scholarly journals Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu’s arteritis: a case-control study

BMJ Open ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. e014451 ◽  
Author(s):  
Lili Pan ◽  
Juan Du ◽  
Taotao Li ◽  
Hua Liao
Keyword(s):  
Disease Activity ◽  
Case Control Study ◽  
Takayasu’S Arteritis ◽  
Case Control ◽  
Neutrophil To Lymphocyte Ratio ◽  
Takayasu's Arteritis ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Control Study

scholarly journals High prevalence of chronic fatigue syndrome in patients with Takayasu's arteritis: A case-control study

2021 ◽  
Author(s):  
Alexandre Moura dos Santos ◽  
Rafael Giovani Misse ◽  
Ana Woo SooK Kim ◽  
Aline Marques Caetano ◽  
Isabela Bruna Pires Borges ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Case Control Study ◽  
Takayasu’S Arteritis ◽  
Chronic Fatigue ◽  
Case Control ◽  
Takayasu's Arteritis ◽  
Fatigue Syndrome ◽  
High Prevalence ◽  
Control Study

scholarly journals Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1308
Author(s):  
Pei Yi Lee ◽  
Kellynn Qi Xuan Oen ◽  
Grace Rui Si Lim ◽  
Juanda Leo Hartono ◽  
Mark Muthiah ◽  
...  
Keyword(s):  
Adverse Events ◽  
Cancer Patients ◽  
Immune Checkpoint ◽  
Case Control Study ◽  
Cox Regression ◽  
Case Control ◽  
Adverse Outcomes ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Control Study

The utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) utility in predicting immune-related adverse events (irAEs) and survival have not been well studied in the context of treatment with immune checkpoint inhibitors (ICIs). We performed a case-control study of cancer patients who received at least one dose of ICI in a tertiary hospital. We examined NLR and PLR in irAE cases and controls. Logistic and Cox regression models were used to identify independent risk factors for irAEs, progression-free survival (PFS), and overall survival (OS). The study included 91 patients with irAEs and 56 controls. Multiple logistic regression showed that NLR < 3 at baseline was associated with higher occurrence of irAEs. Multivariate Cox regression showed that development of irAEs and reduction in NLR from baseline to week 6 were associated with longer PFS. Higher NLR values at baseline and/or week 6 were independently associated with shorter OS. A reduction in NLR from baseline to week 6 was associated with longer OS. In this study of cancer patients treated with ICIs, NLR has a bidirectional relationship with adverse outcomes. Lower NLR was associated with increased occurrence of irAEs while higher NLR values were associated with worse clinical outcomes.

scholarly journals MONOCYTE TO LYMPHOCYTE RATIO AND PLATELET TO LYMPHOCYTE RATIO AS A PREDICTOR OF DISEASE ACTIVITY IN TAKAYASU’S ARTERITIS

2019 ◽  
Author(s):  
RENAN RODRIGUES NEVES RIBEIRO DO NASCIMENTO ◽  
DANIEL VIANA SILVA E SILVA ◽  
RAQUEL MITIE KANNO ◽  
LUIZA SÁ E RÊGO TUPINAMBÁ ◽  
MARIANA DAVIM FERREIRA GOMES ◽  
...  
Keyword(s):  
Disease Activity ◽  
Takayasu’S Arteritis ◽  
Takayasu's Arteritis ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Risk Factors for Venous Thrombosis

2017 ◽  
Vol 24 (5) ◽  
pp. 808-814 ◽  
Author(s):  
Andrea Artoni ◽  
Maria Abbattista ◽  
Paolo Bucciarelli ◽  
Francesca Gianniello ◽  
Erica Scalambrino ◽  
...  
Keyword(s):  
Case Control Study ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cerebral Vein ◽  
Healthy Individuals ◽  
Platelet To Lymphocyte Ratio ◽  
Cerebral Vein Thrombosis ◽  
Lymphocyte Ratio ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Control Study

High platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) are associated with an increased risk of arterial thrombosis, but their role in venous thromboembolism (VTE) has not been fully investigated. A case–control study, of 486 patients with VTE, 100 with cerebral vein thrombosis (CVT), and 299 healthy individuals, was carried out to investigate whether high PLR or NLR values are associated with an increased risk of VTE. Patients with high PLR or NLR did not have an increased risk of VTE (odds ratio [OR] 0.89, 95% confidence interval [CI]: 0.46-1.76; OR: 0.69, 95% CI: 0.34-1.39, respectively) or CVT (OR: 1.65, 95% CI: 0.68-4.00; OR: 0.39, 95% CI: 0.09-1.72, respectively). Subgroups analysis showed that high PLR values were associated with the risk of provoked CVT (OR: 2.65, 95% CI: 1.02-6.92), and there was an interaction with thrombophilia abnormalities (OR: 7.67, 95% CI: 1.67-35.27) in patients with CVT. In conclusion, high PLR and NLR values are not associated with an overall increased risk of VTE or CVT. High PLR values increase the risk of provoked CVT and interact with thrombophilia abnormalities in patients with CVT.

scholarly journals Recompensation factors for patients with decompensated cirrhosis: a multicentre retrospective case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e043083
Author(s):  
Xiaomei Xu ◽  
Haolin Wang ◽  
Wenlong Zhao ◽  
Yong Wang ◽  
Jiayue Wang ◽  
...  
Keyword(s):  
Decision Tree ◽  
Total Protein ◽  
Alanine Aminotransferase ◽  
Case Control Study ◽  
Case Control ◽  
Neutrophil To Lymphocyte Ratio ◽  
Decompensated Cirrhosis ◽  
Retrospective Case ◽  
Lymphocyte Ratio ◽  
Control Study

ObjectivesWe aimed to evaluate recompensation factors among patients with decompensated cirrhosis.DesignA multicentre retrospective case–control study was conducted. Data were collected from and compared between groups of patients with recompensated and acute decompensated cirrhosis. Univariable and multivariable logistic regressions were used to select indicators associated with recompensation among patients with decompensated cirrhosis with different complications. A decision tree with 10-fold cross-validation was used to develop the model to identify patients with recompensation. We followed the transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) guideline for development and reporting of the new model.SettingThe study was conducted in six tertiary public hospitals in Chongqing, China.ParticipantsThis study included 3953 patients with decompensated cirrhosis.ResultsIn the total sample of included patients, there were 553 patients with recompensation and 3400 patients with acute decompensation, including 1158 patients with gastrointestinal bleeding, 1715 patients with a bacterial infection, 104 patients with hepatic encephalopathy and 423 patients with ascites. The most relevant indicator of recompensation selected by the decision tree model was albumin, with a threshold of 40 g/L. Total protein, haemoglobin, basophil percentage, alanine aminotransferase, neutrophil-to-lymphocyte ratio and diabetes were also selected to subsequently distinguish patients. The terminal nodes with a probability of recompensation was 0.89. The overall accuracy rate of the model was 0.92 (0.91–0.93), and it exhibited high specificity (86.9%) and sensitivity (92.6%).ConclusionsThe occurrence of recompensated cirrhosis could be identified by albumin, total protein, haemoglobin, basophil percentage, alanine aminotransferase, neutrophil-to-lymphocyte ratio and diabetes. These simple variables may help clinicians develop a treatment plan to encourage patients with decompensated cirrhosis to recompensate.

scholarly journals The neutrophil to lymphocyte ratio is an independent predictor for severe COVID-19

2021 ◽  
Author(s):  
Jiangli Cheng ◽  
Aijia Ma ◽  
Jing Yang ◽  
Meiling Dong ◽  
Xuelian Liao ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Case Control Study ◽  
Independent Predictor ◽  
Meta Analysis ◽  
Case Control ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Severe Group ◽  
Meta Analyses ◽  
Control Study

Summary Purpose The aim of this study was to determine whether the neutrophil to lymphocyte ratio (NLR) can predict severe Coronavirus disease 2019 (COVID-19). Patients and methods A multicenter case-control study was conducted to investigate whether the NLR can help predict the severity of COVID-19. Patients confirmed to have COVID-19 between 16 January 2020 and 15 March 2020 were enrolled. Furthermore, meta-analyses were conducted based on both previous studies and our case-control study. Results In the case-control study, 213 patients (severe: 81) were included. The results suggested that the NLR was an independent risk factor (odds ratio [OR], 1.155, 95% confidence interval [95% CI]: 1.043–1.279, P = 0.006) and a great predictor (the area under the ROC curve was 0.728, 95% CI: 0.656–0.800) for severe COVID-19. In total, 18 datasets from 16 studies combined with our case-control study (severe: 1211; non-severe: 5838) were included in the meta-analyses and the results showed that the NLR of the severe COVID-19 group was significantly higher than that of the non-severe group (SMD = 1.10, 95% CI: 0.90–1.31, P < 0.001). Based on the 2 × 2 data from 6 studies, the SROC of NLR for predicting severe COVID-19 was 0.802, with a sensitivity of 0.67 (95% CI: 0.61–0.72) and a specificity of 0.75 (95% CI: 0.73–0.78). Conclusion Based on a multicenter case-control study and a meta-analysis, we found that the initial NLR was a great predictor of severe COVID-19.

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