scholarly journals Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study

BMJ Open ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. e005413 ◽  
Author(s):  
Takuya Fukuda ◽  
Masahide Hamaguchi ◽  
Takao Kojima ◽  
Yasuhiro Ohshima ◽  
Akihiro Ohbora ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Health Check ◽  
Sectional Study ◽  
Abdominal Ultrasonography ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women ◽  
Menopausal State

ObjectiveThe purpose of this study was to determine the relationship between serum γ-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.DesignA cross-sectional study.SettingA health check-up centre in Japan.Participants912 Japanese men and women aged 24–84 years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV.Main outcome measuresWe measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1 year after the cessation of menses.ResultsIn women, log2 GGT was positively associated with baPWV (β=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log2 GGT with baPWV was not significant (β=−0.04, 95% CI −0.10 to 0.03, p=0.28) in multivariable linear regression analyses.ConclusionsThe serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.

scholarly journals Heart rate variability and blood pressure among Japanese men and women: a community-based cross-sectional study

2014 ◽  
Vol 37 (8) ◽  
pp. 779-784 ◽  
Author(s):  
Hiromi Mori ◽  
Isao Saito ◽  
Eri Eguchi ◽  
Koutatsu Maruyama ◽  
Tadahiro Kato ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women

Risk factors for snoring among Japanese men and women: a community-based cross-sectional study

2009 ◽  
Vol 15 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Mako Nagayoshi ◽  
◽  
Kazumasa Yamagishi ◽  
Takeshi Tanigawa ◽  
Susumu Sakurai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women

scholarly journals Perceived Stress and Coping Strategies in Relation to Body Mass Index: Cross-Sectional Study of 12,045 Japanese Men and Women

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0118105 ◽  
Author(s):  
Chisato Shimanoe ◽  
Megumi Hara ◽  
Yuichiro Nishida ◽  
Hinako Nanri ◽  
Yasuko Otsuka ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Coping Strategies ◽  
Perceived Stress ◽  
Cross Sectional Study ◽  
Stress And Coping ◽  
Sectional Study ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women ◽  
And Coping

scholarly journals CD36 Polymorphism (rs1761667) Was Associated with Fatty Liver in a Japanese Population

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1253-1253
Author(s):  
Ryosuke Fujii ◽  
Naohiro Ichino ◽  
Keisuke Osakabe ◽  
Keiko Sugimoto ◽  
Hiroya Yamada ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Japanese Population ◽  
Clinical Information ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Health Check ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cd36 Gene

Abstract Objectives Nonalcohol fatty liver disease (NAFLD) is one of the considerable health problems in the world. NAFLD is a representative phenotype in the liver reflecting individual's lifestyle. Previous studies suggested that a single nucleotide polymorphism (SNP) in the CD36 gene was associated with dietary fat intake and fat metabolism. Therefore, we hypothesized that this SNP may be associated with fatty liver (FL) and NAFLD. We conducted this cross-sectional study to examine the association between two CD36 polymorphisms (rs1761667 and rs1527483) and FL and NAFLD in a Japanese population. Methods A total of 525 local residents participated in the health check-up in Yakumo town, Hokkaido, Japan. This cross-sectional study was conducted based on clinical information collected in this health check-up. Among all participants, 57 people were excluded due to the inadequate informed consent, clinical history of liver disease. Genotyping of two polymorphisms in the CD36 gpgbrkkene was performed by using the PCR-CTPP method. Ultrasound examination was performed by four qualified ultrasonographers. In this present, NAFLD was defined as 1) presence of FL and 2) a daily alcohol consumption &lt;10 g in women and &lt;20 g in men. Multivariable regression analysis was performed after adjusting for age, sex, waist circumference, medicine for dyslipidemia. Results The mean age of participants was 63.4 (10.0). The minor allele frequency of rs1761667 and rs1527483 was 0.26 and 0.21, respectively. The presence of FL and NAFLD was 90 (19.2%) and 67 (14.3%), respectively. Multiple regression analyses showed a significant association between rs1761667 and presence of FL (P = 0.04), and FL grade (P = 0.03). However, rs1761667 was not significantly associated with NAFLD (P = 0.11). No significant associations were found between rs1527483 and FL and NAFLD. Conclusions A polymorphism (rs1761667) in the CD36 gene was associated with the presence of FL, but we did not find a significant association between this SNP and NAFLD. Funding Sources This study was supported by the Mishima Kaiun Memorial Foundation.

scholarly journals Association between number of teeth present and mandibular cortical erosion in Japanese men and women aged 40 years and older: A cross-sectional study

2016 ◽  
Vol 2 (4) ◽  
pp. 250-255
Author(s):  
Mizuna Takahashi ◽  
Keiichi Uchida ◽  
Shinichiro Yamada ◽  
Noriyuki Sugino ◽  
Yukihito Higashi ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Japanese Men ◽  
Men And Women ◽  
Number Of Teeth ◽  
Cortical Erosion

scholarly journals Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Kenichi Nobusue ◽  
Hirotomo Yamanashi ◽  
Yasuhiro Nagata ◽  
...  
Keyword(s):  
Handgrip Strength ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Japanese Men ◽  
Vascular Homeostasis ◽  
Endothelial Repair ◽  
High Level

Abstract Background A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the association between handgrip strength and hypertension. Methods A cross-sectional study was conducted with 257 Japanese men aged 60–69 years who underwent an annual health checkup. As individuals with high level of circulating CD34-positive cells might show active endothelial repair, which plays an important role in vascular homeostasis, participants were stratified by circulating CD34-positive cell levels, using the median value of this population (0.96 cells/μL) as the cutoff. Results Independent of known cardiovascular risk factors, for participants with a high CD34-positive cell, handgrip strength is significantly positively associated with hypertension (odds ratio and 95% confidence interval of hypertension for 1 standard deviation increment of handgrip strength were 1.85 (1.19, 2.88) but not for participants with a low CD34-positive cell (0.91 (0.61, 1.37)). Conclusion The positive association between handgrip strength and hypertension is limited to high CD34-positive cells. This result may help clarify the role of vascular homeostasis in maintaining muscle strength.

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