-looking, non-healing ulcer of eight years duration. A punch biopsy revealed a superficially invasive SCC confirmed on immunohistochemical profiling. A wide local excision of the lesion was subsequently performed. Follow-up at three years showed no signs of recurrence. Case 2 presented with T4 N1 M1 disease and rapidly progressing locally destructive mass. A punch biopsy of the scrotal lesion confirmed invasive moderately differentiated focally keratinising SCC. The metastatic evaluation confirmed the presence of metastatic, extensive para-aortic lymphadenopathy. He was managed with cisplatin-based chemoradiotherapy. Conclusion Early detection and management of patients with SCC of the scrotum are essential. If the diagnosis is delayed, treatment options become limited, and the prognosis is poor. Notwithstanding the rarity of this disease, multicentre trials are needed to provide more precise guidelines as to the optimal management of these patients.

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P-113 Oncological Outcomes and Prognostication in Cutaneous Squamous Cell Carcinoma of the Head and Neck with Nodal Metastasis

Oral Oncology ◽

10.1016/s1368-8375(21)00400-0 ◽

2021 ◽

Vol 118 ◽

pp. 1

Author(s):

Mark D. Wilkie ◽

Dorota Chudek ◽

Sankalap Tandon ◽

Christopher Loh ◽

Nicholas J. Roland ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Nodal Metastasis ◽

Cutaneous Squamous Cell Carcinoma ◽

Oncological Outcomes

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Effect of coronavirus disease 2019 on recurrences and follow up of head and neck squamous cell carcinoma

The Journal of Laryngology & Otology ◽

10.1017/s0022215121000918 ◽

2021 ◽

pp. 1-4

Author(s):

E Kytö ◽

E Haapio ◽

I Kinnunen ◽

H Irjala

Keyword(s):

Squamous Cell Carcinoma ◽

Prospective Study ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma ◽

One Year ◽

Diagnostic Delays

Abstract Objective This prospective study aimed to evaluate possible diagnostic delays in head and neck squamous cell carcinoma recurrences due to the changed follow-up protocol during the coronavirus disease 2019 pandemic. Methods The follow-up appointments of head and neck squamous cell carcinoma patients treated more than one year prior to the pandemic were changed to telephone appointments in order to reduce physical visits to the hospital. All contacts, reasons for contact and recurrent cancers were recorded. Results There were 17 recurrences during a seven-month study period among 178 patients treated in the previous year (10 per cent); 14 of these recurrences occurred in patients whose treatment had ended less than one year previously and 3 occurred more than one year after treatment had ended. There was no delay in diagnoses of recurrent tumours or treatment despite reduced visits because of the coronavirus disease 2019 pandemic. Conclusion According to our analyses, no delay was caused in the diagnoses of recurrent diseases. Follow up by telephone or telemedicine can be considered as part of the follow-up protocol one year after the treatment of head and neck squamous cell carcinoma when necessary.

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Squamous dysplasia is the histologic precursor of invasive esophageal squamous cell carcinoma: results from a 13-year prospective follow-up study in a high-risk population

Gastroenterology ◽

10.1016/s0016-5085(03)81500-7 ◽

2003 ◽

Vol 124 (4) ◽

pp. A297-A298

Author(s):

Guo-Qing Wang ◽

Christian C. Abnet ◽

Fu-Sheng Liu ◽

Klaus J. Lewin ◽

Xiu-Di Sun ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

High Risk ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

High Risk Population ◽

Risk Population ◽

Follow Up Study

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P-47 Head and neck squamous cell carcinoma: a stratified follow-up program

Oral Oncology ◽

10.1016/s1368-8375(21)00335-3 ◽

2021 ◽

Vol 118 ◽

pp. 5

Author(s):

Francesca de Felice ◽

Mary Lei ◽

Richard Oakley ◽

Andrew Lyons ◽

Alastair Fry ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Neck Squamous Cell Carcinoma

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Squamous Cell Carcinoma of the External Ear: A Review of 75 Cases

Otolaryngology ◽

10.1177/019459988709700310 ◽

1987 ◽

Vol 97 (3) ◽

pp. 308-312 ◽

Cited By ~ 30

Author(s):

William W. Shockley ◽

Fred J. Stucker

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cancer Control ◽

Surgical Excision ◽

External Ear ◽

Common Cancer ◽

Node Metastases

Squamous cell carcinoma of the external ear can be a potentially lethal lesion. Although it is the most common cancer involving the pinna, the variables that have the greatest impact on prognosis are still in question. We reviewed 75 cases of squamous cell carcinoma of the external ear to determine patterns of occurrence and treatment failure. Forty patients had adequate follow-up for determination of cancer control rates. Local control was successful with initial treatment in 85% of the cases. The incidence of lymph node metastases was 10%, whereas distant metastasis occurred in only one patient (2.5%). This series differs from others in that most patients were unselected and most of the lesions treated were early (less than 1 cm). The significance of positive margins after surgical excision is also analyzed.

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