Azithromycin as an add-on treatment for persistent uncontrolled asthma in adults: protocol of a systematic review and meta-analysis

IntroductionClinical management of asthma remains a public challenge. Despite standard treatment with inhaled corticosteroids (ICS) and long-acting beta-agonists (LABAs), asthma remains uncontrolled in a substantial number of chronic asthma patients who risk reduced lung function and severe exacerbations. Azithromycin could have add-on effects for these patients. This study is proposed to systematically evaluate the efficacy of azithromycin as an add-on treatment for adults with persistent uncontrolled symptomatic asthma.Methods and analysisTwo reviewers will perform a comprehensive search of PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and four Chinese electronic databases including China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), WanFang Data and VIP Database from inception to May 2019. Only randomised controlled trials will be included. There is no restriction on language or publication status. Combined oral azithromycin and an ICS or/and a LABA will be compared with standard treatment alone or with a placebo. The primary outcomes are the number or frequency of asthma exacerbations, changes in asthma symptoms and lung function. Secondary outcomes include the number or frequency of inhalations of beta-agonists with or without corticosteroids for rescue use, eosinophil counts in blood or sputum, adverse events and others. A meta-analysis will be attempted to provide an estimate of the pooled treatment effect. Otherwise, qualitative descriptions of individual studies will be given.Ethics and disseminationEthical approval is not required because no primary data will be collected. Study findings will be presented at scientific conferences or published in a peer-reviewed journal.PROSPERO registration numberCRD42019117272.

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Acupuncture for migraine: a protocol for a meta-analysis and meta-regression of randomised controlled trials

BMJ Open ◽

10.1136/bmjopen-2018-022998 ◽

2018 ◽

Vol 8 (11) ◽

pp. e022998 ◽

Cited By ~ 4

Author(s):

Zishan Gao ◽

Carlo Maria Giovanardi ◽

Hongxiao Li ◽

Chen Hao ◽

Qian Li ◽

...

Keyword(s):

Data Extraction ◽

Meta Analysis ◽

Specific Effect ◽

Episodic Migraine ◽

Biomedical Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Meta Regression ◽

Randomised Controlled

IntroductionAlthough the effectiveness of acupuncture for episodic migraine has been confirmed by multiple clinical trials and Cochrane systematic reviews, the mechanisms underlying the specific effect of acupuncture for migraine remain controversial. We aim to evaluate the effectiveness and safety of acupuncture for both episodic migraine and chronic migraine by meta-analysis and explore the possible factors influencing the specific effect of acupuncture for migraine by meta-regression.Methods and analysisWe will search for randomised control trials of acupuncture for migraine in the following eight databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, AMED (via OVID) and four Chinese databases (Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database and Wanfang Database) from inception to 31 December 2017. We will also search OpenSIGLE (opensigle.inist.fr) for conference abstracts. No language restriction will be applied. The selection of studies, data extraction and coding and assessment of risk of bias of the included studies will be conducted independently by two reviewers. Standard meta-analysis and, if appropriate, meta-regression will be performed using the R packages Meta and Metafor.Ethics and disseminationThe results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The data used in this meta-analysis will not contain individual patient data; therefore, ethical approval is not required.PROSPERO registration numberCRD42018087270.

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Protocol for a systematic review and meta-analysis of respiratory rehabilitation following intensive care unit discharge for COVID-19 survivors

BMJ Open ◽

10.1136/bmjopen-2020-041184 ◽

2020 ◽

Vol 10 (12) ◽

pp. e041184

Author(s):

Dan Wang ◽

Jin Li ◽

Feilong Zhu ◽

Qianqin Hong ◽

Ming Zhang ◽

...

Keyword(s):

Systematic Review ◽

Intensive Care Unit ◽

Intensive Care ◽

Meta Analysis ◽

Biomedical Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

The Impact ◽

Respiratory Rehabilitation

IntroductionBoth physical and mental disorders may be exacerbated in patients with COVID-19 due to the experience of receiving intensive care; undergoing prolonged mechanical ventilation, sedation, proning and paralysis. Pulmonary rehabilitation is aimed to improve dyspnoea, relieve anxiety and depression, reduce the incidence of related complications, as well as prevent and improve dysfunction. However, the impact of respiratory rehabilitation on discharged patients with COVID-19 is currently unclear, especially on patients who have been mechanically ventilated over 24 hours. Therefore, we aim to investigate the efficacy of respiratory rehabilitation programmes, initiated after discharge from the intensive care unit, on the physical and mental health and health-related quality of life in critical patients with COVID-19.Methods and analysisWe have registered the protocol on PROSPERO and in the process of drafting it, we strictly followed the checklist of Preferred Reporting Items for Systematic Review and Meta-Analysis Potocols. We will search the PubMed, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, WanFang, VIP information databases and Chinese Biomedical Literature Database. Additionally, ongoing trials in the WHO International Clinical Trials Registry Platform, ClinicalTrials.gov and ISRCTN registry will be searched as well. Studies in English or Chinese and from any country will be accepted regardless of study design. Two review authors will independently extract data and assess the quality of included studies. Continuous data are described as standard mean differences (SMDs) with 95% CIs. Dichotomous data from randomised controlled trials are described as risk ratio(RR) with 95% CIs; otherwise, it is described as odds ratio(OR) with 95% CIs. I2 and the Cochrane’s Q statistic will be used to conduct heterogeneity assessment. The quality of evidence of main outcomes will be evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation(GRADE) criteria. When included studies are sufficient, we will conduct subgroup analysis and sensitivity analysis; the publication bias will be statistically analysed using a funnel plot analysis and Egger’s test.Ethics and disseminationOur review, planning to include published studies, does not need the request to the ethical committee. The final results of this review will be published in a peer-reviewed journal after completion.Patient and public involvementNo patient involved.PROSPERO registration numberCRD42020186791.

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Acupuncture for patients with vascular dementia: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2017-019066 ◽

2017 ◽

Vol 7 (12) ◽

pp. e019066 ◽

Cited By ~ 1

Author(s):

Yang Ye ◽

Ling-Yong Xiao ◽

Yi-Hua Liu ◽

Jing-Wen Yang ◽

Chao-Qun Yan ◽

...

Keyword(s):

Systematic Review ◽

Vascular Dementia ◽

Data Extraction ◽

Evaluation Study ◽

Biomedical Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

Systematic Review Protocol ◽

China National Knowledge Infrastructure ◽

Review Protocol

IntroductionThis systematic review protocol aims to provide the methods used to evaluate the effectiveness and safety of acupuncture therapy for treating vascular dementia.Methods and analysisThe following eight databases will be searched from inception to July 2017: Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database. All randomised controlled trials in English or Chinese related to acupuncture for vascular dementia will be included. Outcomes will include change in cognitive function and activities of daily living. The incidence of adverse events will be assessed for safety evaluation. Study inclusion, data extraction and quality assessment will be performed independently by two reviewers. Assessment of risk of bias and data synthesis will be performed using Review Manager software.Ethics and disseminationEthics approval is not required because individual patient data are not included. The findings of this systematic review will be disseminated through peer-reviewed publication or conference presentations.PROSPERO registration numberCRD42017071820.

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TaiChi and Qigong for Depressive Symptoms in Patients with Chronic Heart Failure: A Systematic Review with Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/5585239 ◽

2021 ◽

Vol 2021 ◽

pp. 1-12

Author(s):

Wei Jiang ◽

Shaojun Liao ◽

Xiankun Chen ◽

Cecilia Stålsby Lundborg ◽

Gaetano Marrone ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Depressive Symptoms ◽

Meta Analysis ◽

Controlled Trials ◽

Therapeutic Effects ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Beneficial Effects ◽

Meta Analyses

Background. Depression is a debilitating comorbidity of heart failure (HF) that needs assessment and management. Along with mind-body exercise to deal with HF with depression, the use of TaiChi and/or Qigong practices (TQPs) has increased. Therefore, this systematic review assesses the effects of TQPs on depression among patients with HF. Methods. Randomized controlled trials (RCTs) that examined the effect of TQPs on depression in patients with HF were searched by five databases (PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, CINAHL, and China National Knowledge Infrastructure (CNKI)). With standardized mean difference (SMD) and 95% confidence intervals (95% CI), random-effects meta-analyses of the effect of TQPs on depressive symptoms were performed. Results. Of eight included RCTs, seven (481 patients) provided data for the meta-analysis. The pooling revealed that TQPs contribute to depression remission in HF (SMD −0.66; 95% CI −0.98 to −0.33, P < 0.0001 ; I2 = 64%). Its antidepressive effect was not influenced by intervention duration or exercise setting, but rather by ejection fraction subtype, depressive severity, and depression instruments. The beneficial effects were preserved when the study with the largest effect was removed. Conclusion. This study suggests that TQPs might be a good strategy for alleviating depressive symptoms in patients with HF. And rigorous-design RCTs, which focus on the identified research gaps, are needed to further establish the therapeutic effects of TQPs for depression in HF.

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Which Cognitive Behavioral Therapy Formats Work for Depression in Dementia Family Caregivers ?

Innovation in Aging ◽

10.1093/geroni/igab046.2465 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 656-656

Author(s):

Yue Sun ◽

Zhi-wen Wang

Keyword(s):

Cognitive Behavioral Therapy ◽

Behavioral Therapy ◽

Meta Analysis ◽

Cognitive Intervention ◽

Biomedical Literature ◽

Cognitive Behavioral ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Self Help ◽

Delivery Formats

Abstract Cognitive behavioral therapy (CBT) has been shown to be effective to delay cognitive decline for family dementia caregivers (DCs). However, whether cognitive intervention could effectively reduce depression through internet, group, telephone, individual, unguided self-help and combined formats remains unclear. Pubmed, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Central Register of Controlled Trials, Web of science, China National Knowledge Infrastructure database, Chinese Biomedical Literature database and Wan Fang database were systematically searched. A total of 34 studies were included in our analysis based on a series of rigorous screenings, which comprised 3577 DCs. We conducted a network meta-analysis (NMA) to evaluate the relative effects and rank probability of different CBT delivery formats. A series of analyses and assessments, such as the pairwise meta-analysis and the risk of bias, were performed concurrently. Compared with controls, internet, telephone, and individual showed the largest improvement on depressive symptoms, whereas the unguided self-help delivery format was less effective. Internet delivery formats had the highest probability among the five CBT delivery formats. Our study indicated that the internet might be the best delivery formats for reducing the depression of family DCs. The findings from our study may be useful for policy makers and service commissioners when they make choices among different CBT delivery formats.

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Acupuncture for emotional disorders in patients with migraine: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2019-034290 ◽

2020 ◽

Vol 10 (1) ◽

pp. e034290 ◽

Cited By ~ 1

Author(s):

Ning Sun ◽

Mingsheng Sun ◽

Zhengjie Li ◽

Rui-Rui Sun ◽

Ling Zhao ◽

...

Keyword(s):

Systematic Review ◽

Emotional Disorders ◽

Emotional Functioning ◽

Risk Of Bias ◽

Biomedical Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

Systematic Review Protocol ◽

China National Knowledge Infrastructure ◽

Review Protocol

IntroductionMigraine is the second-leading cause of years lived with disability worldwide. The high prevalence of migraine-related emotional disorders is often overlooked. Acupuncture is often used to treat both migraine and emotional disorders. This systematic review protocol aims to analyse whether acupuncture is effective for treating emotional disorders in patients with migraine.Methods and analysisNine databases will be searched from inception to may 2019: cochrane central register of controlled trials, medline, embase, allied and complementary medicine database, cinahl, china national knowledge infrastructure, chinese biomedical literature database, vip database and wanfang database. Randomised controlled trials (rcts) of acupuncture therapy for migraine with emotional functioning outcomes, which were reported in chinese or english, will be included. The primary outcome is the change in emotional functioning. Study selection, data extraction and assessment of the risk of bias will be performed independently by two or more reviewers. Revman software (v.5.3) will be used to perform the assessment of the risk of bias and data synthesis.Ethics and disseminationEthics approval is not be needed because the data will not contain individual patient data, and there are no concerns about privacy. The results of this meta-analysis will be disseminated through publication in a peer-reviewed journal or relevant conference.Trial registration numberCRD42019139433.

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The Effectiveness of Acupuncture and Moxibustion for Rheumatoid Arthritis: A Protocol of an Overview of Systematic Reviews and Meta-analysis

10.21203/rs.3.rs-70147/v1 ◽

2020 ◽

Author(s):

Genhua Tang ◽

Jun Xiong ◽

Siyuan Zhu ◽

Zhiying Zhong ◽

Jun Chen ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Reviews ◽

Meta Analysis ◽

Scientific Journal ◽

Joint Damage ◽

Biomedical Literature ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Acupuncture And Moxibustion ◽

Meta Analyses

Abstract Background: Rheumatoid Arthritis(RA) is a common chronic disease with an annual incidence of 25 per 10000 of the population, which will result in severe joint damage,disability and death. It is strongly supported by systematic reviews (SRs) as part of the treatment of these patients. However, the evidence has not been methodically integrated. This overview aims to describe,synthesize,evaluate the reliability of evidence come from current systematic reviews of acupuncture and moxibustion therapy for RA.Methods: We will search for SRs and meta-analyses from Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, PubMed, MEDLINE, Wan-Fang Databases,China National Knowledge Infrastructure (CNKI), Citation Information by National Institute of Informatics, Chinese Biomedical Literature Database(CBM),Chinese Scientific Journal Database(VIP Database). Additionally, we will search for the ongoing, unpublished, or recently completed SRs on the PROSPERO database. Two reviewers will assess those SRs, select data independently. Any disagreement will be resolved through discussion or arbitrated by the third author if necessary. The overview of SRs and meta-analysis will be reportedaccording to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA)statement.Results: The results in this study will be published in a peer-reviewed journal.Conclusion: The conclusion of our study expects to provide extensive evidence from multiple meta-analysis and systematic reviews for patients with RA.INPLASY registration number:INPLASY202080031.

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Efficacy of tripterygium glycosides combined with ARB on diabetic nephropathy: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20202391 ◽

2020 ◽

Vol 40 (11) ◽

Author(s):

Xue Wu ◽

Youye Huang ◽

Yao Zhang ◽

Chunling He ◽

Yongli Zhao ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Meta Analysis ◽

Combined Treatment ◽

Mean Difference ◽

Biomedical Literature ◽

Controlled Trials ◽

Angiotensin Ii Receptor Blocker ◽

Cochrane Central Register ◽

Significant Difference ◽

Tripterygium Glycosides

Abstract The purpose of this meta-analysis was to evaluate the beneficial and adverse effects of tripterygium glycosides (TGs) combined with angiotensin II receptor blocker (ARB) on diabetic nephropathy (DN). We searched for randomized controlled trials (RCTs) in PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Biomedical Literature Database, China Science and Technology Journal Database up to June 2017. Weighted mean difference (WMD) and standardized mean difference (SMD) were used for continuous variables and all variables were expressed by 95% confidence interval (CI). Twenty-three studies with 1810 DN patients were included in this meta-analysis. TG combined with ARB statistically significantly improved 24-h urinary total protein (24-h UTP) (SMD = −1.46; 95% CI = −1.84 to −1.09; P<0.00001), urinary albumin excretion rate (UAER) (SMD = −6.9; 95% CI = −9.65 to −4.14, P<0.00001), serum creatinine (SCr) (WMD = −7.65.14; 95% CI = −12.99 to −2.31; P=0.005) and albumin (Alb) (WMD = 5.7; 95% CI = 4.44 to 6.96; P<0.00001) more than did ARB alone. TG combined with ARB statistically significantly affected the level of serum glutamic pyruvic transaminase (SGPT) (WMD = 1.08; 95% CI = 0.04 to 2.12, P=0.04) more than did ARB alone. Compared with ARB alone, TG combined with ARB showed no significant difference in improving blood urea nitrogen (BUN) and hemoglobin A1c (HbA1c). Minor side effects from the combined treatment were observed and mainly focused on the abnormal liver function. TG combined with ARB offers a novel concept in treating DN, more high-quality RCTs are needed for better understanding and applying the combined treatment in DN.

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Acupuncture for constipation in patients with stroke: protocol of a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2017-020400 ◽

2018 ◽

Vol 8 (3) ◽

pp. e020400 ◽

Cited By ~ 4

Author(s):

Jingbo Zhai ◽

Wei Mu ◽

Jinhua Si ◽

Yan Li ◽

Chen Zhao ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Meta Analysis ◽

Scientific Journal ◽

Primary Outcome Measure ◽

Integrated System ◽

Primary Data ◽

Controlled Trials ◽

Cochrane Central Register ◽

Medical Database

IntroductionConstipation is one of the most common complications in patients with stroke. Acupuncture has gained increased popularity for the management of constipation. However, there is a lack of supportive evidence on the efficacy of acupuncture for poststroke constipation. This systematic review aims to collect and critically appraise all the available evidence about the efficacy and safety of the acupuncture for constipation in poststroke patients.Methods and analysisA comprehensive search of Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, four Chinese databases (National Knowledge Infrastructure (CNKI), Chinese Biomedical Literatures database (CBM), Wanfang Digital Periodicals (WANFANG) and Chinese Science and Technology Periodicals (VIP) database), one Japanese medical database (National Institute of Informatics, CiNii) and one Korean medical database (Oriental Medicine Advanced Searching Integrated System, OASIS) will be conducted to identify randomised controlled trials of acupuncture for constipation in poststroke patients. There is no restriction on language or publication status. The primary outcome measure will be frequency of bowel movement. The risk of bias will be assessed using the approach recommended by Cochrane Handbook for Systematic Reviews of Interventions. We will conduct the meta-analysis to synthesise the evidence for each outcome, if possible. The heterogeneity will be statistically assessed using a χ2test and I2statistic. This protocol is developed following the guideline of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols 2015.Ethics and disseminationThe ethical approval is not required because no primary data are collected. The findings will be presented at scientific conferences or a peer-reviewed scientific journal.PROSPERO registration numberCRD42017076880.

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Nasogastric Nutrition versus Nasojejunal Nutrition in Patients with Severe Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials

Gastroenterology Research and Practice ◽

10.1155/2016/6430632 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Youfeng Zhu ◽

Haiyan Yin ◽

Rui Zhang ◽

Xiaoling Ye ◽

Jianrui Wei

Keyword(s):

Acute Pancreatitis ◽

Randomized Controlled Trials ◽

Severe Acute Pancreatitis ◽

Small Sample Size ◽

Meta Analysis ◽

Small Sample ◽

Controlled Trials ◽

Cochrane Central Register ◽

China National Knowledge Infrastructure ◽

Randomized Controlled

Introduction.Previous studies have shown that the nasogastric (NG) route seems equivalent to the nasojejunal (NJ) route in patients with severe acute pancreatitis (SAP). However, these studies used a small sample size and old criteria for diagnosing SAP, which may include some patients with moderate SAP, according to the newly established SAP criteria (Atlanta 2012 classification). Based on the changes in the criteria for classifying SAP, we performed an up-to-date meta-analysis.Method.We reviewed the PubMed, EMbase, China National Knowledge Infrastructure, Wanfang Database, and Cochrane Central Register of Controlled Trials electronic databases. We included randomized controlled trials comparing NG and NJ nutrition in patients with SAP. We performed the meta-analysis using the Cochrane Collaborations’ RevMan 5.3 software.Results.We included four randomized controlled trials involving 237 patients with SAP. There were no significant differences in the incidence of mortality, infectious complications, digestive complications, achievement of energy balance, or length of hospital stay between the NG and NJ nutrition groups.Conclusions.NG nutrition was as safe and effective as NJ nutrition in patients with SAP. Further studies are needed to confirm our results.

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